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101 - Nonprofit Hospital Illusion, Genetic Discrimination, and Microbial Athletic Edge - HealthHippieMD Week In Review

Long COVID: An Unsettling Puzzle

Long COVID, a widespread post-infection condition, affects millions globally, significantly impacting health and economies. Despite over 24,000 scientific publications, understanding still needs to be completed. The risk of long COVID has declined due to vaccines and viral changes, yet millions still suffer. It manifests in over 200 symptoms, from respiratory issues to neurological and metabolic disorders, severely impacting daily life and work. Recent studies suggest persistent viral presence and immune dysfunction as causes. Misleading public narratives downplay its threat, but data shows COVID-19 remains a severe and ongoing health risk.Long COVID puzzle pieces are falling into place – the picture is unsettling.

The Need for Genetic Discrimination Safeguards

The increasing popularity of genetic testing, with millions sharing their DNA for health and ancestry insights, raises critical concerns about genetic discrimination. Genetic data, often inadequately secured, poses risks if accessed by insurance companies or employers, leading to potential discrimination. This article highlights the ambiguity in defining genetic discrimination, drawing parallels to historical eugenics. Despite existing laws, varying definitions complicate protection efforts. Newer tests, like those measuring biological age, further complicate the landscape. Policymakers face challenges in creating robust protections, while individuals are urged to scrutinize data-sharing terms and understand their rights. Why we need safeguards against genetic discrimination | MIT Technology Review.

VR: The Body Image Game-Changer?

Virtual reality (VR) is emerging as a promising tool to tackle body image disturbances. These disturbances, often linked to eating disorders and body dysmorphic disorder, stem from faulty multisensory integration, leading to distorted body perceptions. VR-based "embodiment illusions," like the "rubber hand illusion," can trick the mind into feeling it inhabits a different body, potentially realigning these perceptions. Research shows that people with higher body image disturbance are more susceptible to these illusions, which can reduce perceptual distortions and negative emotions about body size and shape. While promising, further research is needed to understand the long-term effects and ethical implications. Can Virtual Reality Help Folks With Body Image Disturbance?

Dream Cuisine

Sleep deprivation affects about one-third of Americans, leading to severe health issues. However, improving sleep quality is achievable through specific dietary habits. Consuming foods rich in tryptophan, like turkey, fish, eggs, and nuts, combined with healthy carbs, can enhance melatonin production, promoting better sleep. Adopting a Mediterranean diet high in fiber, zinc, B vitamins, and magnesium can also aid sleep. Avoiding inflammatory foods such as sugary cereals and saturated fats is crucial. A consistent eating schedule and incorporating gut-friendly foods like yogurt and fermented items can further support restful sleep. 8 Eating Habits That Improve Your Sleep | TIME.

The Nonprofit Hospital Illusion

Many major nonprofit hospitals are barely charitable, maintaining tax-exempt status while running numerous for-profit ventures. They exploit legal loopholes, enjoy regulatory leniency, and engage in extensive lobbying to operate like big businesses yet avoid taxes. Their activities include owning for-profit insurers, venture capital firms, and hospitals abroad. Despite significant earnings, they report "operating surpluses" instead of profits. Critics argue these hospitals should lose tax benefits as their community contributions are minimal compared to the financial advantages they gain. The article calls for stricter regulations and more accountability to prevent such exploitation. Opinion | Many hospitals are nonprofit in name only, and get away with it - The Washington Post (gift article).

The Microbial Edge in Athletic Performance

Endurance athletes constantly seek ways to enhance their performance, often focusing on optimizing their mitochondrial health through rigorous training and precise nutrition. However, emerging research highlights the gut microbiome as a crucial yet overlooked factor in athletic excellence. The gut microbiome, a complex community of microorganisms, aids in nutrient absorption, immune function, and even communication with mitochondria. Elite athletes often exhibit unique microbiomes that directly impact performance and boost VO2 max and lactate thresholds. Integrating microbiome-friendly foods and probiotics into diets can significantly enhance endurance and recovery, presenting a new frontier in sports nutrition. Athletes looking for a competitive edge may find it within their gut microbiome.

+see also: Do Gut Bacteria Improve Athletic Performance? (yes, if you're a mouse, and maybe if you're a human) — HealthHippieMD.

Fun Fitness Challenges Await

7 Fitness Tests to Gauge Your Strength and Mobility - The New York Times (gift article) introduces seven fitness tests to assess strength, mobility, and overall fitness. These tests range from measuring flexibility and balance to evaluating power and VO2 max, catering to various fitness levels. The tests include simple activities like standing on one leg, gripping a bar, and rapidly getting out of a chair. They aim to provide a comprehensive snapshot of one's fitness, helping individuals track progress and set achievable goals. Whether you're training for a marathon or just curious about your fitness, these tests offer valuable insights and fun challenges.

Mind Over Matter

Advanced meditation is revolutionizing our understanding of consciousness. Neuroscientist Matthew Sacchet delves into the brain's behavior during deep meditative states. Unlike mindfulness practices for stress reduction, advanced meditation explores profound states of ecstatic bliss, deep insights, and compassionate experiences. Sacchet, who has meditated since childhood, uses a multidisciplinary approach to study these states, combining personal experiences, wisdom traditions, and empirical neuroscience. His research aims to unlock advanced meditation's potential for enhancing mental health and well-being and even integrating with psychedelics and AI for deeper consciousness insights. Altering Consciousness with Advanced Meditation | Scientific American.

Canines Catch Your Cortisol

Research from the University of Bristol reveals that dogs can detect human stress through scent, specifically the cortisol hormone in sweat. In the study, dogs were exposed to sweat samples from stressed and relaxed volunteers. The results showed that dogs became more pessimistic about ambiguous situations after smelling stress-induced sweat, suggesting they emotionally react to human stress. This emotional contagion between humans and dogs likely evolved for mutual survival benefits. The findings emphasize the profound empathetic bond between humans and their canine companions, highlighting the impact of human emotions on dog behavior. When Dogs Smell Your Stress, They Act Sad | Scientific American.

072 - Spice Odyssey, Pillow Talk, and Filing for Ecstasy - HealthHippieMD Week In Review

AI in Academia

In the University of Mississippi's Department of Writing and Rhetoric, Marc Watkins, a self-proclaimed AI guru, is navigating the transformative impact of large language models like ChatGPT on student learning. These AI tools significantly alter how students engage with writing and reading, sometimes even taking over these tasks for them. Watkins' approach to faculty meetings often starts with the quip, "Remember what I told you last week? Forget it," highlighting the rapidly evolving nature of AI in educational settings and its profound implications for teaching methodologies. Opinion | How AI is transforming education at the University of Mississippi - The Washington Post (gift article).

Spice Odyssey

The article How cinnamon, nutmeg and ginger became the scents of winter holidays, far from their tropical originsexplores how these spices, originally from tropical regions, have become synonymous with winter holiday festivities in the Northern Hemisphere. These spices, known for their 'warm' flavors, have a rich global trade and exploration history. Ginger, used in sweet and savory dishes, requires 8-10 months to mature and can be harvested year-round. Nutmeg, derived from the Myristica fragrans tree in Indonesia, takes years to reach peak production, offering nutmeg and mace from its seeds. Cinnamon, harvested from tree bark, is best collected after heavy rains or soaking in water. These spices add distinctive flavors to holiday dishes and offer health benefits. Cinnamon, for instance, can reduce blood glucose levels, ginger aids digestion, and nutmeg has anti-diabetic properties. Their integration into winter holiday traditions is a testament to the enduring influence of the spice trade and the global exchange of culinary practices.

The Elusive World of Hidden Carcinogens

The article The Fight Against Cancer Turns to a Special Class of Carcinogens in The New Yorker delves into the complexities of identifying and understanding carcinogens that don't directly cause mutations in cells but play a crucial role in cancer development. It highlights the limitations of traditional methods like the Ames test in detecting these carcinogens. The piece explores the work of scientists like Bruce Ames, Allan Balmain, and Charles Swanton, who have contributed to our understanding of carcinogenesis. The article discusses how certain substances, while not directly mutagenic, can act as cancer promoters by altering the environment around cells or interacting with pre-existing mutations. This exploration into the 'dark matter' of carcinogens challenges the conventional approach to cancer research, suggesting a need to broaden our perspective and methodologies to include these elusive cancer-promoting agents.

Aging Gracefully

A BLUEPRINT FOR ANTI-AGING (Apple News+) provides valuable insights into the aging process and offers practical tips for maintaining a youthful appearance and prolonging lifespan. The document covers a range of lifestyle factors that can impact aging, from the importance of exercise and a healthy diet to the benefits of good oral hygiene and quality sleep. Additionally, the PDF explores the biological hallmarks of aging and offers advice for measuring biological age at home. With helpful tips on everything from wearing sunscreen to strength training, this document is a must-read for anyone looking to age gracefully.

Filing For Ecstasy

MAPS Public Benefit Corp. has taken a groundbreaking step by filing an application with the U.S. Food and Drug Administration to approve MDMA, commonly known as Ecstasy, combined with therapy for treating post-traumatic stress disorder (PTSD). This marks a significant milestone in the journey of psychedelic drugs from restricted substances to potential mainstream medical treatments. The application follows decades of research showing the potential of psychedelics like psilocybin and ketamine in treating mental health disorders. If approved, MDMA-assisted therapy would be the first of its kind, potentially setting a precedent for future psychedelic treatments. The treatment involves psychotherapy sessions supplemented with MDMA, aiming to provide a new avenue for those suffering from PTSD. This development reflects a growing recognition of psychedelic treatments, with the FDA increasingly acknowledging their potential therapeutic value. MAPS seeks approval of Ecstasy- or MDMA-assisted therapy - The Washington Post.

MedLM in Medicine

Google's new suite of health-care-specific AI models, MedLM, is set to leave its mark on healthcare. MedLM includes large and medium-sized models built on Med-PaLM 2, a language model trained on medical data. This innovation aims to assist clinicians and researchers in complex studies and summarizing doctor-patient interactions. Companies like HCA Healthcare have been testing Google's technology, using it for tasks like automatic documentation of patient interactions and developing tools for nurse handoffs. While the technology shows promise in improving workflows and reducing clerical work, challenges such as accuracy and implementation remain. Google plans to further enhance MedLM with health-care-specific versions of Gemini, its newest AI model, indicating a significant step towards AI integration in healthcare. How doctors are using Google's new AI models for health care.

Many Holiday Returns

The Atlantic has a curated list of articles on shopping returns. "When my colleague Amanda Mull ventured into the belly of the holiday-returns beast, she learned that somewhere amid a complex system of transporters, warehousers, and resellers, a guy named Michael has to sniff the sweatpants." The Fate of Your Holiday-Season Returns - The Atlantic.

Pillow Talk

Do Sleeping Pills Work? A Guide to Insomnia Drugs and Their Risks - The New York Times (gift article) offers a guide to insomnia medications, their potential risks, and when they should be used. With a variety of prescription and over-the-counter options available, including suvorexant and antihistamines, this article explores the golden age of insomnia drugs. Experts advise limited use, cautioning against habit-forming tendencies and emphasizing the importance of consulting a healthcare provider. Whether it's a short-term relief or a last resort, this informative piece provides valuable insights into managing sleep issues while shedding light on the complexities of sleep medication dependency and safe withdrawal methods.

039 - Centenarian Excrement, Creativity, and Cannabinoids - HealthHippieMD Week In Review

How to Make Peace with Your Feelings

How Leaning Into Negative Emotions Can Help Your Mental Health (gift article) is about accepting negative emotions for what they are: part of the human experience. What you do with the experience strongly influences your health and well-being.

Generative AI in Medicine

Wired had a story about ways generative AI will impact medicine, along with several caveats: ChatGPT Can Help Doctors—and Hurt Patients.

The Two Personality Traits that Predict Well-being

If you lack either (I'm strongly introverted, not extroverted), hope is not lost. Study Finds 2 Personality Traits Predict Well-being — But Don't Worry if You Don't Have Them.

The World's Rarest Eye Colors

Do you have one of the six rarest types of eye color? Read What Is the Rarest Eye Color?.

Is Alcohol in Moderation Good for You?

The Great Alcohol Health Flip-Flop Isn't That Hard to Understand—if You Know Who Was Behind It is an interesting article on how the supposed health benefits of a small amount of alcohol have been turned on its head, again.

What You See Is Not Always What You Get

The NY Times had an article about a recent publication in JAMA focused on melatonin gummies: "A team of researchers analyzed 25 melatonin gummy products from different brands and found that 22 contained different amounts of melatonin than what was listed on their labels; one contained only 74 percent of the advertised amount of melatonin, while another had 347 percent of the labeled amount. Yet another product contained no detectable melatonin at all." 22 Out of 25 Melatonin Products Were Mislabeled, Study Finds. (gift article) See also: ConsumerLab: Independent Testing of Supplements and Botanicals.

Hope

The Atlantic had an interesting article, Why Economists Should Study Hope, that discusses why hope is so important and how to cultivate more.

The Quest for Longevity

The Quest for Longevity Is Already Over is an interesting read. One of the points I strongly agree with in the article is that extending healthspan (the length of time one is healthy) is far more important than extending longevity (the length of time one lives).

Oura Partners with Best Buy

I love my Oura smart ring. I've worn mine for years. The hardest part of the purchase process was the sizing. Sizing will be less of an issue as you can soon walk into Best Buy and find a fitting station. The article Oura Is Proof That Smart Rings Are Here to Stay discusses the Oura Ring and some of the upcoming competitors.

Cannabis, Cannabinoids, and Delta-8 THC / Delta-10 THC

Cannabis-derived products like delta-8 THC and delta-10 THC have flooded the US market – two immunologists explain the medicinal benefits and potential risks is a quick overview of some of medicinal and side effects of cannabinoids. The article discusses hemp, cannabis, and a few of the cannabinoids.

Creativity / Rick Rubin

I enjoy writing words and music. I'm not good at either, but the process brings me joy. Rick Rubin's new book is about the creative process: The Creative Act: A Way of Being: Rubin, Rick. I've been a big fan of Rubin's Broken Record Podcast. I also enjoyed watching Rick Rubin: The 60 Minutes Interview - CBS News and hearing him interviewed on Rick Rubin on How to Make Something Great. I'm adding the book to my "must-read" list.

Brainstorming with ChatGPT

Wired had an article on how to brainstorm better with the generative AI platform: 6 Tips for Using ChatGPT to Brainstorm Better

What Can We Learn About Aging from Centenarian Excrement?

The longest-living people have a more diverse microbiome than their less healthy peers. A study published this month, Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures looked at the gut microbiomes of centenarians — individuals who've reached or surpassed a century in age — and compared them against old, middle-aged, and young adults. Their results showed, "regardless of health status, the centenarians had a unique enterotype that is a combination of the two found in young adults aged 20 to 44 — Bacteroides — and older adults — Escherichia and/or Shigella." Read the study synopsis here: Centenarians Have Super Healthy Gut Microbiomes — Can This Help Us Live Longer?

Pill Popping Polypharmacy

"Getting people off drugs is unfamiliar terrain for modern health systems, mostly set up to put patients on them. But that is beginning to change. Doctors, pharmacists, and nurses are setting up "deprescribing networks" to try to spread the word." The Economist published an article on the overprescription of medication: Too many people take too many pills.

FDA-Approved Video Games

Much of my research at Duke focused on using video game technology in healthcare and healthcare education. It was fantastic to read this synopsis of Akili [^1] and EndeavorRX, an FDA-approved video game for treating ADHD. I can think of many more uses of the platform. The story behind an FDA-Approved Video Game Treatment for ADHD


[^1]: I am an Akili Interactive shareholder.

016 - Vampire Hormones, Zombie Fungi, Micromorts, and Bugs in Space - HealthHippieMD Week In Review (Halloween Edition)

Dungeons and Dragons for Mental Health?

I was called a nerd for playing tabletop role-playing games (TTRGs) back in the '70s and '80s. It warms my heart that TTRGs have had a resurgence. The article, How Therapists Are Using Tabletop Games to Help People, discusses how TTRGs are being leveraged outside of entertainment to improve mental health.

Predicting The Likelihood of Death - Micromorts

We all know riding a motorcycle is more dangerous than driving a car. But have you ever wondered precisely how much more dangerous? Enter the concept of micromorts and superforecasting. Worried About Nuclear War? Consider the Micromorts, covers micromorts in the context of the likelihood of nuclear war. The choice of context is not pleasant, but the concept of micromorts is useful. For more on micromorts and other attempts to quantify the likelihood of dying, see my article: The Spreadsheet of Life and Death. For more on Superforecasting, see How spooks are turning to superforecasting in the Cosmic Bazaar (paywall). For one of my favorite Wired articles of all time, see: Why the Future Doesn't Need Us.. I've added the book Superforecasting: The Art and Science of Prediction to my reading list.

Antibiotics as an Adjunct to Improve Mental Health

An article at Medscape, Antibiotic May Enhance TMS, Improve Depression Outcomes, summarized a new publication that demonstrated the addition of the broad spectrum antibiotic, D-cycloserine, to transcranial magnetic stimulation of the brain, may improve outcomes in major depressive disorder. The study team credits the ability of D-Cycloserine to bind to the NMDA receptors for effect, but I can't help wondering if the effect is mediated through changes in the microbiome.

Mindfulness for Substance Abuse Disorder?

Mindfulness has many benefits. Most people think of mindfulness as modulating anxiety and depression. This researcher believes mindfulness should also be part of addiction-treatment programs.

Melatonin - The Vampire Hormone

Most people in the U.S. take melatonin incorrectly. Melatonin for Sleep: How the Aid Works (gift article), has lots of helpful information on the hormone. During a trip to Australia (where melatonin is unavailable over the counter), I took a self-imposed crash course on naturally occurring sources of melatonin. Here is a good WebMD article on melatonin-rich foods: 6 Foods High in Melatonin and Why You Need It

More on the Psychedelic Gold-Rush

The NY Times had an interesting article on the attempts to cash in on psychedelics by patenting everything from molecular compounds to treatment rooms. With Promise of Legalization, Psychedelic Companies Joust Over Future Profits (gift article).

The Therapeutic Potential of "Zombie Fungus"

I have often used pictures of Cordyceps in my lectures to reinforce the notion that at least some human behavior may not be under our control but instead might be driven by microbes: The Zombie Fungus Takes Over Ants' Bodies to Control Their Minds. I was not aware this same fungus has been used to treat various maladies and is currently being examined by pharma for its therapeutic potential: How to grow a zombie fungus in a lab. (thanks, Laura!)

Canine Gilgamesh

The Search for a Pill That Can Help Dogs—and Humans—Live Longer in Wired tells the story of the start-up Loyal, aiming to increase the life expectancy of dogs, and ultimately, humans. I had not heard of the company before. The article is short on science and long on the political challenges and the venture capital exploits of the founder, Celine Halioua. Whether Loyal is truly onto something, is a flash-in-the-pan, or is another Theranos, remains to be seen.

How to Interpret Scientific Literature

The National Center for Complementary and Integrative Health of the NIH released How To Make Sense of a Scientific Journal Article. This is a good resource if you're not familiar with scientific literature.

Microbiomes in Space

Over the last decade, we've learned much about what happens to gut flora in space. This knowledge will be critical for prolonged space flight like a mission to Mars. Studying astronaut Scott Kelly and his identical twin who remained on earth offered many exciting insights. The article, Gut health in space: How zero gravity could wreak the microbiome reports some of the findings.

Can Sense of Smell Predict Depression?

An article on Medscape discussed a recent publication demonstrating hyperawareness of smell may be an indicator of anxiety and/or depression: Can Sensitivity to Common Smells Sniff Out Depression, Anxiety?

Shinrin-yoku: The Soothing Practice of Forest Bathing

More on forest bathing: Shinrin-yoku: The Soothing Practice of Forest Bathing. As I mentioned in 009 - Doritos Dementia, Pain Clocks, and Forest Bathing, I believe a good portion of the benefits of forest bathing are derived from the forest's microbiome. I'd love to prove/disprove my hypothesis.

How are Memories Encoded in the Brain?

The news release, During Sleep, One Brain Region Teaches Another, Converting Novel Data Into Enduring Memories, discusses work building neural networks to understand human memory encoding processes, especially during sleep. In this case, Androids MIGHT Dream of Electric Sheep.

Quote

"Whoever is careless with the truth in small matters cannot be trusted with important manners." - Albert Einstein.