May 26th is my 60th birthday. As a gift to me, please pass this newsletter on to at least one person you think might be interested. I'd love to double my readership. Thanks for reading and your ongoing support!

Forgive and Let Live

In the podcast, Feel Better, Live More with Dr Rangan Chatterjee: #448 A Proven Prescription for Health and Happiness: Why Being Able To Forgive Improves Your Physical & Mental Wellbeing Dr. Rangan Chatterjee discusses the importance of forgiveness with Dr. Fred Luskin, a clinical psychologist from Stanford University. Dr. Luskin, the director of the Stanford University Forgiveness Projects, emphasizes that forgiveness is a crucial yet often overlooked component of health. He argues that while diet, exercise, stress, and sleep are vital, the ability to forgive can significantly improve both mental and physical wellbeing. According to Dr. Luskin, forgiveness is a perspective that can lead to profound healing and a happier life. (Thanks, Megan).

Hard Facts on Stool

Michael Harrop's Human Microbes has created a controversial black market for fecal microbiota transplants (FMT), used to treat conditions like cystitis and irritable bowel syndrome. Despite the FDA only approving FMT for Clostridioides difficile, desperate patients like Alexandra seek alternative cures from this underground source. Despite lacking medical credentials, Harrop matches "super-donors" with buyers, selling stool for $1,000 per dose. While some report miraculous recoveries, medical experts warn of severe risks and unknown long-term effects, urging caution and further research. Fecal microbiota transplant: Inside the black market for human poop.

Fit or Fat

A recent study by the University of Aberdeen reveals that exercise enhances the body's ability to metabolize saturated fats. The research focused on the "athlete's paradox," which observes that endurance athletes and people with type 2 diabetes store high levels of muscle fat. Through an eight-week experiment involving 29 athletes and 30 people with diabetes, researchers discovered that exercise enables people with diabetes to store and burn saturated fat efficiently, mirroring the athletes' fat metabolism. The study underscores the importance of regular physical activity for improving fat metabolism and overall metabolic health. Exercise improves storage and burning of saturated fat, study finds.

3 M's Sticky Situation

ProPublica's exposé reveals how Kris Hansen, a chemist at 3M, discovered toxic "forever chemicals" (PFAS) in human blood. Initially tasked with verifying external lab results, Hansen confirmed that PFAS contamination was widespread, even in the general population. Despite her findings, 3M executives suppressed the information, halting her research and enforcing secrecy. Decades later, the EPA is now demanding the removal of these chemicals from drinking water. Hansen, who remained silent for years, now grapples with the environmental and health implications of her discovery and 3 M's long-held secrets. How 3M Execs Convinced a Scientist the Forever Chemicals She Found in Human Blood Were Safe — ProPublica.

A Sobering Solution?

Scientists have developed a hydrogel that may be the answer to hangover woes and alcohol-related health issues. Crafted from whey protein and enhanced with iron atoms, sugar molecules, and gold nanoparticles, this gel breaks down alcohol in the gastrointestinal tract. In mouse experiments, it significantly reduced blood alcohol levels and prevented liver damage, weight loss, and gut problems. This novel hydrogel holds promise for both social drinkers and those with chronic alcohol issues, potentially serving as a groundbreaking remedy and preventative measure against alcohol's harmful effects. Clinical trials in humans are anticipated soon. Is this the hangover cure we've been waiting for?

The Brain Microbiome

Recent research suggests that the brain might have its own microbiome, challenging the long-held belief that the brain is a sterile organ. Initial studies from 2013 found non-human genetic material in brain tissue, hinting at the presence of bacteria and viruses. More recent investigations have discovered bacteria and fungi in the brains of both healthy individuals and those with Alzheimer's disease. However, the mechanisms by which these microbes enter the brain remain unclear. This discovery could open new avenues for treating neurological diseases, but further research is needed to fully confirm and understand these findings. Wait, The Brain Has Its Own Microbiome? What New Research Tells Us.

Mellow Yellow

A recent study reveals that D-limonene, a terpene found in citrus fruits and cannabis, reduces anxiety when combined with THC, the psychoactive component in marijuana. Conducted by Johns Hopkins University, the double-blind study involved 20 participants inhaling various doses of THC and limonene. Results showed that higher doses of limonene significantly decreased anxiety and paranoia. While the exact mechanism remains unclear, the study suggests limonene's potential as an anxiolytic agent. This research highlights the need for empirical testing of terpenes' effects, challenging unverified marketing claims in the medicinal cannabis industry. A New Study Found This Molecule Is Linked to Less Anxiety While Stoned.

Sleep Your Way to the Top

In How to Buy Yourself a Longer Life - The New York Times (gift article), Frank Bruni explores Equinox's new luxury membership, "Optimize," costing $40,000 annually and featuring services like a sleep coach, nutritionist, and personal trainer. This deluxe package aims to enhance fitness and longevity, reflecting an increasing obsession among the wealthy with extended youth. Bruni critiques this trend, highlighting the growing economic segregation and the extravagant ways the affluent flaunt their wealth and seek to optimize their lives, underscoring a deepening divide in American society.

Garden Your Way to a Healthier You

Gardening offers multifaceted benefits for both mind and body. Engaging in activities such as shoveling mulch and pulling weeds counts as moderate-intensity exercise, contributing significantly to physical activity goals. Beyond the physical, gardening provides mental health perks, including stress reduction and a sense of purpose. Emilee Weaver from the North Carolina Botanical Garden highlights how nurturing plants can be deeply fulfilling. Studies support these claims, showing that gardeners are more active and enjoy better mental health than non-gardeners. The article briefly mentions exposure to the soil microbiome and its association with mental health. The Health Benefits of Gardening - The New York Times (gift article).

Prior Authorization Frustration

Medicare Advantage plans, touted for reducing waste and inappropriate care, are increasingly criticized for unnecessarily restricting coverage. This issue is starkly illustrated by Marlene Nathanson's experience, whose stroke recovery was abruptly interrupted when her plan denied further treatment coverage. Despite significant progress in therapy, she was given just 48 hours to leave her rehabilitation facility. Traditional Medicare seldom requires prior authorization, but nearly all Advantage plans do, particularly for high-cost services. With more than half of Medicare beneficiaries enrolled in these plans, such denials are becoming alarmingly common. When 'Prior Authorization' Becomes a Medical Roadblock - The New York Times (gift article).

Sweet Relief

Honey, with its long-standing reputation as a natural remedy, is being explored for its potential to alleviate hay fever symptoms. Ancient civilizations utilized honey for medicinal purposes, and today, its anti-inflammatory and anti-allergic properties are of interest. Recent research suggests that honey could act as a form of immunotherapy, desensitizing the immune system to allergens and reducing allergic reactions. Studies have shown that consuming local honey daily can lead to significant improvements in hay fever symptoms. Honey's anti-inflammatory effects, antioxidants, and prebiotic characteristics may contribute to its therapeutic potential. However, not all honey is created equal, and its efficacy can vary depending on its source and processing. While honey shows promise, it should be used alongside conventional therapies and with caution, especially in children under one and individuals with severe allergies. The Truth About Honey And Hay Fever.

Emotional Choreography

The cerebellum, traditionally known for controlling movement, is revealing its deeper role in regulating emotions, social interactions, and complex behaviors. This "little brain" at the back of our heads contains a staggering three-quarters of all brain neurons, organized in a crystalline-like structure. Recent studies, presented at the Society for Neuroscience annual meeting, challenge the long-standing view of the cerebellum's limited function. Using advanced techniques, researchers are uncovering its involvement in maternal behavior, social recognition, and even autism, suggesting it acts as a hub for sensory input and higher cognitive functions. This shift in understanding highlights the cerebellum's integral role in both movement and mental processes, showcasing its significance beyond mere physical coordination. Scientists Are Unlocking the Secrets of Your ‘Little Brain’ | WIRED.

Garden Variety

In this comprehensive guide from The Washington Post, readers are introduced to the basics of starting a vegetable garden. The article emphasizes that anyone can grow vegetables, regardless of space, by selecting the right location, sourcing quality soil, and choosing appropriate plants. It highlights the importance of sunlight, proper drainage, and understanding your hardiness zone for planting. The piece advises starting with easy-to-grow vegetables and incorporating flowers and herbs for a diverse ecosystem. It also stresses the significance of having the right attitude, embracing experimentation, and learning from failures. Overall, the article provides practical tips and encouragement for budding gardeners looking to cultivate their own edible harvest. How to start a vegetable garden - The Washington Post (gift article).

Fortune's Folly

Big Think had an excellent video on the myth of the billionaire genius."wealth is not directly correlated with brain power. Thinking smarter and working harder does not always make you rich; most of the time, it’s just about being positioned at the luckiest spot on the bell curve." Debunking the ‘billionaire = genius’ myth - Big Think.

Jazzing Up the Brain

A study conducted by Drexel University's Creativity Research Lab reveals the neural underpinnings of achieving a state of "flow" in creativity, particularly among jazz musicians in the Philadelphia area. By examining the brain activity of 32 jazz guitarists through EEG scans while they improvised, researchers found that flow is associated with reduced activity in the frontal lobes, which are responsible for executive function and cognitive control. This suggests that letting go of conscious control is key to reaching this state. The study also showed that experienced musicians were more likely to achieve flow, indicating that a foundation of expertise is necessary before one can truly "just wail," as jazz legend Charlie Parker advised. These findings not only shed light on the neural mechanisms of flow but also suggest practical strategies for enhancing creative thinking. Brain scans of Philly jazz musicians reveal secrets to reaching creative flow.

Sleep

Up to 2/3 of adults will suffer from insomnia at some point in their life. The National Center for Integrative and Complementary Health has an excellent science-based overview of various interventions: [Mind and Body Practices for Sleep Disorders: What the Science Says | NCCIH.](https://www.nccih.nih.gov/health/providers/digest/psychological-and-physical-approaches-for-sleep-disorders-science +see also Sleep Disorders – Common Types, Symptoms, Treatments | Sleep Foundation.

Brain Waves from the Grave

The new science of death: ‘There’s something happening in the brain that makes no sense’ explores the enigmatic phenomenon of heightened brain activity in individuals at the brink of death, challenging conventional understanding of the dying process. In particular, it delves into the case of "Patient One," whose brain exhibited remarkable electrical signals and connectivity even after life support was removed. This unexpected discovery, made by neurologist Jimo Borjigin and her team at the University of Michigan, suggests that the brain may enter a hyperactive state during the final moments of life, potentially giving rise to near-death experiences. The findings have profound implications for our comprehension of consciousness and the boundaries between life and death, propelling the scientific community towards new frontiers in the study of the dying brain and the possibility of reversing death itself.

Matrix of Productivity

The Eisenhower matrix, named after the 34th President of the United States, is a powerful tool for enhancing productivity by organizing tasks based on their urgency and importance. Although there's no evidence that Eisenhower himself used the matrix, its principles align with his famous saying, "What is important is seldom urgent and what is urgent is seldom important." The matrix divides tasks into four categories: do (urgent and important), decide (important but not urgent), delegate (urgent but not important), and delete (neither urgent nor important). By regularly revisiting and adjusting the matrix, individuals can maintain focus on their goals and values, ensuring that they invest their time in what truly matters. This method not only aids in managing day-to-day tasks but also helps in aligning efforts with long-term objectives, promoting a balanced and fulfilling life. Why the “Eisenhower matrix” is a fantastic productivity hack - Big Think.

A Nosh Above

Manischewitz, the 136-year-old kosher food brand, is spicing up its image with a vibrant rebrand aimed at attracting new customers and making kosher cuisine a culinary destination. The new packaging features tangerine hues, arched logos, and Hebrew-inspired accents. Shani Seidman, CMO of parent company Kayco, envisions broadening the brand's appeal beyond traditional consumers to those curious about diverse cuisines. The rebrand includes an expanded product range, from frozen matzoh balls to "Mani'z" snacks, and quirky merchandise like "Man I Shvitz" T-shirts. Despite the risks of alienating loyal customers, the move is seen as vital for the brand's long-term survival and relevance in a changing market. Manischewitz hopes its rebrand will make kosher food cool - The Washington Post (gift article).