Cannabinoids

090 - Isolated Minds, High Hopes, and Psychedelics in the C-Suite - HealthHippieMD Week In Review

Isolated Minds

Chronic loneliness not only alters emotional states but significantly impacts brain structure and function, raising the risk for neurodegenerative diseases like Alzheimer's and Parkinson's. This pervasive form of loneliness can lead to changes in brain areas involved in social cognition and emotional processing, likely due to prolonged stress and inflammation. These effects are further exacerbated by associated risks such as increased cardiovascular strain and unhealthy lifestyles. How Loneliness Affects the Brain - The New York Times (gift article ) underscores the importance of interventions, like cognitive behavioral therapy and social engagement, to mitigate these detrimental effects. However, the challenge remains significant, as indicated by recent health reports calling for more robust solutions to combat loneliness.

Lonely Peaks

Recent studies show that loneliness typically spikes during young adulthood and later life, forming a U-shaped curve. This pattern reflects fewer social engagements and weaker community involvement among younger generations, paralleled by a similar decline in older adults due to diminishing social opportunities. Surgeon General Vivek Murthy emphasizes weakening "social muscles" when left unused, analogous to physical muscles. Experts recommend proactive steps to cultivate meaningful connections at all ages, such as conducting a "relationship audit," joining community groups and reducing reliance on social media. They argue that fostering diverse and quality relationships can significantly enhance mental and physical health, urging individuals to take the initiative to maintain and create social bonds. The Ages When You Feel Most Lonely and How to Reconnect - The New York Times (gift article).

Reducing Noise Pollution

In today's bustling world, the relentless barrage of noise disrupts our daily lives and significantly harms our health. Jamie Banks, an environmental scientist driven by the ceaseless din of landscaping equipment in her neighborhood, initiated a movement towards quieter communities. Her advocacy led to actionable change, culminating in a lawsuit against the U.S. Environmental Protection Agency for failing to enforce noise regulations. Scientific evidence supports the detrimental effects of noise, linking it to cardiovascular diseases, sleep disruptions, and cognitive impairments. Furthermore, various studies highlight how excessive noise exposure increases risks of hypertension, heart conditions, and even diabetes. Amid these alarming revelations, noise mitigation strategies like using smartphone apps to detect hazardous noise levels, wearing noise-canceling earbuds, and pushing for regulatory reforms have become more vital than ever. Turning Down the Noise Around You Improves Health in Many Ways | Scientific American.

Gloves that Teach Piano

A novel pair of "smart gloves" designed by MIT researchers may revolutionize learning piano and other tactile skills. These gloves, crafted from thin cotton and embedded with tactile sensors, allow for transmitting piano-playing techniques through vibrations directly to the fingertips. This method helps build muscle memory and enhances precision when performing musical pieces. A study published in Nature Communications demonstrates that these gloves can significantly improve accuracy in piano playing compared to traditional methods. The technology, utilizing machine-learning algorithms to capture and transmit complex hand movements, has potential applications beyond music, such as surgical training and gaming. 'Smart Gloves' Teach Piano Playing through Touch | Scientific American.

High Hopes for Healing

Recent changes in U.S. drug policy signal a potentially transformative era for chronic pain treatment, recognizing the medicinal value of cannabis and psilocybin. Cannabis, long under strict regulation, is being reclassified to allow more medical research, reflecting its safer profile compared to opioids and potential for fewer side effects. Similarly, psilocybin, known for substantial psychological effects, has shown promise in treating psychiatric conditions and is being explored for chronic pain management. With about 50 million Americans suffering from chronic pain, these substances could offer significant relief, promoting a shift towards more natural and possibly more effective therapeutic options. However, the journey from criminalization to acceptance underscores the complex landscape of integrating these ancient drugs into modern medicine. How cannabis and psilocybin might help some of the 50 million Americans who are experiencing chronic pain.

Psychedelics in the C-Suite

A growing trend in corporate leadership involves the integration of psychedelic experiences, such as ayahuasca and psilocybin, to enhance personal and professional development. Leaders like Felix Van de Sand, CEO of COBE, have ventured into jungles and participated in shamanic ceremonies, using these substances to confront personal fears and unearth deep-seated behavioral patterns. These experiences are claimed to foster traits like openness, adaptability, and creative thinking, which are invaluable in leadership. Recognizing these benefits, more executives are now investing in psychedelic retreats for their teams, aiming to fast-track personal growth and improve team dynamics, albeit navigating complex privacy issues and peer pressure. From magic mushrooms to ayahuasca—psychedelics are the new leadership retreat | Fortune Well.

Midlife Mutterings Unmuted

Middle-aged individuals often find themselves talking out loud, which experts suggest is normal and beneficial. This phenomenon, understudied yet widely observed, supports various mental functions such as anxiety management, motivation, and memory. Private speech, as it's called, tends to resurface in midlife, assisting in tasks like planning and problem-solving. Furthermore, it can enhance focus and make solitary moments feel more engaging. Although it might raise eyebrows in public, this self-dialogue typically poses only harm if it becomes disruptively negative. Experts encourage embracing this habit if it proves helpful, highlighting its practicality and mental health benefits. Is It Normal to Talk to Yourself All Day? What Experts Say. - The New York Times (gift article).

Genes and Stress

A recent study by Jacob Crouse and Ian Hickie from the University of Sydney is reevaluating the classifications of depression into reactive and endogenous types. Historically, reactive depression was seen as a response to external stressors, while endogenous depression was thought to stem from internal factors like genetics. However, their research involving over 14,000 individuals in the Australian Genetics of Depression Study shows a more complex interplay. They discovered that people with higher genetic risks for mental disorders reported more exposure to stressful life events, suggesting that genetic predispositions can influence both one's environment and one's reactions to it. This challenges the simple categorization of depression and underscores the intricate relationship between genes and environmental stressors. A New Study Is Finally Attempting to Pin Down The Root Causes of Depression..

089 - High Times, Super-Agers, and Soothing Sounds - HealthHippieMD Week In Review

Secrets of Super-Agers

Research has unveiled the remarkable cognitive resilience of "super-agers," individuals aged 80 and above who exhibit the memory capabilities of people decades younger. Studies by scientists such as Dr. Emily Rogalski and Dr. Bryan Strange have focused on why these elders defy typical age-related cognitive decline. Extensive testing, including brain scans and cognitive assessments, revealed that super-agers possess significantly less brain atrophy, particularly in regions crucial for memory, such as the hippocampus and entorhinal cortex. They also maintain stronger neural connections, contributing to their exceptional cognitive abilities. Despite similar lifestyles and health profiles compared to their peers, super-agers show unique brain preservation, suggesting a blend of genetic factors and possibly earlier life habits contribute to their resilience. A Peek Inside the Brains of 'Super-Agers' - The New York Times. (gift article).

Mechanizing the Mind

A recent tech forum in Beijing, China, showcased a new brain-computer interface (BCI) allowing a monkey to control a robotic arm by thought alone. This development, by NeuCyber NeuroTech and the Chinese Institute for Brain Research, signifies China's rapid advancement in BCI technology, which collects and analyzes brain signals to manipulate external devices like robotic arms or keyboards. While the U.S. has been exploring similar medical and cognitive enhancement technologies, China's aggressive progress includes invasive and noninvasive BCIs, with applications stretching from medical to military uses. China's ambitious approach raises ethical concerns, especially as it looks to enhance cognitive functions in healthy individuals, blurring the lines between human and machine capabilities. China Has a Controversial Plan for Brain-Computer Interfaces | WIRED.

Carnivore's Diet Warning

"Our sexy, lean mice who ate high-protein, low-carb diets were the shortest-lived of all. They made great-looking middle-aged corpses." In the wake of Joe Rogan's promotion, the carnivore diet has surged as a social media phenomenon, with enthusiasts advocating for an all-meat regimen consisting of beef, bacon, butter, and eggs. This diet, championed by influencers like Dr. Shawn Baker and popularized in his 2018 book, excludes vegetables and is promoted as a means to achieve optimal mental and physical health. Despite the lack of medical endorsement and potential health risks outlined by nutrition experts, the diet's appeal grows, possibly reacting to conventional dietary advice. Promoters argue that this approach echoes the nutritional habits of our hunter-gatherer ancestors, offering a simplistic yet radical return to what they consider a more natural state of human nutrition. Meet the Men Who Eat Meat - The New York Times (gift article).

Speed Demons

In a detailed investigation by ProPublica, Dr. Debby Day, a former medical director at Cigna, revealed that she was pressured to review patient cases faster than she deemed professionally responsible. This emphasis on speed over accuracy was reportedly driven by Cigna's productivity metrics, which monitored and compared the case-handling speeds of their medical directors. Day described an environment where the quick denial of cases was encouraged to meet performance benchmarks, often using a "click and close" method. Despite Cigna's insistence on thorough, objective reviews, the emphasis leaned towards fast decision-making, which could potentially lead to wrongful denials of critical care. The report sheds light on the troubling use of productivity metrics in healthcare, raising concerns about patient safety and care quality under such systems. Cigna Pressured Her to Review Patients' Cases Too Quickly, Says Former Cigna Medical Director — ProPublica.

Soothing Sounds

Sound baths, involving meditative experiences with gongs, chimes, and crystal bowls, are gaining popularity across the U.S., from beachside sessions in Santa Monica to urban studios and corporate events. Originating from spiritual practices, these sessions immerse participants in a wash of sonic waves, purportedly easing stress and enhancing mental wellness. While sound baths are lauded for their calming effects, allowing some attendees to experience deep relaxation and emotional release, scientific research on their benefits remains limited. Initial studies suggest the potential for reducing anxiety and promoting a tranquil state of mind, although definitive claims about health impacts like lowered blood pressure or mood improvements require more rigorous investigation. As sound baths continue to resonate with modern wellness enthusiasts, they offer a tranquil escape, weaving harmony into the cacophony of daily life. Can Sound Bath Meditation Actually Benefit You? - The New York Times. (gift article).

+see also: Alzheimer's Disease and Gamma Waves — HealthHippieMD.

Conscious Creatures

A recent declaration by a group of leading animal cognition researchers suggests a broader recognition of consciousness across various species, including vertebrates and many invertebrates like cephalopods, crustaceans, and insects. Inspired by studies, such as playful bumblebees at Queen Mary University of London, this new consensus acknowledges the possibility that even animals with simpler nervous systems may experience phenomena like pain and pleasure. The New York Declaration, which was revealed during a conference at New York University, aims to update and expand previous notions of animal consciousness. This expansion challenges our understanding of neurological complexity and prompts a reevaluation of ethical treatment and scientific standards concerning animal welfare. A New Declaration of Animal Consciousness - The Atlantic.

Karate's Concrete Conquest

In the late 1970s, a trio of karate-enthusiast physicists, including MIT's Michael Feld and astronaut-to-be Ronald McNair, investigated how a karate strike could shatter wood and concrete without harming the hand. Their research revealed that breaking these materials requires precise applications of Newton's laws, involving the exertion of thousands of newtons of force within milliseconds. They discovered that human hands can generate significant force briefly enough to avoid injury, thanks to the resilience of bone and meticulous technique. Their study underscores karate as a physical and mental discipline, highlighting the intricate balance of speed, power, and precision necessary for successful martial arts practices. Karate physics: How a hand can snap concrete without breaking - Big Think.

Intermittent Fasting and Alzheimer's

A study from the University of California San Diego School of Medicine reveals (in mice) the potential of time-restricted feeding (TRF) to combat Alzheimer's disease. This novel approach focuses on alleviating circadian rhythm disruptions associated with Alzheimer's, which affects over 6 million Americans. The study demonstrates that mice on a TRF diet, limiting eating to a six-hour window, showed improved memory, reduced nighttime hyperactivity, and consistent sleep patterns. Assuming the finding holds in humans, this simple lifestyle change, which avoids complex drug interventions, could potentially revolutionize the treatment of Alzheimer's by addressing one of its primary drivers: circadian rhythm disruptions. Surprising link found between intermittent fasting and Alzheimer's disease. (thanks, Dave).

High Time for Science

In a landmark move, the U.S. Drug Enforcement Administration plans to reclassify marijuana from Schedule I to Schedule III, significantly easing research restrictions on the drug. This shift, reported earlier this week, marks a dramatic change in federal drug policy, potentially enhancing scientific understanding of marijuana's health effects. Currently, 24 states permit recreational use of cannabis, yet significant gaps in knowledge remain regarding its impact on health, including mental health and heart and lung function. The reclassification will expand research opportunities, allowing for more comprehensive studies on both the potential harms and benefits of cannabis, which has been both widely used and stigmatized for decades. This development promises a new era of enriched scientific inquiry into a substance that has historically been difficult to study due to regulatory hurdles. Marijuana's Health Effects Are About to Get a Whole Lot Clearer - The Atlantic.

039 - Centenarian Excrement, Creativity, and Cannabinoids - HealthHippieMD Week In Review

How to Make Peace with Your Feelings

How Leaning Into Negative Emotions Can Help Your Mental Health (gift article) is about accepting negative emotions for what they are: part of the human experience. What you do with the experience strongly influences your health and well-being.

Generative AI in Medicine

Wired had a story about ways generative AI will impact medicine, along with several caveats: ChatGPT Can Help Doctors—and Hurt Patients.

The Two Personality Traits that Predict Well-being

If you lack either (I'm strongly introverted, not extroverted), hope is not lost. Study Finds 2 Personality Traits Predict Well-being — But Don't Worry if You Don't Have Them.

The World's Rarest Eye Colors

Do you have one of the six rarest types of eye color? Read What Is the Rarest Eye Color?.

Is Alcohol in Moderation Good for You?

The Great Alcohol Health Flip-Flop Isn't That Hard to Understand—if You Know Who Was Behind It is an interesting article on how the supposed health benefits of a small amount of alcohol have been turned on its head, again.

What You See Is Not Always What You Get

The NY Times had an article about a recent publication in JAMA focused on melatonin gummies: "A team of researchers analyzed 25 melatonin gummy products from different brands and found that 22 contained different amounts of melatonin than what was listed on their labels; one contained only 74 percent of the advertised amount of melatonin, while another had 347 percent of the labeled amount. Yet another product contained no detectable melatonin at all." 22 Out of 25 Melatonin Products Were Mislabeled, Study Finds. (gift article) See also: ConsumerLab: Independent Testing of Supplements and Botanicals.

Hope

The Atlantic had an interesting article, Why Economists Should Study Hope, that discusses why hope is so important and how to cultivate more.

The Quest for Longevity

The Quest for Longevity Is Already Over is an interesting read. One of the points I strongly agree with in the article is that extending healthspan (the length of time one is healthy) is far more important than extending longevity (the length of time one lives).

Oura Partners with Best Buy

I love my Oura smart ring. I've worn mine for years. The hardest part of the purchase process was the sizing. Sizing will be less of an issue as you can soon walk into Best Buy and find a fitting station. The article Oura Is Proof That Smart Rings Are Here to Stay discusses the Oura Ring and some of the upcoming competitors.

Cannabis, Cannabinoids, and Delta-8 THC / Delta-10 THC

Cannabis-derived products like delta-8 THC and delta-10 THC have flooded the US market – two immunologists explain the medicinal benefits and potential risks is a quick overview of some of medicinal and side effects of cannabinoids. The article discusses hemp, cannabis, and a few of the cannabinoids.

Creativity / Rick Rubin

I enjoy writing words and music. I'm not good at either, but the process brings me joy. Rick Rubin's new book is about the creative process: The Creative Act: A Way of Being: Rubin, Rick. I've been a big fan of Rubin's Broken Record Podcast. I also enjoyed watching Rick Rubin: The 60 Minutes Interview - CBS News and hearing him interviewed on Rick Rubin on How to Make Something Great. I'm adding the book to my "must-read" list.

Brainstorming with ChatGPT

Wired had an article on how to brainstorm better with the generative AI platform: 6 Tips for Using ChatGPT to Brainstorm Better

What Can We Learn About Aging from Centenarian Excrement?

The longest-living people have a more diverse microbiome than their less healthy peers. A study published this month, Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures looked at the gut microbiomes of centenarians — individuals who've reached or surpassed a century in age — and compared them against old, middle-aged, and young adults. Their results showed, "regardless of health status, the centenarians had a unique enterotype that is a combination of the two found in young adults aged 20 to 44 — Bacteroides — and older adults — Escherichia and/or Shigella." Read the study synopsis here: Centenarians Have Super Healthy Gut Microbiomes — Can This Help Us Live Longer?

Pill Popping Polypharmacy

"Getting people off drugs is unfamiliar terrain for modern health systems, mostly set up to put patients on them. But that is beginning to change. Doctors, pharmacists, and nurses are setting up "deprescribing networks" to try to spread the word." The Economist published an article on the overprescription of medication: Too many people take too many pills.

FDA-Approved Video Games

Much of my research at Duke focused on using video game technology in healthcare and healthcare education. It was fantastic to read this synopsis of Akili [^1] and EndeavorRX, an FDA-approved video game for treating ADHD. I can think of many more uses of the platform. The story behind an FDA-Approved Video Game Treatment for ADHD


[^1]: I am an Akili Interactive shareholder.

031 - Science / Pseudoscience of Aging, Cannabinoids and Cancer, and The World's Hottest Pepper - HealthHippieMD Week In Review

For Love of the Bean

This author loves their coffee (in reality, caffeine). "A low dose of caffeine can lead to a significant increase in … happiness and calmness and decreases in tenseness." Coffee really does make you happier

What's Your Subjective Age?

There is frequently a difference between our chronological age and our subjective age. This author examines the phenomenon: I'm 53 years old. I'm 36 in my head. - The Atlantic

The Science and Pseudoscience of Aging

Scientists are working diligently to unravel the aging process. I mentioned some of this work in 027 - Wise-Selfishness, Horvath's Clock and GrimAge - HealthHippieMD Week In Review. Here is an excellent video overview of the quest to extend our lives, including an interview with Steve Horvath: The Future with Hannah Fry And another interesting, more scientific overview of the field: Turning back time with epigenetic clocks - Nature

+More on the brave new world of chronological-age testing start-ups: How Old Are You, Really? New Tests Want to Tell You

+More on longevity research: Can We Change How Fast Humans Age? A New Study Is Getting Closer to the Answer

Periodontal Disease and Rheumatoid Arthritis

Scientists at Stanford have been working on why there is an association between poor oral health and more severe rheumatoid arthritis: Oral bacteria trigger rheumatoid arthritis flare-ups

The Last of Us

I'm enjoying the HBO series, The Last of Us. The premise that a fungus infects humans and does everything in its power to spread is borrowed from the animal world. The article, Can a Fungus Really Take Over Our Brains?, is an overview of known pathogens that alter HUMAN behavior. If you want to binge another great sci-fi/horror show, try Fortitude, supposedly one of the most scientifically accurate sci-fi shows ever made.

How to Deal with Dark Personalities at Work

Dark personalities: narcissists, psychopaths, and Machiavellians are common in society. Here is some advice on how to navigate your interactions with them at work: Here's what to do when you encounter people with 'dark personality traits' at work

A Reading List on the Neuroscience of Reading

According to the intro, humans were not designed to read. Here is a series of long-form articles on one of life's greatest pleasures: A Reading List About the Neuroscience of Reading

Digital Declutter

"Just as clutter in your home can cause stress, erode productivity, and hurt your sense of well-being, digital clutter, she said, can bring up similar feelings." Here is an interesting and helpful article from the NY Times on how to clean and organize your digital life: How to Clear Out Digital Clutter - The New York Times (gift article)

The Hottest Peppers in the World

Curious about where your favorite pepper ranks? Here you go... Hottest Pepper in the World and 6 Other Spicy Chilis

Artificial Sweetener Associated with Cardiovascular Events

This week's study in Nature Medicine, The artificial sweetener erythritol and cardiovascular event risk,, demonstrates an association between the use of erythritol and cardiovascular events such as stroke or heart attack. More research is needed. Zero-Calorie Sweetener Possibly Linked to Heart Issues, New Study Suggests (gift article)

The Microbiome and Multiple Sclerosis (pre-clinical)

These scientists are investigating how the microbiome might be manipulated as a therapeutic intervention in Multiple Sclerosis: Bile acids and gut microbes could potentially treat multiple sclerosis, according to new research in mice

Cannabinoids and Cancer

As North Carolina ponders approval of medical marijuana, these scientists are investigating how cannabinoids might be used as therapeutic agents to combat cancer: Can Cannabis Help Treat Cancer? Researchers Are Getting Closer To An Answer

GLP-1 Agonists in Economist

The Economist had a brief but informative overview of the new anti-obesity drugs. A new class of drugs for weight loss could end obesity (subscription required)

The Problem of Fraud in the Scientific Literature

The problem of fraudulent papers in medicine is much more prevalent than I believed. The Economist explains There is a worrying amount of fraud in medical research (subscription required)

Wired Guide to Quantum Computing

Wired continues its excellent series on the hottest technology topics: What Is Quantum Computing? The Complete WIRED Guide

Generative AI does Anime

Unlike the author of this article, I was fascinated by the techniques used with generative AI to make an anime from the video: Corridor Crew's AI-Generated Anime Isn't Just Callous and Craven — It's Also Dangerous Make sure to watch the linked videos in the story.

Words, Not Truths

"On the other hand, if I can talk to a bot that will give me plausible responses to things I say, it would be useful in situations where factual accuracy isn't all that important." A computer scientist chimes in on how he believes generative AI, such as ChatGPT, should be used: ChatGPT is great – you're just using it wrong

Why Some Food Tastes Better the Next Day

Here is some of the science behind why certain leftovers taste better the next day: Why certain foods taste better the next day

019 - Farmaceuticals, Psychobiotics, and Darwinian Medicine - HealthHippieMD Week In Review

Psychobiotic Diet

The article, This diet helps your mental health by boosting your gut health, discusses food to improve mental health. Psychobiotics and nutritional psychiatry are fields in their infancy, but you're going to hear more and more about the role of food on stress, anxiety, and depression.

YAMS and Sweet Potatoes

Yams and sweet potatoes are NOT the same things. But in the U.S., the names are used interchangeably. Here's the story: What's the Difference Between Sweet Potatoes and Yams?

What Are Sugar Alcohols

Sugar alcohols are in many of today's processed foods. What are they? Sugar Alcohols Are in Many Sugar-Free Foods. What Are They? (gift article)

Darwinian Medicine, Evolutionary Psychiatry

What if illness is not a disease but an adaptation to evolutionary pressures? The provocative article Evidence grows that mental illness is more than dysfunction discusses a controversial way of reframing our thoughts about mental illness.

Humor: An Essential Life Skill

Why a good sense of humor is an essential life skill has a lot to say about the importance of humor in your personal and professional lives.

The Formula for Happiness

"What we think it is about is an attachment to another person. And a sense that another person is there for you, particularly when you need them. We think of relationships as safety nets, as stress regulators." There are many important insights in this podcast/transcript from Arthur Brook's How to Build a Happy Life. A New Formula for Happiness

Pursuing Happiness in All the Wrong Places

More Arthur Brooks. Before he taught at Harvard and wrote publicly about happiness, he led a well-known conservative think tank. The article, America Is Pursuing Happiness in All the Wrong Places, adapted from his November remarks at the Irving Kristol Award & Annual Dinner, is packed with wisdom. Although I am not a conservative, and despite some of the political overtones of the article, his words spoke deeply to me.

Farmaceuticals

Antibiotic resistance is an increasing problem across the world. Here is an article about a new antibiotic isolated from potatoes, incredibly potent against certain types of fungus: New antibiotic found in potato bacteria

Lucid Dreaming

Scientists are studying the phenomenon of lucid dreaming. Lucid Dreaming Is a Mystery We're Starting to Crack is focused on the quality of sleep during lucid dreaming.

Gut Microbiome and Prosocial Behavior

Scientists are studying the role of gut bacteria and the gut-brain axis in prosocial behavior. In a preclinical study with implications for neurodevelopment issues, Researchers found Zebra Fish lacking a gut microbiome are less social and have different brain structures than peers who had normal gut flora. Specifically, the lack of bacteria influenced the microglia of Zebra Fish brains and led to structural changes. It will be interesting to see if a similar phenomenon exists in mammals, especially humans.

Wasted Healthcare Spending

It's conceivable that half of the healthcare dollars are wasted. A small portion of the total, a mind-numbing $160 billion, is attributed to absenteeism-not showing up for appointments. According to the article, A big source of wasted healthcare spending is your fault, one in four appointments is missed. I will track down the NEJM article mentioned, although I'm sure it will raise my blood pressure.

Mindfulness vs. Anti-Anxiety Medications

A recent paper compared Mindfulness-Based Stress Reduction (MBSR) to the medication escitalopram's (Lexipro's) ability to reduce stress. Mindfulness meditation may be just as effective as anxiety medication reports the study, published in JAMA Psychiatry. Although 45 minutes of daily mindfulness practice may not be practical for everyone (I usually only do 15-20 minutes), the paper indicates that cultivating mindfulness should be more widely taught (and prescribed).

+See also my lecture on mindfulness/meditation: Mindfulness-The Basics

More Bugs in Space

Knowledge of what happens to microbial life inside and outside the body while in space is important to understand as we contemplate missions to Mars and beyond. Scientists are struggling to figure out how space transforms our gut microbiome is an overview of the emerging science.

Bed Habits

Is Falling Asleep to TV So Bad? An Investigation is an entertaining article written about an insomniac's immersion into the science of sleep.

How to Recognize and Treat Your Pet's Anxiety

Pet anxiety is quite common. Here is an article to help you decode your pet's behavior and some ideas for treating their anxiety: Puppies on Prozac: How to Handle Your Pet's Anxiety.

Do Something Boring, Yet Engaging to Boost Your Creativity

How to unblock your creativity: Scientists say this bad habit can help is an interesting article on how to boost your creativity and get over mental blocks.

Cannabinoids and Opioids for Pain Relief

Cannabis for pain: A scientist reveals how weed activates our body's opioid system is an overview of work to decode these two substances that might safely work together to alleviate pain.

007- The Benign Masochism of Spicy Foods, Non-Nutritive Sweeteners, Psilocybin, and Attachment Theory - HealthHippie Week In Review - August 28, 2022

Non-nutritive Sweeteners and Weight Gain

I have been wary of artificial sweeteners for decades. A recent study in Cell, Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance , examines one potential mechanism how artificial sweeteners paradoxically cause weight GAIN, mediated through the microbiome. Sucralose and saccharine had the most harmful impact on the glycemic index (a measurement of the sugar in your blood). Read a summary article here: Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses. I also found this excellent, recent overview of artificial sweeteners-especially their impact on inflammation: Artificial Sweeteners: History and New Concepts on Inflammation

Knocking Down Publisher's Paywalls

It's nice to see some real momentum in making science freely accessible. This week, the White House pushed journals to drop paywalls on publicly funded research. Naturally, the multibillion-dollar publishers are pushing back. Back in 2016, I wrote Thoughts on Open Access and Traditional Publication.. We published the manuscript I mentioned in my blog in the open access journal Frontiers in Public Health: A Novel Multiplayer Screen-Based Simulation Experience for African Learners Improved Confidence in Management of Postpartum Hemorrhage.

"Bud"wieser - Cannabis-Infused Beverages

With the rapidly expanding legalization of recreational marijuana and THC comes a bevy of products seeking to capitalize on the new trend financially. The article, Are Weed Drinks Safe? What to know About THC and Alcohol discusses the issues associated with these new products

How to Meditate when you Can't Sit Still

Meditation has many health benefits, but many people have difficulty getting a practice started. If this sounds familiar, How to Meditate When You Can't Sit Still was written for you. More information on meditation: Meditation - HealthHippieMD

Fiber, Phytonutrients, and Healthy Soil

The People's Pharmacy had an excellent discussion this week on the microbiome and regenerative farming. Show 1312: Fiber, Phytonutrients, and Healthy Soil If you're interested in regenerative agriculture, don't miss the beautiful documentary, The Biggest Little Farm.

Time-Restricted Eating / Intermittent Fasting

I found an article on intermittent fasting for weight loss, a quick overview of a subset of recent research. Does Time-Restricted Eating Help With Weight Loss?. If you're interested in this topic, Michael Greger at NutritionFacts.org has a great series of videos on the topic: Fasting For Health and Weight Loss.

+Another article on fasting (and inflammation): One form of fasting may be best to fight inflammation. In this study, individuals fasted for 24 hours once a week. People followed a regimen of "low-frequency" intermittent fasting, fasting for 24 hours once a week. The result was a higher galactin-3 in those that fasted. Galactin-3 aids in cellular repair and decreases systemic inflammation. The authors opined this regimen might have similar effects to SGLT-2 inhibitors, the newer diabetes pharmaceuticals.

"Post-Pandemic" Thoughts

Another opinion piece on the discomfort of integrating back into society without a healthy immune system: The covid pandemic has 'ended,' but I'll keep my mask on, thanks

The Benign Masochism of Spicy Foods

Quick--what animal other than humans has a preference for spicy foods? Give up? Did you have the Chinese Tree Shrew on your bingo card? Me either. An article in the Big Think covers the phenomenon of human enjoyment of spicy foods, A pleasure to burn: Why do people like spicy foods?

Neurologist's Tips for Fighting Memory Loss and Staving Off Alzheimer's

A recent Lancet commission on dementia suggested that up to 40% of Alzheimer's cases could be prevented or delayed. The article, Stop drinking, keep reading, look after your hearing: a neurologist's tips for fighting memory loss and Alzheimer's has some helpful advice, no matter your age.

Psilocybin therapy reduces heavy drinking

This week, I saw plenty of news about a manuscript published in JAMA Psychiatry, Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs. Placebo in the Treatment of Adult Patients With Alcohol Use Disorder. The article, Psilocybin therapy reduces heavy drinking by up to 83 percent in landmark trial, summarizes the study. Although the cohort was small (96 subjects), and the control group had a significant response - 51% abstaining from alcohol during the study period, the study is still quite interesting. This report will be another brick in the wall in the psychedelic industry's quest to legalize and use psychedelic compounds medically.

+An interesting article on how psychedelics and near-death experiences change core beliefs in similar ways: Psychedelic trips and near-death experiences result in strikingly similar shifts in mindset.

Attachment Style and Friendship

I read the book Attached a couple of years ago, and it left quite an impression. Unsurprisingly, attachment style influences many types of relationships, not just romantic: How Your Attachment Style Shapes Your Friendships

+What are the most valued traits we look for in friends? The most valued trait in a friend will surprise you

Embracing Idleness

Another excellent article in How to Build a Life series at the Atlantic. How to Embrace Doing Nothing, touches on the importance of leisure time. See my article, Time Poverty: a significant threat to wellness.

Quote of the Week

Knowledge is power. The real test of knowledge is not whether it is true but whether it empowers us. Scientists usually assume that no theory is 100% correct. Truth, consequently, is a poor test for knowledge. The real test is utility. A theory that enables us to do new things constitutes knowledge. - Francis Bacon


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006 - Loneliness, Mucus, and Cannabinoids - HealthHippie Week In Review - August 21, 2022

Loneliness

Loneliness is a significant problem among older adults. For many, feelings of isolation were amplified by the pandemic. Feelings of loneliness impart risks to immunity, cognition, and general health. I read the article, Mindfulness Training Appears To Improve an Immune Function Marker in Lonely Older Adults The critical question was whether MBSR stimulated production of interleukin-6 (IL-6), a measure of the immune system's responsiveness in older, lonely adults (as measured by the UCLA Loneliness Scale). The authors found that MBSR significantly increased IL-6 production in response to challenge, improving responsiveness. The authors pointed out these are only early mechanistic findings-it is unclear whether the results would translate into meaningful health outcomes. An interesting study, nonetheless.

Gut Mucus and Inflammatory Bowel Disease

Fugitive gut bacteria can disrupt our immune system. Here's how we can capture them is an intriguing synopsis of the study, The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces. The study looked at the activation of the immune system by bacteria that cross the gut barrier into circulation. The study reinforced the importance of maintaining a healthy mucus layer in your gut through food choices and the avoidance of emulsifiers (both in food and soaps). Here is an article that touches on the concept A New Theory of Obesity.. I will write something else on emulsifiers soon.

Facing Covid with a Compromised Immune System

The excellent opinion piece, How to Plan for the Future When COVID Isn't Going Away, written by an immunocompromised author, resonated with me.

The Doctor will Zoom you Now

An interesting opinion piece by a physician telemedicine convert: How I Came Around on Telemedicine. The article touches on the many benefits of remote visits, including some unexpected ones. The report also discusses some of the challenges for telemedicine moving forward.

Mad Honey Redux

Two weeks ago, I learned about Mad Honey for the first time. This week, The Washington Post published a story about a Turkish bear that got so stoned on Mad Honey-he had to be rescued. Here is the story (with a video): Meet Balkiz, a bear cub in Turkey who got high on hallucinogenic honey

Plant-Based "Meat"

I read the article Taste alone won't persuade Americans to swap beef for plant-based burgers and had a pretty strong reaction. The piece focused solely on messaging to improve plant-based meat consumption. Isn't the most essential question "what's best for our bodies?" Although plant-based meats may be better for the environment, the jury is still out on whether these highly processed foods are better for our health: Plant-based Meat versus Beef

Psychedelic Capitalism

As a follow-up to my newsletter a few weeks ago, here is an interesting podcast on the rapidly developing market for psychedelics: The corporatization of psychedelics-audio. or transcript

+More on the psychedelic renaissance. Psychedelics and mental health: What to know.

Fish Oil and Endocannabinoids

I read the article, Fish Oil Is Good! No, Bad! No, Good! No, Wait, that focuses on the drug Vascepa. Vascepa was approved after a published study demonstrated that, among high-risk adults already receiving another type of cholesterol-lowering treatment, the drug decreased the risk of heart failure and other serious cardiovascular events by an eye-popping 25 percent. A recent manuscript, Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy calls into question the findings of the original study and raises suspicion it was not the fish oil that made subjects better. Instead, it was the placebo that made control subjects worse. The article is anti-fish oil, but I wouldn't give up on fish oil just yet. Most people don't realize fish oil is a building block for endogenous cannabinoids, the substances your body makes that bind to the same receptors as marijuana. Cannabinoid receptors are everywhere in your body, and we are just beginning to understand what they do. The fact that the receptors are so prevalent tells me they have essential roles to play in physiology. I've touched on some emerging science: Why does running give you a high? A look at the science If you'd like to learn more about the biochemistry: Emerging Class of Omega-3 Fatty Acid Endocannabinoids & Their Derivatives

Medical Gaslighting

A common experience in medicine is having one's concerns dismissed by a provider, often referred to as medical gaslighting. Medical practitioners often quickly ignore symptoms and diseases they don't fully understand. The article, How to Spot 'Medical Gaslighting' and What to Do About It, discusses how to identify these behaviors by medical professionals and how to overcome them.

Love, not Lies

Another great article in the Atlantic's How to Build a Life Series. The latest, Disagreement Can Be an Act of Love, is about the lies we tell ourselves and each other. One of my favorite lines in the article, "Some lies might make life easier, but they don't necessarily make life happier._"

Hyperbarics and Long Covid

An intriguing synopsis of a small study out of Israel, Is Oxygen the Answer to Long Covid?, shows hyperbaric oxygen treatment improves the symptoms of Long Covid. The authors opine on potential mechanisms but do not mention the microbiome. A hyperoxic environment would kill many anaerobic bacteria that typically thrive in the oxygen-poor environment of the gut. The alteration of the gut microbiome through hyperoxic exposure is definitely worth considering.

Daydreaming

I've always enjoyed daydreaming, but not everyone does. Why Daydreaming Is Actually Good For Your Brain is an interesting article on the phenomenon of positive and negative daydreaming. The report includes tips on making your daydreams more positive, productive, and creative.

Are Small Amounts of Alcohol Beneficial to Your Health?

Michael Greger tackles the questions of alcohol use and reverse causation in: Is It Better to Drink Little Alcohol Than None? Do Any Benefits of Alcohol Outweigh the Risks?

Quote of the Week

"You must love in such a way that the person you love feels free." ― Thich Nhat Hanh