Gaming

111 - Fly Brains, Melting Mozzarella, and Super-Potent Psychedelics - HealthHippieMD Week In Review

Neurons Speak Volumes

Scientists have mapped how neurons in the frontal cortex encode word meanings, marking a breakthrough in understanding language processing. By recording neuron activity in epilepsy patients, researchers discovered that specific cells react to words with related meanings, such as foods or objects. Notably, neurons responded differently when words were presented in context versus randomly, emphasizing the role of context in language comprehension. This research opens doors for advanced speech prostheses, possibly enabling the decoding of meanings from neural activity to help those with communication impairments. Scientists map how neurons encode word meanings - Big Think.

The Rise of Super-Potent Psychedelics

Psychedelic Mushrooms Are Getting Much, Much Stronger | WIRED explores the growing trend of breeding increasingly potent psychedelic mushrooms. With advances in cultivation techniques and genetic manipulation, strains are now reaching unprecedented levels of psilocybin content, sometimes exceeding 5% of psychedelic alkaloids. Self-taught mycologist Julian Mattucci, among others, has seen rapid results in potency enhancement, leading to trips more intense than previously experienced, even at lower doses. This push for stronger mushrooms brings excitement but also risks, as some consumers accidentally take too much, leading to challenging or distressing trips.

Happiness Isn't All It's Cracked Up to Be

In "The Techno-Humanist Manifesto," Jason Crawford argues that happiness is a fleeting, relative measure of well-being and not a reliable indicator of human progress. Instead, Crawford suggests that well-being should be measured by the ability to achieve and fulfill personal values. He critiques the idea that wealth or economic growth alone leads to lasting happiness, pointing out that humans adapt to material gains quickly. True well-being, he contends, is found in constant growth, achievement, and the pursuit of values that give life meaning. Why happiness is not the best indicator of well-being - Big Think.

Pattern Recognition Autopilot

A new study reveals that the human brain unconsciously detects patterns in real-time events by integrating "what" and "when" information. Researchers observed the brain activity of epilepsy patients with implanted electrodes, focusing on neurons in the hippocampus and entorhinal cortex, areas involved in memory and navigation. Even when participants were unaware of patterns in sequences of images, their neurons learned and anticipated future events. This discovery highlights the brain's remarkable ability to process and organize information implicitly, suggesting potential applications for memory-enhancement therapies. How Your Brain Detects Patterns without Conscious Thought | Scientific American.

Melting Mozzarella

The science behind why some cheeses melt smoothly while others, like ricotta, don't hinges on the structure of casein proteins and calcium bonds. Cheeses like mozzarella melt into stretchy goodness due to flexible casein networks, while higher acidity or calcium content can result in stiffer textures. The aging process also plays a role, as enzyme activity alters melting characteristics. Understanding how acid, fat, and water content affect cheese provides insight into the culinary variety of melted and non-melted cheeses. Why Cheeses Such as Mozzarella and Cheddar Melt Differently Than Ricotta | Scientific American.

+And if you're as interested in the the science of food and cooking as I am, check out: On Food and Cooking: The Science and Lore of the Kitchen: McGee, Harold.

How Gaming Can Improve Your Sleep

A systematic review (Video gaming and sleep in adults: A systematic review - PubMed) reveals that certain non-arousing video games, such as word games, can enhance sleep quality by promoting relaxation. However, action-packed games like shooters and MMORPGs are detrimental, keeping players mentally engaged and interfering with sleep. Casual gaming, up to seven hours a week, doesn't negatively affect sleep, but excessive gaming can disrupt sleep architecture. Experts recommend low-stimulation gaming before bed to help unwind, emphasizing moderation and caution with screen exposure before bedtime for optimal rest. These Types of Video Games Might Improve Your Sleep, Research Shows.

Lessons in Emotional Health

Happiness class is helping clinically depressed school teachers become emotionally healthy − with a cheery assist from Aristotle explores an innovative course designed to support teachers struggling with stress and depression through evidence-based happiness practices. Led by clinical psychologist John Sommers-Flanagan, the course teaches interventions inspired by Aristotle's concept of eudaimonic happiness, focusing on meaningful relationships, personal growth, and purpose. Participants learn practical techniques like gratitude and mindfulness to improve mental health, sleep, and overall well-being. Early results show significant reductions in clinical depression among educators, highlighting the course's potential as an emotional health tool for teachers and other high-stress professionals.

Mapping a Fly Brain

The most detailed map of an animal brain ever created, a new study reveals the intricate neural connections of the Drosophila melanogaster (fruit fly). With over 140,000 neurons and 50 million synapses, hundreds of scientists have developed this groundbreaking "connectome" since 2013. The brain's network spans 490 feet, and the findings are expected to provide insights into human neuroscience due to the genetic similarities between flies and humans. The study offers 3-D models and diagrams of the fly brain, pushing the boundaries of our understanding of cognition. A New Map of the Fruit Fly Brain (Thanks, Amy, for the recommendation and for helping bring this work to fruition-pun intended!).

Living Immunocompromised

What Does It Mean to Be Immunocompromised? - The New York Times (gift article) delves into the growing population of immunocompromised individuals in the U.S., highlighting the variety of conditions and treatments that weaken immune systems, from cancer to autoimmune diseases. With approximately 18 million adults affected, being immunocompromised presents heightened risks, even from common illnesses like the cold. It underscores the challenges faced by those with compromised immunity, the impacts of treatment, and how the immune system can recover over time. The piece reveals how these vulnerabilities affect everyday life, raising awareness of this expanding health concern.

032 - Bayesian Thinking, Cadavers, and Medical Unions - HealthHippieMD Week In Review

House Staff Local 131

I read an article about physicians unionizing. Although there has been talk about this for quite some time, I did not realize it had already happened in several locations: Doctor Unions Are Good for Your Health

Avatar Now

What do you get when you combine the immersive collaborative experience of an escape room with a video game? You get a Gamebox. Immersive Video Games Are Coming to a Theater Near You

The Plant Whisperer

Are plants sentient? I'm still not convinced, but this scientist theorizes they might be. What Plants Are Saying About Us - Nautilus

Spring Ahead

I read an article from a sleep scientist about the downsides of Daylight Savings time. The report convinces us that we should be on a permanent Standard Daylight schedule, not a permanent Daylight Savings schedule, as is currently suggested in a Congressional Bill.Springing forward into daylight saving time is a step back for health – a neurologist explains the medical evidence and why this shift is worse than the fall time change

Swiss Miss

The iconic Matterhorn of the Swiss Alps will no longer be seen on the wrappers of Toblerone chocolate bars after production moves from Switzerland to Slovakia. Where are Toblerone chocolate bars made?

Taking Control of What you Read on the Internet

Here is an article on the 25-year-old technology, RSS feeds: It's time to take back control of what we read online. I use RSS feeds in various ways. For my daily news, I rely on Feed Bin and Unread. I previously wrote about the ways I use RSS in scholarly activities: Unlock the Power of RSS feeds with DEVONthink — Workflows in Personal and Professional Productivity

This is your Brain on Art

"Art is not a luxury for our downtime, but an important contributor to physical and mental well-being..." I couldn't agree more, especially regarding music. How art, music, and dance affect your brain and body. (gift article)

Non-Nutritive Sweeteners

Artificial sweeteners are in various foods, from bread and cereal to tortillas and greek yogurt. Here is an article on the dark side of sugar substitutes: How sugar substitutes sneak into foods and affect your health (gift article)

Healthy, Redefined

The FDA is cracking down on commercial foods that may be labeled 'healthy.' The food companies are resisting: FDA is redefining 'healthy,' and the food industry is pushing back (gift article)

Personality Testing in the Workplace

Many years ago, I went down the rabbit hole, taking any personality test I could get. Although many personality tests (i.e., MBTI) have not been validated, they are increasingly used to make workplace decisions. Personality testing is now a $2 billion industry. The $2 Billion Question of Who You Are at Work (gift article)

The Argument for Moving Closer to Your Friends

"Many people are prepared to move for a new job, to be with a romantic partner, or even just for an adventure. Moving to be closer to buddies should be no different. Friends are not incidental to a good life; they're essential to one. So why not shorten the distance between you and them?" Live Closer to Your Friends

Health Podcasts Worth Listening To

....at least according to the NY Times. I am going to check out a few of these: Here Are 12 Health Podcasts Worth Listening To (gift article)

What Fuels Teen Anxiety?

Reformers have argued for fewer hours in a workweek. Yet, simultaneously, demands on our children at school have increased. Many believe the time needed to become attractive college applicants at the root of teen anxiety: "Richer and more complex economies require more rigorous and intense education, putting more pressure on kids to be high-achieving perfectionists." We're Missing a Key Driver of Teen Anxiety

Does your Microbiome Influence Interest in Exercise? (pre-clinical)

An interesting article in WaPo about how, in mice, the microbiome influences interest in exercise: How your microbiome may influence your motivation to exercise - The Washington Post (gift article)

Cannabis and Anesthesia

An article in the Economist discusses how cannabis influences the amount of drugs needed for adequate anesthesia. Cannabis and anesthesia do not mix

A Short History of Medical Cadavers

Medical students traditionally dissect cadavers while learning anatomy. Ever wonder where the bodies come from? From grave robbing to giving your own body to science – a short history of where medical schools get cadavers "Where many Americans once regarded medical students as "butchers" for exploiting their beloved dead, contemporary students honor what some of these future doctors call their "first patients" for the precious gift they have been given."

Bayes' Rule

After seeing all the evidence, how strongly should you believe something? That question is at the heart of Bayesian thinking, named after the Reverend Thomas Bayes. Here is an interesting video explaining Bayes Rule: Harvard professor explains Bayes' rule and an interesting article on how to use Bayesian Thinking to influence our relationships: Bayes and Deadweight: Using Statistics to Eject the Deadweight From Your Life.

016 - Vampire Hormones, Zombie Fungi, Micromorts, and Bugs in Space - HealthHippieMD Week In Review (Halloween Edition)

Dungeons and Dragons for Mental Health?

I was called a nerd for playing tabletop role-playing games (TTRGs) back in the '70s and '80s. It warms my heart that TTRGs have had a resurgence. The article, How Therapists Are Using Tabletop Games to Help People, discusses how TTRGs are being leveraged outside of entertainment to improve mental health.

Predicting The Likelihood of Death - Micromorts

We all know riding a motorcycle is more dangerous than driving a car. But have you ever wondered precisely how much more dangerous? Enter the concept of micromorts and superforecasting. Worried About Nuclear War? Consider the Micromorts, covers micromorts in the context of the likelihood of nuclear war. The choice of context is not pleasant, but the concept of micromorts is useful. For more on micromorts and other attempts to quantify the likelihood of dying, see my article: The Spreadsheet of Life and Death. For more on Superforecasting, see How spooks are turning to superforecasting in the Cosmic Bazaar (paywall). For one of my favorite Wired articles of all time, see: Why the Future Doesn't Need Us.. I've added the book Superforecasting: The Art and Science of Prediction to my reading list.

Antibiotics as an Adjunct to Improve Mental Health

An article at Medscape, Antibiotic May Enhance TMS, Improve Depression Outcomes, summarized a new publication that demonstrated the addition of the broad spectrum antibiotic, D-cycloserine, to transcranial magnetic stimulation of the brain, may improve outcomes in major depressive disorder. The study team credits the ability of D-Cycloserine to bind to the NMDA receptors for effect, but I can't help wondering if the effect is mediated through changes in the microbiome.

Mindfulness for Substance Abuse Disorder?

Mindfulness has many benefits. Most people think of mindfulness as modulating anxiety and depression. This researcher believes mindfulness should also be part of addiction-treatment programs.

Melatonin - The Vampire Hormone

Most people in the U.S. take melatonin incorrectly. Melatonin for Sleep: How the Aid Works (gift article), has lots of helpful information on the hormone. During a trip to Australia (where melatonin is unavailable over the counter), I took a self-imposed crash course on naturally occurring sources of melatonin. Here is a good WebMD article on melatonin-rich foods: 6 Foods High in Melatonin and Why You Need It

More on the Psychedelic Gold-Rush

The NY Times had an interesting article on the attempts to cash in on psychedelics by patenting everything from molecular compounds to treatment rooms. With Promise of Legalization, Psychedelic Companies Joust Over Future Profits (gift article).

The Therapeutic Potential of "Zombie Fungus"

I have often used pictures of Cordyceps in my lectures to reinforce the notion that at least some human behavior may not be under our control but instead might be driven by microbes: The Zombie Fungus Takes Over Ants' Bodies to Control Their Minds. I was not aware this same fungus has been used to treat various maladies and is currently being examined by pharma for its therapeutic potential: How to grow a zombie fungus in a lab. (thanks, Laura!)

Canine Gilgamesh

The Search for a Pill That Can Help Dogs—and Humans—Live Longer in Wired tells the story of the start-up Loyal, aiming to increase the life expectancy of dogs, and ultimately, humans. I had not heard of the company before. The article is short on science and long on the political challenges and the venture capital exploits of the founder, Celine Halioua. Whether Loyal is truly onto something, is a flash-in-the-pan, or is another Theranos, remains to be seen.

How to Interpret Scientific Literature

The National Center for Complementary and Integrative Health of the NIH released How To Make Sense of a Scientific Journal Article. This is a good resource if you're not familiar with scientific literature.

Microbiomes in Space

Over the last decade, we've learned much about what happens to gut flora in space. This knowledge will be critical for prolonged space flight like a mission to Mars. Studying astronaut Scott Kelly and his identical twin who remained on earth offered many exciting insights. The article, Gut health in space: How zero gravity could wreak the microbiome reports some of the findings.

Can Sense of Smell Predict Depression?

An article on Medscape discussed a recent publication demonstrating hyperawareness of smell may be an indicator of anxiety and/or depression: Can Sensitivity to Common Smells Sniff Out Depression, Anxiety?

Shinrin-yoku: The Soothing Practice of Forest Bathing

More on forest bathing: Shinrin-yoku: The Soothing Practice of Forest Bathing. As I mentioned in 009 - Doritos Dementia, Pain Clocks, and Forest Bathing, I believe a good portion of the benefits of forest bathing are derived from the forest's microbiome. I'd love to prove/disprove my hypothesis.

How are Memories Encoded in the Brain?

The news release, During Sleep, One Brain Region Teaches Another, Converting Novel Data Into Enduring Memories, discusses work building neural networks to understand human memory encoding processes, especially during sleep. In this case, Androids MIGHT Dream of Electric Sheep.

Quote

"Whoever is careless with the truth in small matters cannot be trusted with important manners." - Albert Einstein.