A healthy microbiome is a diverse microbiome. One of the substances up-regulated in those with the healthiest microbiomes is short-chain fatty acids (SCFAs). SCFAs influence gut health directly by acting as food for the cells lining the gastrointestinal tract and by tightening the junctions between cells, but SCFAs are also are increasingly associated with a wide range of systemic health benefits. These benefits include improved immunologic function, lower systemic inflammation, and anti-cancer effects. Individuals with the highest level of SCFAs tend to have the healthiest and most diverse gut flora.
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