121 - Grief Relief, Fighting Time, Diet and Dementia Risk - HealthHippieMD Week In Review

121 HealthHippie Newsletter Audio Overview

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Food for Thought: How Diet Fuels Dementia Risk

Researchers discovered a clear link between inflammatory diets and increased dementia risk, analyzing 10 years of data from the Framingham Heart Study Offspring cohort. High Dietary Inflammatory Index (DII) scores were associated with all-cause dementia and Alzheimer's disease, suggesting that anti-inflammatory diets could play a preventive role. Although promising, these findings require further validation.Dementia Incidence Linked to Inflammatory Foods | MedPage Today (Thanks, Amy!)

Grief Relief: Navigating the Holidays with Compassion

The holiday season intensifies grief for many, but experts offer strategies for coping, including expressing emotions, engaging in rituals, and creating new traditions. Supporting loved ones involves empathy, practical help, and listening without judgment. Prolonged grief disorder, recognized in 2022, highlights the need for targeted interventions. How to Manage Holiday Grief in Yourself and Others | Scientific American.

Cultural Prescription: Art for What Ails You

Engaging in arts and culture isn't just entertaining—it's scientifically proven to enhance health, happiness, and productivity. A groundbreaking UK study reveals that occasional participation in cultural activities, from concerts to drawing classes, alleviates depression, pain, and loneliness, generating a societal financial benefit of £8 billion annually. Arts engagement boosts cognitive function, reduces reliance on medication, and supports preventative healthcare goals. Researchers highlight these benefits as personal and pivotal to public health, urging against cuts to arts funding. This study underscores art's power to enrich life, making it an essential component of wellness strategies.
Consuming arts and culture is good for health and wellbeing, research finds. (Thanks, Laura!).

Prescription for Competition: PBMs and Drug Pricing Woes

Pharmacy Benefit Managers (PBMs) control drug prices and coverage, but market concentration among a few dominant players stifles competition and inflates costs. While PBMs negotiate discounts, their practices often limit generics and create opaque pricing. Experts call for regulatory reforms to ensure fair competition and consumer savings. What are pharmacy benefit managers? A health economist explains how lack of competition drives up drug prices for everyone.

Antibody Aging Hacks: Fighting Time with Science

Antibodies, vital in combating infection, may now target aging itself. Recent studies reveal their potential to extend lifespan, rejuvenate tissues, and fight age-related diseases. Antibody therapies offer a revolutionary approach to aging, from targeting senescent cells to reducing inflammation. Could these medical breakthroughs be the future of anti-aging Antibodies Could Soon Help Slow the Aging Process.

Mind Your Brain: Practical Tips for Cognitive Wellness

Simple lifestyle changes—like better sleep hygiene, yoga, mindfulness, and gardening—can enhance cognitive and emotional health. Embrace the joy of missing out (JOMO) and make small, impactful shifts to protect your brain. Our best tips for cognitive health - The Washington Post (gift article.)

Mark Hyman's Functional Medicine Empire

Dr. Mark Hyman's functional medicine empire spans supplements, books, and diagnostics, merging holistic care with high-profile allies like Robert F. Kennedy Jr. Despite criticisms of unproven methods, his focus on root-cause medicine aligns with rising interest in preventative health. How RFK Jr's Longtime Friend Mark Hyman Built a Wellness Empire - The New York Times (gift article).

Tackling Depression with VNS Therapy

Vagus Nerve Stimulation (VNS) offers hope for treatment-resistant depression, with recent trials showing improved quality of life for patients with long-term depressive symptoms. Though FDA-approved, limited insurance coverage hinders access. How stimulating the body's largest nerve may relieve severe depression.

Longer Life, Shorter Straws

While global life expectancy has risen, Americans face a grim trade-off: more years of life spent sick. The U.S. lifespan-healthspan gap now averages 12.4 years, the widest globally. Women fare worse, with conditions like musculoskeletal and neurological diseases driving disparity. Researchers attribute this to a "disease paradox," where surviving acute illnesses leads to chronic conditions. The data calls for urgent reform in healthcare priorities to focus on extending not just years, but quality of life. Americans are living longer—but most of the extra time is spent being sick.

Patience in Peril: Conquering the Waiting Game

Anticipating test results can be as stressful as bad news itself. Experts recommend replacing passive distractions with immersive activities like exercise or puzzles to curb anxiety. Avoid "doomscrolling" for diagnoses, and instead, craft clear action plans with healthcare providers to regain control. Even if coping mechanisms falter, there's solace in preparedness—those who worry the most often adapt best to outcomes. Learn to wait wisely and reclaim peace in uncertain moments. How to Stay Calm While Waiting For a Test Result - The New York Times (gift article).

Covid's Lingering Gut Troubles

Post-Covid gastrointestinal issues, from IBS to chronic pain, are an unwelcome surprise for many survivors. Studies show up to 40% of Covid patients experience lasting digestive symptoms, often linked to inflammation or microbiome imbalances. Fortunately, targeted diets, mindfulness techniques, and medical interventions offer relief. While recovery varies, experts stress the importance of early intervention and holistic approaches to managing these life-altering conditions. How Covid Can Change Your Gut - The New York Times (gift article).

Lawn and Order: Farming the Front Yard

In Los Angeles, lawns are transforming into sustainable micro-farms, thanks to Crop Swap LA. These hyper-local gardens provide fresh produce to food-insecure families while using a fraction of the water that grass demands. The initiative, founded by Jamiah Hargins, turns suburban spaces into eco-friendly hubs, demonstrating that small-scale farming can fight food insecurity and environmental waste simultaneously.Growing Food Instead of Lawns in California Front Yards - The New York Times (gift article).

Algorithm Checkup: Regulating AI in Medicine

With AI-driven tools increasingly guiding healthcare decisions, experts warn of unregulated risks in clinical algorithms. A new rule under the Affordable Care Act aims to prevent biases in medical AI but leaves gaps for non-AI tools. Researchers stress the need for consistent standards across all clinical decision aids to ensure transparency and equity in patient care. AI in health should be regulated, but don't forget about the algorithms, researchers say.

109 - Lucid Dreams, Unpacking Chemicals, and Quelling Inflammation - HealthHippieMD Week In Review

Lucid Dreams, Lucid Schemes

Living In A Lucid Dream explores the phenomenon of lucid dreaming, blending personal experiences with scientific and philosophical perspectives. Lucid dreaming, a state where individuals are aware they’re dreaming and can sometimes control their actions, has intrigued thinkers from Aristotle to modern researchers. Evans dives into the history of dream studies, from Buddhist traditions to 20th-century breakthroughs in REM research, and contemplates the philosophical implications of dreams. While lucid dreaming offers exhilarating possibilities, it also raises questions about reality, consciousness, and the balance between control and the dream’s inherent mystery.

Old Phages, New Rages

Once sidelined by antibiotics, phage therapy is being reconsidered to combat antibiotic resistance. Researchers are exploring phages that target bacterial efflux pumps—key in antibiotic resistance—forcing bacteria into an evolutionary trap. If bacteria mutate to avoid phages, they lose antibiotic resistance, and vice versa. This “phage steering” has shown promise against multidrug-resistant bacteria like Pseudomonas aeruginosa and Acinetobacter baumannii. However, challenges remain, including unpredictable results and safety concerns. Despite these hurdles, phage therapy could offer a vital tool in the fight against antibiotic-resistant infections. A Fix for Antibiotic Resistance Could Be Hiding in The Past - The Atlantic.

Brain Drain and COVID Strains

Did the Pandemic Break Our Brains? | TIME explores the cognitive impacts of the COVID-19 pandemic, both from the virus itself and the related social and mental stress. Individuals report memory issues and cognitive slips, which researchers suggest may result from brain inflammation caused by SARS-CoV-2 or the trauma of pandemic life. Studies link COVID-19 to subtle IQ drops and brain fog, but stress and disrupted routines also play a role. While some effects may be reversible with time and brain-healthy habits, the road to full mental recovery is still being studied, offering cautious hope.

Inflammation’s Role in Disease

Emerging research reveals that inflammation may not only be a symptom but a driving factor behind numerous chronic diseases. While essential for healing and infection defense, persistent low-grade inflammation has been linked to conditions like heart disease, dementia, and even infertility. Drugs like GLP-1 agonists, such as Ozempic, promise to reduce this inflammation, offering potential benefits beyond weight loss. However, the complex balance between necessary immune responses and harmful chronic inflammation suggests that treatment must tread carefully to avoid unintended consequences. Opinion | Inflammation May Be the Root of Disease - The New York Times (gift article).

The Gut Benefits of Resistant Carbs

Resistant starch, found in foods like green bananas, raw potatoes, oats, certain nuts and seeds, beans, and legumes, resists digestion in the small intestine and ferments in the colon, feeding beneficial gut bacteria. This prebiotic powerhouse improves gut health, reduces inflammation, supports weight loss, and regulates blood sugar. Despite these benefits, most adults fall short of the recommended daily intake of 15 grams. Experts suggest incorporating more whole grains, legumes, and cooled starchy foods into your diet to harness the many health advantages of this underrated carbohydrate. Why this type of carb is so good for your gut health.

Douse Inflammation with Diet

Chronic inflammation can be mitigated through mindful eating. Foods rich in fiber, antioxidants, and omega-3s—like leafy greens, berries, legumes, and fatty fish—help combat inflammation. Spices such as turmeric and ginger and fermented foods and beverages like yogurt and kombucha offer additional benefits. A diverse diet featuring 30+ foods weekly, including coffee and tea, promotes better inflammation management. While no single food is a cure-all, a balanced diet remains vital to keeping inflammation at bay. The Foods That Fight Inflammation - The New York Times (gift article).

Why OpenAI’s o1 Model is a Game Changer

OpenAI’s new o1 model represents a significant leap in AI reasoning capabilities, focusing on advanced tasks like mathematics and coding rather than just language processing. Unlike its predecessor, GPT-4o, which struggled with reasoning-based challenges, o1 excels at “chain of thought” techniques, breaking down complex problems and learning from its mistakes. This model achieves high accuracy in competitive coding and math challenges, outperforming human experts and previous AI models. While its capabilities are exciting for research and STEM fields, the model’s steep price tag limits its accessibility. Why OpenAI’s new model is such a big deal | MIT Technology Review.

Life: A Problem-Solving Algorithm

Is life a complex computational process? | Aeon Essays explores whether life is a computational process rather than a purely chemical one. By drawing parallels between computation and biological adaptation, it argues that life emerges from problem-solving functions, much like a computer program. It explores three hypotheses—the Tron, Golem, and Maupertuis—each proposing that life can be simulated, synthesized, or follow deeper universal principles beyond chemistry. These perspectives challenge traditional views, suggesting life is not defined by specific materials but by its ability to solve problems and adapt to environments, much like a computational system.

Unpacking Chemicals in Our Food

A recent study highlights the alarming infiltration of over 3,000 chemicals from food packaging into our bodies. Everyday items, like plastic-wrapped meat or takeout containers, expose us to substances that may pose health risks. While the convenience of food packaging is undeniable, the study raises concerns about the cumulative impact these chemicals—such as PFAS and phthalates—could have over time. Researchers are urging for more transparency and better regulation to mitigate potential health risks from materials that come in contact with our food. Scientists just figured out how many chemicals enter our bodies from food packaging - The Washington Post (gift article).

103 - Erythritol Issues, Diet over Drugs for I.B.S., and Preventing Cancer - HealthHippieMD Week In Review

The Risky Truth Behind Erythritol

A recent study reveals that erythritol, a popular sugar substitute found in products like Truvia and Splenda, may increase the risk of heart attack and stroke by elevating platelet activity, which can lead to blood clot formation. The study compared erythritol with sugar and found that while sugar did not affect platelet activity, erythritol significantly did. Despite being classified as “generally recognized as safe” by the F.D.A., this research calls for further long-term studies to assess the cardiovascular risks of erythritol and similar sugar substitutes. This Popular Sugar Substitute May Put Your Heart at Risk, A New Study Reveals.

Rolling Towards Relief

The F.D.A. is nearing a decision on the approval of MDMA-assisted therapy for treating PTSD, a move that could revolutionize psychedelic medicine. This potential approval has sparked a bipartisan lobbying effort from veterans, lawmakers, and researchers, advocating for the drug’s benefits despite concerns over trial data. The therapy, combining MDMA with talk therapy, has shown promising results in reducing PTSD symptoms, but challenges remain, including the stigma surrounding psychedelic drugs and the need for rigorous data. The F.D.A.’s decision could set a precedent for future treatments in the burgeoning field of psychedelic medicine.Veterans and Lawmakers Lobby for Approval of MDMA Therapy - The New York Times (gift article).

+despite the lobbying by some powerful groups, the F.D.A. did not approve MDMA: F.D.A. Officially Rejects MDMA-AT as PTSD Treatment | DoubleBlind Mag.

The Lingering Toll

A recent global study estimates that 400 million people have experienced long-term COVID-19, highlighting the ongoing and severe impact of the condition. With only 7-10% of patients recovering fully within two years, long Covid poses significant challenges for healthcare systems and economies, costing an estimated $1 trillion annually. The report stresses the need for more research into treatments and biological mechanisms while recommending policy changes to support affected individuals. The study underscores the far-reaching effects of long-term COVID-19 on individuals’ lives, work, and communities. About 400 Million People Worldwide Have Had Long Covid, Researchers Say - The New York Times (gift article).

Gender Prescription

Recent research suggests that patients under the care of female doctors have better outcomes than those treated by male doctors. This trend, observed across multiple countries, remains puzzling despite consistent data supporting it. Various factors, such as attentiveness to symptoms and quality of care, are posited as reasons, but the exact cause of this gender discrepancy is still unclear. While the findings provoke thought, they also underline the need to explore how gender influences medical care quality and patient survival rates. Do women make better doctors than men? (gift article).

Beyond the Scale

GLP-1 agonists like semaglutide and tirzepatide, known for their weight loss effects, reveal broader health benefits. Initially developed for diabetes, these drugs show promise in enhancing heart health, protecting kidneys, reducing sleep apnea, and even combating addiction and cognitive decline. Clinical trials highlight their potential to lower cardiovascular risks, reduce inflammation, and support brain health, suggesting these medications may act on multiple body systems beyond weight control. As research progresses, GLP-1 drugs could redefine their role in health promotion, not just weight loss.The Benefits of Ozempic Are Multiplying | WIRED.

Parasites as a Neurological Delivery System

Scientists are exploring using the parasite Toxoplasma gondii as a novel drug delivery system for brain diseases. The blood-brain barrier often prevents effective treatment of neurological conditions, but Toxoplasma naturally crosses this barrier. Researchers have engineered the parasite to deliver therapeutic proteins directly into neurons, potentially offering new treatments for disorders like Rett syndrome. However, the inherent risks of Toxoplasma infection, including its link to neurological issues, present significant challenges before this method can be used in clinical settings. Ick. How Do You Get Drugs to the Brain? Maybe Try a Parasite | WIRED.

Mind Games

Are You Psychic? Nudge, Nudge explores the concept of “population stereotypes,” a psychological phenomenon that explains how predictable human responses can create the illusion of telepathy. Through engaging examples, the author demonstrates how large groups of people consistently choose certain numbers and symbols, making it appear as though psychic abilities are at play. The article delves into the history of these demonstrations, including Uri Geller’s famous televised telepathy act, and uncovers how understanding these patterns can debunk claims of paranormal activity.

Preventing Cancer

# I’m an oncologist. Here’s what I do to reduce my own cancer risk (gift article) explores five practical steps to reduce cancer risk, emphasizing the importance of modifiable behaviors. Key strategies include vigilant sun protection to minimize U.V. exposure, limiting alcohol intake to reduce various cancer risks, abstaining from smoking to lower the likelihood of lung and other cancers significantly, incorporating daily exercise to lower risks of several cancers, and maintaining a balanced diet by avoiding sugary drinks, fast food, and processed meats. While some cancer risks are unavoidable, these proactive measures can play a significant role in prevention.

Diet Beats Drugs for I.B.S. Relief

Irritable bowel syndrome (I.B.S.) is a challenging condition with symptoms like abdominal pain, bloating, and irregular bowel movements. Traditional treatments often include medications like laxatives and antidepressants. However, a new study published in The Lancet highlights that dietary changes, specifically a low-FODMAP diet, may offer more effective symptom relief than medication. This approach, which involves avoiding certain carbohydrates that trigger symptoms, is gaining recognition as a powerful tool in managing I.B.S. for many sufferers. What’s the Best Way to Treat I.B.S.? - The New York Times (gift article).

101 - Nonprofit Hospital Illusion, Genetic Discrimination, and Microbial Athletic Edge - HealthHippieMD Week In Review

Long COVID: An Unsettling Puzzle

Long COVID, a widespread post-infection condition, affects millions globally, significantly impacting health and economies. Despite over 24,000 scientific publications, understanding still needs to be completed. The risk of long COVID has declined due to vaccines and viral changes, yet millions still suffer. It manifests in over 200 symptoms, from respiratory issues to neurological and metabolic disorders, severely impacting daily life and work. Recent studies suggest persistent viral presence and immune dysfunction as causes. Misleading public narratives downplay its threat, but data shows COVID-19 remains a severe and ongoing health risk.Long COVID puzzle pieces are falling into place – the picture is unsettling.

The Need for Genetic Discrimination Safeguards

The increasing popularity of genetic testing, with millions sharing their DNA for health and ancestry insights, raises critical concerns about genetic discrimination. Genetic data, often inadequately secured, poses risks if accessed by insurance companies or employers, leading to potential discrimination. This article highlights the ambiguity in defining genetic discrimination, drawing parallels to historical eugenics. Despite existing laws, varying definitions complicate protection efforts. Newer tests, like those measuring biological age, further complicate the landscape. Policymakers face challenges in creating robust protections, while individuals are urged to scrutinize data-sharing terms and understand their rights. Why we need safeguards against genetic discrimination | MIT Technology Review.

VR: The Body Image Game-Changer?

Virtual reality (VR) is emerging as a promising tool to tackle body image disturbances. These disturbances, often linked to eating disorders and body dysmorphic disorder, stem from faulty multisensory integration, leading to distorted body perceptions. VR-based "embodiment illusions," like the "rubber hand illusion," can trick the mind into feeling it inhabits a different body, potentially realigning these perceptions. Research shows that people with higher body image disturbance are more susceptible to these illusions, which can reduce perceptual distortions and negative emotions about body size and shape. While promising, further research is needed to understand the long-term effects and ethical implications. Can Virtual Reality Help Folks With Body Image Disturbance?

Dream Cuisine

Sleep deprivation affects about one-third of Americans, leading to severe health issues. However, improving sleep quality is achievable through specific dietary habits. Consuming foods rich in tryptophan, like turkey, fish, eggs, and nuts, combined with healthy carbs, can enhance melatonin production, promoting better sleep. Adopting a Mediterranean diet high in fiber, zinc, B vitamins, and magnesium can also aid sleep. Avoiding inflammatory foods such as sugary cereals and saturated fats is crucial. A consistent eating schedule and incorporating gut-friendly foods like yogurt and fermented items can further support restful sleep. 8 Eating Habits That Improve Your Sleep | TIME.

The Nonprofit Hospital Illusion

Many major nonprofit hospitals are barely charitable, maintaining tax-exempt status while running numerous for-profit ventures. They exploit legal loopholes, enjoy regulatory leniency, and engage in extensive lobbying to operate like big businesses yet avoid taxes. Their activities include owning for-profit insurers, venture capital firms, and hospitals abroad. Despite significant earnings, they report "operating surpluses" instead of profits. Critics argue these hospitals should lose tax benefits as their community contributions are minimal compared to the financial advantages they gain. The article calls for stricter regulations and more accountability to prevent such exploitation. Opinion | Many hospitals are nonprofit in name only, and get away with it - The Washington Post (gift article).

The Microbial Edge in Athletic Performance

Endurance athletes constantly seek ways to enhance their performance, often focusing on optimizing their mitochondrial health through rigorous training and precise nutrition. However, emerging research highlights the gut microbiome as a crucial yet overlooked factor in athletic excellence. The gut microbiome, a complex community of microorganisms, aids in nutrient absorption, immune function, and even communication with mitochondria. Elite athletes often exhibit unique microbiomes that directly impact performance and boost VO2 max and lactate thresholds. Integrating microbiome-friendly foods and probiotics into diets can significantly enhance endurance and recovery, presenting a new frontier in sports nutrition. Athletes looking for a competitive edge may find it within their gut microbiome.

+see also: Do Gut Bacteria Improve Athletic Performance? (yes, if you're a mouse, and maybe if you're a human) — HealthHippieMD.

Fun Fitness Challenges Await

7 Fitness Tests to Gauge Your Strength and Mobility - The New York Times (gift article) introduces seven fitness tests to assess strength, mobility, and overall fitness. These tests range from measuring flexibility and balance to evaluating power and VO2 max, catering to various fitness levels. The tests include simple activities like standing on one leg, gripping a bar, and rapidly getting out of a chair. They aim to provide a comprehensive snapshot of one's fitness, helping individuals track progress and set achievable goals. Whether you're training for a marathon or just curious about your fitness, these tests offer valuable insights and fun challenges.

Mind Over Matter

Advanced meditation is revolutionizing our understanding of consciousness. Neuroscientist Matthew Sacchet delves into the brain's behavior during deep meditative states. Unlike mindfulness practices for stress reduction, advanced meditation explores profound states of ecstatic bliss, deep insights, and compassionate experiences. Sacchet, who has meditated since childhood, uses a multidisciplinary approach to study these states, combining personal experiences, wisdom traditions, and empirical neuroscience. His research aims to unlock advanced meditation's potential for enhancing mental health and well-being and even integrating with psychedelics and AI for deeper consciousness insights. Altering Consciousness with Advanced Meditation | Scientific American.

Canines Catch Your Cortisol

Research from the University of Bristol reveals that dogs can detect human stress through scent, specifically the cortisol hormone in sweat. In the study, dogs were exposed to sweat samples from stressed and relaxed volunteers. The results showed that dogs became more pessimistic about ambiguous situations after smelling stress-induced sweat, suggesting they emotionally react to human stress. This emotional contagion between humans and dogs likely evolved for mutual survival benefits. The findings emphasize the profound empathetic bond between humans and their canine companions, highlighting the impact of human emotions on dog behavior. When Dogs Smell Your Stress, They Act Sad | Scientific American.

050 - Metformin for Long-Covid, Aging Gracefully, and Loneliness - HealthHippieMD Week In Review

Metformin and Long Covid

A recent study published in The Lancet Infectious Diseases reveals that metformin, a commonly used diabetes drug, may reduce the risk of developing long COVID by 41 percent for individuals who are overweight or have obesity. Long COVID, a condition characterized by persistent symptoms after a COVID-19 infection, has no approved treatment. The study's findings offer hope, but further research is needed to validate the results and explore how metformin prevents long COVID. Although the mechanism is unclear, unlike the authors, who opine that metformin may interfere with viral replication, I think a more likely explanation is that it modulates the immune system through its influence on the microbiome. A Common Diabetes Drug May Prevent Long COVID in Some People - Scientific American

Covid and the Introversion - Extroversion Dynamic

An interesting piece in WaPo about how Covid (permanently?) flipped the script in social dynamics: Opinion | The world has become more introverted. And I hate it. - The Washington Post (gift article)

How to Age Gracefully

A new study suggests that learning new skills can have significant cognitive benefits for older adults. The authors hypothesize that cognitive slowing as a senior is akin to the "summer slide" that schoolchildren experience (every year, teachers and parents observe how summer vacations lead some children's academic progress to backslide). What if the elderly experience a similar phenomenon? The research found that a three-month intervention program involving classes on various skills, such as singing, drawing, and language learning, improved participants' memory and attention. Surprisingly, the cognitive gains continued even after the program ended, with participants' abilities resembling those of individuals 30 years younger. Encouraging lifelong learning and creating enriched environments for older adults could enhance their cognitive skills and support healthy aging. To Stay Sharp as You Age, Learn New Skills - Scientific American

Consciousness Conundrum: Animal Awareness and Neural Correlates

Here is another story from the 26th meeting of the Association for the Scientific Study of Consciousness (mentioned last week). The article discusses the potential consciousness of vertebrates, cephalopods, and arthropods, with debates on their complex behaviors and brain structures. Additionally, the possibility of achieving conscious artificial intelligence and its ethical concerns were discussed. Thousands of species of animals probably have consciousness

How Susceptible are you to Misinformation?

A new test designed to measure susceptibility to misinformation reveals that younger Americans struggle more with identifying fake news than older generations. Researchers developed the "misinformation susceptibility test" (MIST) at the University of Cambridge in collaboration with YouGov. Participants were presented with authentic and AI-generated false headlines and had to differentiate between them. The study found that individuals who spent more time online and relied on social media platforms for news were more prone to falling for misinformation. Age and personality traits also played a role in susceptibility. While the test has some limitations, it underscores the importance of media literacy in navigating the information landscape. How Susceptible Are You to Misinformation? There's a Test You Can Take - Scientific American

Can Math and Physics Save an Arrhythmic Heart?

"Abnormal waves of electrical activity can cause a heart's muscle cells to beat out of sync."_ In Can Math and Physics Save an Arrhythmic Heart?, Flavio Fenton, an expert in cardiac dynamics, discusses ways to treat heart arrhythmias without resorting to painful defibrillators.

Weighing In: The Hidden Costs of Dieting

In the article Why You Don't Just Lose Fat When You're on a Diet Adam Collins explores the consequences of dieting beyond fat loss. While being in a calorie deficit helps shed weight, it also results in the loss of muscle mass. The depletion of glycogen stores leads to the release of water weight. Moreover, the body turns to metabolizing muscle tissue for energy, impacting metabolism and potentially causing weight regain. The article emphasizes the importance of exercise, protein intake, and sustainable lifestyle changes for maintaining muscle mass and preventing metabolic shifts during weight loss.

Ozempic: A Treatment for Addictive Behaviors?

This week, Scientific American published an article on a phenomenon I first mentioned in Newsletter 43. A surprising side effect of Ozempic, a diabetes drug that aids weight loss, has emerged: users report a reduction in cravings for addictive substances such as nicotine, alcohol, and gambling. Scientists are now investigating whether these weight-loss drugs, including Ozempic, can be used to treat addiction. Ozempic targets a hormone that regulates appetite and weakens the brain's Association between food and pleasure. Animal studies have shown promising results, but human trials are still limited. Researchers are initiating their studies to determine the safety and effectiveness of these drugs in addiction treatment. Could New Weight-Loss Drugs like Ozempic Treat Addiction? - Scientific American (Thanks Dave Pell, NextDraft)

The Epidemic of Loneliness

"Research has shown that a lonely brain is transformed. Neurotransmitters important for bonding and social connection go haywire. The hypothalamic-pituitary-adrenal axis, responsible for modulating stress, is hyperactive. The amygdala, which triggers our fight-or-flight response and helps process emotional reactions, is in overdrive: In previous studies, Dr. Cacioppo found that lonely people detect negative or threatening pictures and words in under 400 milliseconds. The neuroscience might explain the sadness that accompanies loneliness and the palpable sense of danger." The New York Times had an insightful piece on loneliness: Opinion | How to Treat Loneliness With Medicine. (gift article)

Psychedelics in the U.S. Defense Funding Bill

Lawmakers included funding in the National Defense Authorization Act to look at psychedelics' role in treating PTSD, depression, anxiety, and chronic pain. Psychedelics like MDMA play a part in US defense funding bill

038 - Ice Cream, Understanding Animal Communication, and Circadian Immunity - HealthHippieMD Week In Review

Wait, Ice Cream Might be Healthy?

I enjoyed the article, Could Ice Cream Possibly Be Good for You?. The report not only discusses the controversial, non-spurious outcome that won't go away but also demonstrates what happens in the scientific world when a new finding bucks traditional thinking. And the article contains puns.....

How Generative AI Will Change the Music Industry

Generative AI is not just for text and image creation. AI-Generated Music Is About to Flood Streaming Platforms discusses how AI is changing the music industry and music itself.....

Amyloidosis

The same misfolded proteins found in Alzheimer's Disease can also be found in other organs. Alzheimer's-Like Diseases Can Affect the Body — Scientists Are Working to Find Out Why is an overview of Amyloidosis and its treatment.

Chartreuse Shortage

For my 21st birthday, some friends bought me Chartreuse, a bright green herbal liqueur. That was the only time I tasted it. But now, even if I wanted more, it might not be possible. Chartreuse is getting more difficult to find. Why Is There a Chartreuse Shortage? Ask the Monks Who Make It.

Altered States of Memory

"Memory is "reconstructive." People actively alter the information they remember according to their biases and expectations." Short-term memories were thought to be less subject to alteration, but a recent study demonstrates otherwise: Our expectations can create fake short-term memories. If you'd like to learn more about the fragility/malleability of memory, take a listen to one of my favorite Revisionist History episodes: Free Brian Williams.

How Ultra-processed Food Starves the Microbiome

Another article on how processing alters food--and not in healthy ways: You Could Be Unknowingly Starving Your Gut Bacteria — But The Fix Is Surprisingly Simple. I feel like a broken record....

Is "Non-Communicable Disease" a Misnomer?

Human ailments such as heart disease were thought to be non-communicable. But findings from microbiome research call that belief into question: The Biggest Microbiome Study Sheds New Light on Shared Health Risks.

Covid, Population Risk, and Personal Risk

There is a 1% mortality rate from COVID. If 1% of COVID-19 cases result in death, does that mean you have a 1% chance of dying if you catch it?

FDA Approves Second Bivalent COVID Booster

"Federal health officials will not formally urge that people get a second booster. Instead, the "permissive" policy says they may get a second dose if they want." FDA okays second omicron booster for people at high risk from covid

Why Does Hair Turn Grey?

"A new study suggests stem cells may get stuck as hair ages and lose their ability to mature and maintain hair color." Scientists may have discovered why hair turns grey._

Belated Happy Waldo Day!

This week marked 4/20. In honor of the day, Longreads compiled a list of cannabis-related stories: Weed Between the Lines: A Longreads Cannabis Collection.

Talking to the Animals

I've often joked that I wish Theodore, a six-year-old Labradoodle, could talk. Now, thanks to AI and bioacoustics, my wish may become a reality: How Scientists Are Using AI to Talk to Animals.

Food and Hot Flashes

We don't understand the physiology of hot flashes, but it appears food can influence the severity of this common occurrence: Could Certain Foods Help With Hot Flashes? (gift article)

Us versus Them

"It's been said, "There are two kinds of people in the world: those who divide the world into two kinds of people and those who don't." In reality, there are lots more of the former. And it can be vastly consequential when people are divided into Us and Them, ingroup and outgroup, "the people" (i.e., our kind) and the Others." An stimulating article in Nautilus about us/them dichotomies: Why Your Brain Hates Other People.

Reinvent Yourself According to Experts

Giving credence to your "possible selves" is an evidence-based way to reinvent yourself. How to Reinvent Yourself, According to the Experts tells you how. See also the fantastic podcast: zigzag project.

A Key Character Trait for Happiness

Enthusiasm Is Key to Happiness is an interesting article that touches on psychology and finishes with ways of improving your happiness, regardless of personality type.

Huge Umbrella Analysis of Dietary Sugar

The British Medical Journal published an article that aggregated a huge (8600+) studies on the effects of sugar on health outcomes: Dietary sugar consumption and health: an umbrella review. Read the synopsis here: Study Offers Dozens of Reasons to Cut Sugar

Circadian Rhythms and Immunity

How Circadian Rhythms and Time of Day Control the Immune System describes recent breakthroughs into how our body's internal clock seems to regulate immunity and susceptibility to disease.

029 - Coffee College, Facebook, Resilience and Despair - HealthHippieMD Week In Review

Life may get in the way of newsletter publication next week. I'm apologizing in advance for an abreviated or absent edition. I'll resume normal publication on Sunday, February 26.

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Demoralization of Healthcare Workers

Here is a provocative piece about diminished morale amongst healthcare workers. Although written by a physician about physicians, the same is true for other healthcare professionals. Opinion | Doctors Aren't Burned Out From Overwork. We’re Demoralized by Our Health System (gift article)

Food Choice and Cognition / Dementia

Here is another article on the cognitive value of eating whole, plant-based food: How Your Diet Could Help (or Hurt) Your Aging Brain. For a nice review paper on food and supplements, see: In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function.

Exercise and Resilience

"Resilience is the ability to bounce back from adversity... Resilience is essentially an emotional muscle, but a growing body of research shows that exercising our physical muscles is one way to increase our capacity to cope with daily stress." WaPo had an article on the physiology behind the phenomenon: How exercise can help you build resilience at any age (gift article)

Your Lying Mind

The Atlantic procured several articles on how our minds can deceive us, especially when something threatens our identity: Your Lying Mind - The Atlantic (requires subscription)

Psychedelics Medically Approved Down-Under

Starting July 1, 2023, authorized Australian psychiatrists have another tool in their armamentarium: psychedelics. On February 3, MDMA and psilocybin, but the training standards and hoops to jump through to prescribe these drugs are still formidable: MDMA and Psilocybin Are Approved as Medicines for the First Time | WIRED (thanks, Richard!)

Relationship Contracts

A relationship contract looks pretty unromantic, but it seems to work for this couple: Creating a contract — yes, a contract! — could help you get what you want from your relationship |

Sound Therapy

Sound therapy instruments like the Digeridoo and Tibetan Singing Bowls have been used for thousands of years to calm the mind and heal the body. Is Sound Therapy the New Way to Zen? discusses the phenomenon. I was skeptical about sound therapy until I read literature on how specific frequencies of sound activate immune pathways (in rodents): Alzheimer's Disease and Gamma Waves

Coffee College

I'm interested in perfecting my coffee-making abilities. In the article, Coffee College: Everything You Wanted to Know about Coffee Making in One Lecture, I learned of the coffee-education service Barista Hustle and its associated Youtube channel. I'm setting aside 80 minutes to watch: Advanced Coffee Making Lecture at Assembly Coffee London.

Your Healthcare System: Official Corporate Partner of the NFL

A provocative opinion piece in WaPo about hospital marketing. "So when people see any TV commercial or billboard highlighting a hospital system's quality of care, then walk into that same hospital system's emergency room only to find it dangerously overcrowded and understaffed, it is worth connecting the dots. Imagine how many lives would be saved if only we were to take the bold step of demanding that our healthcare dollars be spent on actual healthcare." Opinion | Super Bowl ads are not where hospitals in crisis should spend money (gift article)

Artificial Intelligence Primer: Wired Complete Guides

Wired has been doing background pieces on today's important technology. Two examples to help you get up to speed: What Is Blockchain? The Complete WIRED Guide and What Defines Artificial Intelligence? The Complete WIRED Guide. Both are worth a read.

A New Approach to Graft-vs-Host Disease and Inflammatory Bowel Disease (pre-clinical)

GI GVHD Link to Microbiome Dysbiosis Addressed by Reducing Intestinal Oxygen discusses a study looking at treating GVHD (and perhaps inflammatory bowel disease) by decreasing the oxygen content in the bowel using iron chelation. "The findings suggested that restoring the normal environment by reducing the oxygen level in the intestine could help re-establish the balance of the microbial community and lead to attenuation of GVHD."

The Science of Pleasurable Touch (pre-clinical)

You've probably heard of "skin hunger," the craving to be touched by another. Scientists are beginning to unravel why being touched by others is pleasurable: Scientists mapped the brain circuitry involved in pleasing touch in mice

How Do You Serve a Friend in Despair

Love oozed from a journalist's writing about his good friend who sunk into depression and ultimately committed suicide. "I learned, very gradually, that a friend's job in these circumstances is not to cheer the person up. It's to acknowledge the reality of the situation; it's to hear, respect, and love the person; it's to show that you haven't given up on them or walked away." Opinion | How Do You Serve a Friend in Despair? (gift article)

All Things Zuckerberg

"We are the germs, but Facebook is the wind." Facebook seems to be at the center of many controversies today. I just read the 2018 article, Can Mark Zuckerberg Fix Facebook Before It Breaks Democracy?, The article was insightful and informative and is a must-read for anyone that wonders what all the hullaballoo is about.

Covid Evolved

A Crucial Group of Covid Drugs Has Stopped Working discusses how Covid has evolved, negating the effectiveness of drugs that were once the mainstay of prophylaxis for immunocompromised patients.