May 26th is my 60th birthday. As a gift to me, please pass this newsletter on to at least one person you think might be interested. I'd love to double my readership. Thanks for reading and your ongoing support!

Forgive and Let Live

In the podcast, Feel Better, Live More with Dr Rangan Chatterjee: #448 A Proven Prescription for Health and Happiness: Why Being Able To Forgive Improves Your Physical & Mental Wellbeing Dr. Rangan Chatterjee discusses the importance of forgiveness with Dr. Fred Luskin, a clinical psychologist from Stanford University. Dr. Luskin, the director of the Stanford University Forgiveness Projects, emphasizes that forgiveness is a crucial yet often overlooked component of health. He argues that while diet, exercise, stress, and sleep are vital, the ability to forgive can significantly improve both mental and physical wellbeing. According to Dr. Luskin, forgiveness is a perspective that can lead to profound healing and a happier life. (Thanks, Megan).

Hard Facts on Stool

Michael Harrop's Human Microbes has created a controversial black market for fecal microbiota transplants (FMT), used to treat conditions like cystitis and irritable bowel syndrome. Despite the FDA only approving FMT for Clostridioides difficile, desperate patients like Alexandra seek alternative cures from this underground source. Despite lacking medical credentials, Harrop matches "super-donors" with buyers, selling stool for $1,000 per dose. While some report miraculous recoveries, medical experts warn of severe risks and unknown long-term effects, urging caution and further research. Fecal microbiota transplant: Inside the black market for human poop.

Fit or Fat

A recent study by the University of Aberdeen reveals that exercise enhances the body's ability to metabolize saturated fats. The research focused on the "athlete's paradox," which observes that endurance athletes and people with type 2 diabetes store high levels of muscle fat. Through an eight-week experiment involving 29 athletes and 30 people with diabetes, researchers discovered that exercise enables people with diabetes to store and burn saturated fat efficiently, mirroring the athletes' fat metabolism. The study underscores the importance of regular physical activity for improving fat metabolism and overall metabolic health. Exercise improves storage and burning of saturated fat, study finds.

3 M's Sticky Situation

ProPublica's exposé reveals how Kris Hansen, a chemist at 3M, discovered toxic "forever chemicals" (PFAS) in human blood. Initially tasked with verifying external lab results, Hansen confirmed that PFAS contamination was widespread, even in the general population. Despite her findings, 3M executives suppressed the information, halting her research and enforcing secrecy. Decades later, the EPA is now demanding the removal of these chemicals from drinking water. Hansen, who remained silent for years, now grapples with the environmental and health implications of her discovery and 3 M's long-held secrets. How 3M Execs Convinced a Scientist the Forever Chemicals She Found in Human Blood Were Safe — ProPublica.

A Sobering Solution?

Scientists have developed a hydrogel that may be the answer to hangover woes and alcohol-related health issues. Crafted from whey protein and enhanced with iron atoms, sugar molecules, and gold nanoparticles, this gel breaks down alcohol in the gastrointestinal tract. In mouse experiments, it significantly reduced blood alcohol levels and prevented liver damage, weight loss, and gut problems. This novel hydrogel holds promise for both social drinkers and those with chronic alcohol issues, potentially serving as a groundbreaking remedy and preventative measure against alcohol's harmful effects. Clinical trials in humans are anticipated soon. Is this the hangover cure we've been waiting for?

The Brain Microbiome

Recent research suggests that the brain might have its own microbiome, challenging the long-held belief that the brain is a sterile organ. Initial studies from 2013 found non-human genetic material in brain tissue, hinting at the presence of bacteria and viruses. More recent investigations have discovered bacteria and fungi in the brains of both healthy individuals and those with Alzheimer's disease. However, the mechanisms by which these microbes enter the brain remain unclear. This discovery could open new avenues for treating neurological diseases, but further research is needed to fully confirm and understand these findings. Wait, The Brain Has Its Own Microbiome? What New Research Tells Us.

Mellow Yellow

A recent study reveals that D-limonene, a terpene found in citrus fruits and cannabis, reduces anxiety when combined with THC, the psychoactive component in marijuana. Conducted by Johns Hopkins University, the double-blind study involved 20 participants inhaling various doses of THC and limonene. Results showed that higher doses of limonene significantly decreased anxiety and paranoia. While the exact mechanism remains unclear, the study suggests limonene's potential as an anxiolytic agent. This research highlights the need for empirical testing of terpenes' effects, challenging unverified marketing claims in the medicinal cannabis industry. A New Study Found This Molecule Is Linked to Less Anxiety While Stoned.

Sleep Your Way to the Top

In How to Buy Yourself a Longer Life - The New York Times (gift article), Frank Bruni explores Equinox's new luxury membership, "Optimize," costing $40,000 annually and featuring services like a sleep coach, nutritionist, and personal trainer. This deluxe package aims to enhance fitness and longevity, reflecting an increasing obsession among the wealthy with extended youth. Bruni critiques this trend, highlighting the growing economic segregation and the extravagant ways the affluent flaunt their wealth and seek to optimize their lives, underscoring a deepening divide in American society.

Garden Your Way to a Healthier You

Gardening offers multifaceted benefits for both mind and body. Engaging in activities such as shoveling mulch and pulling weeds counts as moderate-intensity exercise, contributing significantly to physical activity goals. Beyond the physical, gardening provides mental health perks, including stress reduction and a sense of purpose. Emilee Weaver from the North Carolina Botanical Garden highlights how nurturing plants can be deeply fulfilling. Studies support these claims, showing that gardeners are more active and enjoy better mental health than non-gardeners. The article briefly mentions exposure to the soil microbiome and its association with mental health. The Health Benefits of Gardening - The New York Times (gift article).

Prior Authorization Frustration

Medicare Advantage plans, touted for reducing waste and inappropriate care, are increasingly criticized for unnecessarily restricting coverage. This issue is starkly illustrated by Marlene Nathanson's experience, whose stroke recovery was abruptly interrupted when her plan denied further treatment coverage. Despite significant progress in therapy, she was given just 48 hours to leave her rehabilitation facility. Traditional Medicare seldom requires prior authorization, but nearly all Advantage plans do, particularly for high-cost services. With more than half of Medicare beneficiaries enrolled in these plans, such denials are becoming alarmingly common. When 'Prior Authorization' Becomes a Medical Roadblock - The New York Times (gift article).