Senesence

023 - Aspartame Anxiety, Psychedelic Spirituality, and Hopewashing - HealthHippieMD Week In Review

Nutritional Psychiatry

An emerging body of literature shows that what we eat impacts our mood. The Economist published an article on the emerging field of nutritional psychiatry: How food affects the mind, as well as the body.

Aspartame and Anxiety

A pre-clinical study (in rodents) demonstrated that the non-nutritive sweetener, Aspartame, at a fraction of the maximum allowable amount suggested by the FDA, may raise the risk of anxiety: Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala. The food industry has pitched non-nutritive sweeteners as being inert. But recent studies show a link between artificial sweeteners and diabetes, heart disease, stroke, and cancer. Can a Common Artificial Sweetener Fuel Anxiety?

Silicon Valley Focuses on Gut Health

Silicon Valley is always looking for the next investment opportunity. Silicon Valley is coming for your gut biome, discusses the burgeoning investment opportunities focused on gut health, supplements, and the microbiome.

+Another article about the future use of microbial therapeutics: Prescription poop could be the future of medicine

Sleep, Phases of Life, and Cognition

A study of 730,000 adults recently published in Nature Communications titled "Reported sleep duration reveals segmentation of the adult life-course into three phases" demonstrated a link between sleep duration and cognitive performance later in life. Sleep duration divides adult lifespan into 3 phases discusses the findings.

Psychedelics and Spirituality

A recent study, Belief changes associated with psychedelic use, found that using psychedelics increased belief in God and the afterlife and altered people's understanding of consciousness. Psychedelics alter beliefs about God, reality, superstition discusses the findings.

Thinking about the future

As each year ends, we spend more time contemplating the future. The Case Against Hopewashing and How to Live on the Precipice of Tomorrow are the first two of three featured articles in Wired Magazine.

Synthetic Brain Cells Taught to Play Pong

Earlier this year, an Australian neuroscientist taught lab-grown neurons to play the video game Pong. The article This neuroscientist taught brain cells to play Pong — and shifted how we view human intelligence forever discusses the implications.

You Can't Unsee This

Public restrooms are just as dirty as you imagine. I've seen many articles about "fecal patinas" caused by aerosolizing toilet water. Of course, scientists had to capture the process on film: Toilets spew invisible aerosol plumes with every flush – here's the proof, captured by high-powered lasers

Toxic Self-Talk Toolkit

We constantly talk to ourselves, and most self-talk is negative. Here is a toolkit to combat the negativity: How to stop toxic self-talk, explained in 6 minutes

Drugs to Fight Aging

Scientists are looking for ways to slow aging and age-related combat diseases like cancer and neurodegeneration. Wired had a short article on new pharmaceuticals based upon the biology of aging: A Drug to Treat Aging May Not Be a Pipe Dream.

The Most Important Thing About Exercise

Slate has a new column, Good Fit, focused on exercise. The first article of the series, Fitness Goals: In 2023, weight loss and even health aren't the most important things about exercise, describes society's movement toward "healthism," and the mixed messages we receive.

New Year's Seven-Day Relationship Challenge

One of the most potent predictors of happiness is the quality of one's relationships. To this end, How to Have a Happier New Year, (gift article) describes a seven-day program to bolster your relationships.

Step-By-Step Guide to Breaking Bad Habits and Starting New Ones

The beginning of the year is a time to reflect on our behavior. Do you have a habit you want to break but have struggled to do so? Wired has a step-by-step guide to aid in your success: How to (Finally) Break That Bad Habit | WIRED +On setting goals: You've Been Choosing Your Goals All Wrong | WIRED

Happy New Year!

018 - Living Medicines, Dangerous Cookware, and Toad Licking - HealthHippieMD Week In Review

No Matter Your Age, Improving Your Diet can Extend Your Life - NEJM

At any age, a healthy diet can extend your life is a recap of the 2018 NEJM Paper, Association of Changes in Diet Quality with Total and Cause-Specific Mortality. The take-home message is "No matter how old you are or how much junk food you consume, it's never too late to start undoing the damage caused by a poor diet."

Gut Check

Radiolab replayed an episode on the importance of your gut: Radiolab: Guts. The episode features stories on a UC Davis fistulated cow, the microbiome, the gut-brain axis, and autoimmune disease. As my daughter exclaimed when she sent me the episode, "This is the most dad-like episode I've ever listened to." She knows me well.

Psychedelics and End-of-Life Care

Colorado approved the legalization of medicinal psilocybin on Tuesday. A physician and nurse wrote an opinion piece on How Psychedelics Can Transform End-of-Life Care.

Wood-Wide Web

Do the trees in the forest "talk" to one another? The debate continues. The Wood Wide Web: Scientists Debate Whether Trees Really Talk (paywall-I'm waiting for my gift articles to replenish)

The Race to Develop "Living Medicines."

This Gulp of Engineered Bacteria Is Meant to Treat Disease features a company engineering E. coli, a gut bacteria, as therapeutic agents. Microbiome therapeutics is a hot area of development these days, with a market expected to grow to $1.5 billion by 2027. Here is a list of some of the top microbiome startups by the amount of funding raised: Top 10 Microbiome startups. (disclosure - I own shares of Seres Therapeutics and Finch Therapeutics)

Dangerous Cookware

The EPA has labeled "forever chemicals," such as PFAS—perfluoroalkyl and polyfluoroalkyl, commonly found in traditional nonstick pans, hazardous substances. That means your nonstick pans are now considered dangerous. Teflon Nonstick Pans Are Bad. Consider These Alternatives discusses the various options to replace your cookware. Time to get my Le Creuset out of storage!

National Park Service Asks Visitors to Stop Licking Toads

Stop licking psychedelic Sonoran Desert toads, National Park Service says is an article about attempts to stop visitors from sampling Bufotoxin, a potent hallucinogen, secreted by Sonoran Desert Toads. The article reminded me of one of my favorite NPR radio stories ever: The Dog Who Loved to Suck on Toads. (listen, don't read)

Cell Senescence, Immunology, Stem Cells, and the Gut

Longevity by Design: Dr. Jennifer Elisseeff—Regenerative Medicine and Immunology was a fascinating discussion about aging, tissue repair, immunology, and cell senescence. The part that most excited me was her current studies investigating the role of the microbiome in stem cell activation. I'm going to track down some of Dr. Elisseeff's papers.

COMPASS Synthetic Psilocybin Study - NEJM

In 003 - Mad Honey, Frisson, and Psychedelic Capitalism I mentioned the controversy behind COMPASS and their attempts to corner the psychedelic market via intellectual property. This week, COMPASS published the results of a study in the NEJM: Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression. Here is an article summarizing the findings: A single dose of psilocybin may alleviate major depression for 12 weeks, study finds.

Quiet Quitting and Going to the "Neutral Zone."

"More of us want to find ways to align our work with our values. And for some of us, those values have changed." Post-pandemic, many people are considering the nature of their employment and, in many cases, "quiet quitting." Quiet quitting is a work phenomenon in which employees do no more than the minimum required by the rules of their contract or job. The author of Have you quietly quit? Your next step: Go to the neutral zone recommends rather than jumping directly into a new job, to take time to reflect before drastically changing the way we work and live. The ZigZag Project is a great resource to help contemplate your professional direction.

How do "Super-Agers" Maintain Their Cognitive Abilities?

Super-agers are elderly individuals for whom aging doesn't seem to impact cognitive abilities. "SuperAgers" with super memory have super neurons summarizes a study attempting to figure out why.

Dietary Fiber and the Efficacy of Immunotherapy

The article, More fiber for the microbiome may boost immunotherapy cancer drugs is an overview of recent studies demonstrating an increased efficacy of immunotherapy drugs based on dietary intake. The microbiome mediates the effect.

Brain Training with Crossword Puzzles

A study published in NEJM Evidence has found that regularly attempting a crossword may help slow decline in some people with mild cognitive impairment, an early stage of faltering memory that can sometimes progress to dementia. Read the summary of the study here: Crossword puzzles may benefit people with mild cognitive impairment .

Quote

"The future influences the present just as much as the past."- Friedrich Nietzsche