Dreaming

109 - Lucid Dreams, Unpacking Chemicals, and Quelling Inflammation - HealthHippieMD Week In Review

Lucid Dreams, Lucid Schemes

Living In A Lucid Dream explores the phenomenon of lucid dreaming, blending personal experiences with scientific and philosophical perspectives. Lucid dreaming, a state where individuals are aware they’re dreaming and can sometimes control their actions, has intrigued thinkers from Aristotle to modern researchers. Evans dives into the history of dream studies, from Buddhist traditions to 20th-century breakthroughs in REM research, and contemplates the philosophical implications of dreams. While lucid dreaming offers exhilarating possibilities, it also raises questions about reality, consciousness, and the balance between control and the dream’s inherent mystery.

Old Phages, New Rages

Once sidelined by antibiotics, phage therapy is being reconsidered to combat antibiotic resistance. Researchers are exploring phages that target bacterial efflux pumps—key in antibiotic resistance—forcing bacteria into an evolutionary trap. If bacteria mutate to avoid phages, they lose antibiotic resistance, and vice versa. This “phage steering” has shown promise against multidrug-resistant bacteria like Pseudomonas aeruginosa and Acinetobacter baumannii. However, challenges remain, including unpredictable results and safety concerns. Despite these hurdles, phage therapy could offer a vital tool in the fight against antibiotic-resistant infections. A Fix for Antibiotic Resistance Could Be Hiding in The Past - The Atlantic.

Brain Drain and COVID Strains

Did the Pandemic Break Our Brains? | TIME explores the cognitive impacts of the COVID-19 pandemic, both from the virus itself and the related social and mental stress. Individuals report memory issues and cognitive slips, which researchers suggest may result from brain inflammation caused by SARS-CoV-2 or the trauma of pandemic life. Studies link COVID-19 to subtle IQ drops and brain fog, but stress and disrupted routines also play a role. While some effects may be reversible with time and brain-healthy habits, the road to full mental recovery is still being studied, offering cautious hope.

Inflammation’s Role in Disease

Emerging research reveals that inflammation may not only be a symptom but a driving factor behind numerous chronic diseases. While essential for healing and infection defense, persistent low-grade inflammation has been linked to conditions like heart disease, dementia, and even infertility. Drugs like GLP-1 agonists, such as Ozempic, promise to reduce this inflammation, offering potential benefits beyond weight loss. However, the complex balance between necessary immune responses and harmful chronic inflammation suggests that treatment must tread carefully to avoid unintended consequences. Opinion | Inflammation May Be the Root of Disease - The New York Times (gift article).

The Gut Benefits of Resistant Carbs

Resistant starch, found in foods like green bananas, raw potatoes, oats, certain nuts and seeds, beans, and legumes, resists digestion in the small intestine and ferments in the colon, feeding beneficial gut bacteria. This prebiotic powerhouse improves gut health, reduces inflammation, supports weight loss, and regulates blood sugar. Despite these benefits, most adults fall short of the recommended daily intake of 15 grams. Experts suggest incorporating more whole grains, legumes, and cooled starchy foods into your diet to harness the many health advantages of this underrated carbohydrate. Why this type of carb is so good for your gut health.

Douse Inflammation with Diet

Chronic inflammation can be mitigated through mindful eating. Foods rich in fiber, antioxidants, and omega-3s—like leafy greens, berries, legumes, and fatty fish—help combat inflammation. Spices such as turmeric and ginger and fermented foods and beverages like yogurt and kombucha offer additional benefits. A diverse diet featuring 30+ foods weekly, including coffee and tea, promotes better inflammation management. While no single food is a cure-all, a balanced diet remains vital to keeping inflammation at bay. The Foods That Fight Inflammation - The New York Times (gift article).

Why OpenAI’s o1 Model is a Game Changer

OpenAI’s new o1 model represents a significant leap in AI reasoning capabilities, focusing on advanced tasks like mathematics and coding rather than just language processing. Unlike its predecessor, GPT-4o, which struggled with reasoning-based challenges, o1 excels at “chain of thought” techniques, breaking down complex problems and learning from its mistakes. This model achieves high accuracy in competitive coding and math challenges, outperforming human experts and previous AI models. While its capabilities are exciting for research and STEM fields, the model’s steep price tag limits its accessibility. Why OpenAI’s new model is such a big deal | MIT Technology Review.

Life: A Problem-Solving Algorithm

Is life a complex computational process? | Aeon Essays explores whether life is a computational process rather than a purely chemical one. By drawing parallels between computation and biological adaptation, it argues that life emerges from problem-solving functions, much like a computer program. It explores three hypotheses—the Tron, Golem, and Maupertuis—each proposing that life can be simulated, synthesized, or follow deeper universal principles beyond chemistry. These perspectives challenge traditional views, suggesting life is not defined by specific materials but by its ability to solve problems and adapt to environments, much like a computational system.

Unpacking Chemicals in Our Food

A recent study highlights the alarming infiltration of over 3,000 chemicals from food packaging into our bodies. Everyday items, like plastic-wrapped meat or takeout containers, expose us to substances that may pose health risks. While the convenience of food packaging is undeniable, the study raises concerns about the cumulative impact these chemicals—such as PFAS and phthalates—could have over time. Researchers are urging for more transparency and better regulation to mitigate potential health risks from materials that come in contact with our food. Scientists just figured out how many chemicals enter our bodies from food packaging - The Washington Post (gift article).

059 - Enacted Dreams, MDMA, and Chillin' Like a Monk - HealthHippieMD Week In Review

How Enacted Dreams Predict Parkinson's

Enacted dreams during the rapid eye movement (REM) phase of sleep may be an early sign of Parkinson's disease and other brain disorders, according to a Scientific American article. Known as REM sleep behavior disorder (RBD), this phenomenon affects a small percentage of the population and often precedes neurodegenerative diseases, such as Parkinson's and Lewy body dementia. Researchers increasingly recognize RBD as a valuable early marker for these conditions, offering potential opportunities for early intervention and clinical trials to slow or prevent disease progression. Acting Out Dreams Predicts Parkinson's and Other Brain Diseases - Scientific American

Checklist for AI Self-Awareness Emerges

As artificial intelligence (AI) continues to advance, whether AI systems can become conscious is gaining traction. To address this, 19 experts, including neuroscientists, philosophers, and computer scientists, have developed a checklist of criteria that could indicate AI consciousness. Published in the arXiv preprint repository, their approach draws from six neuroscience-based theories of consciousness, emphasizing "phenomenal consciousness" or subjective experience. By assessing AI systems against these criteria, the authors aim to provide a more nuanced evaluation of consciousness potential in AI, highlighting the need for more precise theories of AI consciousness in the future. If AI Becomes Conscious, Here's How We Can Tell - Scientific American

New Book on Happiness

"The common strategy of trying to eliminate problems from life to get happier is futile and mistaken. We must instead look for the "why" of life to make our problems an opportunity for learning and growth," Arthur Brooks writes in Three Myths and Four Truths About How to Get Happier - The Atlantic. The column refers to his new book, Build the Life You Want: The Art and Science of Getting Happier, , co-written with Oprah.

Chillin' Like A Monk: The Quest for Biostasis

Can We Stop Time in the Body? - Nautilus delves into the intriguing concept of biostasis—essentially, hitting the pause button on the body's metabolic processes. The article begins with a captivating Tibetan ceremony involving monks sleeping and surviving a Himalayan mountainside in sub-freezing temperatures, sparking curiosity about the physiological mechanisms at play. DARPA's pioneering biostasis project aims to develop a drug that can temporarily halt metabolism, offering potential lifesaving benefits in emergencies. The article introduces SNC80, a drug that slows metabolism in tadpoles, showcasing its reversible effects without harm to vital organs. Although not a perfect solution, the quest for biostasis continues, inspired by nature's examples, from hibernating bears to the remarkable spiny desert mouse. Ultimately, the article highlights the fascinating pursuit of slowing down time within the human body.

How Artificial Intelligence Can Revolutionize Science

How artificial intelligence can revolutionize science was an interesting article in the Economist. It cited two ways AI could accelerate scientific discovery: "The first is "literature-based discovery" (LBD), which involves analyzing existing scientific literature, using ChatGPT-style language analysis, to look for new hypotheses, connections or ideas that humans may have missed." (I mentioned some of the emerging tools in a previous newsletter: 052 - Genetic Judo, Young Blood, and Gray Hair). "The second area is "robot scientists," also known as "self-driving labs." These robotic systems use AI to form new hypotheses, based on analysis of existing data and literature, and then test those hypotheses by performing hundreds or thousands of experiments, in fields including systems biology and materials science." And for more on this topic, see my friend and colleague, Gary Kantor's excellent LinkedIn article: Can Generative AI Close The Knowledge Gap?

The Happiest States in the Union

Utah Named the Happiest State in New Study Where does your state fit? Happiest States in America (2023)

Ever find yourself at a loss for a familiar face or the whereabouts of your car keys? Don't fret; it's not just you. Our memory can take a quirky turn as we age, often leaving us in moments of blank confusion. The good news? It's usually nothing to worry about. While memory retrieval becomes less efficient in our fifties, it doesn't necessarily mean a problem. Experts suggest that embracing mindfulness, reducing multitasking, managing stress, getting enough sleep, maintaining a healthy diet, and even indulging in some cardiovascular exercise can keep your memory on its toes. If memory loss significantly disrupts your daily life, then it's time to chat with your doctor. Why Memory Lapses Are Not Always a Cause for Concern - The New York Times (gift article).

What OpenAI Really Wants

Wired had a long-form story on OpenAI and its CEO, Sam Altman. What OpenAI Really Wants | WIRED

Anxiety and Creativity

Anxiety is not always a boon to creatives. "Depending on the situation, fear, and anxiety can inspire or impede. But when anxiety becomes overwhelming, creative work often stalls." Anxiety can often be a drag on creativity, upending the trope of the tortured artist.

MDMA for PTSD

"Results of a new study may offer regulators enough evidence to allow the psychedelic, also known as Ecstasy, to be considered for use as a PTSD treatment." MDMA Therapy for PTSD Inches Closer to U.S. Approval - The New York Times (gift article).

008 - U.S. Food Czar, 9-Volt Nirvana, Dragons and Thymi - HealthHippie Week In Review - September 4, 2022

White House Conference on Hunger, Nutrition, and Health

The most exciting news story of the week came from NPR, How the White House nutrition conference may tackle Americans' unhealthy diets. The article discusses the recommendations of the report, Informing the White House Conference, to be discussed on September 28. Re-calibrating America's relationship with food is the first (and arguably the most important) step to digging ourselves out of our current exorbitantly priced, low-value healthcare model (value=quality/cost). I'm hoping a "Food Czar" for the USA is named as an end-product of the meeting.

Skeptical Reflections of a Cancer Patient

What I've Learned From Having Cancer Is Nothing, is a reflection on common thoughts while living with cancer. Despite what the author says, you'll learn something.

The Best Diet for Healthy Aging

Michael Gregor explores how simple dietary modifications can profoundly impact one's health and well-being. The Best Diet for Healthy Aging. Spoiler alert: eat more plants!

The Joy of Why - Dreams

I found a new podcast I like, The Joy of Why. The latest episode on dreaming: Why and How Do We Dream, was great. (transcript) The discussion on lucid dreams and dream engineering was fascinating. I need to learn more about dream engineering. One of the best non-fiction books I've read in the last few years is Matthew Walker's Why We Sleep: Unlocking the Power of Sleep and Dreams.

Dragon Meet Maggots

I mentioned maggot therapy in 001 - Friendship, Psychedelics, and Maggots, Oh My. Now, maggot therapy has hit popular culture. Maggots made a cameo appearance In Episode 2 of House of Dragons. 'House of the Dragon' Episode 2's maggot scene is scientifically accurate I'm enjoying the Game of Thrones prequel.

Science behind Complementary Approaches to Irritable Bowel Syndrome

If you or someone you love suffer from IBS, the NCCIH has the evidence behind several complementary treatments: Irritable Bowel Syndrome and Complementary Health Approaches: What the Science Says

Dreaming of You(rself)

Everything you might want to know about experiencing memories/dreams in the first and third person: You've Probably Seen Yourself in Your Memories. I hadn't considered this phenomenon before, but the article points out the implications for the law, traumatic and near-death experiences, and more.

Thinking about Thinking

Rather than continuously constructing images based on all your sensory input, your brain likely conserves energy by predicting what it should see based on your previous experience and context, keying in on aspects that do not conform. The article, Your Brain Is an Energy-Efficient 'Prediction Machine', discusses efforts to understand the predictive processing framework.

9-Volt Nirvana

Two items on transcranial electrical stimulation hit my awareness in one of those "messages from the universe" (or maybe it's just the algorithms doing their thing). I'm fellowship trained in neuro-electrophysiology but was unaware of the studies focused on using mild electrical stimulation to enhance brain function (my fellowship focused on monitoring, not therapeutics). Early in the week, I read the article Brain stimulation boosts memory for at least a month. Then, without searching, a previous episode of Radiolab, 9-Volt Nirvana, , was in my podcast queue. After reading and listening to the podcast, I wondered if this technology might improve my quest to learn to play the guitar. I found an article I plan to read: Differential Effects of Transcranial Direct Current Stimulation-tDCS-Depending on Previous Musical Training. The jury is still out on the efficacy and safety of transcranial stimulation. Although there are already commercially available devices, I will wait to see how the field develops before I try it out.

Seven Simple Actions to Improve Your Mental Health

I read an article with pragmatic and easily actionable advice on improving your mental health. Feeling stressed? Here are 7 simple actions to boost your mental health.

The Down-Side of Dangerous World Beliefs

All of us want our children and loved ones to be safe. But teaching kids the world is dangerous in order to improve their vigilance is terrible, ultimately, for their health, happiness, and success. I learned a lot from the article, Don't Teach Your Kids to Fear the World. As a counter-narrative to all the negative news about the world, see the book What Are You Optimistic About?: Today's Leading Thinkers on Why Things Are Good and Getting Better.

Current Models of Aging

Eric Topol tweeted a link to an interesting paper that summarizes current thinking on aging. New hallmarks of aging: a 2022 Copenhagen aging meeting summary. I especially appreciated the first figure in the paper that graphically shows how our bodies break down.

My Thymus, Myself

The Radiolab episode, My Thymus, Myself was a whirlwind tour of the function of the thymus. You should listen if you're interested in the immune system and who isn't these days? Understanding the thymus could significantly impact infectious disease, autoimmunity, and transplant medicine. Bonus, the story featured a shoutout to Duke Cardiothoracic Surgery.

Quote of the Week

"All great truths begin as blasphemies." - George Bernard Shaw


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