123 - Dog:Human Lookalikes, Midlife Marriage Makeovers, and Mental Health - HealthHippieMD Week in Review

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Happy New Year and welcome to the first issue of HealthHippieMD on Substack mirrored on Squarespace.. If you haven’t yet subscribed to the newsletter click on the “Subscribe” button in the menu and sign up. Eventually, I will fully transition the Newsletter to Substack and stop posting here.

This space is where wellness meets curiosity, blending evidence-based insights with a sprinkle of holistic wisdom. Together, we'll explore innovative approaches to health, the latest in wellness trends, and practical tips to help you thrive in body, mind, and spirit. Please help me grow our community by liking, commenting, or sharing what you read.

Thank you for joining me on this journey—let's grow, learn, and inspire each other to live our healthiest lives.

Be Inspired. Be Informed. Be Well.

Jeff Taekman, M.D.

01

Gut Check on Alzheimer's

Could a common gut virus hold the key to Alzheimer's? A groundbreaking study explores how the human cytomegalovirus may travel along the vagus nerve, stirring immune responses linked to dementia. "Our results indicate a complex, cross-tissue interaction between HCMV and the host adaptive immune response," researchers revealed. This cross-tissue dynamic may open the door to antiviral therapies, potentially slowing or preventing Alzheimer's progression. As researcher Benjamin Readhead puts it, "We're motivated to understand whether these findings have implications for clinical care." Could this be the tipping point in understanding Alzheimer's? Common Gut Infection Tied to Alzheimer's Disease.

02

Ink and Lymphoma: A Risky Canvas?

Tattoos are more than skin deep—they may affect your health. A population-based study reveals a startling 20% increase in lymphoma risk among tattooed individuals, likely tied to carcinogens in tattoo ink and the immune system's response. "The study underscores the importance of regulatory measures to control the chemical composition of tattoo ink," the researchers emphasize, highlighting the urgency as tattoo culture grows. The question lingers: Is beauty worth the risk, or is it time for a regulatory makeover? Tattoos Linked to Malignant Lymphoma-Medscape.

03

Relationship Tips for the New Year

From "repotting" friendships to navigating "yellow flags" in dating to making over your marriage, these expert-backed strategies invite a more profound connection in every relationship. "Grieving and digesting the limits of one another's human imperfections is a central part of long-term intimacy," says family therapist Terrence Real, encouraging self-reflection and mutual understanding. Whether tackling tough conversations or finding joy in shared moments, these tips might transform your connections this year. Strengthen Your Relationships in 2025 - The New York Times (gift article).

04

Mental Health Hacks for 2025

Small changes can make a big difference. Whether moving your body, quieting your inner critic, or learning to embrace uncertainty, these science-backed tips are designed to help you thrive. Mental Health Advice for 2025 - The New York Times (gift article).

05

Midlife Marriage Makeover

Middle age often brings more than gray hairs—it's also a critical juncture for couples. Experts share six essential questions to rejuvenate your relationship, from reflecting on your dreams to uncovering your role in recurring conflicts. "When couples revisit the qualities that first drew them together, it shifts the emotional climate of the conversation," psychologist Harriet Lerner suggests, offering a powerful way to rekindle intimacy. Questions to Ask Your Partner at Midlife, According to Couples Counselors - The New York Times (gift article).

06

Insomnia's Emotional Cost

Sleep deprivation doesn't just leave you tired—it reshapes your mood, your thoughts, and even your mental health. Chronic insomnia, described as "a fire that jumps the fence" by one sufferer, can create a vicious cycle where anxiety disrupts sleep, which in turn exacerbates mental health issues. Cognitive-behavioral therapy for insomnia (CBT-I) has been transformative for many, teaching strategies like reframing negative thoughts and breaking harmful associations with sleepless nights. Is the answer to better mental health lying in bed? How Sleep Affects Your Mood: The Link Between Insomnia and Mental Health - The New York Times (gift article).

07

Who Let the Lookalikes Out?

Do you and your dog share a striking resemblance? Science suggests it's not just coincidence. Psychologist Yana Bender notes, "People consistently match dogs and their owners in photographs, even when the resemblance is subtle." Beyond physical similarities, personality traits also align—extraverted owners often have sociable dogs, while more anxious individuals report pets with heightened stranger-directed fear. Are we choosing pets that mirror us, or are they learning from us over time? Why We Look Like Our Dogs.

08

Mastering Calm

Can a simple breath change your brain? Science says yes. From ancient yoga practices to modern neuroscience, intentional breathing techniques are a powerful tool against stress. Could the rhythm of your breath be the symphony your mind needs? How to use breathwork to calm your mind - The Washington Post (gift article).

09

GLP-1s: A Weighty Solution?

With the obesity epidemic spiraling into a trillion-dollar crisis, GLP-1 drugs offer hope for weight loss and chronic disease prevention. But who benefits—patients, or the bottom line? Will these medications revolutionize care or reinforce inequalities as the health ecosystem pivots? Growth of GLP-1s has implications for multiple stakeholders-Deloitte.

10

Weight-Loss Wonders

Could a lizard's venom hold the secret to curing addiction and preventing Alzheimer's? The unexpected benefits of GLP-1 drugs, born from obesity treatments, are reshaping medical landscapes. These "wonder drugs" may alleviate cravings, protect against heart disease, and slow brain degeneration. With pharmaceutical giants like Eli Lilly racing to unlock their full potential, the question arises: Are GLP-1s medicine's new multi-tool, or just a weighty fix?
https://arstechnica.com/health/2024/12/weight-loss-drugs-may-also-treat-addiction-alzheimers-and-heart-disease/

11

Mindfulness: A Practice of Remembering

What if mindfulness isn't just about calm but transformation? Returning to its Buddhist roots reveals a practice steeped in remembrance—not of the past, but of the present moment. Can you "remember" your way to a more meaningful life? Mindfulness is about 'remembering' − a practice of coming back to the now.

If you enjoyed this newsletter, please comment, like, or share on Substack. Until next week.....

Be Inspired. Be Informed. Be Well.

120 - Mirror Cells, Fighting Inflammation with Food, and Artful Healing - HealthHippieMD Week In Review

120 -- HealthHippieMD Week In Review Audio Overview

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Curiosity Killed the Bias

How to see the humanity in anyone | Psyche Guides explores the transformative practice of "deep curiosity," a tool for fostering empathy, connection, and understanding across divides. The author recounts a yearlong journey meeting individuals with opposing beliefs and challenging stereotypes fueled by assumptions and social media. Through the DIVE model—Detach, Intend, Value, Embrace—he teaches how to unlearn biases, prepare for meaningful dialogue, and honor others' dignity. By viewing challenges as opportunities for growth, deep curiosity strengthens relationships and enriches self-awareness. This guide empowers readers to break barriers and connect authentically in an increasingly polarized world. (Thanks, Laura!).

+see also: The War For Kindness - The Happiness Lab with Dr. Laurie Santos - Apple Podcasts.

Food Fights Inflammation

An anti-inflammatory diet swaps processed foods for whole, nutrient-dense options to combat chronic inflammation. Foods rich in antioxidants, polyphenols, and essential nutrients help reduce oxidative stress and regulate hormones. A Mediterranean-inspired diet—packed with fruits, vegetables, fish, nuts, and olive oil—nurtures a healthy gut biome, while magnesium-rich and brightly colored foods fight stress and free radicals. Spices like turmeric and garlic add flavor and anti-inflammatory benefits. While diet is just one piece of the wellness puzzle, adopting these habits offers long-term physical and mental health benefits—making it a marathon worth running. An anti-inflammatory diet can boost your health. What to eat and what to avoid | Fortune Well.

How Seed Oils May Ignite Cancer Risks

A new study highlights the potential role of omega-6 fatty acids—abundant in seed oils used in ultra-processed foods—in promoting inflammation that fuels colon cancer. Researchers found high levels of these proinflammatory lipids in tumor samples, alongside a deficiency in inflammation-resolving omega-3s. Experts point to dietary shifts since the 1950s, with ultra-processed foods and seed oils dominating modern diets, as a likely factor. While diet isn't the sole contributor, the findings emphasize the complex interplay of food, lifestyle, and genetics in cancer risk, advocating for moderation in omega-6 consumption pending further research. Ultraprocessed Foods High in Seed Oils Could Be Fueling Colon Cancer Risk | Scientific American.

Chasing Happiness

What can ancient philosophy teach us about a well lived life? Examining different schools of philosophical thought can teach us a lot about different ways to create happiness. The philosophy of happiness, explained in 10 minutes - Big Think.

Love Is a Marathon, Not a Sprint

Arthur C. Brooks explores the paradox of love and happiness, arguing that the exhilarating, passionate phase of romance—while thrilling—isn't what brings enduring joy. Instead, he highlights "companionate love," rooted in friendship, mutual understanding, and commitment, as the foundation of lasting happiness. Backed by research like the Harvard Study of Adult Development, Brooks demonstrates that stable relationships, especially those built on deep friendship, are the strongest predictors of lifelong contentment. With humor and personal anecdotes, he underscores that the secret to staying in love lies in simply liking your partner—your best friend. The Kind of Love That Makes People Happiest - The Atlantic.

+see also: This heartwarming video from Coldplay featuring Dick Van Dyke. All My Love Official Version, Director's Cut.

Press Paws

A recent study suggests that dogs may communicate intentionally by pressing buttons linked to words. Researchers found that some dogs form two- or three-word combinations, such as "want food," which appear deliberate rather than random. The study monitored button-pressing behaviors in over 150 dogs using soundboards, finding that dogs can express needs akin to a young child. However, skeptics argue the behavior could stem from training or reinforcement rather than true language understanding. While questions remain, the research highlights dogs' intelligence and their potential for deeper interaction with humans. Dogs may be able to communicate by pressing buttons, research suggests - The Washington Post (gift article).

Snooze You Can Use

Science-Backed Sleep Tips from 2024 to Help You Snooze Better | Scientific American explores 2024's popular sleep trends and their scientific validity. Highlights include the benefits of short naps for memory and mood and caution against "bed rotting," which disrupts circadian rhythms. TikTok's "sleepy girl mocktail" sheds light on magnesium's role in relaxation, while sleeping on the floor offers mixed results for back health. Sleep divorces—partners sleeping separately—can improve rest for mismatched sleepers. To combat election-induced insomnia, experts recommend unplugging, meditating, and reframing anxious thoughts with gratitude. These evidence-backed strategies aim to optimize sleep quality for a more restful 2025.

Artful Healing

Susan Magsamen's exploration of neuroaesthetics reveals the profound effects of art on mental health, trauma recovery, and cognitive disorders. This emerging field connects art, science, and well-being, showing how aesthetic experiences—from painting and dance to music—positively reshape our brains. Programs like Creative Forces empower trauma survivors, while dance improves cognition and mobility in Parkinson's patients. The arts, accessible to all, offer transformative benefits, reducing stress and fostering resilience. By embracing creativity, we can enhance our mental and physical health, proving that the arts are as essential as exercise or nutrition. 'Neuroaesthetics' Reveals How the Arts Help with Dementia and Trauma | Scientific American.

Neuroinflammation and Muscle Fatigue

Neuroinflammation, sparked by the brain's immune response to infections or chronic diseases like Long COVID and Alzheimer's, disrupts the brain-muscle connection, leading to muscle fatigue. This research uncovers how brain-released cytokines alter muscle energy production without damaging muscle structure. Studying fruit flies and mice, scientists identify a universal brain-to-muscle communication pathway that reallocates energy to combat infection. Potential treatments, such as neutralizing antibodies, aim to block this signaling. With further exploration, targeting this axis could alleviate fatigue in long COVID and other neuroinflammatory conditions, improving life for millions worldwide. Brain inflammation may be the reason behind muscle fatigue after infection and injury.

Mirror Cells: The Dark Reflection of Life

Scientists warn of the existential risks posed by "mirror cells," organisms built with reverse-handed DNA and proteins, defying the fundamental biology of Earth's life forms. These synthetic microbes, immune to natural defenses and capable of ecological devastation, could trigger pandemics or disrupt ecosystems if released. While promising medical advancements like long-acting drugs, their potential to bypass immune systems and evolve uncontrollably outweighs the benefits. Leading researchers advocate banning this technology, urging global dialogue to prevent catastrophic consequences before these innovations take root. A 'Second Tree of Life' Could Wreak Havoc, Scientists Warn - The New York Times (gift article).

+see also: one of the most memorable articles from Wired (from 25 years ago!)-Why the Future Doesn't Need Us | WIRED.

The Gut: The New Frontier of Mental Health Treatment

Emerging research highlights the potential of targeting gut cells, rather than brain cells, to treat depression and anxiety. Traditional SSRIs, while effective, often cause systemic side effects. Scientists have observed mood improvements in mice without the usual drawbacks by focusing on serotonin production in the intestines, unveiling the gut-brain connection's crucial role in emotional regulation. This novel approach may also address concerns about SSRI safety during pregnancy, offering a safer alternative for both mothers and babies. These findings could revolutionize mental health care by delivering effective relief without compromising physical well-being. Drugs targeting gut cells, not brain cells, fight depression better - Earth.com. (thanks, Amy!).

+see also: Gut Feelings: The Role of the Microbiome in Behavioral Health — HealthHippieMD.

093 - Electric Dreams, Face Time, and Your Gut on Salt - HealthHippieMD Week In Review

Face Time

Unlike virtual connections, regular face-to-face interactions with friends significantly enhance physical and mental health. Studies reveal that in-person meetings boost the immune system, reduce stress, and improve overall well-being, comparable to the effects of a Mediterranean diet. Frequent physical contact, such as hugs, also benefits the hypothalamic-pituitary-adrenal axis, lowering inflammation and improving sleep. Additionally, our sense of smell and neural synchrony are crucial in forming deeper, more empathetic connections. Decreased time spent with friends underscores the importance of rekindling in-person socializing for better health. In-person friendships are better for health than virtual connections - The Washington Post (gift article) (Thanks, Amy!).

Paws-in

The viral "paws-in" challenge on TikTok sees dogs imitating their owners by placing a paw atop a stack of human hands. The trend delights viewers, showcasing dogs' ability to mimic, seek attention, and connect with their human families. Experts highlight the role of training and innate behavior in dogs' responses. Even if some dogs don't join in perfectly, their varied reactions—using their muzzle or looking for cues—emphasize the deep bond between humans and their pets. The challenge underscores the joy and heartwarming connection pets bring to their owners' lives. Dogs are doing the viral 'paws in' challenge. Here's why. - The Washington Post (gift article).

Electric Dreams

Researchers have explored using electricity to control the immune system for over a decade, promising a revolution in treating chronic diseases like rheumatoid arthritis and diabetes. Despite substantial investment, electroceuticals—implants designed to replace drugs—haven't yet fulfilled their early promise. Meanwhile, new research into bioelectric medicine shows potential for innovative treatments, including fast-healing bandages and cancer therapies. The field faces challenges, including precise targeting and overcoming biases toward nervous system-centric approaches. As research evolves, the dream of electrically hacking the body for better health remains an electrifying possibility. The decade-long quest to hack the body's immune system with electricity | MIT Technology Review.

+see also: 091 - Meta Heads, Embracing Solitude, and The Brain's Immunity Master Switch - HealthHippieMD Week In Review — HealthHippieMD.

Mediterranean Eating May Boost Brain Health

A new study in Nature Aging suggests the Mediterranean diet, rich in fatty acids, carotenoids, and vitamin E, may slow cognitive decline. Researchers from the University of Illinois and the University of Nebraska-Lincoln found that participants aged 65-75 with delayed brain aging had larger brain volumes, better connectivity, and higher cognitive scores. Essential nutrients included α-linolenic acid and eicosapentaenoic acid from fish and plants, carotenoids from colorful vegetables, and vitamin E from nuts and oils. While promising, the study calls for further research across diverse populations. New Study Suggests Mediterranean Diet May Slow Cognitive Decline.

Cognitive Harmony

Understanding cognition requires viewing the brain's large-scale coordination of neural activity, driven by rhythmic electric fields, rather than focusing on individual neurons. MIT neuroscientists argue that brain rhythms, once dismissed as mere byproducts, are crucial for organizing neural activity. These rhythms influence cognition and could be key to treating disorders like schizophrenia and epilepsy. Brain waves like beta and gamma rhythms coordinate complex cognitive tasks, acting like stencils guiding neural activity. Scientists hope to unlock deeper insights into how thoughts and memories form and function by studying these rhythms. To understand cognition, neuroscientists must learn its rhythms - Big Think.

The Brain-Belly Connection

In this episode of the Huberman Lab Podcast, Stanford's Dr. Andrew Huberman hosts Dr. Diego Bohórquez of Duke University. Dr. Bohórquez, an expert in gastrointestinal physiology and neuroscience, delves into the gut-brain axis, focusing on how our gut senses food. Unlike the popular microbiome focus, Dr. Bohórquez explores how our gut detects nutrients like amino acids, fats, and sugars, akin to how our eyes sense light. This episode reveals the intricate sensory mechanisms within our digestive system, offering a deeper understanding of how our gut communicates with our brain. ‎Huberman Lab: Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis.

Following the Pharma Funds

How much Big Pharma is paying doctors discusses the financial relationships between doctors and pharmaceutical companies, highlighting the Open Payments website. This platform, run by Medicare, allows the public to see the payments made to doctors by healthcare companies. A recent JAMA study revealed that many physicians endorsing products on social media have received payments from the companies behind these products. The article emphasizes the importance of transparency in understanding these financial ties and their potential impact on healthcare costs and quality in the U.S.

Your Gut on Salt

Excessive salt, though essential historically, disrupts the gut microbiome, likely contributing to health issues like high blood pressure, heart disease, and metabolic disorders. Modern diets, laden with processed foods, exacerbate these problems. High sodium intake alters beneficial gut bacteria, leading to inflammation and metabolic disruptions and increasing cravings and weight gain. Reducing salt intake and focusing on unprocessed, plant-based foods can help maintain a healthy microbiome and prevent disease. The push for lower sodium in diets faces challenges from industry lobbyists, but evidence for its necessity continues to grow. How Salty Food Can Poison Your Microbiome.

Jazz Mind and Flow

Researchers at Drexel University's Creativity Research Lab studied how jazz musicians reach a creative "flow state." They discovered that flow involves a balance between expertise and releasing focus. Using EEG, they recorded the brain activity of 32 jazz guitarists, finding that flow states correlated with reduced frontal lobe activity, indicating low cognitive control. Experienced musicians showed enhanced sensory brain activity. The study suggests achieving flow requires extensive practice and the ability to let go of conscious control, allowing automatic, creative responses. This dual approach can help in mastering any creative task. Brain Scans of Jazz Musicians Reveal How to Reach a Creative' Flow State' | Scientific American.

+see also: We all can reach a "flow state." Here's how. - Big Think.

080 - Entrepreneurial Hearts, Microbial Moodiness, and an Ode to Pop-Tarts - HealthHippieMD Week In Review

I increased the number of articles today since I won't publish a newsletter next week. The newsletter will return on March 3, 2024.

Tidying Up for Sanity

"The average person likely loses 5 percent of their time due to disorganization. Take your annual salary, multiply that by 5 percent, and you can measure what disorganization may be costing you." In Being organized can improve mental health. This is why., Daryl Austin explores how organization can positively impact mental health. Research suggests that living in a cluttered environment is associated with memory issues, poor eating habits, mood disorders, and decreased impulse control. It also is associated with increased stress levels, affecting overall well-being. However, organizing can enhance productivity, reduce exhaustion, and improve quality of life. Experts recommend starting small, setting aside specific time for decluttering, and enlisting support if needed. Digital decluttering is also emphasized. Ultimately, organizing sends a message of self-worth and can lead to a more intentional and loving relationship with one's home.

Aging Gracefully

As life expectancy increases, researchers are shifting focus from merely extending lifespan to enhancing healthspan—the years free from debilitating diseases. Key strategies include studying centenarians for genetic insights, promoting healthy lifestyles through diet, exercise, and mental engagement, and exploring experimental medications like metformin and rapamycin. Self-monitoring and social connectivity also play pivotal roles. While the quest for longevity continues, experts stress the importance of prevention and personalized approaches to optimize healthspan and ensure a healthier, more fulfilling life as we age.It's not your life span you need to worry about. It's your health span.

Long COVID's Exercise Paradox

A recent study sheds light on why many long COVID sufferers struggle with exercise. Post-exertional malaise (PEM), a defining symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), leads to a debilitating cycle of fatigue and worsened condition in Long-COVID patients. The study reveals that after exercise, these patients experience muscle damage, changes in muscle composition, and disrupted energy metabolism. Notably, they exhibit lower energy-generating processes and an impaired ability to recover from exercise. These findings underscore the importance of pacing oneself to minimize the severity and duration of post-exertional malaise in long COVID patients. Long COVID can destroy your ability to exercise. Now we know why.

Wired for Sound

Exploring the neuroscience of musical preference reveals intriguing connections to our personalities, emotions, and social identities. Our brains are naturally drawn to music with unexpected elements, triggering pleasurable responses. Studies show that our musical tastes evolve, influenced by our emotions and experiences. This suggests a deep link between music preference and personal identity. Understanding these connections can help bridge gaps between individuals with different tastes, highlighting musical enjoyment's universal and individual aspects. The Neuroscience of Musical Tastes - Neuroscience News.

Mastering the Apology

Why is it so challenging to deliver a genuine apology? Experts say a sincere apology requires vulnerability and humility, admitting wrongdoing without justifications or excuses. Research shows that effective apologies can lead to forgiveness, benefiting both the giver and the receiver. To craft a meaningful apology, experts suggest expressing regret without using conditional language, explaining the offense briefly, acknowledging the harm caused, promising not to repeat the mistake, offering to make amends, and gently requesting forgiveness. These steps can help repair relationships and foster understanding. How to Apologize Like You Mean It - The New York Times (gift article).

Self-Training Paradox: AI's Strange Evolution

As AI evolves, researchers turn to self-training methods, using machines to teach machines. This approach, while promising, raises concerns about the technology's opacity and potential to produce "unintelligible intelligence." With AI models already exhibiting complex behaviors and the ability to "cheat" in tasks, the path to actual artificial teaching is fraught with challenges. While self-training could lead to groundbreaking discoveries and efficiencies, it also poses risks of reinforcing biases and producing outcomes humans struggle to understand or control. As AI advances, so does the need to consider its capabilities and implications carefully. Things Get Strange When AI Starts Training Itself - The Atlantic.

Ageless Wonders

From the depths of the oceans to the ancient lands, Earth's inhabitants boast lifespans that defy human comprehension. Bowhead whales roaming Arctic waters can live over 200 years, while Jonathan, the Seychelles giant tortoise, has thrived for over 190 years. By unlocking the secrets of these long-lived creatures, scientists aim to understand the complex interplay of genetics, environment, and lifestyle that contributes to their exceptional lifespans. What Is the Longest Living Animal? From Tortoises to Whales | HowStuffWorks.

Memory Meltdown

A night of less than six hours of sleep can significantly impact your short-term memory, impairing your ability to recall information the next day. Sleep-deprived individuals may also experience reduced attention, emotional instability, and difficulty encoding new information. Lack of sufficient sleep can negatively affect the brain's frontal lobe, impacting memory retrieval and executive function. While remote memories remain intact, short-term memory and cognitive performance decline with each additional hour of missed sleep. Proper rest is crucial for memory consolidation and overall cognitive health. How Sleep Deprivation Can Affect Memory - The New York Times (gift article).

An Ode to Pop-Tarts

The passing of Bill Post, one of the creators of Pop-Tarts, stirs memories of this iconic childhood treat. Originally released in Cleveland 60 years ago, Pop-Tarts have become a pop-culture phenomenon, evolving into various forms and flavors. From the classic Frosted Pop-Tarts to the quirky Ted's Tarts knockoffs, these toaster pastries have captured hearts and taste buds. Comedians like Jerry Seinfeld have even immortalized them in routines. As we remember Post's legacy, we also celebrate the enduring appeal of these sweet treats that symbolize American nostalgia (and ultra-processed food). A toast to Pop-Tarts, the childhood treat I couldn't resist - The Washington Post (gift article).

Mood Mice-robials

Recent research has shown that the bacteria in your gut, particularly strains of Lactobacillus, can significantly influence mood and stress resilience. Studies on mice have revealed that specific bacterial strains can reduce stress and anxiety-like behavior, suggesting a direct link between the gut microbiome and mental health. This research opens new avenues for developing probiotics that target mood regulation, highlighting the importance of a healthy, probiotic-rich diet for mental well-being. Bacteria in your gut can improve your mood − new research in mice tries to zero in on the crucial strains.

Funny Bone-obos

Research conducted by Erica Cartmill and her colleagues reveals that great apes, including chimpanzees, bonobos, orangutans, and gorillas, engage in playful teasing behaviors resembling humor's building blocks. These actions, which include prodding, tickling, and stealing, are believed to have evolved over 13 million years ago and may serve to strengthen social bonds and provide insight into the tolerance levels of their peers. The study, which analyzed 75 hours of footage from two zoos, suggests that these behaviors demonstrate social intelligence and foresight, as successful teasing requires understanding others' psychological boundaries. This research sheds light on the early precursors of joking and the complex social dynamics within great ape communities. Great Apes Possess the Building Blocks of Humor - The Atlantic.

The Entrepreneurial Heart

In an article by Arthur Brooks for The Atlantic, the author parallels romantic love and entrepreneurship, suggesting that both ventures require a healthy attitude towards failure for ultimate success. Brooks argues that just as aspiring entrepreneurs must be prepared for the likelihood of failure, individuals seeking love must also embrace the possibility of heartbreak. He suggests that, much like failed business ventures, failed romances offer valuable lessons that can lead to greater happiness in future relationships. The article emphasizes the importance of learning from romantic failures, avoiding the "doom loop" of repeated mistakes, and maintaining a positive outlook on love despite setbacks. By adopting an entrepreneurial mindset, individuals can increase their chances of finding true romance.What to Do If the Course of True Love Is Not Running Smoothly - The Atlantic.

073 - Whiskey Business, British Bake Off, and the Sinister Secrets of Sugar - HealthHippieMD Week In Review

Life in the Fast Lane (podcast)

Ever wonder why time seems to accelerate as you age? Radiolab: The Secret to a Long Life explores the phenomenon.

Chronic Pain Conundrum (podcast)

Chronic pain casts its shadow over approximately one-third of the global population. Shockingly, for one in ten of these individuals, the pain reaches such devastating levels that it incapacitates them, thus establishing itself as the foremost cause of disability worldwide. The enigma surrounding certain types of chronic pain perplexes medical practitioners who struggle to provide effective treatments or unravel the underlying causal mechanisms. This enigmatic challenge looms large over societies, demanding innovative solutions to alleviate the burden on healthcare systems and provide much-needed relief for those enduring this relentless agony. Babbage from The Economist: The mystery of chronic pain (paywall).

Whiskey Business

In the article A bottle of scotch recently sold for $2.7 million – what's behind such outrageous prices? the author explores the unprecedented rise in Scotch whisky prices, exemplified by a recent $2.7 million sale. The article delves into the factors contributing to this trend, such as rarity, age, brand prestige, and collector demand. It discusses the allure of owning a piece of liquid history and how whisky has become a status symbol and investment opportunity for affluent enthusiasts. With captivating insights, the article unveils the fascinating world of ultra-high-end Scotch whisky auctions, shedding light on the intoxicating allure of these extravagant prices.

All I Needed to Know, I Learned in Grade School

In the article Teaching positive psychology skills at school may be one way to help student mental health and happiness the author explores the potential benefits of incorporating positive psychology into school curricula. By introducing students to techniques that promote resilience, optimism, and well-being, educators can empower them to navigate life's challenges better and enhance their mental health. The article emphasizes that fostering positive emotions, relationships, and personal strengths can increase happiness and improve overall mental well-being, ultimately providing students with essential life skills for a brighter future.

Age Beyond the Numbers

A New York Times article explored the intriguing world of "biological age testing." The article delves into the cutting-edge scientific methods used to determine one's biological age, including DNA analysis, biomarkers, and artificial intelligence. While these approaches hold promise in uncovering hidden health risks and offering longevity predictions, the article also highlights the skepticism surrounding the accuracy and practicality of these tests. As researchers continue to refine these techniques, the concept of biological age testing challenges our conventional understanding of aging and raises important questions about its role in the future of healthcare. Is Biological Age Testing Accurate or Useful? - The New York Times (gift article).

BMJ Christmas Edition: The British Bake Off

"Conclusion: Recipes for Christmas desserts from The Great British Bake Off often use ingredient groups associated with reductions, rather than increases, in the risk of death or disease. This Christmas, if concerns about the limitations of observational nutrition research are set aside, you can have your cake and eat it too." The BMJ's Christmas issue is now a well-established tradition. "Its mix of quirky comment articles, features, and peer-reviewed research was perhaps best described in a 2012 New York Times article as "lighthearted but rigorous." This year's articles include:

• Association of health benefits and harms of Christmas dessert ingredients in recipes from The Great British Bake Off: umbrella review of umbrella reviews of meta-analyses of observational studies | The BMJ
• Common Healthcare Related Instruments Subjected To Magnetic Attraction Study (CHRISTMAS): prospective in situ experimental study | The BMJ
• Retail demand for emergency contraception in the United States following New Year holiday: time series study | The BMJ
• Chocolate brownies and calorie restriction: the sweetest paradox? | The BMJ
• Cheers, not tears: champagne corks and eye injury | The BMJ
• The manosphere and men's well-being: How healthcare can help young men find alternatives to toxic online spaces | The BMJ

Sinister Secrets of Sugar (podcast)

In this enlightening episode, Dr. Andrew Huberman welcomes Dr. Robert Lustig, a renowned neuroendocrinologist and nutrition expert. Together, they dissect the conventional "calories in - calories out" model of metabolism and shed light on the role of macronutrients, fiber, and sugar in the equation. Delving into the nuances of sugar, particularly fructose, they explore its addictive qualities and how it rewires the brain's circuits related to cravings and satisfaction. The conversation extends to the profound impact of sugar on obesity, gut health, mental well-being, and the food industry's manipulation of refined sugars. The podcast is long but a must-listen for those curious about the profound impact of dietary choices on the mind and body. Huberman Lab: Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health.

The Funniest Articles of the Year

WaPo featured the funniest stories of the year. Opinion | Today's Opinions: The pieces that made us laugh the most in 2023 - The Washington Post (gift article).

Boomers Go Green

In this thought-provoking Wired article, the beef industry faces a seismic shift as baby boomers, traditionally avid beef consumers, pivot towards more sustainable and health-conscious eating habits. The article delves into the reasons behind this transformation, highlighting environmental concerns, health consciousness, and a growing appetite for plant-based alternatives. As boomers increasingly embrace greener diets, the meat industry adapts to changing consumer preferences. With captivating insights and statistics, this piece sheds light on the evolving landscape of food consumption and its implications for the beef industry's future. A Demographic Time Bomb Is About to Hit the Beef Industry | WIRED.

Misled to Misread

In the article Health misinformation is rampant on social media – here's what it does, why it spreads and what people can do about it the author delves into the pervasive issue of false health information circulating on social media platforms. The piece explores the damaging consequences of this misinformation, including the amplification of public health risks and the erosion of trust in medical experts. The article also sheds light on the mechanisms behind the rapid dissemination of such content and offers valuable insights into how individuals can combat this problem by promoting accurate information and critical thinking.

070 - Gut Glia, Quercetin, and Defining Death - HealthHippieMD Week In Review

Inoculating Against the Blues

A Vaccine for Depression - Nautilus delves into the pioneering research on developing a vaccine-like treatment for depression. This innovative approach focuses on targeting the immune system, which plays a crucial role in mental health. Researchers have discovered that certain immune responses can exacerbate depressive symptoms. By modulating these responses, it's possible to alleviate depression. This groundbreaking work opens up a new frontier in mental health treatment, moving beyond traditional methods and offering hope for more effective and lasting solutions for those battling depression.

A Grape Pain

A recent study has identified quercetin, a compound in red wine, as a potential cause of the notorious red wine headaches. This discovery challenges previous beliefs that tannins, sulfites, or histamines were to blame. Quercetin, found in grape skins, is beneficial as a grape sunscreen and a human antioxidant, but when combined with alcohol, it can disrupt the body's process of breaking down alcohol, leading to headaches. The study, co-authored by Andrew Waterhouse and Morris Levin, reveals that quercetin blocks an enzyme crucial for converting acetaldehyde into acetate, causing a buildup of toxins and resulting in headaches. Interestingly, cheaper wines tend to have less quercetin due to less exposure to the sun on grapes, potentially offering a workaround for those prone to these headaches. However, there's no definitive cure yet, and further research will explore this phenomenon more deeply. Why red wine gives you headaches, according to science - The Washington Post (gift article).

The Double-Edged CAR-T Sword

The FDA has raised concerns that CAR-T, a groundbreaking cancer treatment, might paradoxically cause new cancers in some patients. Approved in November 2017 for severe blood cancers, CAR-T therapy involves genetically modifying a patient's T cells to attack cancer cells. Despite its life-saving potential, the FDA reported 19 cases of new blood cancers post-treatment. While the risk is considered small and the benefits significant, this development has sparked a debate in the medical community. The FDA is investigating these cases to determine if there's a direct causal link between the treatment and the emergence of new cancers amidst CAR-T's remarkable success in saving thousands of lives. CAR-T, Lifesaving Cancer Treatment, May Sometimes Cause Cancer, FDA Says - The New York Times (gift article).

New Coursera Course on Generative AI

Coursera has fabulous free courses taught by the world's experts. I'm adding the course mentioned in Generative AI for Everyone: A Free Course from AI Pioneer Andrew Ng | Open Culture to my list to take after I finish my current course: Songwriting: Writing the Music | Coursera.

Symphony of Health

Speaking of music, are you curious about how to harness the power of music to help manage different conditions or symptoms? If so, you might be interested in the National Center for Complementary and Integrative Health's free virtual meeting, "[Music as Medicine: The Science and Clinical Practice][1]," on December 14–15, 2023. The 2-day event will share what's been learned in recent years and chart a path forward for growing the research to drive deeper scientific understanding of this topic. See you there!

Gut Glia

In the Gut's 'Second Brain,' Key Agents of Health Emerge delves into the fascinating world of glial cells in the enteric nervous system, often overshadowed by neurons. These cells play a crucial role in digestion and disease, a fact that scientists are just beginning to unravel. The gut, equipped with its complex network of nerve cells, functions almost independently from the brain and is responsible for digestion, from breaking down food to nutrient absorption and waste elimination. Recent studies have highlighted enteric glia's diverse and active role in this process, including their involvement in nutrient absorption, blood flow, immune responses, and even gut motility. This newfound understanding of glial cells in the gut could pave the way for novel treatments for gastrointestinal disorders and enhance our comprehension of the digestive system's intricate workings.

Hypnotic Gut Healing

In a surprising turn of medical treatment, hypnotherapy emerges as a potential relief for gut disorders. A story in the Atlantic centers around Zack Rogers, who, on his 12th birthday, began experiencing severe stomach pain, leading to a drastic weight loss and a prolonged struggle with his health. After years of ineffective medical treatments and facing the prospect of major surgery, Zack's mother sought a second opinion, which led to hypnotherapy. This unconventional approach gradually brought significant improvements, involving deep focus and relaxation to alter thought patterns. Zack's recovery was so profound that he regained his everyday life, including playing sports and attending college, a future that seemed impossible before the hypnotherapy. This case highlights hypnotherapy's unexpected yet impactful role in treating severe gut disorders. Hypnosis Could Work Wonders on IBS - The Atlantic.

How Much Protein Do You Really Need?

The NY Times summed up the current recommendations in How Much Protein You Need As You Age - The New York Times (gift article).

Defining Death

What is death? | MIT Technology Review delves into the evolving understanding of death in neuroscience. It challenges traditional perceptions of death, suggesting it should be viewed as a transient process rather than an irreversible event. This shift in perspective emerged with medical advancements like CPR and mechanical ventilators, which blurred the lines between life and death. The concept of brain death, arising from observations of patients with severe brain damage, further complicated the definition of death. This has sparked medical, ethical, and legal debates. The article highlights that despite these advancements, the scientific understanding of the dying brain remains complex and filled with unanswered questions.

057 - Blue Zones, Mini-Siestas, and Nociplastic Pain - HealthHippieMD Week In Review

The Mind Diet and Dementia

"Experts have estimated that 40 percent of dementia cases worldwide might be prevented or delayed with certain modifiable factors, such as by prioritizing exercise and sleep and addressing health conditions like hearing loss or hypertension. But a growing body of evidence suggests that diet may play a role in dementia prevention, too." What Is the MIND Diet? And Can It Prevent Dementia? - The New York Times (gift article).

An Apple a Day

Researchers examined produce prescription programs, where patients received fresh produce for free with a doctor's prescription. Blood sugar levels, blood pressure, and weight showed significant improvement. This innovative approach not only enhances health but also reduces food insecurity. As the food-is-medicine movement gains momentum, producing prescriptions could become a ripe solution to combat diet-related ailments, emphasizing that good health begins with what's on your plate. Prescriptions for fruits and vegetables can improve the health of people with diabetes and other ailments, new study finds.

Protein Paradox

Is "eating like The Rock" the key to health? As researchers debate protein intake, some argue that the recommended daily allowance (RDA) of 0.8 grams per kilogram of body weight is insufficient. Jose Antonio, a health researcher, suggests sedentary adults aim for double, while active individuals need more than 2.2 grams per kilogram. However, other experts counter that too much protein might have diminishing returns, causing bodily discomfort and potential nutrient imbalances. The dilemma lies between protein's undeniable importance and avoiding excess. Amidst the protein frenzy, moderation appears vital to maintain personal well-being and environmental sustainability. You'll Probably Never Know How Much Protein You Actually Need - The Atlantic.

Mini-Siestas

Napping isn't just for lazy days – it's scientifically shown to enhance memory, productivity, and overall well-being. Short daytime naps of around 20 to 30 minutes offer many perks, from improved mental functioning and creativity to better problem-solving abilities and reduced stress. However, excessive napping, significantly beyond 30 minutes, can lead to sleep inertia – grogginess upon waking. Striking a balance and adopting good practices, like timing naps right and avoiding caffeine dependency, can make napping a refreshing addition to a healthy lifestyle. Remember, naps should complement, not replace, regular nighttime sleep.Short naps can improve memory, increase productivity, reduce stress, and promote a healthier heart.

On Procrastination

"A more realistic definition of procrastination is that it's not a blockage of inherent reason but a simple absence of desire." Slate had an interesting article on why we put things off: Why do I procrastinate, and how do I stop procrastinating? Procrastination advice fails to account for one key thing.

+I could not mention procrastination without mentioning Wait But Why. Why Procrastinators Procrastinate — Wait But Why

Blue Zones on Netflix

Netflix has a new documentary series on Blue Zones, regions where people are claimed to live or have recently lived longer than average. Secrets of the Blue Zones.

Medicare's Drug Cost Cutting

The healthcare giant Medicare is starting its journey towards slashing drug prices with a ten-drug hit list. These ten medications, known to cost $50.5 billion annually, are in the hot seat for negotiations that could offer relief for seniors and save the US government almost $100 billion by 2031 as part of President Biden's Inflation Reduction Act. Though Democrats are celebrating, skeptics, like the health policy analyst behind this explanation, foresee hurdles, legal battles, and potential industry resistance slowing down the process. The prescription price saga, starring high stakes and complex dynamics, has just begun. Medicare starts a long road to cutting prices for drugs, starting with ten costing it $50.5 billion annually – a health policy analyst explains why negotiations are promising but will take years.

• +my journey thinking about American healthcare economic reform continues. I've added We've Got You Covered: Rebooting American Health Care. to my reading list.

How to Become a Morning Person

I am most decidedly a night owl. If I had an intention of change, I'd pay attention to the advice in this article: How to Wake Up Earlier: 4 Ways to Become a Morning Person - The New York Times. (gift article)

Nociplastic Pain

Chronic pain affects nearly a third of the world's population. This mysterious, lingering affliction is more than physical; it carries psychological burdens like depression. Traditional painkillers often fall short of bringing relief. A new category, nociplastic pain, baffles researchers as it seems to have no anatomical cause. Emerging theories point to glitches in the brain's altered pain-processing network or immune system. New creative solutions for relief include harnessing neuroplasticity with psychedelics and personalized treatments using quantitative sensory testing. While relief remains elusive, understanding the enigma of chronic pain offers hope for future therapies. Some forms of chronic pain are particularly mysterious-The Economist.

Talking to Strangers

Embracing diversity isn't just about virtue signaling; it's a happiness hack. Research suggests that engaging with people from different walks of life enhances society and enriches individual well-being. Our natural tendency to flock to those who mirror us might feel cozy, but stepping out of this comfort zone fosters personal growth and contentment. Shaking hands with strangers, seeking out divergent viewpoints, and promoting a friend circle that celebrates heresy can bring zest to life. Happiness thrives where minds mingle. Talk to a Stranger and Be Happier - The Atlantic.

054 - Cheating Death, Ultralearning, and Harmonious Disputes - HealthHippieMD Week In Review

Cheating Death

In the article How Old Can Humans Get? - Scientific American, scientist João Pedro de Magalhães speculates on extending human lifespans to 1,000 years through genetic alterations. By studying the genomes of long-lived animals, Magalhães envisions reprogramming aging at the cellular level, envisioning a future where humans could defy their genetic "software" to delay or reverse aging. Though practical challenges remain, Magalhães' geroscience insights prompt consideration of profound interventions that might extend human lifespans far beyond the present norm.

Books to Enhance Creativity

The Economist published a list of books on fostering creativity: What to read to become more creative

Ultralearning

On my quest to learn to play the guitar, I came across multiple mentions of the book Ultralearning: Master Hard Skills, Outsmart the Competition, and Accelerate Your Career. Although I bought the book in 2019, I have yet to dig in. Ultralearning is now on top of my "to read" pile.

Scentinel Health

Smell's connection to memory and emotion is being recognized anew, as studies reveal its crucial role in detecting brain diseases early. Loss of smell, or hyposmia, has emerged as an indicator of neurodegenerative disorders such as Parkinson's and Alzheimer's, even including conditions like Huntington's disease and multiple sclerosis. Researchers propose that olfactory bulb neurons, responsible for smell processing, could play a role in the early stages of brain diseases. Beyond disease prediction, smell also correlates with overall health and mortality risk, making the nose a potential health "scentinel." Why Loss of Smell Can Be an Early Sign of Brain Diseases Like Alzheimer's.

Constipation Linked to Cognitive Decline

New research from AAIC 2023 suggests chronic constipation, infrequent bowel movements, may indicate cognitive decline. Individuals facing such constipation exhibit cognitive aging equivalent to three years, with a 73% higher likelihood of subjective cognitive decline. This groundbreaking study highlights the interconnectedness of gut health and brain function, encouraging discussions about constipation and its management to mitigate dementia risks potentially. Studies exploring the relationship between gut bacteria and Alzheimer's biomarkers reveal intriguing connections, paving the way for novel therapeutic avenues. Constipation Associated with Cognitive Aging & Decline | alz.org

Unraveling Traveler's Constipation

Why do trips lead to constipation? The phenomenon is "traveler's constipation," which affects approximately one in three individuals, disrupting regular bathroom habits. Dehydration, immobility during flights, changes in sleep routines, and shifts in eating habits contribute to the issue. Scientists suggest staying hydrated, exercising, and incorporating fiber-rich foods like fruits and vegetables to prevent constipation. Hydrating foods, adjusting sleep schedules, and managing alcohol intake can also help. Why Do I Get Constipated When I Travel? - The New York Times

AI Enabled (Travel) Lists? Yes, Please

A new app, Soka, caught my attention. I spent the morning generating automated local and international lists of things I'd like to do, see, and eat. Söka: An AI Assisted App to Track Your Bucket Lists

Obesity Drug Reduces Heart Risks

The obesity drug Wegovy has demonstrated a 20% reduction in serious heart problems in a recent clinical trial, potentially pressuring insurers to cover the treatment. This trial marks the first to reveal that obesity drugs like Wegovy can enhance heart health, reinforcing the link between obesity and medical risks. The findings, as yet unpublished in a peer-reviewed journal, may encourage insurers to support the treatment, despite its high cost. Wegovy's capacity to improve patients' lives and medical outcomes could change the perspective on treating obesity, emphasizing aggressive intervention. Wegovy Cuts Risk of Heart Problems, Novo Nordisk Trial Says - The New York Times

The Healthy Info Pitfall

While HIPAA (Health Insurance Portability and Accountability Act) covers medical institutions' data security, personal health data collected at home isn't protected. Wearable trackers and health-related apps fall outside HIPAA's umbrella, putting users at risk. Patients must remember that individual-generated data isn't secure under HIPAA. What Doctors Wish You Knew About HIPAA and Data Security | WIRED

Grain Brain (mice)

A study by University of Otago researchers reveals that wheat gluten consumption triggers brain inflammation in mice, with potential implications for humans. While prior research linked gluten to weight gain and inflammation in the digestive system, this study identifies the first-ever connection between gluten and brain inflammation in the hypothalamic region, which regulates metabolism. Though the exact mechanism remains uncertain, this discovery raises concerns about long-term effects, including weight gain, blood sugar disruption, and memory impairment. While not advocating a blanket gluten-free diet, the findings suggest avenues for future research in human health. Wheat Gluten Spurs Brain Inflammation - Neuroscience News

Colonic Sensation (mice)

In a groundbreaking study, Harvard researchers have distinguished five distinct sensory neuron types in the colon, shedding light on the gut-brain connection. These neurons transmit diverse signals to the brain, with some responding to gentle movements and others to intense sensations like pain. Mimicking neurons found in the skin, this discovery in mice suggests potential cross-organ function conservation. If confirmed in humans, the findings could revolutionize gastrointestinal treatments by targeting specific neurons and understanding how mechanical forces translate into nervous system signals. Untangling Gut Feelings: Revealing the Colon's Sensory Neurons - Neuroscience News

Harmonious Disputes

When disagreements arise between partners, unfounded assumptions can intensify arguments. Termed "unconscious storytelling," this phenomenon involves imagining what the other person is thinking or feeling. Instead, renowned family therapist Terrence Real suggests using "the feedback wheel," a concise four-sentence method for sharing perceived slights. The phrases include describing facts of the situation, sharing your perspective, expressing emotions, and stating what would help. Shifting from anger to vulnerability fosters effective communication and promotes relationship repair. Fighting With Your Partner? Use These 4 Phrases - The New York Times

What Are Functional Foods

Here is an excellent article on functional foods: Does an apple a day keep the doctor away? A nutritionist explains the science behind 'functional' foods

045 - Dying Brains, Frenemies, and the Physiology of Hangry - HealthHippieMD Week In Review

Flavanols Combat Memory Loss in Aging Adults

A new study reveals that flavanols, nutrients found in select fruits and vegetables, are crucial in mitigating age-related memory decline. The research demonstrates a positive correlation between flavanol intake and memory test scores among older adults. Notably, individuals over 60 with low-flavanol diets experienced significant memory improvement after reintroducing these dietary components. This study supports the emerging understanding that specific nutrients are essential for maintaining optimal brain health as we age. By highlighting the power of flavanols, the research offers potential avenues for improving cognitive function in older adults and underscores the importance of a flavanol-rich diet or supplements. Memory Boosting Power of Flavanols in Aging Adults

Gut Check

Scientists have discovered the mechanism behind how chronic stress can lead to gut inflammation. Signals originating in the brain reach gut nerve cells, triggering the release of inflammatory chemicals. The study, The enteric nervous system relays psychological stress to intestinal inflammation glucocorticoids act on gut neurons and glial cells, which then activate immune cells. These immune cells release molecules that cause painful bowel inflammation. The findings suggest that managing stress levels could significantly impact the effectiveness of treatments for inflammatory bowel disease (IBD). The research opens possibilities for targeting the brain-to-gut signaling pathway for new therapies. Chronic stress can inflame the gut — now scientists know why

Frenemies Take a Toll

According to psychologists, ambivalent relationships, known as frenemies, which combine positive and negative aspects, can be more detrimental to health than purely negative relationships. Research reveals that interacting with individuals who evoke mixed feelings can raise blood pressure and lead to negative physical symptoms. Even a single ambivalent interaction can have adverse effects on well-being. Unpredictability increases pain from unpleasant interactions, and rumination contributes to the negative impact of such relationships. Recognizing the harmful effects of frenemies is important for maintaining overall health and well-being. Opinion | Ambivalent Relationships May Be Hazardous to Your Health. (gift article)

The Neuroscience of Hangry

Neuroscientists have discovered a cluster of cells called AgRP neurons that stimulate appetite and play a vital role in the infamous "hangry" feeling. These cells near the brain's blood supply receive signals from the stomach and fat tissue, influencing our hunger levels. By manipulating AgRP neuron activity in mice, researchers have identified how they trigger food-seeking behavior and respond to the presence of nutrients. This breakthrough could lead to new therapies for eating disorders like anorexia and overeating. By understanding and controlling the hangry feeling, scientists hope to revolutionize our ability to manage our diets effectively. Neuroscientists May Have Found the Part of Your Brain That Makes You Hangry

Electrical Activity Surges in the Dying Brain

A new study reveals that dying brains experience a surge of electrical activity, challenging the assumption that brain activity decreases during dying. Researchers monitored four comatose patients who died in a neurointensive care unit and observed a surge of neurophysiological activity in regions associated with conscious processing. This surge included increased synchronization and connectivity between different brain regions. While the study doesn't directly explain near-death experiences, it suggests that the observed brain activity pattern may contribute to the vivid perceptions reported during such experiences, prompting further investigation into the nature of human consciousness. Scientists monitored four dying patients' brains. Here's what they saw . In the late 2000s, David Auyong and I observed the same phenomenon while on call: Processed electroencephalogram during donation after cardiac death.

Biochemistry of Psychedelics, BDNF, and Neuroplasticity

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience reveals that LSD and magic mushrooms dramatically rewire the brain, offering new possibilities for treating depression. The research conducted by an international team of scientists from the University of Helsinki shows that, at least in a test tube, these psychedelics bind to a protein called receptor tyrosine kinase beta (TrkB), which activates brain-derived neurotrophic factor (BDNF). BDNF plays a crucial role in neuron growth and development. This discovery paved the way for developing safer and more effective treatments for mental health disorders. LSD and Magic Mushrooms Dramatically Rewire the Brain, New Study Reveals.

AIHits (Generative AI Music and Podcasts)

"What makes pop work is that it's always changing and always responding. This is just a feedback loop between systems." AI is having a profound effect on artistic expression in music. Now there's a website to listen to. AI Could Usher in a New Era of Music. Will It Suck?

+The Generative AI gold rush is on in the podcasting space, too, as if the genre wasn't already overcrowded: Generative AI Podcasts Are Here. Prepare to Be Bored.

The Evolutionary Significance of Dreaming

"REM [sleep] has been crucial to human creativity."The evolutionary significance of dreaming is an interesting video on BigThink.

External Stressors Affect Cancer Mortality

Surprise, surprise! Higher allostatic load, a quantitive measure of the cumulative physiological damage from stress, is associated with worse cancer outcomes: Evidence Emerges Showing External Stressors Adversely Affect Cancer Outcomes

Sucralose-Genotoxic?

At least in test tubes, new evidence shows that Sucralose (Splenda) can disrupt DNA. "It's time to revisit the safety and regulatory status of sucralose because the evidence is mounting that it carries significant risks." Sucralose Damages DNA, Linked to Leaky Gut: Study (thanks, Diana!)

019 - Farmaceuticals, Psychobiotics, and Darwinian Medicine - HealthHippieMD Week In Review

Psychobiotic Diet

The article, This diet helps your mental health by boosting your gut health, discusses food to improve mental health. Psychobiotics and nutritional psychiatry are fields in their infancy, but you're going to hear more and more about the role of food on stress, anxiety, and depression.

YAMS and Sweet Potatoes

Yams and sweet potatoes are NOT the same things. But in the U.S., the names are used interchangeably. Here's the story: What's the Difference Between Sweet Potatoes and Yams?

What Are Sugar Alcohols

Sugar alcohols are in many of today's processed foods. What are they? Sugar Alcohols Are in Many Sugar-Free Foods. What Are They? (gift article)

Darwinian Medicine, Evolutionary Psychiatry

What if illness is not a disease but an adaptation to evolutionary pressures? The provocative article Evidence grows that mental illness is more than dysfunction discusses a controversial way of reframing our thoughts about mental illness.

Humor: An Essential Life Skill

Why a good sense of humor is an essential life skill has a lot to say about the importance of humor in your personal and professional lives.

The Formula for Happiness

"What we think it is about is an attachment to another person. And a sense that another person is there for you, particularly when you need them. We think of relationships as safety nets, as stress regulators." There are many important insights in this podcast/transcript from Arthur Brook's How to Build a Happy Life. A New Formula for Happiness

Pursuing Happiness in All the Wrong Places

More Arthur Brooks. Before he taught at Harvard and wrote publicly about happiness, he led a well-known conservative think tank. The article, America Is Pursuing Happiness in All the Wrong Places, adapted from his November remarks at the Irving Kristol Award & Annual Dinner, is packed with wisdom. Although I am not a conservative, and despite some of the political overtones of the article, his words spoke deeply to me.

Farmaceuticals

Antibiotic resistance is an increasing problem across the world. Here is an article about a new antibiotic isolated from potatoes, incredibly potent against certain types of fungus: New antibiotic found in potato bacteria

Lucid Dreaming

Scientists are studying the phenomenon of lucid dreaming. Lucid Dreaming Is a Mystery We're Starting to Crack is focused on the quality of sleep during lucid dreaming.

Gut Microbiome and Prosocial Behavior

Scientists are studying the role of gut bacteria and the gut-brain axis in prosocial behavior. In a preclinical study with implications for neurodevelopment issues, Researchers found Zebra Fish lacking a gut microbiome are less social and have different brain structures than peers who had normal gut flora. Specifically, the lack of bacteria influenced the microglia of Zebra Fish brains and led to structural changes. It will be interesting to see if a similar phenomenon exists in mammals, especially humans.

Wasted Healthcare Spending

It's conceivable that half of the healthcare dollars are wasted. A small portion of the total, a mind-numbing $160 billion, is attributed to absenteeism-not showing up for appointments. According to the article, A big source of wasted healthcare spending is your fault, one in four appointments is missed. I will track down the NEJM article mentioned, although I'm sure it will raise my blood pressure.

Mindfulness vs. Anti-Anxiety Medications

A recent paper compared Mindfulness-Based Stress Reduction (MBSR) to the medication escitalopram's (Lexipro's) ability to reduce stress. Mindfulness meditation may be just as effective as anxiety medication reports the study, published in JAMA Psychiatry. Although 45 minutes of daily mindfulness practice may not be practical for everyone (I usually only do 15-20 minutes), the paper indicates that cultivating mindfulness should be more widely taught (and prescribed).

+See also my lecture on mindfulness/meditation: Mindfulness-The Basics

More Bugs in Space

Knowledge of what happens to microbial life inside and outside the body while in space is important to understand as we contemplate missions to Mars and beyond. Scientists are struggling to figure out how space transforms our gut microbiome is an overview of the emerging science.

Bed Habits

Is Falling Asleep to TV So Bad? An Investigation is an entertaining article written about an insomniac's immersion into the science of sleep.

How to Recognize and Treat Your Pet's Anxiety

Pet anxiety is quite common. Here is an article to help you decode your pet's behavior and some ideas for treating their anxiety: Puppies on Prozac: How to Handle Your Pet's Anxiety.

Do Something Boring, Yet Engaging to Boost Your Creativity

How to unblock your creativity: Scientists say this bad habit can help is an interesting article on how to boost your creativity and get over mental blocks.

Cannabinoids and Opioids for Pain Relief

Cannabis for pain: A scientist reveals how weed activates our body's opioid system is an overview of work to decode these two substances that might safely work together to alleviate pain.