Phages

109 - Lucid Dreams, Unpacking Chemicals, and Quelling Inflammation - HealthHippieMD Week In Review

Lucid Dreams, Lucid Schemes

Living In A Lucid Dream explores the phenomenon of lucid dreaming, blending personal experiences with scientific and philosophical perspectives. Lucid dreaming, a state where individuals are aware they’re dreaming and can sometimes control their actions, has intrigued thinkers from Aristotle to modern researchers. Evans dives into the history of dream studies, from Buddhist traditions to 20th-century breakthroughs in REM research, and contemplates the philosophical implications of dreams. While lucid dreaming offers exhilarating possibilities, it also raises questions about reality, consciousness, and the balance between control and the dream’s inherent mystery.

Old Phages, New Rages

Once sidelined by antibiotics, phage therapy is being reconsidered to combat antibiotic resistance. Researchers are exploring phages that target bacterial efflux pumps—key in antibiotic resistance—forcing bacteria into an evolutionary trap. If bacteria mutate to avoid phages, they lose antibiotic resistance, and vice versa. This “phage steering” has shown promise against multidrug-resistant bacteria like Pseudomonas aeruginosa and Acinetobacter baumannii. However, challenges remain, including unpredictable results and safety concerns. Despite these hurdles, phage therapy could offer a vital tool in the fight against antibiotic-resistant infections. A Fix for Antibiotic Resistance Could Be Hiding in The Past - The Atlantic.

Brain Drain and COVID Strains

Did the Pandemic Break Our Brains? | TIME explores the cognitive impacts of the COVID-19 pandemic, both from the virus itself and the related social and mental stress. Individuals report memory issues and cognitive slips, which researchers suggest may result from brain inflammation caused by SARS-CoV-2 or the trauma of pandemic life. Studies link COVID-19 to subtle IQ drops and brain fog, but stress and disrupted routines also play a role. While some effects may be reversible with time and brain-healthy habits, the road to full mental recovery is still being studied, offering cautious hope.

Inflammation’s Role in Disease

Emerging research reveals that inflammation may not only be a symptom but a driving factor behind numerous chronic diseases. While essential for healing and infection defense, persistent low-grade inflammation has been linked to conditions like heart disease, dementia, and even infertility. Drugs like GLP-1 agonists, such as Ozempic, promise to reduce this inflammation, offering potential benefits beyond weight loss. However, the complex balance between necessary immune responses and harmful chronic inflammation suggests that treatment must tread carefully to avoid unintended consequences. Opinion | Inflammation May Be the Root of Disease - The New York Times (gift article).

The Gut Benefits of Resistant Carbs

Resistant starch, found in foods like green bananas, raw potatoes, oats, certain nuts and seeds, beans, and legumes, resists digestion in the small intestine and ferments in the colon, feeding beneficial gut bacteria. This prebiotic powerhouse improves gut health, reduces inflammation, supports weight loss, and regulates blood sugar. Despite these benefits, most adults fall short of the recommended daily intake of 15 grams. Experts suggest incorporating more whole grains, legumes, and cooled starchy foods into your diet to harness the many health advantages of this underrated carbohydrate. Why this type of carb is so good for your gut health.

Douse Inflammation with Diet

Chronic inflammation can be mitigated through mindful eating. Foods rich in fiber, antioxidants, and omega-3s—like leafy greens, berries, legumes, and fatty fish—help combat inflammation. Spices such as turmeric and ginger and fermented foods and beverages like yogurt and kombucha offer additional benefits. A diverse diet featuring 30+ foods weekly, including coffee and tea, promotes better inflammation management. While no single food is a cure-all, a balanced diet remains vital to keeping inflammation at bay. The Foods That Fight Inflammation - The New York Times (gift article).

Why OpenAI’s o1 Model is a Game Changer

OpenAI’s new o1 model represents a significant leap in AI reasoning capabilities, focusing on advanced tasks like mathematics and coding rather than just language processing. Unlike its predecessor, GPT-4o, which struggled with reasoning-based challenges, o1 excels at “chain of thought” techniques, breaking down complex problems and learning from its mistakes. This model achieves high accuracy in competitive coding and math challenges, outperforming human experts and previous AI models. While its capabilities are exciting for research and STEM fields, the model’s steep price tag limits its accessibility. Why OpenAI’s new model is such a big deal | MIT Technology Review.

Life: A Problem-Solving Algorithm

Is life a complex computational process? | Aeon Essays explores whether life is a computational process rather than a purely chemical one. By drawing parallels between computation and biological adaptation, it argues that life emerges from problem-solving functions, much like a computer program. It explores three hypotheses—the Tron, Golem, and Maupertuis—each proposing that life can be simulated, synthesized, or follow deeper universal principles beyond chemistry. These perspectives challenge traditional views, suggesting life is not defined by specific materials but by its ability to solve problems and adapt to environments, much like a computational system.

Unpacking Chemicals in Our Food

A recent study highlights the alarming infiltration of over 3,000 chemicals from food packaging into our bodies. Everyday items, like plastic-wrapped meat or takeout containers, expose us to substances that may pose health risks. While the convenience of food packaging is undeniable, the study raises concerns about the cumulative impact these chemicals—such as PFAS and phthalates—could have over time. Researchers are urging for more transparency and better regulation to mitigate potential health risks from materials that come in contact with our food. Scientists just figured out how many chemicals enter our bodies from food packaging - The Washington Post (gift article).

036 - Xenopharmacology, Serious Play, and the Happiest Country on Earth - HealthHippieMD Week In Review

Phages and Multi-Resistant Bacteria

What will we use when traditional antibiotics are no longer effective? Many believe we will use phages: In the War on Bacteria, It's Time to Call in the Phages

Prebiotics > Probiotics

Probiotics are not the panacea the industry would lead you to believe: Probiotic supplements claim to boost gut health, but may do opposite (gift article). See also Are Probiotics Making You Fat? probiotics, prebiotics, and fermented food — HealthHippieMD

Telehealth Facility Fees. Really?

I read an interesting story about facility fees. It doesn't seem right patients are charged a facility fee, even if they don't visit the facility. Making a telehealth appointment? You might still pay a facility fee. (gift article)

Hiccups and Cancer

Here is an article with everything you'd like to know about hiccups and a few things you might not: Hiccups have a curious connection to cancer

The Neuroscience of Spiritual Experiences

What is the science behind spiritual experiences, and how do they work from a neuroscientific standpoint? I learned quite a bit from the video: The neuroscience of spiritual experiences +More on mysticism and spirituality: The psychedelic origins of ancient mystical rites

Dad Jokes

Ever wonder why dads are singled out for their groan-worthy humor? This article is for you: What Makes a 'Dad Joke'?

Humor's Impact on Happiness

Here are some valuable hints on humor and happiness from the "How to Build a Life" Series: You Can Tell Bad Jokes and Have a Great Sense of Humor

You Could Care Less

"Humans, by nature, are social beings who crave connection, intimacy, and relationships. Caring about what others think of us is part of that desire to make connections and feel accepted." But what if you put too much weight on what others think? How to Not Care What People Think: 15 Expert Tips. See also: Why You Should Stop Caring What Other People Think (Taming the Mammoth) - Wait But Why

Tofu

The New York Times tackles tofu. Is it healthy or not? Is Tofu Good for You?

How Psychedelics Influence Depression

Psychedelic psychotherapy is all the rage now. What is the science behind psychedelics' potentially beneficial effects on mental health? How psychedelic drugs may help with depression | National Institutes of Health (NIH)

Xenopharmacology

I'm fascinated by this topic, especially for pharmaceutical-dependent areas of medicine such as anesthesiology. As always, Scientific American publishes scientific ideas on the cutting edge. Further kudos to SI for featuring a neighbor (Matt Redinbo) in their article: How Gut Microbes Shape Our Response to Drugs

Animals and Childhood Allergies

An article in the Economist summarized a recent study published in PLOS One. "Children in households with dogs, the researchers found, had lower rates than average of allergies to eggs, milk, and nuts. Those cohabiting with cats seemed more tolerant of eggs, wheat, and soybeans. However, children whose parents kept "turtles" (terrapins, in particular, are popular pets in Japan) appeared unaffected. And, curiously, those exposed to hamsters appeared more likely than average to be allergic to nuts." More evidence that animals reduce childhood allergies

FDA's Dietary Supplement Ingredient Database

"To help manufacturers, retailers, and consumers of dietary supplements stay informed about recent developments and locate information on FDA's website quickly, we have put together an "ingredient directory" with links to FDA's actions and communications concerning particular dietary ingredients and other ingredients used in products marketed as dietary supplements." Dietary Supplement Ingredient Directory

Tripping in the Bronze Age

"A new study based on strands of hair found in a Spanish burial cave reveals that humans living about 3,000 years ago used hallucinogens, likely derived from local plants, as part of their rituals." Tripping in the Bronze Age

On the Topic of Earworms

Everything you'd like to know about the musical phenomenon of Earworms: Song Stuck in Your Head? What Earworms Reveal About Health

Pet Head-Tilts

Dogs have many endearing behaviors. One of my favorites is the head-tilt: Why do dogs tilt their heads? It may signal intelligence.

Finland: The Happiest Country on Earth?

Finland once again led the list of the world's happiest countries. The why is far from cut and dry: "It turns out even the happiest people in the world aren't that happy. But they are something more like the content." Why Is Finland the Happiest Country on Earth? The Answer Is Complicated.

Getting to the Bottom of Fatigue

Fatigue is an important sign. Here is what to pay attention to Fatigue can have many causes. There are ways to ease it. (gift article)

Spring Cleaning (Your Brain)

Here are some tips from WaPo on using the Spring to revamp your life: How to spring clean your brain (gift article)

Play, Video Games, and Learning

Much of my research over my last years at Duke had to do with the use of video games in education and patient care. Here is a look at state of the art in the field: To Supercharge Learning, Look to Play [^1] See also Education is Broken and my other lectures at Presentations on my ePortfolio.


[^1]: I own shares of Akili Interactive whose EndeavorRx is mentioned in the article.

012 - Phages, Cravings, and Fasting for Cancer - HealthHippieMD Week In Review

Helping Loved Ones Through a Medical Crisis

"...ask if they'd like you just to listen or if they need help with problem-solving. Then respect their answer." is often good advice when speaking with close friends or loved ones but is especially important if the person you care about is facing a severe medical crisis: How to help a loved one through a medical crisis

Phages

Medicine is struggling with more and more drug-resistant bacteria. A future without effective antibiotics is almost incomprehensible. The article, Viruses to Fight Superbugs, talks about the renewed interest in phage therapy. A friend (and phage researcher) gave me the book The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug. Adding the text to my queue.

Long-Covid and Chronic Fatigue Syndrome

Another article on how the symptoms of Long-Covid are influencing insight into another poorly understood disease, myalgic encephalomyelitis, or chronic fatigue syndrome (ME/CFS). Long COVID Has Forced the U.S. to Take Chronic Fatigue Syndrome Seriously

White House Conference on Hunger, Nutrition, and Health

It has been 50 years since the American government showed a significant interest in nutrition. The White House Conference on Hunger, Nutrition, and Health, took place on Wednesday and began with a statement by President Biden outlining their commitment before the meeting. Here is a commitment fact sheet released just before the conference: FACT SHEET: The Biden-Harris Administration Announces More Than $8 Billion in New Commitments as Part of Call to Action for White House Conference on Hunger, Nutrition, and Health. The call to action is focused on five pillars:

  • Pillar 1 – Improve Food Access and Affordability
  • Pillar 2 – Integrate Nutrition and Health
  • Pillar 3 – Empower Consumers to Make and Have Access to Healthy Choices
  • Pillar 4 – Support Physical Activity for All
  • Pillar 5 – Enhance Nutrition and Food Security Research I'm anxious to see what other recommendations emerge from this historic conference.

F.D.A. Changes Definition of Healthy Food

The F.D.A. is trying to catch up with nutrition science and limit the burden of diet-related diseases. On Wednesday, the F.D.A. announced a new proposal to change the criteria for which packaged foods may be labeled "healthy." See the news article, F.D.A. Moves to Change 'Healthy' Food Definition. It's exciting to see our government focus on food's important influence on health.

Fasting and Cancer

Here's another video in the fasting and cancer series at Nutrition Facts: Fasting-Mimicking Diet Before and After Chemotherapy

Online Atlas of The Microbiome and Their Metabolites

Our microbial passengers have co-evolved along with us. Under normal conditions, the microbiome works synergistically with human physiology and biochemistry to maintain physical and mental well-being. A recent study, An online atlas of human plasma metabolite signatures of gut microbiome composition, found strong links between certain bacteria living in the gut and small molecules found in the blood. Read the study here: Microbiome and Metabolite Links Uncovered Using Online Atlas. Thanks, Gary!

Why Does Exercise Stick?

Virtually everyone agrees that physical activity is essential for health. Yet less than 5% of us get the recommended 150 minutes of moderate exercise per week. The article How Hard Should Your Workout Be, looks at the factors that make a difference in maintaining an exercise habit.

The Season of Mindfulness and Resilience

If you are prone to Season Affective Disorder, Fall Is the Season for Building Mindfulness and Resilience - The New York Times has some good advice for you.

Cravings and the Addicted Brain

Humans crave all sorts of things, from substances (e.g., alcohol, nicotine, opiates ) to activities (e.g., gambling, sex, or social media). Substance addictions lend some insight into the nature of human craving. Why the pull of addictive cravings is so hard to resist has lots to say.

Quote of the Week

"You can't help what you feel, but you can help how you behave" ― Margaret Atwood.

004 - Fighting Food Waste, Dark Cheerfulness, What We Smell in Our Friends - HealthHippie Week In Review - August 7, 2022

Revamping the Food Expiration System

Americans waste about one-third of their food. The article, Food expiration dates are broken — a microbiologist explains how to fix them discusses revamping the system to be more beneficial for consumers (and to decrease food waste).

Hospital Rankings

This week, the U.S. News and World Report released its hospital rankings. The podcast episode, Should We Trust Hospital Rankings? is an interesting discussion of the ranking system and how the rankings could be improved. "Hospitals compete for prime spots on the U.S. News rankings — but could those lists do more harm than good?"

The Dark Side of Cheerfulness

"Emotions are usually defined by their ungovernability, experienced as forces that wash over us and challenge our sense of agency. That quality is what makes most seem authentic and trustworthy to us. Fake anger or love feels like a betrayal. But fake cheer?..." The excerpt is taken from the book review, The Dark Side of American Cheerfulness on the book: Cheerfulness: A Literary and Cultural History. The review is well worth the read, touching on psychology, culture, history, philosophy, and politics.

Smell you Later

Many of us believe we have cognitive control over most aspects of our lives, including the people we call friends and the people we choose as romantic partners. With all types of human connections, some just "click," but the basis behind interpersonal chemistry remains elusive. As with all things physiological, the story is complex. Do we like our friends because they stink like we do is a reminder that at our core, we are just evolved animals. These researchers claim they can determine "chemistry" between two individuals with 71% accuracy using only their smell.

Pandemic and Positive Emotions

Listened to the Pushkin Podcast from the Happiness Lab with Laurie Santos, What Did the Pandemic Teach Us About Happiness? about the role the pandemic played in happiness. The discussion referred to Surgeon General Vivek Murthy's NEJM article, Confronting Health Worker Burnout and Well-Being. In 2017 I tried to get my proposal, Measuring the impact of biofeedback-enhanced meditation on resident stress, burnout, and well-being, funded. The plan was to begin with residents but ultimately study the entire perioperative healthcare workforce. The proposal was not funded. I remain just as interested today as I was back then, maybe more so now that my daughter has started her long medical training.

Questioning the Theory of Chemical Imbalance in Depression

The manuscript, The serotonin theory of depression: a systematic umbrella review of the evidence. stirred quite a bit of controversy. The commentary in Slate, Why has the misleading chemical imbalance theory of mental illness persisted for so long was one of the better articles I read.

Nutrition and Mental Health

And while we are on the topic of mental health, I discovered a new podcast this week from ZOE Science and Nutrition. I listened to two of the episodes. Both were excellent with a mix of science and actionable advice: How food can improve your mood and Can you reverse damage from a bad diet?

Can We Cure Aging?

Medscape published an excellent brief overview of longevity research: Is There a Cure for Aging?

Dr. Amazon is In

Several interesting stories about Amazon this week. First, an article about Alexa's potential utility in early diagnosis of cognitive decline: Alexa could diagnose Alzheimer's and other brain conditions — should it? The article discusses the technology and some of the ethics behind continuous digital monitoring—food for thought. Voice technology will continue to improve in its ability to "diagnose" many mood and cognitive disorders.

+I woke up to news that Amazon is interested in purchasing iRobot, the company that makes the Roomba. Roomba has a "Smart Maps" feature that maps the interior of your living area. The article focuses on Amazon as a surveillance company. I don't necessarily agree. I wouldn't be surprised if Amazon's interest in iRobot has medical applications--perhaps mapping the safety of an elder's environment to minimize falls. I look forward to hearing more about this deal.

Bacteriophages and IBD

I read an exciting news story on Inverse, Bacteria-eating virus cocktails may effectively treat gut inflammation, that covers the findings in the manuscript, Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation. An Israeli-led team (that includes UNC's Dr. Ryan Balfour Sartor) zeroed in on a strain of bacteria, Klebsiella pneumoniae, and demonstrated the bacteria could cause IBD like symptoms in mice. They then developed a cocktail of phages (viruses that selectively attack particular bacteria) that targeted K. pneumonia and ameliorated damage caused by the bacteria. The authors are now beginning clinical trials. I plan to follow this work carefully.

Thanks for reading. See you next week! Please forward the newsletter to a friend.