110 - Rapamycin, Genes on Sale, and Flowing Through Jazz - HealthHippieMD Week In Review

There will be no newsletter next week as I gather with family and friends to celebrate my son's wedding. The newsletter will resume on Sunday, October 6.

Forever in Your Food

PFAS, or "forever chemicals," are increasingly found in food, raising concerns about long-term health impacts. These synthetic substances, used in products like nonstick cookware and food packaging, resist breakdown, contaminating farmland through sewage sludge fertilizer. Linked to cancer, liver disease, and developmental issues, PFAS can accumulate in food, particularly in items like milk, eggs, and seafood. While the FDA's tests show low levels in most foods, the full extent of contamination remains to be seen, and regulatory gaps leave questions about how safe our food supply truly is. How Dangerous Is PFAS in Food? - The New York Times (gift article).

Leaky Gut Instinct

Emerging research suggests long-term COVID-19 in children might be linked to gut permeability, or "leaky gut." Dr. Lael Yonker, a pediatric pulmonologist, has launched the first clinical trial testing larazotide, a drug to tighten intestinal walls. This trial seeks to address symptoms such as headaches, gastrointestinal pain, and attention issues in children with long-term COVID-19. While long Covid research has primarily focused on adults, Yonker's trial could provide an essential treatment option for young patients, possibly offering a breakthrough in combating this debilitating condition. The Gut Might Hold the Key to Treating Long Covid in Kids | WIRED.

Plastic Fantasy

In a lawsuit backed by ProPublica's reporting, California accuses ExxonMobil of deceptive marketing regarding its chemical recycling process, pyrolysis. The oil giant claims the technology transforms plastic waste into reusable products, such as fruit cups, but evidence shows less than 0.1% of the recycled content ends up in new products. Despite this, ExxonMobil advertises 30% recycled content using controversial accounting methods. The lawsuit likens this practice to past tobacco industry deceptions, calling for billions in penalties to fund public education and sustainability efforts. ExxonMobil Accused of Deceptive Marketing of Plastics Recycling Process — ProPublica.

Genes on Sale

Remember That DNA You Gave 23andMe? - The Atlantic explores the potential sale of 23andMe and its genetic data, raising concerns about DNA privacy. As the company struggles financially, with stock declines and leadership upheavals, its most valuable asset—customers' genetic information—may be sold. This creates uncertainties about how future owners might use sensitive data, with risks extending beyond current privacy policies. Insurance companies, law enforcement, and other third parties could exploit the DNA data for profit or surveillance. The article underscores that once DNA is shared, it cannot be fully controlled, posing long-term consumer risks.

AI Doctor's Notes

As physicians face overwhelming patient messages, AI tools like MyChart's "In Basket Art" are stepping in to draft responses. These tools use AI models to mimic doctors' voices, providing medical advice or administrative replies. Though many hospitals embrace efficiency, concerns over transparency and potential errors in AI-generated responses grow. Experts worry about automation bias, where physicians may rely too much on AI, risking patient safety. As AI edges into clinical decision-making, ethical questions arise about the role of technology in personal doctor-patient communication. That Message From Your Doctor? It May Have Been Drafted by AI - The New York Times (gift article).

The Rapamycin Gamble

Rapamycin, a drug traditionally used as an immunosuppressant, has gained attention in the longevity community for its potential anti-aging benefits. Early studies in animals, including mice, show promise, suggesting the drug can extend lifespan by inhibiting the mTOR complex, which is linked to cellular health. However, human studies remain inconclusive, with mixed results and limited long-term data. While some users report improvements in energy, reduced inflammation, and other minor health benefits, skeptics caution about the drug's potential risks, such as immune suppression. The quest for a longer, healthier life continues—cautiously. Rapamycin and Anti-Aging: What to Know - The New York Times (gift article).

A Recipe for Health

How UTSW's Food as Medicine Program Is Revolutionizing Physician Education - D Magazine explores the Food as Medicine program at UT Southwestern (UTSW) and how it is transforming physician education by incorporating culinary medicine into medical training. Spearheaded by Dr. Jaclyn Albin and Program Director Milette Siler, the initiative teaches medical students and residents how to use food to combat chronic illness. With cooking classes and real-world nutrition lessons, physicians learn to help patients manage conditions like diabetes and heart disease through diet. The program partners with local communities and aims to make healthy eating accessible and culturally sensitive, tackling health outcomes and social isolation. I am currently enrolled in a similar class offered online: Culinary Health Education Fundamentals (CHEF) Coaching—The Basics-Overview | Continuing Education Catalog. (thanks, Amy!).

Flowing Through Jazz

In a study of jazz musicians, researchers used EEG scans to explore the brain activity behind entering a "flow state," a heightened, effortless creative focus. Jazz guitarists of varying experience levels improvised while their brain activity was recorded, revealing that more experienced musicians frequently entered flow. Brain scans showed reduced activity in areas associated with cognitive control, suggesting that expertise enables performers to "let go" mentally, allowing creativity to flourish. This research sheds light on how mastery and relaxed focus foster spontaneous innovation. Brain Scans of Jazz Musicians Reveal How to Reach a Creative 'Flow State' | Scientific American.

Empathy: A Team Sport?

Empathy isn't just an individual endeavor—it's socially driven. Research shows that empathy flourishes when it's a group norm, not just a personal skill. Programs like "empathy cafes" and classroom workshops reveal that structured dialogues and reflective listening can foster understanding, even across deep divides. Neuroscience supports this: empathetic behavior lights up specific brain regions, and witnessing empathy in others boosts our empathetic response. The key takeaway? Empathy thrives when nurtured in communities, showing that togetherness can make the cognitive challenge of empathy more manageable and rewarding. Being Empathetic Is Easier when Everyone's Doing It | Scientific American.

101 - Nonprofit Hospital Illusion, Genetic Discrimination, and Microbial Athletic Edge - HealthHippieMD Week In Review

Long COVID: An Unsettling Puzzle

Long COVID, a widespread post-infection condition, affects millions globally, significantly impacting health and economies. Despite over 24,000 scientific publications, understanding still needs to be completed. The risk of long COVID has declined due to vaccines and viral changes, yet millions still suffer. It manifests in over 200 symptoms, from respiratory issues to neurological and metabolic disorders, severely impacting daily life and work. Recent studies suggest persistent viral presence and immune dysfunction as causes. Misleading public narratives downplay its threat, but data shows COVID-19 remains a severe and ongoing health risk.Long COVID puzzle pieces are falling into place – the picture is unsettling.

The Need for Genetic Discrimination Safeguards

The increasing popularity of genetic testing, with millions sharing their DNA for health and ancestry insights, raises critical concerns about genetic discrimination. Genetic data, often inadequately secured, poses risks if accessed by insurance companies or employers, leading to potential discrimination. This article highlights the ambiguity in defining genetic discrimination, drawing parallels to historical eugenics. Despite existing laws, varying definitions complicate protection efforts. Newer tests, like those measuring biological age, further complicate the landscape. Policymakers face challenges in creating robust protections, while individuals are urged to scrutinize data-sharing terms and understand their rights. Why we need safeguards against genetic discrimination | MIT Technology Review.

VR: The Body Image Game-Changer?

Virtual reality (VR) is emerging as a promising tool to tackle body image disturbances. These disturbances, often linked to eating disorders and body dysmorphic disorder, stem from faulty multisensory integration, leading to distorted body perceptions. VR-based "embodiment illusions," like the "rubber hand illusion," can trick the mind into feeling it inhabits a different body, potentially realigning these perceptions. Research shows that people with higher body image disturbance are more susceptible to these illusions, which can reduce perceptual distortions and negative emotions about body size and shape. While promising, further research is needed to understand the long-term effects and ethical implications. Can Virtual Reality Help Folks With Body Image Disturbance?

Dream Cuisine

Sleep deprivation affects about one-third of Americans, leading to severe health issues. However, improving sleep quality is achievable through specific dietary habits. Consuming foods rich in tryptophan, like turkey, fish, eggs, and nuts, combined with healthy carbs, can enhance melatonin production, promoting better sleep. Adopting a Mediterranean diet high in fiber, zinc, B vitamins, and magnesium can also aid sleep. Avoiding inflammatory foods such as sugary cereals and saturated fats is crucial. A consistent eating schedule and incorporating gut-friendly foods like yogurt and fermented items can further support restful sleep. 8 Eating Habits That Improve Your Sleep | TIME.

The Nonprofit Hospital Illusion

Many major nonprofit hospitals are barely charitable, maintaining tax-exempt status while running numerous for-profit ventures. They exploit legal loopholes, enjoy regulatory leniency, and engage in extensive lobbying to operate like big businesses yet avoid taxes. Their activities include owning for-profit insurers, venture capital firms, and hospitals abroad. Despite significant earnings, they report "operating surpluses" instead of profits. Critics argue these hospitals should lose tax benefits as their community contributions are minimal compared to the financial advantages they gain. The article calls for stricter regulations and more accountability to prevent such exploitation. Opinion | Many hospitals are nonprofit in name only, and get away with it - The Washington Post (gift article).

The Microbial Edge in Athletic Performance

Endurance athletes constantly seek ways to enhance their performance, often focusing on optimizing their mitochondrial health through rigorous training and precise nutrition. However, emerging research highlights the gut microbiome as a crucial yet overlooked factor in athletic excellence. The gut microbiome, a complex community of microorganisms, aids in nutrient absorption, immune function, and even communication with mitochondria. Elite athletes often exhibit unique microbiomes that directly impact performance and boost VO2 max and lactate thresholds. Integrating microbiome-friendly foods and probiotics into diets can significantly enhance endurance and recovery, presenting a new frontier in sports nutrition. Athletes looking for a competitive edge may find it within their gut microbiome.

+see also: Do Gut Bacteria Improve Athletic Performance? (yes, if you're a mouse, and maybe if you're a human) — HealthHippieMD.

Fun Fitness Challenges Await

7 Fitness Tests to Gauge Your Strength and Mobility - The New York Times (gift article) introduces seven fitness tests to assess strength, mobility, and overall fitness. These tests range from measuring flexibility and balance to evaluating power and VO2 max, catering to various fitness levels. The tests include simple activities like standing on one leg, gripping a bar, and rapidly getting out of a chair. They aim to provide a comprehensive snapshot of one's fitness, helping individuals track progress and set achievable goals. Whether you're training for a marathon or just curious about your fitness, these tests offer valuable insights and fun challenges.

Mind Over Matter

Advanced meditation is revolutionizing our understanding of consciousness. Neuroscientist Matthew Sacchet delves into the brain's behavior during deep meditative states. Unlike mindfulness practices for stress reduction, advanced meditation explores profound states of ecstatic bliss, deep insights, and compassionate experiences. Sacchet, who has meditated since childhood, uses a multidisciplinary approach to study these states, combining personal experiences, wisdom traditions, and empirical neuroscience. His research aims to unlock advanced meditation's potential for enhancing mental health and well-being and even integrating with psychedelics and AI for deeper consciousness insights. Altering Consciousness with Advanced Meditation | Scientific American.

Canines Catch Your Cortisol

Research from the University of Bristol reveals that dogs can detect human stress through scent, specifically the cortisol hormone in sweat. In the study, dogs were exposed to sweat samples from stressed and relaxed volunteers. The results showed that dogs became more pessimistic about ambiguous situations after smelling stress-induced sweat, suggesting they emotionally react to human stress. This emotional contagion between humans and dogs likely evolved for mutual survival benefits. The findings emphasize the profound empathetic bond between humans and their canine companions, highlighting the impact of human emotions on dog behavior. When Dogs Smell Your Stress, They Act Sad | Scientific American.

088 - Fasting, Happiness, and the Skin-Gut Axis - HealthHippieMD Week In Review

A.I. Designs New Tools for DNA Editing

The realm of CRISPR gene editing is experiencing a technological revolution with the introduction of generative A.I. Profluent, a startup based in Berkeley, California, has unveiled an A.I. system that crafts blueprints for novel gene editing tools. This innovation, which employs methods similar to those driving the popular A.I. chatbot ChatGPT, can enhance the precision and speed of combating illnesses and diseases. Profluent's A.I. analyzes vast amounts of biological data to create gene editors that could surpass those formed through natural evolution. Their recent creation, OpenCRISPR-1, has already been used to edit human DNA and is now freely available for further experimentation. This breakthrough could herald a new era of medical treatments, tailor-made at unprecedented speeds. Generative A.I. Arrives in the Gene Editing World of CRISPR - The New York Times (gift article).

Skin-Gut Axis

Researchers at the University of California San Diego have discovered that skin injuries can significantly affect gut health in mice. This study reveals a skin-gut axis, showing that damage to the skin disrupts the intestinal defenses and alters the gut microbiome. The findings challenge the traditional belief that gut microbes primarily influence skin health, instead highlighting a bidirectional relationship. The experiments demonstrated that skin wounds and artificial increases in skin-specific enzyme levels led to more severe colitis, a gut disorder, by altering the microbial balance. This research, published in Nature Communications, suggests a new perspective on the interplay between skin injuries and gut health, with implications for understanding human diseases. A Skin-Deep Wound Can Trigger Gut Bacteria Changes: ScienceAlert (thanks, Amy).

Fever Dreams

Fever dreams, typically vivid, intense, and disturbing, are often a part of the ill experience when body temperature rises due to sickness. These dreams are characterized by bizarre, repetitive, and negative imagery, influenced by altered brain neurochemistry and rapid eye movement (REM) sleep disturbances. Research indicates these dreams often feature surreal scenarios and threatening elements, such as oversized creatures or menacing figures. Experts suggest fever-induced alterations in body and brain function could trigger these dreams, which also hold psychological significance, potentially representing inner fears or conflicts. While generally harmless, persistent fever dreams should be discussed with a healthcare provider as they could signal underlying health issues. What Does It Mean to Have a Fever Dream?

Fasting Time

Could a Calorie-Restricted Diet or Fasting Help You Live Longer? - The New York Times delves into the scientific intrigue surrounding calorie restriction and intermittent fasting as potential longevity boosters, a concept borne from decades of animal research. Studies suggest that cutting calorie intake can significantly extend the lifespan of various species, from worms to monkeys, by inducing key biological changes and reducing susceptibility to age-related illnesses like cancer. However, the application of these findings to human longevity remains uncertain. Although some evidence hints that these dietary adjustments could benefit human metabolic health and potentially slow aging, definitive long-term human studies are lacking, and the mixed results, including some contrary findings in human obesity, prompt ongoing debate among scientists.

Fact or Fiction

Chatbot answers are all made up. This new tool could help you figure out which ones to trust. | MIT Technology Review discusses a new tool developed by A.I. startup Cleanlab, aimed at evaluating the reliability of responses from large language models (LLMs). This tool, emerging from a quantum computing lab at MIT, scores outputs from LLMs on a scale from 0 to 1 to determine their trustworthiness, addressing businesses' concerns about these models' tendency to "hallucinate" or generate inaccurate information. By providing a reliability score, the tool allows users to discern which responses to trust. This innovation is especially pertinent as chatbots become more integrated into daily digital interactions, from search engines to office software. The Trustworthy Language Model could significantly reduce the risk of using LLMs in high-stakes business environments, enhancing their appeal and utility.

Sweet Nothings

In a recent article from The Atlantic, the introduction of brazzein, a new sugar substitute, is explored alongside older alternatives like aspartame and stevia. Despite its promise, brazzein must replicate sugar's unique sweetness, much like its predecessors. The narrative recounts a personal journey of managing blood sugar levels through various sweeteners, underscoring the dissatisfaction with their aftertaste and health concerns. Even with technological advancements, sugar substitutes still mimic sugar's flavor and texture, leading to continued disappointment for those seeking a healthier, yet equally satisfying, alternative to sugar. A New Sweetener Has Joined the Ranks of Aspartame and Stevia - The Atlantic

Happiness: Marriage and Money

The Happiness Trinity - The Atlantic delves into the complex question of what truly fuels our happiness. Marriage, according to W. Bradford Wilcox's new book, Get Married: Why Americans Must Defy the Elites, Forge Strong Families, and Save Civilization, emerges as a significant predictor of life satisfaction in America, outshining education, income, and job satisfaction. However, the discourse extends beyond matrimony, exploring "social fitness" — the quality of relationships in one's life — as an even stronger happiness determinant. The article also highlights the intertwined roles of income and social well-being, noting that higher income levels correspond with better marriage and social outcomes. Ultimately, the discussion suggests that happiness in America might morph into a luxury, stratified by income levels, with significant implications for society's overall well-being.

Unraveling the Complexities of Consciousness

The quest to understand consciousness remains elusive, yet tantalizing advances have sparked renewed interest. Grounded in the Orchestrated Objective Reduction (Orch OR) theory, pioneered by Roger Penrose and Stuart Hameroff, researchers posit that consciousness emerges from quantum processes within brain microtubules. Recent explorations extend this theory, demonstrating that microtubules might maintain quantum coherence far longer than expected, suggesting that our brains can sustain these quantum states despite their warm, wet conditions. Complementarily, Timothy Palmer's Invariant Set Theory proposes that consciousness and free will reflect our entanglement in a universal fractal geometry. While far from conclusive, these insights offer intriguing possibilities about the structure and reach of consciousness, bridging scientific inquiry with profound philosophical implications. Where Does Our Consciousness Live? It's Complicated.

077 - Art's Heart, Genes to Screens, and the Neuroscience of Creativity - HealthHippieMD Week In Review

Genes to Screens

In 2017, the East Bay Regional Park District Police Department turned to Parabon NanoLabs to help solve the 1990 murder of Maria Jane Weidhofer. Parabon, using DNA from the crime scene, created a 3D model of the potential suspect's face, a process known as DNA phenotyping. This method predicts physical features based on genetic attributes, although its accuracy and scientific validity are debated. Controversially, a detective later attempted to use facial recognition technology on this DNA-generated image, a move criticized by civil liberties experts and contrary to Parabon NanoLabs' terms of service. This attempt underscores the growing concern over the misuse of technology in law enforcement, particularly the blending of unproven methods that could lead to misidentification and potential miscarriages of justice. Despite these concerns, several police departments are interested in combining these technologies, citing the potential benefits of cold cases. However, experts like Jennifer Lynch from the Electronic Frontier Foundation argue that such practices are based on "junk science" and pose significant risks of falsely identifying suspects. Cops Used DNA to Predict a Suspect's Face—and Tried to Run Facial Recognition on It | WIRED.

Navigating the Seas of Self-Doubt

The Slate article A simple trick to get over impostor syndrome offers insight into overcoming impostor syndrome, where individuals doubt their achievements and fear being exposed as frauds. The author, a psychologist, suggests shifting from seeing oneself as an expected expert to embracing a "voyager" role in one's professional journey. This approach encourages continuous learning, adaptability, and acceptance of mistakes as part of growth. It alleviates the pressure to be perfect, aligning with qualities valued by employers and fostering a balance of confidence and humility. This mindset shift enables personal and professional development without the burden of impostor syndrome.

NCCIH on Bodybuilding and Performance Enhancement

Resistance training is integral to one's exercise regimen at any age. The National Center on Complementary and Integrative Health has a health information page on enhancement supplements: Bodybuilding and Performance Enhancement Supplements | NCCIH.

Neuroscience's Secrets to Creativity

"Find what you love and let it kill you." I love that quote when thinking about one's passions (although the original context was about alcohol addiction). How the "salience network" can unleash your creativity - Big Think delves into how breaking free from conventional thought processes can lead to significant creative breakthroughs, a concept supported by neuroscience. It highlights historical examples like Archimedes and Isaac Newton, who achieved their eureka moments not through relentless analysis but by stepping away from their habitual cognitive patterns. The brain's "salience network" plays a pivotal role in this process, signaling when things deviate from the norm and allowing for a fresh perspective. Essentially, the first step towards innovation is to move away from the "House of Habit." The article emphasizes that this ability to disrupt the default mode network (DMN) and embrace new sensory inputs isn't just for geniuses but is an intrinsic part of the human brain, helping to foster creativity and problem-solving in various fields.

Reflective Resolutions

The article, Five Questions to Ask Yourself Every Evening, explores the importance of self-reflection to understand our daily barrage of thoughts and emotions. It suggests that our minds, busy with a constant stream of ideas and feelings, often repress these thoughts, leading to potential mental health issues. To address this, the article proposes five introspective questions to help identify true worries, sadness, annoyances, bodily needs, and joys. This practice, inspired by Socrates' emphasis on self-knowledge, aims to bring peace and clarity to our minds, fostering a more joyful and balanced life. (Thanks, Allyssa)

The Write Way to Think

I've used journaling for years to clarify my thinking. The article How to Use Writing to Sharpen Your Thinking delves into how writing remains a vital tool for sharpening our intellectual abilities, even in the age of advanced AI. An influential venture capitalist and essayist, Paul Graham, emphasizes that writing is integral to clear thinking and understanding. In his article "Putting Ideas into Words," Graham notes that writing about a topic reveals gaps in one's knowledge, leading to more precise and complete ideas. Another Silicon Valley notable, Tim Ferriss, concurs and offers practical advice on enhancing thinking through writing. He suggests writing anything regularly, focusing on editing and re-editing to refine thoughts. Ferriss also recommends seeking feedback, particularly highlighting the "ten percent rule," where readers identify the most crucial parts of the writing. This process, he argues, is not just for aspiring writers but for anyone who wants to maintain mental sharpness in their pursuits. Graham's pithy tweet encapsulates the essence: "Reading won't be obsolete till writing is, and writing won't be obsolete till thinking is."

Art's Heart: Reviving Our Cultural Pulse

David Brook's excellent Opinion | How Art Creates Us - The New York Times (gift article) discusses the decline in cultural engagement in society and its impact on human empathy and character. Brooks advocates for the transformative power of art and culture, emphasizing their role in enriching emotional intelligence and understanding. He highlights how cultural experiences, like those of novelist Alice Walker, deepen connections and broaden perspectives. Arguing that society's increasing malaise partly stems from a cultural disconnect, Brooks urges a re-embrace of the humanities to enhance personal growth and societal well-being, underscoring the moral and emotional enrichment the arts provide.

Bitter Buzz - Caffeine's Dirty Little Secret

Panera's Charged Lemonade, introduced in 2022, has sparked controversy with its high caffeine content, leading to lawsuits and health concerns. Containing more caffeine than standard energy drinks, it's implicated in wrongful death cases and health issues. Panera responded by adding warnings, reducing caffeine levels, and limiting access. This situation reignites the complex debate on safe caffeine limits. Symptoms of excessive intake, known as caffeinism, include severe health risks. With varying individual tolerances and an array of highly caffeinated products available, the article underscores the challenge of regulating and understanding safe caffeine consumption. Caffeine’s Dirty Little Secret - The Atlantic (thanks, Diana).

034 - Social Anxiety, Beethoven's DNA, and Tattoos - HealthHippieMD Week In Review

New Year's Anti-Resolutions and To-Don't Lists

"when you don't know the right way forward, you might succeed by focusing on what you know to be wrong instead." I learned quite a bit from Your bad attitude can make you happier.

Galentine's Day-Dinner with Strangers

The Radical Act of Eating With Strangers was an interesting article about friendship and social connection. I wonder how it might work here in North Carolina. (I ran out of gift articles)

How to Combat Loneliness

An article from Harvard Health with suggestions to combat loneliness: 3 ways to create community and counter loneliness

Social Anxiety - Fear of Failing

What is the neuroscience behind social anxiety, an affliction that affects 40 million people in the U.S.? Fear of Failing: The Secrets Behind Social Anxiety

Steven Pinker Interview

Steven Pinker is an influential cognitive psychologist and author. In the interview, The ultimate guide to rationality, , he touches on "topics such as human progress, the tragedy of the commons, Bayesian reasoning, and strategies to curb our most destructive instincts, with the ultimate goal of improving the world for everyone."

Tattoos and Immunity

The skin is the body's first line of defense. For thousands of years, humans have been decorating their bodies with tattoos. Scientists still aren't sure what happens to our immune system when we receive one.Tattoos do odd things to the immune system

Foods that Fight Inflammation

Here is a brief but informative article from Harvard on anti-inflammatory foods: Foods that fight inflammation

GPT-4 AI Scores 85% on USMLE

Microsoft released a paper this week that showed that the latest GPT model could pass the USMLE: GPT-4 on Medical Challenge Problems - Microsoft Research. +Eric Topal breaks down the implications of AI for medicine: Multimodal AI for medicine, simplified - by Eric Topol

Intelligence and (un)Happiness

"Your intelligence is more likely to bring you happiness if you put it to use by chasing better ways to love and serve others rather than elbowing others aside and hoarding worldly rewards." Another interesting article in the Atlantic's How to Build a Life: Intelligence Is More Than a Tool to Get Ahead

Defining "Life" and "Death."

Technology forces us to reexamine what we consider alive and dead. The ideas are far-reaching, including law, medicine, ethics, and morality. Another thought-provoking article in Wired: The End of 'Life' As You Know It

Applying Scarcity to Gym Membership

Years ago, Robert Cialdini wrote a classic book on sales techniques: Influence, New and Expanded: The Psychology of Persuasion. The rise of pricey, application-only gyms is an exemplar of Cialdini's principles: The Rise of Exclusive, Application-Only Gym Memberships (gift article)

Animal Personality and Scientific Results

Here is an interesting article questioning whether animal personality might alter scientific results. Animal Personalities Can Trip Up Science, But There's a Solution

Cancer and Circadian Rhythm

A study published in Trends in Cell Biology reviewed the influence of circadian rhythms on cancer biology. "The circadian rhythm governs most of the cellular functions implicated in cancer progression, and its exploitation, therefore, opens new promising directions in the fight against metastasis. In this review, we summarize the role of the circadian rhythm in tumor development and progression, with emphasis on the circadian rhythm-regulated elements that control the generation of circulating tumor cells (CTCs) and metastasis. We then present data on chronotherapy and discuss how circadian rhythm investigations may open new paths to more effective anticancer treatments." A new time dimension in the fight against metastasis

Beethoven's DNA

An article on how sleuths tracked down and analyzed strands of Beethoven's hair. The findings are fascinating: DNA From Beethoven's Hair Unlocks Medical and Family Secrets (gift article) and Beethoven's Genome Has Been Sequenced for the First Time, Revealing Clues About the Great Composer's Health & Family History

Meat Lobbies

Here is an article on how the meat industry changed the proposed recommendations of the Intergovernmental Panel on Climate Change report. I learned quite a bit from the article, including that the global beef industry is estimated at around $400 billion and that meat and dairy produce about 14.5% of global greenhouse emissions. The meat industry got the IPCC to edit a climate change report

Using Google Maps to Plan your Vacation

I'm going to try this: How To Use Google Maps Immersive View To Vacation Plan Like a Pro

Who is Most at Risk for Long-Covid?

A meta-analysis revealed the risk factors for long-covid: being female, obese, over 40, a smoker, and having previous medical conditions. Who Is Most At Risk for Long Covid? (gift article)