Psychobiotics

019 - Farmaceuticals, Psychobiotics, and Darwinian Medicine - HealthHippieMD Week In Review

Psychobiotic Diet

The article, This diet helps your mental health by boosting your gut health, discusses food to improve mental health. Psychobiotics and nutritional psychiatry are fields in their infancy, but you're going to hear more and more about the role of food on stress, anxiety, and depression.

YAMS and Sweet Potatoes

Yams and sweet potatoes are NOT the same things. But in the U.S., the names are used interchangeably. Here's the story: What's the Difference Between Sweet Potatoes and Yams?

What Are Sugar Alcohols

Sugar alcohols are in many of today's processed foods. What are they? Sugar Alcohols Are in Many Sugar-Free Foods. What Are They? (gift article)

Darwinian Medicine, Evolutionary Psychiatry

What if illness is not a disease but an adaptation to evolutionary pressures? The provocative article Evidence grows that mental illness is more than dysfunction discusses a controversial way of reframing our thoughts about mental illness.

Humor: An Essential Life Skill

Why a good sense of humor is an essential life skill has a lot to say about the importance of humor in your personal and professional lives.

The Formula for Happiness

"What we think it is about is an attachment to another person. And a sense that another person is there for you, particularly when you need them. We think of relationships as safety nets, as stress regulators." There are many important insights in this podcast/transcript from Arthur Brook's How to Build a Happy Life. A New Formula for Happiness

Pursuing Happiness in All the Wrong Places

More Arthur Brooks. Before he taught at Harvard and wrote publicly about happiness, he led a well-known conservative think tank. The article, America Is Pursuing Happiness in All the Wrong Places, adapted from his November remarks at the Irving Kristol Award & Annual Dinner, is packed with wisdom. Although I am not a conservative, and despite some of the political overtones of the article, his words spoke deeply to me.

Farmaceuticals

Antibiotic resistance is an increasing problem across the world. Here is an article about a new antibiotic isolated from potatoes, incredibly potent against certain types of fungus: New antibiotic found in potato bacteria

Lucid Dreaming

Scientists are studying the phenomenon of lucid dreaming. Lucid Dreaming Is a Mystery We're Starting to Crack is focused on the quality of sleep during lucid dreaming.

Gut Microbiome and Prosocial Behavior

Scientists are studying the role of gut bacteria and the gut-brain axis in prosocial behavior. In a preclinical study with implications for neurodevelopment issues, Researchers found Zebra Fish lacking a gut microbiome are less social and have different brain structures than peers who had normal gut flora. Specifically, the lack of bacteria influenced the microglia of Zebra Fish brains and led to structural changes. It will be interesting to see if a similar phenomenon exists in mammals, especially humans.

Wasted Healthcare Spending

It's conceivable that half of the healthcare dollars are wasted. A small portion of the total, a mind-numbing $160 billion, is attributed to absenteeism-not showing up for appointments. According to the article, A big source of wasted healthcare spending is your fault, one in four appointments is missed. I will track down the NEJM article mentioned, although I'm sure it will raise my blood pressure.

Mindfulness vs. Anti-Anxiety Medications

A recent paper compared Mindfulness-Based Stress Reduction (MBSR) to the medication escitalopram's (Lexipro's) ability to reduce stress. Mindfulness meditation may be just as effective as anxiety medication reports the study, published in JAMA Psychiatry. Although 45 minutes of daily mindfulness practice may not be practical for everyone (I usually only do 15-20 minutes), the paper indicates that cultivating mindfulness should be more widely taught (and prescribed).

+See also my lecture on mindfulness/meditation: Mindfulness-The Basics

More Bugs in Space

Knowledge of what happens to microbial life inside and outside the body while in space is important to understand as we contemplate missions to Mars and beyond. Scientists are struggling to figure out how space transforms our gut microbiome is an overview of the emerging science.

Bed Habits

Is Falling Asleep to TV So Bad? An Investigation is an entertaining article written about an insomniac's immersion into the science of sleep.

How to Recognize and Treat Your Pet's Anxiety

Pet anxiety is quite common. Here is an article to help you decode your pet's behavior and some ideas for treating their anxiety: Puppies on Prozac: How to Handle Your Pet's Anxiety.

Do Something Boring, Yet Engaging to Boost Your Creativity

How to unblock your creativity: Scientists say this bad habit can help is an interesting article on how to boost your creativity and get over mental blocks.

Cannabinoids and Opioids for Pain Relief

Cannabis for pain: A scientist reveals how weed activates our body's opioid system is an overview of work to decode these two substances that might safely work together to alleviate pain.

010 - Caloric Restriction, Vulnerability Hangovers, and Psychobiotics - HealthHippie Week In Review

Caloric Restriction and Healthspan

An email from the NIH, Calorie restriction, immune function, and health span gave an overview of a recent publication in Science focused on the immune system. In humans, the primary study (called the CALERIE Study) found caloric restriction led to changes in gene activity in body fat and related immune cells. Those that underwent caloric restriction had more prominent, less fatty thymi than controls. Based on findings in the original study, these authors studied a gene (Pla2g7) in mice. Mice who lacked this gene had less inflammation, larger thymi, gained less weight from eating a high-fat diet, burned more fat, and were less likely to develop fatty liver disease than the controls. The authors are trying to identify potential therapeutic targets to enhance longevity.

+If you're interested in this topic, Peter Attia's recent conversation with Matt Kaeberlein, How nutrition impacts longevity, is an insightful discussion. Although sadly, there is not a single mention of the microbiome.

Melanoma and the Microbiome

Within the last several years, there has been convincing evidence that dietary choices (specifically increasing dietary fiber) positively influence the efficacy of melanoma immunotherapy by way of the microbiome: Fiber boosts melanoma patients' response to immunotherapy In a recent paper, unsurprisingly, broad-spectrum antibiotics, at least in mice, seem to have the opposite effect, accelerating tumor growth: Melanoma: Gut microbiome-depleting antibiotics may make it worse

ARPA-H

President Biden named the head of the new Biomedical Research Agency, focused on fighting cancer and other diseases. The new agency, ARPA-H (Advanced Research Projects Agency-Health), jumpstarted by a $1 billion investment from Congress, is modeled after the military's futuristic Defense Advanced Research Projects Agency (DARPA). ARPA-H focuses on high-risk, high-reward areas of innovation. Biden Picks Biotech Executive to Lead New Biomedical Research Agency. Exciting times!

An Overview of Brain Fog

The NY Times had a fascinating overview of brain fog: What Is Brain Fog and How Can I Treat It?

+More on brain fog by one of my favorite science writers: Ed Yong on One of Long COVID's Most Misunderstood Symptoms

CRISPR Musings

Jennifer Doudna was co-recipient of the Nobel Prize in Chemistry for her discovery of CRISPR: Nobel Prize Awarded to Jennifer Doudna And Emmanuelle Charpentier For CRISPR Discovery This week, Dr. Doudna published her thoughts on CRISPR in the Atlantic: Starting a CRISPR Revolution Isn't Enough I highly recommend Walter Isaacson's fantastic biography, The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race.

Does Psychological Stress Increase the Incidence of Long Covid?

This study offers some preliminary evidence that it does: Psychological distress may increase your odds of getting long Covid, study finds.

Why Do Some People Seem Immune to Covid?

Scientists are trying to figure out why: The Mystery of Why Some People Don't Get Covid. Interestingly, there is no mention of interest in the microbiome, which we know influences immunity.

Exercise and Immunity

As if you needed another reason to exercise: The article, Can Exercise Strengthen Your Immunity, gives a synopsis of a recent meta-analysis published in the British Journal of Sports Medicine. The authors of the study found preliminary evidence they believe showed both a protective effect for contracting Covid and a lower likelihood of experiencing severe Covid. Interpretation of the results is controversial, but few argue the overall positive impact of exercise on health.

Alzheimer's Uproar

You've likely seen news stories about a foundational Alzheimer's paper whose findings were recently called into question. The podcast episode, An Alzheimer's uproar, explains the controversy.

+Tools to tease out scientific misconduct: Fake research can be harmful to your health – a new study offers a tool for rooting it out.

Talking to Strangers

When meeting a new person, the prevailing wisdom is you should listen more than you speak. A recent study shows that strategy is wrong: People think they should talk less to be liked, but new research suggests you should speak up in conversations with strangers.

+The benefits of talking to strangers: Why talking to strangers is good for you, them, and all of us.

Vulnerability Hangovers

Shared a little too much with a friend last night? The New York Times has you covered: How to Nurse a Vulnerability Hangover

The Wandering Mind

"...mind-wandering is rarely a waste of time. It is merely our brain trying to get a bit of work done when it is under the impression that there isn't much else going on." Unhappy minds wander in the past, while happy minds often ponder the future." Scientists finally know why we get distracted — and how we can stay on track

CAR-T for Auto-Immunity

CAR-T drugs, today, are used primarily in hard-to-treat cancers. A recent manuscript, Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus, shows how these "living drugs" may play a role in the treatment of autoimmune diseases: How a 'Living Drug' Could Treat Autoimmune Disease

Mental Health, Food, and the Microbiome

Nutritional psychiatry and psychobiotics are reaching popular consciousness. As I was readying this newsletter for publication, the article, Nutritional approaches targeting gut microbiome could improve brain disorders, hit my inbox. Adding the paper, Diet and the microbiota–gut–brain-axis: a primer for clinical nutrition to my reading list.

Quote of the Week

“History doesn't repeat itself, but it often rhymes” – Mark Twain