MAPS

072 - Spice Odyssey, Pillow Talk, and Filing for Ecstasy - HealthHippieMD Week In Review

AI in Academia

In the University of Mississippi's Department of Writing and Rhetoric, Marc Watkins, a self-proclaimed AI guru, is navigating the transformative impact of large language models like ChatGPT on student learning. These AI tools significantly alter how students engage with writing and reading, sometimes even taking over these tasks for them. Watkins' approach to faculty meetings often starts with the quip, "Remember what I told you last week? Forget it," highlighting the rapidly evolving nature of AI in educational settings and its profound implications for teaching methodologies. Opinion | How AI is transforming education at the University of Mississippi - The Washington Post (gift article).

Spice Odyssey

The article How cinnamon, nutmeg and ginger became the scents of winter holidays, far from their tropical originsexplores how these spices, originally from tropical regions, have become synonymous with winter holiday festivities in the Northern Hemisphere. These spices, known for their 'warm' flavors, have a rich global trade and exploration history. Ginger, used in sweet and savory dishes, requires 8-10 months to mature and can be harvested year-round. Nutmeg, derived from the Myristica fragrans tree in Indonesia, takes years to reach peak production, offering nutmeg and mace from its seeds. Cinnamon, harvested from tree bark, is best collected after heavy rains or soaking in water. These spices add distinctive flavors to holiday dishes and offer health benefits. Cinnamon, for instance, can reduce blood glucose levels, ginger aids digestion, and nutmeg has anti-diabetic properties. Their integration into winter holiday traditions is a testament to the enduring influence of the spice trade and the global exchange of culinary practices.

The Elusive World of Hidden Carcinogens

The article The Fight Against Cancer Turns to a Special Class of Carcinogens in The New Yorker delves into the complexities of identifying and understanding carcinogens that don't directly cause mutations in cells but play a crucial role in cancer development. It highlights the limitations of traditional methods like the Ames test in detecting these carcinogens. The piece explores the work of scientists like Bruce Ames, Allan Balmain, and Charles Swanton, who have contributed to our understanding of carcinogenesis. The article discusses how certain substances, while not directly mutagenic, can act as cancer promoters by altering the environment around cells or interacting with pre-existing mutations. This exploration into the 'dark matter' of carcinogens challenges the conventional approach to cancer research, suggesting a need to broaden our perspective and methodologies to include these elusive cancer-promoting agents.

Aging Gracefully

A BLUEPRINT FOR ANTI-AGING (Apple News+) provides valuable insights into the aging process and offers practical tips for maintaining a youthful appearance and prolonging lifespan. The document covers a range of lifestyle factors that can impact aging, from the importance of exercise and a healthy diet to the benefits of good oral hygiene and quality sleep. Additionally, the PDF explores the biological hallmarks of aging and offers advice for measuring biological age at home. With helpful tips on everything from wearing sunscreen to strength training, this document is a must-read for anyone looking to age gracefully.

Filing For Ecstasy

MAPS Public Benefit Corp. has taken a groundbreaking step by filing an application with the U.S. Food and Drug Administration to approve MDMA, commonly known as Ecstasy, combined with therapy for treating post-traumatic stress disorder (PTSD). This marks a significant milestone in the journey of psychedelic drugs from restricted substances to potential mainstream medical treatments. The application follows decades of research showing the potential of psychedelics like psilocybin and ketamine in treating mental health disorders. If approved, MDMA-assisted therapy would be the first of its kind, potentially setting a precedent for future psychedelic treatments. The treatment involves psychotherapy sessions supplemented with MDMA, aiming to provide a new avenue for those suffering from PTSD. This development reflects a growing recognition of psychedelic treatments, with the FDA increasingly acknowledging their potential therapeutic value. MAPS seeks approval of Ecstasy- or MDMA-assisted therapy - The Washington Post.

MedLM in Medicine

Google's new suite of health-care-specific AI models, MedLM, is set to leave its mark on healthcare. MedLM includes large and medium-sized models built on Med-PaLM 2, a language model trained on medical data. This innovation aims to assist clinicians and researchers in complex studies and summarizing doctor-patient interactions. Companies like HCA Healthcare have been testing Google's technology, using it for tasks like automatic documentation of patient interactions and developing tools for nurse handoffs. While the technology shows promise in improving workflows and reducing clerical work, challenges such as accuracy and implementation remain. Google plans to further enhance MedLM with health-care-specific versions of Gemini, its newest AI model, indicating a significant step towards AI integration in healthcare. How doctors are using Google's new AI models for health care.

Many Holiday Returns

The Atlantic has a curated list of articles on shopping returns. "When my colleague Amanda Mull ventured into the belly of the holiday-returns beast, she learned that somewhere amid a complex system of transporters, warehousers, and resellers, a guy named Michael has to sniff the sweatpants." The Fate of Your Holiday-Season Returns - The Atlantic.

Pillow Talk

Do Sleeping Pills Work? A Guide to Insomnia Drugs and Their Risks - The New York Times (gift article) offers a guide to insomnia medications, their potential risks, and when they should be used. With a variety of prescription and over-the-counter options available, including suvorexant and antihistamines, this article explores the golden age of insomnia drugs. Experts advise limited use, cautioning against habit-forming tendencies and emphasizing the importance of consulting a healthcare provider. Whether it's a short-term relief or a last resort, this informative piece provides valuable insights into managing sleep issues while shedding light on the complexities of sleep medication dependency and safe withdrawal methods.

059 - Enacted Dreams, MDMA, and Chillin' Like a Monk - HealthHippieMD Week In Review

How Enacted Dreams Predict Parkinson's

Enacted dreams during the rapid eye movement (REM) phase of sleep may be an early sign of Parkinson's disease and other brain disorders, according to a Scientific American article. Known as REM sleep behavior disorder (RBD), this phenomenon affects a small percentage of the population and often precedes neurodegenerative diseases, such as Parkinson's and Lewy body dementia. Researchers increasingly recognize RBD as a valuable early marker for these conditions, offering potential opportunities for early intervention and clinical trials to slow or prevent disease progression. Acting Out Dreams Predicts Parkinson's and Other Brain Diseases - Scientific American

Checklist for AI Self-Awareness Emerges

As artificial intelligence (AI) continues to advance, whether AI systems can become conscious is gaining traction. To address this, 19 experts, including neuroscientists, philosophers, and computer scientists, have developed a checklist of criteria that could indicate AI consciousness. Published in the arXiv preprint repository, their approach draws from six neuroscience-based theories of consciousness, emphasizing "phenomenal consciousness" or subjective experience. By assessing AI systems against these criteria, the authors aim to provide a more nuanced evaluation of consciousness potential in AI, highlighting the need for more precise theories of AI consciousness in the future. If AI Becomes Conscious, Here's How We Can Tell - Scientific American

New Book on Happiness

"The common strategy of trying to eliminate problems from life to get happier is futile and mistaken. We must instead look for the "why" of life to make our problems an opportunity for learning and growth," Arthur Brooks writes in Three Myths and Four Truths About How to Get Happier - The Atlantic. The column refers to his new book, Build the Life You Want: The Art and Science of Getting Happier, , co-written with Oprah.

Chillin' Like A Monk: The Quest for Biostasis

Can We Stop Time in the Body? - Nautilus delves into the intriguing concept of biostasis—essentially, hitting the pause button on the body's metabolic processes. The article begins with a captivating Tibetan ceremony involving monks sleeping and surviving a Himalayan mountainside in sub-freezing temperatures, sparking curiosity about the physiological mechanisms at play. DARPA's pioneering biostasis project aims to develop a drug that can temporarily halt metabolism, offering potential lifesaving benefits in emergencies. The article introduces SNC80, a drug that slows metabolism in tadpoles, showcasing its reversible effects without harm to vital organs. Although not a perfect solution, the quest for biostasis continues, inspired by nature's examples, from hibernating bears to the remarkable spiny desert mouse. Ultimately, the article highlights the fascinating pursuit of slowing down time within the human body.

How Artificial Intelligence Can Revolutionize Science

How artificial intelligence can revolutionize science was an interesting article in the Economist. It cited two ways AI could accelerate scientific discovery: "The first is "literature-based discovery" (LBD), which involves analyzing existing scientific literature, using ChatGPT-style language analysis, to look for new hypotheses, connections or ideas that humans may have missed." (I mentioned some of the emerging tools in a previous newsletter: 052 - Genetic Judo, Young Blood, and Gray Hair). "The second area is "robot scientists," also known as "self-driving labs." These robotic systems use AI to form new hypotheses, based on analysis of existing data and literature, and then test those hypotheses by performing hundreds or thousands of experiments, in fields including systems biology and materials science." And for more on this topic, see my friend and colleague, Gary Kantor's excellent LinkedIn article: Can Generative AI Close The Knowledge Gap?

The Happiest States in the Union

Utah Named the Happiest State in New Study Where does your state fit? Happiest States in America (2023)

Ever find yourself at a loss for a familiar face or the whereabouts of your car keys? Don't fret; it's not just you. Our memory can take a quirky turn as we age, often leaving us in moments of blank confusion. The good news? It's usually nothing to worry about. While memory retrieval becomes less efficient in our fifties, it doesn't necessarily mean a problem. Experts suggest that embracing mindfulness, reducing multitasking, managing stress, getting enough sleep, maintaining a healthy diet, and even indulging in some cardiovascular exercise can keep your memory on its toes. If memory loss significantly disrupts your daily life, then it's time to chat with your doctor. Why Memory Lapses Are Not Always a Cause for Concern - The New York Times (gift article).

What OpenAI Really Wants

Wired had a long-form story on OpenAI and its CEO, Sam Altman. What OpenAI Really Wants | WIRED

Anxiety and Creativity

Anxiety is not always a boon to creatives. "Depending on the situation, fear, and anxiety can inspire or impede. But when anxiety becomes overwhelming, creative work often stalls." Anxiety can often be a drag on creativity, upending the trope of the tortured artist.

MDMA for PTSD

"Results of a new study may offer regulators enough evidence to allow the psychedelic, also known as Ecstasy, to be considered for use as a PTSD treatment." MDMA Therapy for PTSD Inches Closer to U.S. Approval - The New York Times (gift article).