Immunotherapy

086 - Emotional Choreography, Musical Flow States, and Brain Waves from the Grave - HealthHippieMD Week In Review

Sweet Relief

Honey, with its long-standing reputation as a natural remedy, is being explored for its potential to alleviate hay fever symptoms. Ancient civilizations utilized honey for medicinal purposes, and today, its anti-inflammatory and anti-allergic properties are of interest. Recent research suggests that honey could act as a form of immunotherapy, desensitizing the immune system to allergens and reducing allergic reactions. Studies have shown that consuming local honey daily can lead to significant improvements in hay fever symptoms. Honey's anti-inflammatory effects, antioxidants, and prebiotic characteristics may contribute to its therapeutic potential. However, not all honey is created equal, and its efficacy can vary depending on its source and processing. While honey shows promise, it should be used alongside conventional therapies and with caution, especially in children under one and individuals with severe allergies. The Truth About Honey And Hay Fever.

Emotional Choreography

The cerebellum, traditionally known for controlling movement, is revealing its deeper role in regulating emotions, social interactions, and complex behaviors. This "little brain" at the back of our heads contains a staggering three-quarters of all brain neurons, organized in a crystalline-like structure. Recent studies, presented at the Society for Neuroscience annual meeting, challenge the long-standing view of the cerebellum's limited function. Using advanced techniques, researchers are uncovering its involvement in maternal behavior, social recognition, and even autism, suggesting it acts as a hub for sensory input and higher cognitive functions. This shift in understanding highlights the cerebellum's integral role in both movement and mental processes, showcasing its significance beyond mere physical coordination. Scientists Are Unlocking the Secrets of Your ‘Little Brain’ | WIRED.

Garden Variety

In this comprehensive guide from The Washington Post, readers are introduced to the basics of starting a vegetable garden. The article emphasizes that anyone can grow vegetables, regardless of space, by selecting the right location, sourcing quality soil, and choosing appropriate plants. It highlights the importance of sunlight, proper drainage, and understanding your hardiness zone for planting. The piece advises starting with easy-to-grow vegetables and incorporating flowers and herbs for a diverse ecosystem. It also stresses the significance of having the right attitude, embracing experimentation, and learning from failures. Overall, the article provides practical tips and encouragement for budding gardeners looking to cultivate their own edible harvest. How to start a vegetable garden - The Washington Post (gift article).

Fortune's Folly

Big Think had an excellent video on the myth of the billionaire genius."wealth is not directly correlated with brain power. Thinking smarter and working harder does not always make you rich; most of the time, it’s just about being positioned at the luckiest spot on the bell curve." Debunking the ‘billionaire = genius’ myth - Big Think.

Jazzing Up the Brain

A study conducted by Drexel University's Creativity Research Lab reveals the neural underpinnings of achieving a state of "flow" in creativity, particularly among jazz musicians in the Philadelphia area. By examining the brain activity of 32 jazz guitarists through EEG scans while they improvised, researchers found that flow is associated with reduced activity in the frontal lobes, which are responsible for executive function and cognitive control. This suggests that letting go of conscious control is key to reaching this state. The study also showed that experienced musicians were more likely to achieve flow, indicating that a foundation of expertise is necessary before one can truly "just wail," as jazz legend Charlie Parker advised. These findings not only shed light on the neural mechanisms of flow but also suggest practical strategies for enhancing creative thinking. Brain scans of Philly jazz musicians reveal secrets to reaching creative flow.

Sleep

Up to 2/3 of adults will suffer from insomnia at some point in their life. The National Center for Integrative and Complementary Health has an excellent science-based overview of various interventions: [Mind and Body Practices for Sleep Disorders: What the Science Says | NCCIH.](https://www.nccih.nih.gov/health/providers/digest/psychological-and-physical-approaches-for-sleep-disorders-science +see also Sleep Disorders – Common Types, Symptoms, Treatments | Sleep Foundation.

Brain Waves from the Grave

The new science of death: ‘There’s something happening in the brain that makes no sense’ explores the enigmatic phenomenon of heightened brain activity in individuals at the brink of death, challenging conventional understanding of the dying process. In particular, it delves into the case of "Patient One," whose brain exhibited remarkable electrical signals and connectivity even after life support was removed. This unexpected discovery, made by neurologist Jimo Borjigin and her team at the University of Michigan, suggests that the brain may enter a hyperactive state during the final moments of life, potentially giving rise to near-death experiences. The findings have profound implications for our comprehension of consciousness and the boundaries between life and death, propelling the scientific community towards new frontiers in the study of the dying brain and the possibility of reversing death itself.

Matrix of Productivity

The Eisenhower matrix, named after the 34th President of the United States, is a powerful tool for enhancing productivity by organizing tasks based on their urgency and importance. Although there's no evidence that Eisenhower himself used the matrix, its principles align with his famous saying, "What is important is seldom urgent and what is urgent is seldom important." The matrix divides tasks into four categories: do (urgent and important), decide (important but not urgent), delegate (urgent but not important), and delete (neither urgent nor important). By regularly revisiting and adjusting the matrix, individuals can maintain focus on their goals and values, ensuring that they invest their time in what truly matters. This method not only aids in managing day-to-day tasks but also helps in aligning efforts with long-term objectives, promoting a balanced and fulfilling life. Why the “Eisenhower matrix” is a fantastic productivity hack - Big Think.

A Nosh Above

Manischewitz, the 136-year-old kosher food brand, is spicing up its image with a vibrant rebrand aimed at attracting new customers and making kosher cuisine a culinary destination. The new packaging features tangerine hues, arched logos, and Hebrew-inspired accents. Shani Seidman, CMO of parent company Kayco, envisions broadening the brand's appeal beyond traditional consumers to those curious about diverse cuisines. The rebrand includes an expanded product range, from frozen matzoh balls to "Mani'z" snacks, and quirky merchandise like "Man I Shvitz" T-shirts. Despite the risks of alienating loyal customers, the move is seen as vital for the brand's long-term survival and relevance in a changing market. Manischewitz hopes its rebrand will make kosher food cool - The Washington Post (gift article).

070 - Gut Glia, Quercetin, and Defining Death - HealthHippieMD Week In Review

Inoculating Against the Blues

A Vaccine for Depression - Nautilus delves into the pioneering research on developing a vaccine-like treatment for depression. This innovative approach focuses on targeting the immune system, which plays a crucial role in mental health. Researchers have discovered that certain immune responses can exacerbate depressive symptoms. By modulating these responses, it's possible to alleviate depression. This groundbreaking work opens up a new frontier in mental health treatment, moving beyond traditional methods and offering hope for more effective and lasting solutions for those battling depression.

A Grape Pain

A recent study has identified quercetin, a compound in red wine, as a potential cause of the notorious red wine headaches. This discovery challenges previous beliefs that tannins, sulfites, or histamines were to blame. Quercetin, found in grape skins, is beneficial as a grape sunscreen and a human antioxidant, but when combined with alcohol, it can disrupt the body's process of breaking down alcohol, leading to headaches. The study, co-authored by Andrew Waterhouse and Morris Levin, reveals that quercetin blocks an enzyme crucial for converting acetaldehyde into acetate, causing a buildup of toxins and resulting in headaches. Interestingly, cheaper wines tend to have less quercetin due to less exposure to the sun on grapes, potentially offering a workaround for those prone to these headaches. However, there's no definitive cure yet, and further research will explore this phenomenon more deeply. Why red wine gives you headaches, according to science - The Washington Post (gift article).

The Double-Edged CAR-T Sword

The FDA has raised concerns that CAR-T, a groundbreaking cancer treatment, might paradoxically cause new cancers in some patients. Approved in November 2017 for severe blood cancers, CAR-T therapy involves genetically modifying a patient's T cells to attack cancer cells. Despite its life-saving potential, the FDA reported 19 cases of new blood cancers post-treatment. While the risk is considered small and the benefits significant, this development has sparked a debate in the medical community. The FDA is investigating these cases to determine if there's a direct causal link between the treatment and the emergence of new cancers amidst CAR-T's remarkable success in saving thousands of lives. CAR-T, Lifesaving Cancer Treatment, May Sometimes Cause Cancer, FDA Says - The New York Times (gift article).

New Coursera Course on Generative AI

Coursera has fabulous free courses taught by the world's experts. I'm adding the course mentioned in Generative AI for Everyone: A Free Course from AI Pioneer Andrew Ng | Open Culture to my list to take after I finish my current course: Songwriting: Writing the Music | Coursera.

Symphony of Health

Speaking of music, are you curious about how to harness the power of music to help manage different conditions or symptoms? If so, you might be interested in the National Center for Complementary and Integrative Health's free virtual meeting, "[Music as Medicine: The Science and Clinical Practice][1]," on December 14–15, 2023. The 2-day event will share what's been learned in recent years and chart a path forward for growing the research to drive deeper scientific understanding of this topic. See you there!

Gut Glia

In the Gut's 'Second Brain,' Key Agents of Health Emerge delves into the fascinating world of glial cells in the enteric nervous system, often overshadowed by neurons. These cells play a crucial role in digestion and disease, a fact that scientists are just beginning to unravel. The gut, equipped with its complex network of nerve cells, functions almost independently from the brain and is responsible for digestion, from breaking down food to nutrient absorption and waste elimination. Recent studies have highlighted enteric glia's diverse and active role in this process, including their involvement in nutrient absorption, blood flow, immune responses, and even gut motility. This newfound understanding of glial cells in the gut could pave the way for novel treatments for gastrointestinal disorders and enhance our comprehension of the digestive system's intricate workings.

Hypnotic Gut Healing

In a surprising turn of medical treatment, hypnotherapy emerges as a potential relief for gut disorders. A story in the Atlantic centers around Zack Rogers, who, on his 12th birthday, began experiencing severe stomach pain, leading to a drastic weight loss and a prolonged struggle with his health. After years of ineffective medical treatments and facing the prospect of major surgery, Zack's mother sought a second opinion, which led to hypnotherapy. This unconventional approach gradually brought significant improvements, involving deep focus and relaxation to alter thought patterns. Zack's recovery was so profound that he regained his everyday life, including playing sports and attending college, a future that seemed impossible before the hypnotherapy. This case highlights hypnotherapy's unexpected yet impactful role in treating severe gut disorders. Hypnosis Could Work Wonders on IBS - The Atlantic.

How Much Protein Do You Really Need?

The NY Times summed up the current recommendations in How Much Protein You Need As You Age - The New York Times (gift article).

Defining Death

What is death? | MIT Technology Review delves into the evolving understanding of death in neuroscience. It challenges traditional perceptions of death, suggesting it should be viewed as a transient process rather than an irreversible event. This shift in perspective emerged with medical advancements like CPR and mechanical ventilators, which blurred the lines between life and death. The concept of brain death, arising from observations of patients with severe brain damage, further complicated the definition of death. This has sparked medical, ethical, and legal debates. The article highlights that despite these advancements, the scientific understanding of the dying brain remains complex and filled with unanswered questions.

018 - Living Medicines, Dangerous Cookware, and Toad Licking - HealthHippieMD Week In Review

No Matter Your Age, Improving Your Diet can Extend Your Life - NEJM

At any age, a healthy diet can extend your life is a recap of the 2018 NEJM Paper, Association of Changes in Diet Quality with Total and Cause-Specific Mortality. The take-home message is "No matter how old you are or how much junk food you consume, it's never too late to start undoing the damage caused by a poor diet."

Gut Check

Radiolab replayed an episode on the importance of your gut: Radiolab: Guts. The episode features stories on a UC Davis fistulated cow, the microbiome, the gut-brain axis, and autoimmune disease. As my daughter exclaimed when she sent me the episode, "This is the most dad-like episode I've ever listened to." She knows me well.

Psychedelics and End-of-Life Care

Colorado approved the legalization of medicinal psilocybin on Tuesday. A physician and nurse wrote an opinion piece on How Psychedelics Can Transform End-of-Life Care.

Wood-Wide Web

Do the trees in the forest "talk" to one another? The debate continues. The Wood Wide Web: Scientists Debate Whether Trees Really Talk (paywall-I'm waiting for my gift articles to replenish)

The Race to Develop "Living Medicines."

This Gulp of Engineered Bacteria Is Meant to Treat Disease features a company engineering E. coli, a gut bacteria, as therapeutic agents. Microbiome therapeutics is a hot area of development these days, with a market expected to grow to $1.5 billion by 2027. Here is a list of some of the top microbiome startups by the amount of funding raised: Top 10 Microbiome startups. (disclosure - I own shares of Seres Therapeutics and Finch Therapeutics)

Dangerous Cookware

The EPA has labeled "forever chemicals," such as PFAS—perfluoroalkyl and polyfluoroalkyl, commonly found in traditional nonstick pans, hazardous substances. That means your nonstick pans are now considered dangerous. Teflon Nonstick Pans Are Bad. Consider These Alternatives discusses the various options to replace your cookware. Time to get my Le Creuset out of storage!

National Park Service Asks Visitors to Stop Licking Toads

Stop licking psychedelic Sonoran Desert toads, National Park Service says is an article about attempts to stop visitors from sampling Bufotoxin, a potent hallucinogen, secreted by Sonoran Desert Toads. The article reminded me of one of my favorite NPR radio stories ever: The Dog Who Loved to Suck on Toads. (listen, don't read)

Cell Senescence, Immunology, Stem Cells, and the Gut

Longevity by Design: Dr. Jennifer Elisseeff—Regenerative Medicine and Immunology was a fascinating discussion about aging, tissue repair, immunology, and cell senescence. The part that most excited me was her current studies investigating the role of the microbiome in stem cell activation. I'm going to track down some of Dr. Elisseeff's papers.

COMPASS Synthetic Psilocybin Study - NEJM

In 003 - Mad Honey, Frisson, and Psychedelic Capitalism I mentioned the controversy behind COMPASS and their attempts to corner the psychedelic market via intellectual property. This week, COMPASS published the results of a study in the NEJM: Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression. Here is an article summarizing the findings: A single dose of psilocybin may alleviate major depression for 12 weeks, study finds.

Quiet Quitting and Going to the "Neutral Zone."

"More of us want to find ways to align our work with our values. And for some of us, those values have changed." Post-pandemic, many people are considering the nature of their employment and, in many cases, "quiet quitting." Quiet quitting is a work phenomenon in which employees do no more than the minimum required by the rules of their contract or job. The author of Have you quietly quit? Your next step: Go to the neutral zone recommends rather than jumping directly into a new job, to take time to reflect before drastically changing the way we work and live. The ZigZag Project is a great resource to help contemplate your professional direction.

How do "Super-Agers" Maintain Their Cognitive Abilities?

Super-agers are elderly individuals for whom aging doesn't seem to impact cognitive abilities. "SuperAgers" with super memory have super neurons summarizes a study attempting to figure out why.

Dietary Fiber and the Efficacy of Immunotherapy

The article, More fiber for the microbiome may boost immunotherapy cancer drugs is an overview of recent studies demonstrating an increased efficacy of immunotherapy drugs based on dietary intake. The microbiome mediates the effect.

Brain Training with Crossword Puzzles

A study published in NEJM Evidence has found that regularly attempting a crossword may help slow decline in some people with mild cognitive impairment, an early stage of faltering memory that can sometimes progress to dementia. Read the summary of the study here: Crossword puzzles may benefit people with mild cognitive impairment .

Quote

"The future influences the present just as much as the past."- Friedrich Nietzsche