106 - Power Plays, Slices of Life, and a Touching Discovery - HealthHippieMD Week In Review

Power Play

Mitochondria keep your brain cells alive − helping them run smoothly may protect against Parkinson's disease explores the vital role mitochondria play in maintaining brain cell health and their potential in combating Parkinson's disease. Researchers at Florida International University have identified a key protein, Drp1, that controls mitochondrial dynamics, which, when manipulated, can protect neurons from degeneration. Their findings suggest restoring mitochondrial function may prevent cell death caused by toxic protein buildup, a hallmark of Parkinson's. Ongoing studies are testing FDA-approved compounds targeting Drp1, offering hope for new treatments against this neurodegenerative disease.

Plastic Numbers Don't Add Up

The EPA has officially rejected the controversial mass balance accounting method, which has been used to exaggerate the recycled content in plastic products. The decision strengthens the agency's Safer Choice program, requiring that recycled content be calculated by actual weight rather than through paper-based number manipulation. This move marks a significant step in the Biden administration's efforts to tackle plastic pollution, drawing a clear line against deceptive greenwashing tactics in the industry and setting a new standard for sustainable packaging. EPA Rejects Use of Mass Balance Accounting for "Safer Choice" Recycled Plastic — ProPublica.

The Art of Persuasive Listening

The key to effective persuasion is not aggressive argumentation but genuine listening and understanding. Individuals can influence others more positively by focusing on shared values, avoiding combative rhetoric, and offering one's beliefs as a gift rather than a weapon. The article highlights the importance of empathy, patience, and humility in conversations, particularly during divisive times. Drawing lessons from early Christian practices and modern psychology, it advocates for transforming confrontational exchanges into opportunities for meaningful connection and mutual respect. How to Influence People—And Make Friends - The Atlantic.

Touching Discovery

As revealed by groundbreaking research, Pacinian corpuscles, specialized touch sensors, detect subtle environmental vibrations and transmit this information to the auditory midbrain. These sensors are more sensitive than previously believed, firing in response to vibrations from surfaces like sandpaper, cardboard, and even tree branches. Notably, high-frequency vibrations travel through an alternate pathway to the inferior colliculus, a midbrain region typically associated with auditory processing rather than the somatosensory cortex. This discovery highlights the interconnectedness of sensory pathways and opens new avenues for understanding touch perception and behavior in mammals.Touch sensors detect subtle environmental vibrations, send information to auditory midbrain | The Transmitter: Neuroscience News and Perspectives (Thanks, Amy!).

Slice of Your Past for a Fuller Future

A 'Life Review' Can Be Powerful, at Any Age - The New York Times (gift article) explores the concept of "life review," a therapeutic process traditionally used in late life but now recognized for its benefits across all ages. By reflecting on past experiences through writing or conversation, individuals can develop self-awareness, acceptance, and a clearer sense of purpose. Originally aimed at older people to make peace with their legacies, life reviews have been shown to reduce depression, increase life satisfaction, and help people navigate life transitions. The process can be facilitated by professionals or pursued independently, offering powerful insights at any stage of life.

Grounds for Change

This startup is making coffee without coffee beans | MIT Technology Review explores how the Singaporean startup, Prefer Coffee, is revolutionizing the coffee industry by creating a coffee-like beverage without using coffee beans. Faced with traditional coffee production's environmental impact and sustainability challenges, cofounders DJ Tan and Jake Berber turned to upcycle food industry leftovers like stale bread, soybean pulp and spent barley grains. By leveraging fermentation and innovative roasting techniques, they've crafted a drink that mimics coffee's taste, offering a sustainable alternative. Their approach exemplifies the potential of upcycling in tackling global challenges.

Memory Lane's Sticky Situation

Researchers have identified the molecular "glue" responsible for cementing long-term memories in the brain. The study focuses on two key molecules, PKMzeta and KIBRA, which work together to strengthen synaptic connections crucial for memory retention. While PKMzeta has long been associated with memory, its fleeting presence puzzled scientists. The discovery that KIBRA tags specific synapses, allowing PKMzeta to maintain their strength, fills gaps in our understanding. This research not only strengthens the PKMzeta theory but also opens new avenues for memory-related therapies, including potential treatments for conditions like Alzheimer's and PTSD. Brain Scientists Finally Discover the Glue that Makes Memories Stick for a Lifetime | Scientific American.

A New Hope for Chronic Pain

Suzetrigine, initially known as VX-548, is a groundbreaking pain medication that blocks sodium channels in peripheral nerves, preventing pain signals from reaching the brain. Unlike opioids, it offers significant pain relief without the risk of addiction. While primarily tested for acute pain, Suzetrigine shows promise in treating chronic conditions like diabetic neuropathy. Though early trials are encouraging, more research is needed to confirm its long-term safety and effectiveness, particularly for chronic pain sufferers seeking non-opioid alternatives. New Pain Medication Suzetrigine Prevents Pain Signals from Reaching Brain | Scientific American.

Coach Caution

Is 'coaching' a shortcut to mental health care? Not so fast − here are key differences explores the rise of life coaching as an alternative to traditional mental health care, driven by shortages in professional healthcare services and the appeal of personalized guidance. However, it warns against viewing coaching as a substitute for therapy due to significant differences in regulation, training, and legal responsibilities. While coaching can be helpful in specific contexts, it lacks the rigorous standards required for licensed therapy, leading to potential risks such as misinformation and unethical practices. Consumers are advised to thoroughly vet coaches before engaging in their services.

096 - TV Trap, Fiber Fix, and Sound Health - HealthHippieMD Week In Review

TV Trap for Healthy Aging

A Harvard study reveals a strong inverse correlation between TV watching and healthy aging. Researchers found that for every two additional hours of TV time, the likelihood of aging healthily decreased by 12%. This effect was independent of other sitting forms, suggesting a unique risk associated with TV time. Data from over 45,000 women in the Nurses Health Study showed that those who limited their TV watching to less than three hours per week had significantly better odds of aging healthily. Replacing TV time with physical activity further improved these odds. Doing this one thing may improve your odds of healthy aging - Los Angeles Times.

The New Health Consensus on Alcohol

Alcohol, once considered a heart-friendly indulgence, is now recognized for its health risks even in moderation. Recent studies debunk the myth of beneficial drinking, revealing links to heart disease, cancer, and brain shrinkage. This shift in public health messaging has led to new guidelines and warnings, notably in Ireland and Canada. The pandemic's spike in alcohol consumption has also driven interest in alcohol-free alternatives. As society reevaluates its relationship with alcohol, individuals face personal decisions on the trade-offs between social enjoyment and health risks. Is That Drink Worth It to You? - The New York Times (gift article).

+see also: Ozempic, weight loss drugs could help fight addiction: study.

Sound Health

Music isn't just a delight for the ears; it's medicine for the soul. Research shows that music can significantly enhance mental and physical well-being. A 2022 review of 26 studies revealed that music interventions improve mental health-related quality of life. Brainwave entrainment plays a crucial role, where our brain syncs with musical rhythms. Additionally, music therapy increases heart rate variability, indicating better stress adaptation. Artists contribute to this therapeutic potential by creating diverse soundscapes. While the science is still evolving, it's clear that hitting play on your favorite track can be a powerful tool for healing. Music as medicine: The therapeutic potential of sound - Big Think.

+and if you're interested in this topic, the NIH published links to the Music as Medicine: The Science and Clinical Practice Workshop Summaries and Video Recordings: Music as Medicine: The Science and Clinical Practice | NCCIH.

Optimism Unleashed

Optimism is not about ignoring negative emotions but embracing them and focusing on positive outcomes. Optimistic people enhance their mental health and resilience by practicing mindfulness, expressing gratitude, engaging in positive self-talk, and staying in the present moment. They view failures as learning opportunities and surround themselves with supportive individuals. Saying "no" to things that deplete them and maintaining a good sense of humor also contribute to their positive outlook. Adopting these habits can help anyone cultivate a more positive mindset and improve overall well-being. Want to Be More Positive? Here Are 10 Things Optimistic People Do.

Sniffing Out Parkinson's

Joy Milne, a woman with an extraordinary sense of smell, detected a unique odor on her husband years before he was diagnosed with Parkinson's. Her ability to identify the scent has led to groundbreaking research on early disease detection. Joy's hyperosmia has allowed her to collaborate with scientists, identifying specific chemicals in sebum linked to Parkinson's. Her contributions may revolutionize early diagnosis and treatment, offering hope for early intervention. Joy's journey underscores the untapped potential of olfactory science in medical diagnostics. The Woman Who Could Smell Parkinson's - The New York Times (gift article).

The Warmth Behind Sentience

The article explores the role of warm-bloodedness in the evolution of sentience. Nicholas Humphrey suggests that maintaining a constant high body temperature, unique to birds and mammals, enabled significant changes in lifestyle and brain functionality. This physiological trait allowed animals to remain active across diverse climates and enhanced brain efficiency, fostering complex cognitive functions. The increased nerve conduction speed and reduced refractory period in warmer brains likely facilitated the development of consciousness. Thus, the evolution of warm-bloodedness played a critical role in shaping the autonomous and self-aware minds of mammals and birds. Did warm-bloodedness pave the path to sentience? - Big Think.

Counterfeit Calamity

Counterfeit Ozempic, a diabetes drug repurposed for weight loss, has become a lucrative global black market. Amid soaring demand and global shortages, counterfeiters exploit the gaps in the pharmaceutical supply chain, distributing fake versions that can cause severe health risks. This intricate network involves small-time intermediaries, criminal organizations, and unscrupulous distributors. As authorities struggle to track and control these fake medications, the health of desperate patients, who often fall victim to too-good-to-be-true deals, hangs in the balance. The FDA and pharmaceutical companies are racing against time to curb this growing threat. Why Counterfeit Ozempic Is a Global-Growth Industry | Vanity Fair.

+see also: Eli Lilly cracks down on counterfeit Zepbound and Mounjaro.

Walking Back the Pain

A recent study published in The Lancet confirms that regular walking can significantly reduce the recurrence of lower back pain. Researchers followed 701 adults with a history of back pain, splitting them into two groups: one receiving a personalized walking program and the other with no intervention. The walking group experienced nearly twice as long without pain recurrence as the control group. This study bolsters existing evidence that physical activity, including walking, is an effective, accessible remedy for back pain, offering a cost-effective alternative to clinical treatments. How Helpful Is Walking for Lower Back Pain? - The New York Times (gift article).

Fiber Fix: Gut Reaction to Chronic Inflammation

Recent research highlights the profound impact of diet on gut microbiome health and chronic inflammation. Diets rich in fiber and whole foods can reduce inflammation and prevent diseases like cancer and cardiovascular issues. Jennifer Wargo, an oncologist, emphasizes the importance of consuming 50 grams of fiber daily to manage inflammation. Mediterranean diets, rich in fruits, vegetables, and healthy fats, have shown significant anti-inflammatory effects. Conversely, diets high in processed foods increase inflammation markers. Ultimately, dietary choices, particularly fiber intake, can act as medicine, enhancing disease prevention and treatment. What foods you really need to eat to reduce inflammation.

090 - Isolated Minds, High Hopes, and Psychedelics in the C-Suite - HealthHippieMD Week In Review

Isolated Minds

Chronic loneliness not only alters emotional states but significantly impacts brain structure and function, raising the risk for neurodegenerative diseases like Alzheimer's and Parkinson's. This pervasive form of loneliness can lead to changes in brain areas involved in social cognition and emotional processing, likely due to prolonged stress and inflammation. These effects are further exacerbated by associated risks such as increased cardiovascular strain and unhealthy lifestyles. How Loneliness Affects the Brain - The New York Times (gift article ) underscores the importance of interventions, like cognitive behavioral therapy and social engagement, to mitigate these detrimental effects. However, the challenge remains significant, as indicated by recent health reports calling for more robust solutions to combat loneliness.

Lonely Peaks

Recent studies show that loneliness typically spikes during young adulthood and later life, forming a U-shaped curve. This pattern reflects fewer social engagements and weaker community involvement among younger generations, paralleled by a similar decline in older adults due to diminishing social opportunities. Surgeon General Vivek Murthy emphasizes weakening "social muscles" when left unused, analogous to physical muscles. Experts recommend proactive steps to cultivate meaningful connections at all ages, such as conducting a "relationship audit," joining community groups and reducing reliance on social media. They argue that fostering diverse and quality relationships can significantly enhance mental and physical health, urging individuals to take the initiative to maintain and create social bonds. The Ages When You Feel Most Lonely and How to Reconnect - The New York Times (gift article).

Reducing Noise Pollution

In today's bustling world, the relentless barrage of noise disrupts our daily lives and significantly harms our health. Jamie Banks, an environmental scientist driven by the ceaseless din of landscaping equipment in her neighborhood, initiated a movement towards quieter communities. Her advocacy led to actionable change, culminating in a lawsuit against the U.S. Environmental Protection Agency for failing to enforce noise regulations. Scientific evidence supports the detrimental effects of noise, linking it to cardiovascular diseases, sleep disruptions, and cognitive impairments. Furthermore, various studies highlight how excessive noise exposure increases risks of hypertension, heart conditions, and even diabetes. Amid these alarming revelations, noise mitigation strategies like using smartphone apps to detect hazardous noise levels, wearing noise-canceling earbuds, and pushing for regulatory reforms have become more vital than ever. Turning Down the Noise Around You Improves Health in Many Ways | Scientific American.

Gloves that Teach Piano

A novel pair of "smart gloves" designed by MIT researchers may revolutionize learning piano and other tactile skills. These gloves, crafted from thin cotton and embedded with tactile sensors, allow for transmitting piano-playing techniques through vibrations directly to the fingertips. This method helps build muscle memory and enhances precision when performing musical pieces. A study published in Nature Communications demonstrates that these gloves can significantly improve accuracy in piano playing compared to traditional methods. The technology, utilizing machine-learning algorithms to capture and transmit complex hand movements, has potential applications beyond music, such as surgical training and gaming. 'Smart Gloves' Teach Piano Playing through Touch | Scientific American.

High Hopes for Healing

Recent changes in U.S. drug policy signal a potentially transformative era for chronic pain treatment, recognizing the medicinal value of cannabis and psilocybin. Cannabis, long under strict regulation, is being reclassified to allow more medical research, reflecting its safer profile compared to opioids and potential for fewer side effects. Similarly, psilocybin, known for substantial psychological effects, has shown promise in treating psychiatric conditions and is being explored for chronic pain management. With about 50 million Americans suffering from chronic pain, these substances could offer significant relief, promoting a shift towards more natural and possibly more effective therapeutic options. However, the journey from criminalization to acceptance underscores the complex landscape of integrating these ancient drugs into modern medicine. How cannabis and psilocybin might help some of the 50 million Americans who are experiencing chronic pain.

Psychedelics in the C-Suite

A growing trend in corporate leadership involves the integration of psychedelic experiences, such as ayahuasca and psilocybin, to enhance personal and professional development. Leaders like Felix Van de Sand, CEO of COBE, have ventured into jungles and participated in shamanic ceremonies, using these substances to confront personal fears and unearth deep-seated behavioral patterns. These experiences are claimed to foster traits like openness, adaptability, and creative thinking, which are invaluable in leadership. Recognizing these benefits, more executives are now investing in psychedelic retreats for their teams, aiming to fast-track personal growth and improve team dynamics, albeit navigating complex privacy issues and peer pressure. From magic mushrooms to ayahuasca—psychedelics are the new leadership retreat | Fortune Well.

Midlife Mutterings Unmuted

Middle-aged individuals often find themselves talking out loud, which experts suggest is normal and beneficial. This phenomenon, understudied yet widely observed, supports various mental functions such as anxiety management, motivation, and memory. Private speech, as it's called, tends to resurface in midlife, assisting in tasks like planning and problem-solving. Furthermore, it can enhance focus and make solitary moments feel more engaging. Although it might raise eyebrows in public, this self-dialogue typically poses only harm if it becomes disruptively negative. Experts encourage embracing this habit if it proves helpful, highlighting its practicality and mental health benefits. Is It Normal to Talk to Yourself All Day? What Experts Say. - The New York Times (gift article).

Genes and Stress

A recent study by Jacob Crouse and Ian Hickie from the University of Sydney is reevaluating the classifications of depression into reactive and endogenous types. Historically, reactive depression was seen as a response to external stressors, while endogenous depression was thought to stem from internal factors like genetics. However, their research involving over 14,000 individuals in the Australian Genetics of Depression Study shows a more complex interplay. They discovered that people with higher genetic risks for mental disorders reported more exposure to stressful life events, suggesting that genetic predispositions can influence both one's environment and one's reactions to it. This challenges the simple categorization of depression and underscores the intricate relationship between genes and environmental stressors. A New Study Is Finally Attempting to Pin Down The Root Causes of Depression..

078 - Panpsychism, Unleashing Joy, and Dream Teams - HealthHippieMD Week In Review

NCCIH on Mindfulness and Meditation

I wanted to remind you about the terrific National Center for Complementary and Integrative Health resources. Here is their fact sheet on Mindfulness and Meditation: Meditation and Mindfulness: What You Need To Know | NCCIH

The Dream Team

I thought I'd feature an article on the importance of sleep and athletics with the Super Bowl approaching. The significance of a good night's sleep is often overlooked. However, sleep is vital in enhancing athletes' performance, from boosting muscle repair to strengthening the immune system. This article highlights the crucial connection between quality sleep and athletic success. It explains the different stages of sleep and their impact on physical and cognitive health. Athletes prioritizing sleep can improve speed, accuracy, cognitive skills, and pain tolerance, ultimately gaining a competitive edge. The article also provides practical tips for athletes to optimize their sleep routines, emphasizing that sleep is a performance enhancer. Sleep can give athletes an edge over competitors − but few recognize how fundamental sleep is to performance.

+And if you're curious how exceptionally talented professional athletes are compared to the Average Joe, listen to this podcast (where a journalist went through the NFL combine and was rated against NFL players): People I (Mostly) Admire: 123. Walt Hickey Wants to Track Your Eyeballs.

A Fitness Folly

In The Apple Watch May Have a Calorie Problem, The Atlantic explores the complex relationship between users and their fitness trackers, particularly the notorious red "Move" ring on the Apple Watch. The article delves into the challenges users face in trying to meet daily activity goals set by these devices, revealing the potential pitfalls of relying on them too heavily. The piece highlights the inaccuracy of calorie measurements on fitness trackers and how these devices can sometimes lead users to prioritize external motivation over the intrinsic joy of staying active. Ultimately, it raises thought-provoking questions about the role of technology in shaping our fitness routines.

Edibles vs. Smoking Cannabis

As the popularity of cannabis-infused edibles surges, people are questioning whether they offer a safer alternative to traditional smoking methods. While the answer is not straightforward, experts weigh in on the pros and cons of each. Edibles take longer to kick in, making it easier to overconsume, potentially leading to adverse effects. They can also produce more intense highs. On the other hand, smoking poses respiratory risks due to harmful chemicals in the smoke, though conclusive evidence on lung cancer is lacking. Regardless of the method, cannabis use has some short and long-term health risks, emphasizing the importance of moderation and informed choices. Are Cannabis Edibles Safer Than Smoking? - The New York Times (gift article).

Panpsychism: Is Consciousness Woven into the Universe?

"Somehow, the water of the physical brain is turned into the wine of consciousness." In a thought-provoking article, Dan Falk explores the age-old question of consciousness and its place in the Universe. The article delves into the theory of panpsychism, which suggests that consciousness is an intrinsic component of reality, akin to mass or electrical charge. Scholars gathered at a recent workshop to discuss the idea, highlighting its appeal as a solution to the enigmatic "hard problem" of consciousness. However, critics argue that panpsychism faces challenges, such as the "combination problem" and the dilemma of explaining the consciousness of other beings. The article offers a captivating glimpse into the ongoing debate between panpsychism and alternative views, shedding light on the profound philosophical implications of our understanding of consciousness. Is Consciousness Part of the Fabric of the Universe? | Scientific American.

Nature's Wegovy / Ozempic

The article, A Gastroenterologist Reveals How To Tap Into Your Body's Natural Processes That Inspired Ozempic explores the role of natural gut hormones and healthy food in metabolism and weight loss. It delves into how drugs like Wegovy, Ozempic, and Mounjaro, designed for weight loss and diabetes, mimic natural incretin hormones found in the gut. Specialized gut bacteria help transform undigestible components of food into molecules that regulate appetite and metabolism, emphasizing the importance of a diverse, healthy gut microbiome. These drugs reinvigorate the body's natural systems, making them effective for weight loss and blood sugar control, but lifestyle changes and whole foods are still vital for long-term health.

Snooze Control: How Your Diet Affects Your Sleep Quality

Research suggests that our dietary choices can significantly impact the quality of our sleep. Nutritional epidemiologist Erica Jansen explores the intricate relationship between diet and sleep, highlighting that adherence to nutritional guidelines, such as consuming fruits, vegetables, legumes, and whole grains, can lead to longer and better sleep—furthermore, healthier diets like the Mediterranean and anti-inflammatory are associated with improved sleep quality. While specific foods and nutrients like fatty fish, dairy, and melatonin-rich fruits play a role, the complexity of this relationship remains challenging to unravel. The article also cautions against consuming certain foods and substances that can disrupt sleep, emphasizing the importance of overall dietary patterns and good sleep hygiene practices. One Simple Change to Your Diet Could Help You Sleep Better, Study Finds.

Unleash the Joy

In A Pet Psychologist Reveals How To Give Your Dog The Best Walk of Its Life, , a pet psychologist shares valuable insights into the art of dog walking. Rather than focusing on steps, it emphasizes the importance of time spent outdoors, allowing dogs to engage in their favorite activity: sniffing. Sniffing and marking territory are crucial to a dog's experience, making it a mental exercise as much as a physical one. Rushing through walks or encouraging dogs to hurry up with their business can be detrimental, potentially leading to behavioral problems. By customizing walks to suit each dog's preferences and reframing the experience, dogs and owners can enjoy the best walks of their lives.

Awe

Here is a balanced critique and interview with the author of the book Awe: The New Science of Everyday Wonder and How It Can Transform Your Life.. I'm adding this book to my queue.

073 - Whiskey Business, British Bake Off, and the Sinister Secrets of Sugar - HealthHippieMD Week In Review

Life in the Fast Lane (podcast)

Ever wonder why time seems to accelerate as you age? Radiolab: The Secret to a Long Life explores the phenomenon.

Chronic Pain Conundrum (podcast)

Chronic pain casts its shadow over approximately one-third of the global population. Shockingly, for one in ten of these individuals, the pain reaches such devastating levels that it incapacitates them, thus establishing itself as the foremost cause of disability worldwide. The enigma surrounding certain types of chronic pain perplexes medical practitioners who struggle to provide effective treatments or unravel the underlying causal mechanisms. This enigmatic challenge looms large over societies, demanding innovative solutions to alleviate the burden on healthcare systems and provide much-needed relief for those enduring this relentless agony. Babbage from The Economist: The mystery of chronic pain (paywall).

Whiskey Business

In the article A bottle of scotch recently sold for $2.7 million – what's behind such outrageous prices? the author explores the unprecedented rise in Scotch whisky prices, exemplified by a recent $2.7 million sale. The article delves into the factors contributing to this trend, such as rarity, age, brand prestige, and collector demand. It discusses the allure of owning a piece of liquid history and how whisky has become a status symbol and investment opportunity for affluent enthusiasts. With captivating insights, the article unveils the fascinating world of ultra-high-end Scotch whisky auctions, shedding light on the intoxicating allure of these extravagant prices.

All I Needed to Know, I Learned in Grade School

In the article Teaching positive psychology skills at school may be one way to help student mental health and happiness the author explores the potential benefits of incorporating positive psychology into school curricula. By introducing students to techniques that promote resilience, optimism, and well-being, educators can empower them to navigate life's challenges better and enhance their mental health. The article emphasizes that fostering positive emotions, relationships, and personal strengths can increase happiness and improve overall mental well-being, ultimately providing students with essential life skills for a brighter future.

Age Beyond the Numbers

A New York Times article explored the intriguing world of "biological age testing." The article delves into the cutting-edge scientific methods used to determine one's biological age, including DNA analysis, biomarkers, and artificial intelligence. While these approaches hold promise in uncovering hidden health risks and offering longevity predictions, the article also highlights the skepticism surrounding the accuracy and practicality of these tests. As researchers continue to refine these techniques, the concept of biological age testing challenges our conventional understanding of aging and raises important questions about its role in the future of healthcare. Is Biological Age Testing Accurate or Useful? - The New York Times (gift article).

BMJ Christmas Edition: The British Bake Off

"Conclusion: Recipes for Christmas desserts from The Great British Bake Off often use ingredient groups associated with reductions, rather than increases, in the risk of death or disease. This Christmas, if concerns about the limitations of observational nutrition research are set aside, you can have your cake and eat it too." The BMJ's Christmas issue is now a well-established tradition. "Its mix of quirky comment articles, features, and peer-reviewed research was perhaps best described in a 2012 New York Times article as "lighthearted but rigorous." This year's articles include:

• Association of health benefits and harms of Christmas dessert ingredients in recipes from The Great British Bake Off: umbrella review of umbrella reviews of meta-analyses of observational studies | The BMJ
• Common Healthcare Related Instruments Subjected To Magnetic Attraction Study (CHRISTMAS): prospective in situ experimental study | The BMJ
• Retail demand for emergency contraception in the United States following New Year holiday: time series study | The BMJ
• Chocolate brownies and calorie restriction: the sweetest paradox? | The BMJ
• Cheers, not tears: champagne corks and eye injury | The BMJ
• The manosphere and men's well-being: How healthcare can help young men find alternatives to toxic online spaces | The BMJ

Sinister Secrets of Sugar (podcast)

In this enlightening episode, Dr. Andrew Huberman welcomes Dr. Robert Lustig, a renowned neuroendocrinologist and nutrition expert. Together, they dissect the conventional "calories in - calories out" model of metabolism and shed light on the role of macronutrients, fiber, and sugar in the equation. Delving into the nuances of sugar, particularly fructose, they explore its addictive qualities and how it rewires the brain's circuits related to cravings and satisfaction. The conversation extends to the profound impact of sugar on obesity, gut health, mental well-being, and the food industry's manipulation of refined sugars. The podcast is long but a must-listen for those curious about the profound impact of dietary choices on the mind and body. Huberman Lab: Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health.

The Funniest Articles of the Year

WaPo featured the funniest stories of the year. Opinion | Today's Opinions: The pieces that made us laugh the most in 2023 - The Washington Post (gift article).

Boomers Go Green

In this thought-provoking Wired article, the beef industry faces a seismic shift as baby boomers, traditionally avid beef consumers, pivot towards more sustainable and health-conscious eating habits. The article delves into the reasons behind this transformation, highlighting environmental concerns, health consciousness, and a growing appetite for plant-based alternatives. As boomers increasingly embrace greener diets, the meat industry adapts to changing consumer preferences. With captivating insights and statistics, this piece sheds light on the evolving landscape of food consumption and its implications for the beef industry's future. A Demographic Time Bomb Is About to Hit the Beef Industry | WIRED.

Misled to Misread

In the article Health misinformation is rampant on social media – here's what it does, why it spreads and what people can do about it the author delves into the pervasive issue of false health information circulating on social media platforms. The piece explores the damaging consequences of this misinformation, including the amplification of public health risks and the erosion of trust in medical experts. The article also sheds light on the mechanisms behind the rapid dissemination of such content and offers valuable insights into how individuals can combat this problem by promoting accurate information and critical thinking.

069 - Microbiome's Influence on Itchiness, Time Perception, and Doomscrolling - HealthHippieMD Week In Review

Seniors Swapping Pills for Pot

The article Cannabis for Seniors: Why Older Adults Are Opting for Medical Marijuana - The New York Times (gift article) explores the rising trend of older Americans using cannabis for medicinal purposes. Frustrated with the side effects of traditional medications, seniors are increasingly turning to marijuana for relief from pain, insomnia, and anxiety. The article notes a significant rise in cannabis use among this demographic, from 0.4% in 2007 to over 8% in 2022. Personal anecdotes and expert opinions highlight both the potential benefits and the need for more research and education regarding cannabis use in older adults.

The Super Agers' Guide to Staying Sharp

7 Super Secrets of Super Agers offering insights into the lifestyles of those who age exceptionally well. Contrary to popular belief, it's not just about lucky genes; lifestyle plays a pivotal role. The article highlights key habits of superagers, such as maintaining healthy blood pressure and blood sugar levels, often achieved through a diet rich in whole grains, vegetables, and berries and low in red meat and sweets. This dietary approach has been linked to slower brain aging and a reduced risk of Alzheimer's and dementia. Furthermore, super-agers don't necessarily exercise more but engage in more physically demanding activities. Mental health is also a priority for them, with lower levels of anxiety and depression reported compared to their peers. This comprehensive guide offers practical tips for anyone aspiring to super age, emphasizing the importance of a balanced lifestyle that nurtures physical and mental well-being.

+and an article from earlier this year: 3 Steps to Age Exuberantly - The New York Times (gift article)

Friendship in the U.S.

In a recent study by the Pew Research Center, the landscape of friendship in the U.S. was explored, revealing intriguing insights about the role and importance of friends in Americans' lives. The study found that 61% of U.S. adults consider having close friends essential for a fulfilling life, surpassing the value placed on marriage, children, or money. A majority (53%) reported having between one and four close friends, while 38% claimed to have five or more. Surprisingly, about 8% admitted to having no close friends, highlighting a concerning trend of loneliness. The research also showed that those with larger friend groups felt more satisfied with their friendships. Discussions among friends typically revolve around work, family, and current events, with variations observed based on gender. This study underscores the significant impact of friendship on mental and physical well-being, emphasizing its importance in today's fast-paced and often isolated world. How many friends do Americans have? A survey crunched the numbers: NPR.

Mind the Gap

The article, Nearly Everyone With Mild Cognitive Impairment Goes Undiagnosed, highlights a concerning gap in the diagnosis of Mild Cognitive Impairment (MCI) among older people. Recent studies reveal a staggering 92% of MCI cases in the U.S. go undiagnosed, depriving many of access to emerging Alzheimer's treatments that could slow cognitive decline. The research, led by statistician Ying Liu, utilized data from the Health and Retirement Study and Medicare beneficiaries to uncover this diagnostic disparity. The findings are particularly alarming for Black and Hispanic communities and lower-income groups, who are even less likely to receive an MCI diagnosis. The article underscores the complexity of diagnosing MCI, the challenges faced by primary care physicians, and the societal stigma surrounding dementia. It also touches on the potential of new Alzheimer's medications while acknowledging their limitations and the need for early detection. The piece concludes by emphasizing the importance of addressing this diagnostic gap to manage better and treat cognitive impairments.

Insights Into Time Perception

I've researched time for 15 years – here's how my perception of it has changed explores Ruth Ogden's journey into understanding time perception revealing its intricate connection with our emotions and environment. Stemming from a near-death experience where time seemed to stand still, Ogden's fascination led her to explore why time appears to slow down in life-threatening situations and speed up as we age. Her research involved extreme scenarios, from electric shocks to isolation in Antarctica, to study time's elasticity. She discovered that our brain's time processing is intertwined with emotional responses, causing time to stretch or shrink during various emotional states. The pandemic further highlighted this, as lockdowns distorted our sense of time, merging work, home, and personal time. Ogden's work underscores the subjective nature of time and its profound impact on our lives, hinting at the possibility of one day controlling our perception of it.

Unlocking Cosmic Secrets Through Consciousness

Understanding Consciousness Is Key to Unlocking Secrets of the Universe, an article in Scientific American by George Musser, explores the pivotal role of human consciousness in comprehending the universe. It highlights advancements in neuroscience and AI, particularly in neural networks, to probe the enigma of consciousness. Musser's book, "Putting Ourselves Back in the Equation: Why Physicists Are Studying Human Consciousness and AI to Unravel the Mysteries of the Universe" navigates through theories like Karl Friston's predictive coding and Giulio Tononi's integrated information theory, suggesting that consciousness shapes our reality. The piece intriguingly links the study of the mind with quantum physics, raising profound questions about reality, free will, and the nature of spacetime, positing our consciousness as a key to unraveling the universe's mysteries. I'm adding this book to my reading list.

Itcheresting New Finding

Recent research has uncovered a surprising culprit behind itchy skin: a common microbe, Staphylococcus aureus. This bacterium, often found on human skin, releases an enzyme that directly triggers itchiness by acting on nerve cells. The study, published in the journal Cell, reveals that this bacterial enzyme, protease V8, activates a protein on skin nerve cells, leading to the itch sensation. Interestingly, an existing FDA-approved anti-clotting medication can block this effect, offering potential new treatments for itchy skin conditions like eczema. This groundbreaking discovery shifts the focus from traditional immune response-based treatments to targeting microbial interactions with nerve cells, opening new avenues for addressing itchy skin disorders. What can trigger an itch? Scientists have found a new culprit.

Doomscrolling

In the digital age, doomscrolling has become a pervasive habit, where individuals incessantly consume negative news on social media, leading to heightened stress and mental health issues. The article "It's Time to Log Off" from Wired delves into this phenomenon, highlighting how social media algorithms amplify contentious content, thereby intensifying the impact of bad news. Psychological experts warn that this constant exposure to distressing information can exacerbate anxiety, depression, and PTSD, particularly in those with a history of these conditions. The cycle of seeking resolution through more information only adds to the stress, affecting individuals and societal interactions. The solution lies in balancing awareness with mental well-being by limiting exposure to social media and focusing on positive, local actions. This approach helps maintain a healthier perspective, reducing the overwhelming sense of global peril and promoting mental resilience. It's Time to Log Off | WIRED.

068 - Mitophagy, Crapsules, and VR for Pain - HealthHippieMD Week In Review

Artificial Inaccuracy

The article ChatGPT Quickly Authored 100 Blogs Full of Healthcare Disinformation, discusses a study where generative AI, particularly ChatGPT, was used to produce a large volume of healthcare disinformation rapidly. ChatGPT created 102 blog articles with over 17,000 words of disinformation on vaccines and vaping in just 65 minutes. The study, conducted by Australian researchers and reported in "JAMA Internal Medicine," also involved using AI tools like DALL-E 2 and HeyGen to create realistic images and a deep-fake video to accompany the blog posts. Notably, other AI programs like Google Bard and Microsoft Bing Chat did not facilitate such disinformation production. The study underscores the potential misuse of AI in spreading persuasive, customized disinformation efficiently, posing significant risks if exploited by malicious actors.

Dose of Reality: Unraveling the Complex Prescription Drug Financing in the U.S.

The article Following the Money: Untangling U.S. Prescription Drug Financingprovides a critical analysis of America's high prescription drug costs. It reveals that the U.S. leads in per capita drug spending, averaging $1,432 per person in 2021. This in-depth investigation into the U.S. healthcare system uncovers the multifaceted reasons behind this substantial financial burden. The article aims to shed light on the convoluted nature of prescription drug financing in the U.S., contrasting it with its international counterparts.

The Honest Truth About Fibs

Recent research reveals intriguing insights into lying habits. Surprisingly, 59.9% of people reported not lying in a day, with half of all lies coming from just 5.3% of participants. The study found that the frequency of lying is relatively unaffected by the communication medium, whether face-to-face, text, or email. Additionally, while minor lies are commonly told to strangers, significant lies are often reserved for close partners or family members. These findings, although reliant on self-reported data (leading to the possibility of significant inaccuracy), suggest that most people are generally truthful in their daily interactions. A New Study Estimated The Number of Times An Average Person Lies Per Day.

U.S. Dietary Guidelines Eyeing Ultra-processed Food

The upcoming revision of the U.S. dietary guidelines may mark a significant shift in nutritional focus by potentially warning against consuming ultra-processed foods. This change, influenced by mounting evidence linking these foods to a range of chronic diseases like obesity, heart disease, and diabetes, could profoundly impact national food programs, including the National School Lunch Program, and the overall dietary habits of Americans. Critics have long criticized current guidelines for overlooking the effects of food processing and additives. The food industry, fearing potential impacts, has already begun lobbying against such recommendations. The next guidelines edition is due in 2025, with an advisory committee report expected next year, potentially leading to a major overhaul in how Americans perceive and consume food. Nutrition guidelines may soon warn against ultra-processed foods - The Washington Post. (gift article)

FTC Takes a Bite Out of Misleading Influencer Marketing of Food

The FTC has warned significant food and beverage industry groups and numerous dietitian influencers, spotlighting a crackdown on undisclosed paid advertising on social media. Targeting American Beverage and the Canadian Sugar Institute, alongside influencers with over 6 million followers, the FTC points out non-transparent endorsements of artificial sweeteners and sugary foods. This move, spurred by The Washington Post and The Examination investigations, aims to enforce clear disclosure standards across influencer marketing. It represents a significant shift in the FTC's approach, with potential fines exceeding $50,000 per violation, signaling a tougher stance against deceptive social media advertising practices. FTC cracks down on food industry for paid dietitian influencer posts - The Washington Post. (gift article)

Mitophagy and Aging

Scientists at the Buck Institute have made a breakthrough in understanding aging by focusing on mitochondria, the cell's powerhouses. Their study, published in Nature Aging, highlights a natural compound, Mitophagy-Inducing Coumarin (MIC), that extends the lifespan of Caenorhabditis elegans, a model organism in aging research. MIC boosts the cell's waste management system, mainly targeting old and damaged mitochondria for disposal, a process known as mitophagy, which naturally declines with age. This discovery could lead to new therapies for age-related diseases by enhancing autophagy, the body's innate rejuvenation process. However, while MIC has shown promising results in worms, further research is needed to determine its effects on human aging. New Anti-aging Molecule May Work By Keeping the Cell's "Powerhouse" Healthy.

Crapsules: The Future of Medicine

In the field of microbiome medicine, a revolutionary shift is underway. Medical teams are transforming donated fecal matter into pills to combat infections like Clostridium difficile. These "crapsules" represent a broader scientific awakening to the importance of the gut's microbiome. Fecal transplants have proven to be efficacious in treating Clostridium dificile (a common life-threatening gut infection, often seen after broad-spectrum antibiotic treatment). Researchers are now exploring advanced strategies, including metabolite manipulation and genetically engineered bacteria, to treat a range of conditions more effectively. The FDA's recent approval of Seres Therapeutic's SER-109, an oral microbiome therapeutic, signifies a major leap in this field. With companies like Seres Therapeutics and Vedanta Biosciences at the forefront, the future of microbiome medicine appears promising, moving beyond the crude efficacy of FMT towards more sophisticated treatments. Microbiome treatments are taking off. (disclosure: I own shares of Seres Therapeutics)

Virtual Reality: A Real Game-Changer in Pain Management

The pain is real. The painkillers are virtual reality. | MIT Technology Review discusses RelieVRx, a virtual reality (VR) system designed to manage pain. Unlike traditional painkillers, RelieVRx aims to teach patients pain relief strategies such as mindfulness, cognitive-behavioral therapy, and relaxation rather than just providing a distraction. The approach is based on "unlearning" physiological pain responses and reinforcing alternative coping mechanisms. This innovative method offers a new frontier in pain management, leveraging the immersive capabilities of VR technology.

057 - Blue Zones, Mini-Siestas, and Nociplastic Pain - HealthHippieMD Week In Review

The Mind Diet and Dementia

"Experts have estimated that 40 percent of dementia cases worldwide might be prevented or delayed with certain modifiable factors, such as by prioritizing exercise and sleep and addressing health conditions like hearing loss or hypertension. But a growing body of evidence suggests that diet may play a role in dementia prevention, too." What Is the MIND Diet? And Can It Prevent Dementia? - The New York Times (gift article).

An Apple a Day

Researchers examined produce prescription programs, where patients received fresh produce for free with a doctor's prescription. Blood sugar levels, blood pressure, and weight showed significant improvement. This innovative approach not only enhances health but also reduces food insecurity. As the food-is-medicine movement gains momentum, producing prescriptions could become a ripe solution to combat diet-related ailments, emphasizing that good health begins with what's on your plate. Prescriptions for fruits and vegetables can improve the health of people with diabetes and other ailments, new study finds.

Protein Paradox

Is "eating like The Rock" the key to health? As researchers debate protein intake, some argue that the recommended daily allowance (RDA) of 0.8 grams per kilogram of body weight is insufficient. Jose Antonio, a health researcher, suggests sedentary adults aim for double, while active individuals need more than 2.2 grams per kilogram. However, other experts counter that too much protein might have diminishing returns, causing bodily discomfort and potential nutrient imbalances. The dilemma lies between protein's undeniable importance and avoiding excess. Amidst the protein frenzy, moderation appears vital to maintain personal well-being and environmental sustainability. You'll Probably Never Know How Much Protein You Actually Need - The Atlantic.

Mini-Siestas

Napping isn't just for lazy days – it's scientifically shown to enhance memory, productivity, and overall well-being. Short daytime naps of around 20 to 30 minutes offer many perks, from improved mental functioning and creativity to better problem-solving abilities and reduced stress. However, excessive napping, significantly beyond 30 minutes, can lead to sleep inertia – grogginess upon waking. Striking a balance and adopting good practices, like timing naps right and avoiding caffeine dependency, can make napping a refreshing addition to a healthy lifestyle. Remember, naps should complement, not replace, regular nighttime sleep.Short naps can improve memory, increase productivity, reduce stress, and promote a healthier heart.

On Procrastination

"A more realistic definition of procrastination is that it's not a blockage of inherent reason but a simple absence of desire." Slate had an interesting article on why we put things off: Why do I procrastinate, and how do I stop procrastinating? Procrastination advice fails to account for one key thing.

+I could not mention procrastination without mentioning Wait But Why. Why Procrastinators Procrastinate — Wait But Why

Blue Zones on Netflix

Netflix has a new documentary series on Blue Zones, regions where people are claimed to live or have recently lived longer than average. Secrets of the Blue Zones.

Medicare's Drug Cost Cutting

The healthcare giant Medicare is starting its journey towards slashing drug prices with a ten-drug hit list. These ten medications, known to cost $50.5 billion annually, are in the hot seat for negotiations that could offer relief for seniors and save the US government almost $100 billion by 2031 as part of President Biden's Inflation Reduction Act. Though Democrats are celebrating, skeptics, like the health policy analyst behind this explanation, foresee hurdles, legal battles, and potential industry resistance slowing down the process. The prescription price saga, starring high stakes and complex dynamics, has just begun. Medicare starts a long road to cutting prices for drugs, starting with ten costing it $50.5 billion annually – a health policy analyst explains why negotiations are promising but will take years.

• +my journey thinking about American healthcare economic reform continues. I've added We've Got You Covered: Rebooting American Health Care. to my reading list.

How to Become a Morning Person

I am most decidedly a night owl. If I had an intention of change, I'd pay attention to the advice in this article: How to Wake Up Earlier: 4 Ways to Become a Morning Person - The New York Times. (gift article)

Nociplastic Pain

Chronic pain affects nearly a third of the world's population. This mysterious, lingering affliction is more than physical; it carries psychological burdens like depression. Traditional painkillers often fall short of bringing relief. A new category, nociplastic pain, baffles researchers as it seems to have no anatomical cause. Emerging theories point to glitches in the brain's altered pain-processing network or immune system. New creative solutions for relief include harnessing neuroplasticity with psychedelics and personalized treatments using quantitative sensory testing. While relief remains elusive, understanding the enigma of chronic pain offers hope for future therapies. Some forms of chronic pain are particularly mysterious-The Economist.

Talking to Strangers

Embracing diversity isn't just about virtue signaling; it's a happiness hack. Research suggests that engaging with people from different walks of life enhances society and enriches individual well-being. Our natural tendency to flock to those who mirror us might feel cozy, but stepping out of this comfort zone fosters personal growth and contentment. Shaking hands with strangers, seeking out divergent viewpoints, and promoting a friend circle that celebrates heresy can bring zest to life. Happiness thrives where minds mingle. Talk to a Stranger and Be Happier - The Atlantic.

026 - Organic Fraud, Self-Schemas, and Improving Creativity - HealthHippieMD Week In Review

Wellness on Wheels

Wellness on Wheels Is Possible discusses how car makers are building "wellness" into their new vehicles in an attempt to decrease driving fatalities.

Attention, Attention

The ability to focus is an essential skill for physical and mental wellness, yet modern society pulls our attention in multiple directions. How to unlock your "peak mind" discusses the implications of poor attention and how to build your capacity to pay attention.

Soloman's Paradox

King Solomon was wise when it came to other people, but he was less successful in taking care of his personal affairs. The dichotomy gives rise to Soloman's Paradox, the fact that most people are better at advising others than themselves. How to use "Solomon's paradox" to give yourself good life advice discusses how to overcome the phenomenon.

Are Protein Bars Healthy?

Protein bars have come a long way since they were invented in the San Francisco Bay Area in the 1980s. Although many people associate "protein" with health, many choices are ultra-processed and high in sugars and additives. In the long run, you're always better off with whole food: Are Protein Bars Good for You? What to Know About Nutrition. (gift article)

How to Change your Habits to Exercise in the Morning

The jury is still out on what is better for you, exercising in the morning vs. the evening. Some evidence suggests morning workouts are superior for fat loss, while afternoon exercise improves your laboratory profile. If you want to transition to morning exercise, How to Become a Morning Exercise Person (gift article) is for you.

Learning/Understanding Multiple Languages Slows Alzheimer's Onset

Although no clinical trials have explored the impact size, multiple studies have shown that speaking two languages slows the onset of Alzheimer's Disease. The thought behind this phenomenon is that knowing more than one language builds cognitive reserve: Duolingo is a better Alzheimer's treatment than drugs. There are similar findings for playing musical instruments. Does playing a musical instrument prevent dementia?

Cancer-Mortality Rate Falls in the U.S.

Since the early 1990s, the U.S. cancer mortality rate has fallen by one-third, according to a new report from the American Cancer Society. Behavioral changes and screening are just as significant (or maybe more so) than treatment. The Surprising Reason for the Decline in Cancer Mortality.

Biotech Trends for 2023

BigThink had an article on the biotech trends we should keep an eye on for 2023: 5 biotech trends to watch in 2023.

Self-Schemas

Self-schemas profoundly affect how we feel and interact with the world. A positive self-schema has numerous benefits, while a negative self-schema can be highly detrimental to our success and happiness. Feeling insecure? 5 science-backed strategies could help break the cycle, gives some insight into how to improve how you see yourself.

Meditation and the Microbiome

A small observational study of 37 Tibetan Monks, published in General Psychiatry, attempted to link meditation to the microbiome's health. The methodology is loaded with problems, but the article is interesting nonetheless. Deep Meditation May Alter Gut Microbes for Better Health

The Key to a Good Life

The Harvard Study of Adult Development established a strong correlation between deep relationships and well-being. How does one nurture those deep relationships? What the Longest Study on Human Happiness Found Is the Key to a Good Life. +More wisdom on prioritizing friendships and relationships: 6 Keys to Lifelong Friendship +Tim Urban tackles relationships and quality time in The Tail End — Wait But Why

Animal Self-Awareness

The discovery that a wide range of animals possess self-awareness has called into question their captivity in zoos and for research. Aeon published a thought-provoking article on the fight over human exceptionalism and our right to exploit other species: Why nonhuman beings should be granted personhood rights.

One Simple Way to Improve Your Wellness and Creativity

Emotional reappraisal has many benefits. Study reveals one brilliant brain hack that can unlock your creativity discusses emotional reappraisal and how to use it to improve your well-being.

Memories vs. Perception

As I mentioned in 024 - Musical Instruments and Cognition, Law of Jante, McGurk Effect, Awe, our perception can vary from reality. Here is an article on how your brain stores information: How the Brain Distinguishes Memories From Perceptions

USDA to Crack Down on 'Organic' Fraud

Sales of organic foods in the United States have more than doubled in the past ten years, jumping by a record 12.4 percent in 2020 to $61.9 billion as consumers became more concerned about eating healthy foods, thereby increasing the incentive for fraud. USDA's Strengthening Organic Enforcement rule aims to stamp out fraud (gift article) is about the government's attempts to cut down on deceptive practices in the organic food space.

Using Virtual Worlds to Minimize Pain

An interesting article about how researchers are using virtual environments to help alleviate pain: SnowWorld melts away the pain for burn patients, using virtual reality snowballs (thanks, Josh)

Another Study Tying Hearing Loss to Dementia

A new study in JAMA demonstrated a 61% higher incidence of dementia among older people with moderate to severe [hearing loss][1] compared to those with normal hearing. Even mild hearing loss posed a risk: Hearing Loss Strongly Tied to Increased Dementia Risk

011 - CVS, Amazon, and the Disruption of Primary Care, Anxiety Inoculants, Wabi Sabi, and AI. - HealthHippieMD Week In Review

Wabi Sabi - An Inoculant for Perfectionism

Perfectionism can have a devastating effect on mental health. The Japanese concept of wabi-sabi can help: Escape the perfectionist trap with the philosophy of "wabi-sabi"

CVS, Amazon, and the Disruption of Traditional Primary Care

Traditional primary care practices and healthcare systems should be quaking in their boots. The article CVS, Amazon Deals Might Be Good for Patients, Bad for Primary Care, gives the good and bad of the disruption of healthcare. We are in the early days of this transformation that will include technology and place a much greater emphasis on preventative care/wellness. Exciting times!

+For some of the challenges, see this article extracted from a recent Harvard Business Review: Amazon's Foray into Primary Care Won't Be Easy "....a fundamental question looms: Can profit-driven entrepreneurship and bottom-up innovation make the U.S. health care system work anywhere nearly as well as those in places like France, Sweden, Norway, Australia, the Netherlands, New Zealand, Germany, and Switzerland? They may be relatively dull, but they keep people healthy at an affordable cost.".

How to be Bold

Anxiety short-circuits many decision-making processes for a wide range of the population. The article How to Be Bold discusses the implications and how to overcome anxiety inertia. Thanks, Laura!

Fasting and Cancer

I am interested in extending lifespan and health span, so I have read many papers on caloric restriction. Fasting to combat cancer is somewhat controversial but gaining momentum. Dr. Michael Gregor over at NutritionFacts has a great series of introductory videos for you:

• Fasting for Cancer: What About Cachexia?
• Fasting Before and After Chemotherapy and Radiation - mostly in vitro (test tube) and pre-clinical (mice).
• A third video, yet to be released, looks at the literature on humans...

+For a decent scientific review on caloric restriction and cancer, see this 2018 paper from Valter Longo's Lab: Starvation, Stress Resistance, and Cancer

Immersive Rights in the Metaverse

The Metaverse, "a broad societal shift in how we engage digital content, going from flat media viewed in the 3rd person to immersive experiences engaged in the 1st person," is coming, ready or not. As with all powerful technologies, we must consider their use and implications. The article The case for demanding "immersive rights" in the Metaverse touches on many of the potential issues. This article reminded me of some of the early warnings on the use and potential abuse of social media.

Immersive Virtual Environments Eases Pain During Hand Surgery

The article, Gaming tech could ease pain during surgery, reports the findings of a recent preliminary study looking at the effects of immersive VR on surgical pain: Virtual reality immersion compared to monitored anesthesia care for hand surgery. Adding this to my reading list.

Life Lessons Gleaned from Free Soloing El Capitan

The advice and life lessons came rapidly in the podcast, How free solo climber Alex Honnold faces fear. The interviewer, Adam Grant, an organizational psychologist at Penn, was positively giddy during the interview. This episode is well worth your time.

Rethinking Alzheimers

Last week I mentioned the re-examination of a foundational paper whose findings have been questioned. That re-examination, coupled with the little to no progress in the prevention or treatment of the disease, has led to renewed interest in alternate theories. The article Alzheimer's Might Not Be Primarily a Brain Disease, examines some of the leading alternate views.

Anxiety Screening Recommended for all Adults

A panel of experts gathered by the U.S. Department of Health and Human Services issued a draft guidance this week recommending all adults 65 and younger are screened for anxiety: Health Panel Recommends Anxiety Screening for All Adults Under 65. One of the issues mentioned is what the U.S. will do with the increased volume of newly diagnosed anxious adults. The mental health infrastructure was inadequate before the pandemic. During the pandemic, the existing volume of patients struggled to find licensed mental health providers. It is unlikely the system will be able to keep up with all the newly diagnosed patients in need of services.

Stool Banking - Your Poop May Hold the Secret to Longevity

As we learn more about the microbiome and the aging process, the two are intertwined--especially around inflammation. Ten years ago, when trying to convince my chairman about the importance of this emerging area, I remember telling him that as we learn how important the microbiome is to health and wellbeing, the inevitable outcome would be the prevalence of personal stool banking. The article Your Poop May Hold the Secret to Long Life focuses on the logistical and ethical questions surrounding storing your stool.

Eric Topol

Eric Topol is constantly tweeting out fantastic resources. My favorite finds from this week:

• Long covid—an update for primary care | The BMJ features a great infographic.
• SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages | Science Translational Medicine investigates why obesity is a risk factor for severe Covid.
• Multimodal biomedical AI | Nature Medicine covers the promise of artificial intelligence in medicine.

Humans Evolved with their Microbiomes

The gut microbiome plays many vital roles in health and well-being. Humans evolved with their microbiomes, and like genes, gut microbes pass from one generation to the next discusses the co-evolution of humans and their microbial passengers.

The Search for New Pain Medication

The Economist had a great article on the search for new analgesics: Better medicines are needed to relieve pain

Quote of the Week

"Blind belief in authority is the greatest enemy of truth." - Albert Einstein.