110 - Rapamycin, Genes on Sale, and Flowing Through Jazz - HealthHippieMD Week In Review

There will be no newsletter next week as I gather with family and friends to celebrate my son's wedding. The newsletter will resume on Sunday, October 6.

Forever in Your Food

PFAS, or "forever chemicals," are increasingly found in food, raising concerns about long-term health impacts. These synthetic substances, used in products like nonstick cookware and food packaging, resist breakdown, contaminating farmland through sewage sludge fertilizer. Linked to cancer, liver disease, and developmental issues, PFAS can accumulate in food, particularly in items like milk, eggs, and seafood. While the FDA's tests show low levels in most foods, the full extent of contamination remains to be seen, and regulatory gaps leave questions about how safe our food supply truly is. How Dangerous Is PFAS in Food? - The New York Times (gift article).

Leaky Gut Instinct

Emerging research suggests long-term COVID-19 in children might be linked to gut permeability, or "leaky gut." Dr. Lael Yonker, a pediatric pulmonologist, has launched the first clinical trial testing larazotide, a drug to tighten intestinal walls. This trial seeks to address symptoms such as headaches, gastrointestinal pain, and attention issues in children with long-term COVID-19. While long Covid research has primarily focused on adults, Yonker's trial could provide an essential treatment option for young patients, possibly offering a breakthrough in combating this debilitating condition. The Gut Might Hold the Key to Treating Long Covid in Kids | WIRED.

Plastic Fantasy

In a lawsuit backed by ProPublica's reporting, California accuses ExxonMobil of deceptive marketing regarding its chemical recycling process, pyrolysis. The oil giant claims the technology transforms plastic waste into reusable products, such as fruit cups, but evidence shows less than 0.1% of the recycled content ends up in new products. Despite this, ExxonMobil advertises 30% recycled content using controversial accounting methods. The lawsuit likens this practice to past tobacco industry deceptions, calling for billions in penalties to fund public education and sustainability efforts. ExxonMobil Accused of Deceptive Marketing of Plastics Recycling Process — ProPublica.

Genes on Sale

Remember That DNA You Gave 23andMe? - The Atlantic explores the potential sale of 23andMe and its genetic data, raising concerns about DNA privacy. As the company struggles financially, with stock declines and leadership upheavals, its most valuable asset—customers' genetic information—may be sold. This creates uncertainties about how future owners might use sensitive data, with risks extending beyond current privacy policies. Insurance companies, law enforcement, and other third parties could exploit the DNA data for profit or surveillance. The article underscores that once DNA is shared, it cannot be fully controlled, posing long-term consumer risks.

AI Doctor's Notes

As physicians face overwhelming patient messages, AI tools like MyChart's "In Basket Art" are stepping in to draft responses. These tools use AI models to mimic doctors' voices, providing medical advice or administrative replies. Though many hospitals embrace efficiency, concerns over transparency and potential errors in AI-generated responses grow. Experts worry about automation bias, where physicians may rely too much on AI, risking patient safety. As AI edges into clinical decision-making, ethical questions arise about the role of technology in personal doctor-patient communication. That Message From Your Doctor? It May Have Been Drafted by AI - The New York Times (gift article).

The Rapamycin Gamble

Rapamycin, a drug traditionally used as an immunosuppressant, has gained attention in the longevity community for its potential anti-aging benefits. Early studies in animals, including mice, show promise, suggesting the drug can extend lifespan by inhibiting the mTOR complex, which is linked to cellular health. However, human studies remain inconclusive, with mixed results and limited long-term data. While some users report improvements in energy, reduced inflammation, and other minor health benefits, skeptics caution about the drug's potential risks, such as immune suppression. The quest for a longer, healthier life continues—cautiously. Rapamycin and Anti-Aging: What to Know - The New York Times (gift article).

A Recipe for Health

How UTSW's Food as Medicine Program Is Revolutionizing Physician Education - D Magazine explores the Food as Medicine program at UT Southwestern (UTSW) and how it is transforming physician education by incorporating culinary medicine into medical training. Spearheaded by Dr. Jaclyn Albin and Program Director Milette Siler, the initiative teaches medical students and residents how to use food to combat chronic illness. With cooking classes and real-world nutrition lessons, physicians learn to help patients manage conditions like diabetes and heart disease through diet. The program partners with local communities and aims to make healthy eating accessible and culturally sensitive, tackling health outcomes and social isolation. I am currently enrolled in a similar class offered online: Culinary Health Education Fundamentals (CHEF) Coaching—The Basics-Overview | Continuing Education Catalog. (thanks, Amy!).

Flowing Through Jazz

In a study of jazz musicians, researchers used EEG scans to explore the brain activity behind entering a "flow state," a heightened, effortless creative focus. Jazz guitarists of varying experience levels improvised while their brain activity was recorded, revealing that more experienced musicians frequently entered flow. Brain scans showed reduced activity in areas associated with cognitive control, suggesting that expertise enables performers to "let go" mentally, allowing creativity to flourish. This research sheds light on how mastery and relaxed focus foster spontaneous innovation. Brain Scans of Jazz Musicians Reveal How to Reach a Creative 'Flow State' | Scientific American.

Empathy: A Team Sport?

Empathy isn't just an individual endeavor—it's socially driven. Research shows that empathy flourishes when it's a group norm, not just a personal skill. Programs like "empathy cafes" and classroom workshops reveal that structured dialogues and reflective listening can foster understanding, even across deep divides. Neuroscience supports this: empathetic behavior lights up specific brain regions, and witnessing empathy in others boosts our empathetic response. The key takeaway? Empathy thrives when nurtured in communities, showing that togetherness can make the cognitive challenge of empathy more manageable and rewarding. Being Empathetic Is Easier when Everyone's Doing It | Scientific American.

106 - Power Plays, Slices of Life, and a Touching Discovery - HealthHippieMD Week In Review

Power Play

Mitochondria keep your brain cells alive − helping them run smoothly may protect against Parkinson's disease explores the vital role mitochondria play in maintaining brain cell health and their potential in combating Parkinson's disease. Researchers at Florida International University have identified a key protein, Drp1, that controls mitochondrial dynamics, which, when manipulated, can protect neurons from degeneration. Their findings suggest restoring mitochondrial function may prevent cell death caused by toxic protein buildup, a hallmark of Parkinson's. Ongoing studies are testing FDA-approved compounds targeting Drp1, offering hope for new treatments against this neurodegenerative disease.

Plastic Numbers Don't Add Up

The EPA has officially rejected the controversial mass balance accounting method, which has been used to exaggerate the recycled content in plastic products. The decision strengthens the agency's Safer Choice program, requiring that recycled content be calculated by actual weight rather than through paper-based number manipulation. This move marks a significant step in the Biden administration's efforts to tackle plastic pollution, drawing a clear line against deceptive greenwashing tactics in the industry and setting a new standard for sustainable packaging. EPA Rejects Use of Mass Balance Accounting for "Safer Choice" Recycled Plastic — ProPublica.

The Art of Persuasive Listening

The key to effective persuasion is not aggressive argumentation but genuine listening and understanding. Individuals can influence others more positively by focusing on shared values, avoiding combative rhetoric, and offering one's beliefs as a gift rather than a weapon. The article highlights the importance of empathy, patience, and humility in conversations, particularly during divisive times. Drawing lessons from early Christian practices and modern psychology, it advocates for transforming confrontational exchanges into opportunities for meaningful connection and mutual respect. How to Influence People—And Make Friends - The Atlantic.

Touching Discovery

As revealed by groundbreaking research, Pacinian corpuscles, specialized touch sensors, detect subtle environmental vibrations and transmit this information to the auditory midbrain. These sensors are more sensitive than previously believed, firing in response to vibrations from surfaces like sandpaper, cardboard, and even tree branches. Notably, high-frequency vibrations travel through an alternate pathway to the inferior colliculus, a midbrain region typically associated with auditory processing rather than the somatosensory cortex. This discovery highlights the interconnectedness of sensory pathways and opens new avenues for understanding touch perception and behavior in mammals.Touch sensors detect subtle environmental vibrations, send information to auditory midbrain | The Transmitter: Neuroscience News and Perspectives (Thanks, Amy!).

Slice of Your Past for a Fuller Future

A 'Life Review' Can Be Powerful, at Any Age - The New York Times (gift article) explores the concept of "life review," a therapeutic process traditionally used in late life but now recognized for its benefits across all ages. By reflecting on past experiences through writing or conversation, individuals can develop self-awareness, acceptance, and a clearer sense of purpose. Originally aimed at older people to make peace with their legacies, life reviews have been shown to reduce depression, increase life satisfaction, and help people navigate life transitions. The process can be facilitated by professionals or pursued independently, offering powerful insights at any stage of life.

Grounds for Change

This startup is making coffee without coffee beans | MIT Technology Review explores how the Singaporean startup, Prefer Coffee, is revolutionizing the coffee industry by creating a coffee-like beverage without using coffee beans. Faced with traditional coffee production's environmental impact and sustainability challenges, cofounders DJ Tan and Jake Berber turned to upcycle food industry leftovers like stale bread, soybean pulp and spent barley grains. By leveraging fermentation and innovative roasting techniques, they've crafted a drink that mimics coffee's taste, offering a sustainable alternative. Their approach exemplifies the potential of upcycling in tackling global challenges.

Memory Lane's Sticky Situation

Researchers have identified the molecular "glue" responsible for cementing long-term memories in the brain. The study focuses on two key molecules, PKMzeta and KIBRA, which work together to strengthen synaptic connections crucial for memory retention. While PKMzeta has long been associated with memory, its fleeting presence puzzled scientists. The discovery that KIBRA tags specific synapses, allowing PKMzeta to maintain their strength, fills gaps in our understanding. This research not only strengthens the PKMzeta theory but also opens new avenues for memory-related therapies, including potential treatments for conditions like Alzheimer's and PTSD. Brain Scientists Finally Discover the Glue that Makes Memories Stick for a Lifetime | Scientific American.

A New Hope for Chronic Pain

Suzetrigine, initially known as VX-548, is a groundbreaking pain medication that blocks sodium channels in peripheral nerves, preventing pain signals from reaching the brain. Unlike opioids, it offers significant pain relief without the risk of addiction. While primarily tested for acute pain, Suzetrigine shows promise in treating chronic conditions like diabetic neuropathy. Though early trials are encouraging, more research is needed to confirm its long-term safety and effectiveness, particularly for chronic pain sufferers seeking non-opioid alternatives. New Pain Medication Suzetrigine Prevents Pain Signals from Reaching Brain | Scientific American.

Coach Caution

Is 'coaching' a shortcut to mental health care? Not so fast − here are key differences explores the rise of life coaching as an alternative to traditional mental health care, driven by shortages in professional healthcare services and the appeal of personalized guidance. However, it warns against viewing coaching as a substitute for therapy due to significant differences in regulation, training, and legal responsibilities. While coaching can be helpful in specific contexts, it lacks the rigorous standards required for licensed therapy, leading to potential risks such as misinformation and unethical practices. Consumers are advised to thoroughly vet coaches before engaging in their services.

053 - Scienceploitation, Successful Psychopaths, and Swedish Death Cleaning - HealthHippieMD Week In Review

Scienceploitation

The wellness industry is flooded with products making dubious claims, relying on fake science to deceive consumers. Brands use scientific-sounding buzzwords for marketing unproven products, exploiting emerging areas of science. Buyers seeking scientific evidence are often overwhelmed with confusing options. Vague terms like "boosts" and "supports" suggest positive health outcomes without clear definitions. Questionable studies and jam-packed ingredient lists further confuse consumers. Without strict monitoring, consumers must learn to assess claims, verify reputable sources, and be cautious of "too good to be true" promises in the pursuit of wellness. How to Spot False Claims in Your Wellness Products - The New York Times (gift article)

We Are Already Paying the Cost of Universal Healthcare

Here is an interesting opinion piece in the NY Times on the economic feasibility of universal healthcare: Opinion | Fixing Health Care Starts With the Already Insured - The New York Times (gift article)

On Boundaries

The article, No One Knows What Boundaries Are, explores the concept of boundaries and how it is often misunderstood. The piece delves into the cultural and generational factors contributing to the struggle to set and enforce boundaries. While boundaries are increasingly discussed in popular psychology, the article emphasizes that they are not rules for others but rather a personal yardstick for comfort and self-preservation. The true test of boundaries lies in how individuals respond when others violate them, and it highlights the importance of maintaining healthy relationships while respecting personal boundaries.

GenerativeAI for Music

Meta's new AI-powered tool is like Dall-E but for music discusses Meta's new sound generators that include music and effects. Right now, these tools are only available for research. I can't wait until they are publicly announced so I can take them for a spin.

Successful Psychopaths

While psychopaths are often associated with Hollywood villains, researchers are shedding light on a less-known aspect: "successful psychopaths." These individuals possess psychopathic tendencies but manage to avoid trouble and even excel in certain areas due to their unique traits. A dimensional approach has replaced the binary view, with boldness identified as a crucial factor alongside meanness and disinhibition. Though controversial, some argue that certain psychopathic traits can be advantageous in fields like business. Understanding these traits using new scales may help debunk stereotypes and discover the hidden potential of those who possess them. The Psychopathic Path to Success - Nautilus

Personality and Dementia Risk

A study examining nearly 2,000 individuals revealed a significant link between personality traits and the likelihood of developing dementia. Researchers found that individuals with higher levels of conscientiousness were less likely to experience cognitive decline, while those with neurotic tendencies were more prone to it. The study highlighted the role of personality traits in influencing the transitions between different cognitive statuses. While personality can influence the progression of minor or moderate cognitive impairment, it appears to have less impact once dementia sets in. Understanding these links could offer valuable insights into dementia prevention and management. Your personality is linked to risk of dementia - Big Think

Weighing the Evidence: Exercise and Weight Loss Debate

The global fitness industry is booming, and many exercise to lose weight—however, a debate in the scientific community questions whether exercise truly helps with weight loss. The constrained total energy expenditure hypothesis suggests the body compensates for activity by burning fewer calories outside workouts. While some evidence supports exercise-induced weight loss, other studies indicate that exercise may not prevent weight regain after dieting. The mixed findings suggest that exercise provides numerous health benefits, but its direct impact on weight loss remains uncertain. Exercise may or may not help you lose weight and keep it off – here's the evidence for both sides of the debate

The Art of Swedish Death Cleaning

"Rather than making do with less, it's about getting more from the things that make you happy." How Swedish death cleaning works to declutter your life (gift article) discusses the concept of "Swedish death cleaning," a method of decluttering and reevaluating our relationship with possessions. Inspired by the book of Margareta Magnusson, the method encourages people to let go of unnecessary belongings, reduce their carbon footprint, and prioritize experiences over material possessions. By recognizing the stories we tell about our stuff, we can make decluttering easier, create a framework for future purchases, and find happiness in owning only what truly matters.

Free Will: The Key to a Happier Life?

In To Get Happier, Choose to Read This Column, Arthur Brooks delves into the philosophical debate about free will and its impact on happiness. Drawing on concepts from science fiction and philosophy, the article explores the mind-body problem and the existence of free will. While uncertainty remains, the article suggests that embracing the idea of free will can lead to greater life satisfaction and positive decision-making. Whether a firm believer or a skeptic, acting as if you have free will can bring positive changes in your life.

Fraudulent Scientific Research

Allegations of data tampering in a 2012 study on dishonesty, co-authored by prominent researchers Dan Ariely and Francesca Gino, have raised concerns about the extent of scientific fraud. The study, involving separate experiments, was retracted after suspicions of manipulated data. Recent revelations from the insurance company involved in the study indicate inappropriate data manipulation. The possibility of dual fraud in the same paper has experts bewildered, suggesting that scientific fraud might be more common than believed. The lack of systematic fraud detection and assumptions about researchers' integrity add to the unsettling uncertainty surrounding scientific research ethics. Did Francesca Gino and Dan Ariely Fabricate Data for the Same Study?

Microwaving Plastic

For the Love of God, Stop Microwaving Plastic | WIRED has me seriously considering replacing my SnapWare.....