Melanoma

047 - Quiet Cravings, Post-Truth World, and Microbiome/Melanoma - HealthHippieMD Week In Review

Aging Time Warp

In I'm 53 years old. I'm 36 in my head, Jennifer Senior delves into the mysterious phenomenon of feeling younger than one's actual age. Drawing from various studies, Senior reveals that adults over 40 tend to perceive themselves as approximately 20 percent younger. The discrepancy between chronological and internal age can be attributed to various factors, including a sense of optimism and the reminiscence bump. Senior highlights the cultural and societal influences on subjective age, ultimately suggesting that feeling younger can positively affect health and well-being.

Countering Amygdala Hijacking

Conflict is inevitable in human relationships, but it doesn't have to be destructive. In the article, 6 steps to manage conflict with emotional intelligence,, the importance of emotional intelligence in handling conflict is highlighted. The author explains the concept of "amygdala hijacking," where our emotional responses take over during disputes, and offers strategies to counteract this effect. The six methods include:

  • Understanding your conflict style.
  • Identifying the core issues.
  • Practicing self-regulation and calmness.
  • Avoiding destructive communication habits.
  • Fostering appreciation and empathy.
  • Developing these skills through practice.

By employing these strategies, individuals can transform conflicts into opportunities for growth and deeper connections.

Beyond B.M.I.

The American Medical Association (A.M.A.) has acknowledged the limitations and potential harm of relying solely on body mass index (B.M.I.) to measure weight and health. The A.M.A. recognizes the historical exclusion and racial bias associated with B.M.I in a new policy. The recommendation encourages doctors to consider additional factors such as visceral fat, body adiposity index, body composition, and genetic/metabolic factors when assessing a patient's health. While B.M.I. may have its uses at a population level, the policy signifies a shift towards a more holistic approach to patient care, emphasizing the need to move beyond B.M.I. as a sole determinant of health. B.M.I. Alone Is Not Enough to Assess Health, American Medical Association says - The New York Times (gift article)

A.I. and a "Post-Truth" World

"A.I. will make it easier to produce disinformation—from fake images to deepfakes to fake news. That will affect people's trust as they're scrolling on social media" Wired had an interesting (dystopian) article on how A.I. might influence humanity. It's not pretty. Humans Aren't Mentally Ready for an AI-Saturated' Post-Truth World' | WIRED

Combatting Chemo Brain

"Chemo brain," a condition characterized by cognitive impairment and memory loss, affects many cancer patients during and after treatment. The causes and persistence of symptoms remain unclear. A multi-pronged approach is recommended to alleviate the chemo brain, including exercise, cognitive behavioral therapy, prioritizing sleep, practicing mindfulness, and potentially exploring psychostimulant medications. While no FDA-approved medicines for chemobrain exist yet, promising research on repurposing drugs initially used for other conditions offers hope for future solutions. Cognitive behavioral therapy may help ease 'chemo brain' - The Washington Post (gift article)

Anxiety Screening During Routine Healthcare

In response to the growing mental health crisis, primary care providers in the United States are encouraged to incorporate anxiety screenings into routine checkups. The U.S. Preventive Services Task Force has published new guidelines recommending that asymptomatic adults, including pregnant and postpartum individuals aged 19 to 64, be screened for anxiety disorders. The aim is to identify and treat anxiety disorders earlier, improving patient outcomes. However, concerns about the burden on an already overburdened mental healthcare system and the potential overdiagnosis of anxiety disorders in communities of color have been raised. Anxiety screening for adults under 65 now recommended at health checkups - The Washington Post (gift article)

Quieting the Cravings

In the article, What Is 'Food Noise'? How Ozempic Quiets Obsessive Thinking About Food - The New York Times (gift article) the New York Times explores the intriguing phenomenon of individuals experiencing diminished "food noise" after taking medications like Ozempic and Wegovy. "Food noise" refers to the constant preoccupation with food and cravings that some people struggle with. The active ingredient in these drugs, semaglutide, affects appetite-regulating areas in the brain and promotes a feeling of fullness. Through interviews and social media stories, the article highlights the relief and freedom reported by individuals who have successfully silenced their "food noise" with these medications.

100 Places to See AFTER You Die

The book 100 Places to See After You Die: A Travel Guide to the Afterlife "surveys ideas from around the world about what happens to us after we die. It's written as a travel guide, with an eclectic mix of 100 accounts, ranging from mythology and religion to ideas floated in books, movies, and T.V. shows." I'm going to check this one out. Ken Jennings visits the afterlife in '100 Places to See After You Die' - The Washington Post (gift article)

Melanoma and the Microbiome

Jamie Rettinger, the first person to undergo a fecal transplant to treat melanoma, shares his remarkable journey. Jamie's cancer spread after being misdiagnosed and mistreated, leaving him with limited treatment options. The experimental approach of fecal transplant, aimed at restoring beneficial bacteria in the gut, showed promising results. The transplant engrafted successfully, and Jamie's body responded to subsequent immunotherapy treatment, leading to the shrinking of melanoma signs. This groundbreaking research offers hope for improved melanoma treatments and emphasizes the potential role of the gut microbiome in shaping immune responses in cancer therapy and beyond. Man who got the first fecal transplant to cure melanoma shares his experience.

010 - Caloric Restriction, Vulnerability Hangovers, and Psychobiotics - HealthHippie Week In Review

Caloric Restriction and Healthspan

An email from the NIH, Calorie restriction, immune function, and health span gave an overview of a recent publication in Science focused on the immune system. In humans, the primary study (called the CALERIE Study) found caloric restriction led to changes in gene activity in body fat and related immune cells. Those that underwent caloric restriction had more prominent, less fatty thymi than controls. Based on findings in the original study, these authors studied a gene (Pla2g7) in mice. Mice who lacked this gene had less inflammation, larger thymi, gained less weight from eating a high-fat diet, burned more fat, and were less likely to develop fatty liver disease than the controls. The authors are trying to identify potential therapeutic targets to enhance longevity.

+If you're interested in this topic, Peter Attia's recent conversation with Matt Kaeberlein, How nutrition impacts longevity, is an insightful discussion. Although sadly, there is not a single mention of the microbiome.

Melanoma and the Microbiome

Within the last several years, there has been convincing evidence that dietary choices (specifically increasing dietary fiber) positively influence the efficacy of melanoma immunotherapy by way of the microbiome: Fiber boosts melanoma patients' response to immunotherapy In a recent paper, unsurprisingly, broad-spectrum antibiotics, at least in mice, seem to have the opposite effect, accelerating tumor growth: Melanoma: Gut microbiome-depleting antibiotics may make it worse

ARPA-H

President Biden named the head of the new Biomedical Research Agency, focused on fighting cancer and other diseases. The new agency, ARPA-H (Advanced Research Projects Agency-Health), jumpstarted by a $1 billion investment from Congress, is modeled after the military's futuristic Defense Advanced Research Projects Agency (DARPA). ARPA-H focuses on high-risk, high-reward areas of innovation. Biden Picks Biotech Executive to Lead New Biomedical Research Agency. Exciting times!

An Overview of Brain Fog

The NY Times had a fascinating overview of brain fog: What Is Brain Fog and How Can I Treat It?

+More on brain fog by one of my favorite science writers: Ed Yong on One of Long COVID's Most Misunderstood Symptoms

CRISPR Musings

Jennifer Doudna was co-recipient of the Nobel Prize in Chemistry for her discovery of CRISPR: Nobel Prize Awarded to Jennifer Doudna And Emmanuelle Charpentier For CRISPR Discovery This week, Dr. Doudna published her thoughts on CRISPR in the Atlantic: Starting a CRISPR Revolution Isn't Enough I highly recommend Walter Isaacson's fantastic biography, The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race.

Does Psychological Stress Increase the Incidence of Long Covid?

This study offers some preliminary evidence that it does: Psychological distress may increase your odds of getting long Covid, study finds.

Why Do Some People Seem Immune to Covid?

Scientists are trying to figure out why: The Mystery of Why Some People Don't Get Covid. Interestingly, there is no mention of interest in the microbiome, which we know influences immunity.

Exercise and Immunity

As if you needed another reason to exercise: The article, Can Exercise Strengthen Your Immunity, gives a synopsis of a recent meta-analysis published in the British Journal of Sports Medicine. The authors of the study found preliminary evidence they believe showed both a protective effect for contracting Covid and a lower likelihood of experiencing severe Covid. Interpretation of the results is controversial, but few argue the overall positive impact of exercise on health.

Alzheimer's Uproar

You've likely seen news stories about a foundational Alzheimer's paper whose findings were recently called into question. The podcast episode, An Alzheimer's uproar, explains the controversy.

+Tools to tease out scientific misconduct: Fake research can be harmful to your health – a new study offers a tool for rooting it out.

Talking to Strangers

When meeting a new person, the prevailing wisdom is you should listen more than you speak. A recent study shows that strategy is wrong: People think they should talk less to be liked, but new research suggests you should speak up in conversations with strangers.

+The benefits of talking to strangers: Why talking to strangers is good for you, them, and all of us.

Vulnerability Hangovers

Shared a little too much with a friend last night? The New York Times has you covered: How to Nurse a Vulnerability Hangover

The Wandering Mind

"...mind-wandering is rarely a waste of time. It is merely our brain trying to get a bit of work done when it is under the impression that there isn't much else going on." Unhappy minds wander in the past, while happy minds often ponder the future." Scientists finally know why we get distracted — and how we can stay on track

CAR-T for Auto-Immunity

CAR-T drugs, today, are used primarily in hard-to-treat cancers. A recent manuscript, Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus, shows how these "living drugs" may play a role in the treatment of autoimmune diseases: How a 'Living Drug' Could Treat Autoimmune Disease

Mental Health, Food, and the Microbiome

Nutritional psychiatry and psychobiotics are reaching popular consciousness. As I was readying this newsletter for publication, the article, Nutritional approaches targeting gut microbiome could improve brain disorders, hit my inbox. Adding the paper, Diet and the microbiota–gut–brain-axis: a primer for clinical nutrition to my reading list.

Quote of the Week

“History doesn't repeat itself, but it often rhymes” – Mark Twain