A lecture I gave last week.
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Anxiety in the general population has been increasing for years. Add the fear, social isolation, economic impact, and disruption to our routines that go along with a global pandemic, and we have a real problem on our hands. And then there's the comfort food we're eating. Ultra-processed diet is associated with anxiety and depression. The systemic inflammation is thought to at least partially involve the microbiome.
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Obesity is a global epidemic and is far more prevalent in countries that adopt Western patterns of eating. Western patterns of eating include highly processed foods with lots of sugar and fat and the removal of fiber. The U.S. Department of Agriculture (USDA) defines processed food as one that has undergone any change to its natural state
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An article in the New York Times called attention to a recent study that investigated the biochemical / molecular changes of the body with exercise. The study, published in Cell, used multi-omics to catalog and quantify over 9000 different molecules that changed with exertion.
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A healthy microbiome is a diverse microbiome. One of the substances up-regulated in those with the healthiest microbiomes is short-chain fatty acids (SCFAs). SCFAs influence gut health directly by acting as food for the cells lining the gastrointestinal tract and by tightening the junctions between cells, but SCFAs are also are increasingly associated with a wide range of systemic health benefits. These benefits include improved immunologic function, lower systemic inflammation, and anti-cancer effects. Individuals with the highest level of SCFAs tend to have the healthiest and most diverse gut flora.
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If I had to pick one recommendation to improve most people's health, that recommendation would be to decrease inflammation. Inflammation is your body's way of protecting itself from injury, illness, and infection. However, runaway inflammation has profound effects on your health. Uncontrolled inflammation is implicated in a wide range of chronic diseases, including obesity, anxiety/depression, cardiovascular disease, diabetes, Alzheimer's Disease, inflammatory bowel disease, cancer, and many others.
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