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067 - Invisible Wounds, Stellar Departures, and Shakespeare on Sleep - HealthHippieMD Week In Review

Moth Matriarchy

In an unexpected twist of fate, researchers in Japan have stumbled upon a virus that could revolutionize pest control by inducing a matriarchal society in moth populations. This unique virus, discovered within the tobacco cutworm, can eliminate male offspring, resulting in generations of female-only moths. This finding challenges our understanding of viral evolution and offers a promising tool for managing agricultural pests and disease vectors. The discovery, which could have easily fluttered unnoticed, now stands as a beacon of potential in the ongoing battle against crop-destroying insects, highlighting nature's intricate balance of power. Male-Killing Virus Is Discovered in Insects - The New York Times. (gift article)

Diet Debts

The United Nations has published a significant new tally of the world's food system's impact on our health and the planet, a staggering $12.7 trillion annually (about 10% of the world's GDP). The FAO report highlights that the majority of these costs stem from health-related issues due to poor diets leading to obesity and diseases. Environmental impacts follow, with significant disparities between low and high-income countries. The study suggests that better dietary choices, fairer trade practices, and sustainable farming could alleviate these financial burdens. The FAO urges a multifaceted approach involving government policy, consumer behavior, and industry practices to reduce these hidden costs. The World's Broken Food System Costs $12.7 Trillion a Year | WIRED.

Stellar Departures

In an exploration of humanity's final frontier, Their Final Wish? A Burial in Space, (gift article) delves into the lives of individuals who have chosen the cosmos as their final resting place. Contracting with Celestis, a company that offers memorial spaceflights, these seven people have opted to send their ashes or DNA into the vastness of space. Their reasons range from spiritual to pragmatic, with many driven by a lifelong passion for the stars. As traditional earthly bonds loosen, space burials represent a profound acceptance of the unknown, a testament to the human spirit's unyielding curiosity and desire for exploration.

Invisible Wounds: A Closer Look at the Markers of PTSD

How Post-traumatic Stress Disorder Works delves into the harrowing journey of Adam Kelley, a U.S. Army specialist who, despite returning home from Iraq, could not escape the clutches of PTSD, ultimately leading to his tragic suicide 13 years later. PTSD, a mental health condition triggered by traumatic experiences, is characterized by 17 symptoms, including agitation, anxiety, concentration issues, memory problems, depression, and mood swings. These symptoms can manifest in various intensities and are not uniform across all individuals. The article also explores the evolution of PTSD's understanding, from its initial identification in the American Civil War to modern research that includes genetic factors and the importance of social support. It highlights the military's vulnerability to PTSD, given the intense and life-threatening nature of combat experiences. The article concludes with insights into counseling and medication treatments for PTSD, cutting-edge research, and innovative approaches like virtual reality therapy and resilience training for soldiers.

Amazon's One Medical Priming the Market

Amazon is making its primary care boutique clinic, One Medical, cheaper for Prime subscribers. Amazon links One Medical primary care to Prime memberships - The Washington Post. (gift article)

Shakespeare on Sleep

Arthur Brook's article, Five Ways to Make Sure You Get More Sleep, using quotes from Shakespeare, delves into the elusive quest for restful slumber, a journey often hijacked by the mind's nocturnal wanderings. With 15% of American adults struggling to fall asleep, the nation's sleep debt is not just a personal nuisance but a public health concern. Sleep deprivation is linked to a myriad of health issues, from metabolic disturbances to mental health problems like depression and anxiety. The piece underscores the profound impact of sleep on our well-being and happiness, offering practical sleep hygiene tips and advocating for a personalized approach to sleep patterns. It suggests that embracing one's unique sleep rhythm and addressing life's stressors could be the key to unlocking the rejuvenating power of sleep and a happier life.

Mind Matters

Emerging research underscores a significant connection between mental health disorders in later life and an increased risk of dementia. Studies suggest that late-life mental illnesses, such as depression, maybe early indicators of dementia or could exacerbate its onset. While not all late-life psychiatric disorders lead to dementia, the correlation is strong enough to warrant cognitive testing for older adults presenting new psychiatric symptoms. The relationship between early-life mental health issues and later dementia is less definitive, though severe early mental illness does raise dementia risk. Overall, maintaining mental and physical health is emphasized as a preventative measure against dementia. Mental Illness May Affect Dementia Risk, Research Suggests - The New York Times. (gift article)

Psychedelics and Depression: Neuroplasticity without the Trip

Recent insights suggest that the mental health benefits of psychedelics like psilocybin and MDMA may not stem from their hallucinogenic effects. Researchers are now developing non-hallucinogenic variants that target neuroplasticity without the trip, potentially offering depression and PTSD treatments to a broader patient base. These novel compounds could reset emotional control and improve mood without the psychedelic experience by enhancing brain adaptability. This shift could redefine psychedelic therapy, focusing on neuroplastic potential rather than transcendental experiences, and streamline regulatory processes for easier access and research. What If Psychedelics' Hallucinations Are Just a Side Effect? - The Atlantic.

+More on the importance of neuroplasticity in mental health. Neuroscientists are Tantalizingly Close to Mastering How Psychedelics Redesign Our Brains.

Urban Wellness

Urban epidemiologist Tolullah Oni's research underscores a stark contrast in urban living conditions, revealing that affluent neighborhoods often boast better air quality, cooler temperatures, and safer spaces for physical activity. This disparity is critical as urban populations are set to double by 2050. Oni's work emphasizes the need for cities to address these inequalities proactively. The article highlights the importance of urban planning that considers health impacts, equitable access to public spaces, and the role of governments and the private sector in building healthier cities. Where You Live Is As Important As What You Eat | WIRED.

027 - Wise-Selfishness, Horvath's Clock and GrimAge - HealthHippieMD Week In Review

Wise Selfishness

"....a truly enlightened self-interest also means recognizing that acting in great and altruistic ways makes you happier than solely being out for yourself." I enjoyed reading The Benefits of Being Selfish.

Nobody Has My Condition But Me

We often think that in modern medicine all maladies have been cataloged. That is far from the truth. Nobody Has My Condition But Me is about the trials and tribulations of a woman with a unique condition.

Recycling Plastic

More on recycling of plastic: Is plastic recycling a scam? Here's the truth about the common practice. We have a long way to go....

David Crosby's 15 Essential Songs

Another rock icon passed away last week. The NY Times published a list of David Crosby's best songs: David Crosby's 15 Essential Songs. (gift article)

10 Myths in Nutrition

An interesting article for both the myth-busting and the experts consulted: 10 Nutrition Myths Experts Wish Would Die (gift article)

The Microbiome and Thermoregulation

This summary article had a wealth of provocative information:

  1. The presence or absence of certain bacteria was associated with the body's temperature response in sepsis (in both humans and mice).
  2. Mice without a microbiome have a lower basal body temperature than conventional mice.
  3. The administration of antibiotics lowers basal body temperature.

The authors of the study opine that changes in the microbiome may account for the reduction in basal body temperatures of humans over the last 150 years: Gut Microbes Control the Body's Thermostat

Mixed Feelings

Feeling conflicted can feel worse than feeling bad and can bring with them a great deal of distress. Mixed Feelings Can Be Worse Than Bad Ones offers advice on how to overcome the distress.

Amazon is Happy to be Your Pharmacy

Here's an article on Amazon's RxPass, the newest service from Amazon. With a Prime Membership, you can receive as many of the 80 generic medications the service offers for a flat fee of $5 (assuming you have insurance and are not on Medicare or Medicaid). Amazon Will Now Be Your Pharmacist, If You Subscribe to Prime

Food Compass

A relatively new system aims to demystify identifying healthy and unhealthy foods. Parsing which foods are healthy and which are less so isn't always straightforward – a new rating system aims to demystify the process explains.

Gene Snippets from Mother Shape a Baby's Microbiome

A recent study published in Cell demonstrated that it's not just pure bacterial transfer between mother and baby that's important in developing a newborn's microbiome. Small pieces of DNA called mobile genetic elements hop between maternal and newborn bacteria and ultimately influence the baby's microbial development: Mobile Genes From the Mother Shape the Baby's Microbiome.

Odors Change Purchasing Decisions

I did not realize there was a body of research on the sense of smell and consumerism. How body odors influence your buying behavior explains the latest research.

Yerba Mate

Although Yerba Mate is a staple of South American dietary traditions, traction in the U.S. has slowly evolved. The recurrent description of the taste, "like freshly cut green grass," will not help to stimulate demand. The Coffee Alternative Americans Just Can't Get Behind

The Universal Aging Clock and GrimAge

Aging research is all the rage. Here is an interesting article on Horvath's Clock, GrimAge, and the effects of umbilical and young blood plasma transfusion: The Universal Clock of Aging. I learned about the GrimAge metric. I'm continuing to keep a close eye on this body of research.

The Benefits of Yoga

Another article on the benefits of yoga: Yoga: Modern research shows a variety of benefits to both body and mind from the ancient practice. For the latest science: Yoga: What You Need To Know | NCCIH

Adding New Life to Friendships and Relationships

TED had an article with helpful information on how to revitalize interactions with the people most important to you: How to add new life to your relationships (even your best ones!) |

Neurocognitive Testing for Aging Physicians

An interesting interview tackling the subject of competency exams for physicians: Age Competency Exams for Physicians -- Yes or No? For the record, I think it's a good idea.

Physicians Open Notes

Being able to read what your physician writes about you in your chart is a good thing, right? Not so fast. Why Reading Your Doctor's Notes Can Be Painful covers some of the issues.

021 - Freudenfreude, Covert Consciousness, and Friend Recessions - HealthHippieMD Week In Review

The Neuroscience of Music Appreciation

"When we listen to music, the greatest amount of pleasure stems from events predicted with only a moderate level of accuracy." The article, Why Certain Types of Music Make Our Brains Sing, and Others Don't, was my favorite of the week. If you like this article, you will also like Oliver Sack's Musicophilia: Tales of Music and the Brain

Who Knew? Zebra Stripes Repel Flies

Science is fascinating. Here is an article that made me say, "Huh." Scientists Reexamine Why Zebra Stripes Mysteriously Repel Flies

A Mandatory Retirement Age for Physicians?

Many high-risk professions require individuals to retire at a certain age (airline pilots, air traffic controllers, etc.). Opinion | How Would You Feel About a 100-Year-Old Doctor? - The New York Times (gift article) discusses the controversy of forced retirement for physicians.

Friendship Recessions

Americans, especially American men, are facing a "friendship recession." The article Why Is It So Hard for Men to Make Close Friends offers tips on how to overcome this worrisome trend.

Freudenfreude and Schadenfreude

Finding joy in another person's good fortune is what social scientists call "freudenfreude." Freudenfreude is a social glue, making relationships more enjoyable. The article What is Freudenfreude? And How to Cultivate It discusses how to have more of it, and less schadenfreude: the pleasure we feel when witnessing someone's misfortune.

Stutz on Netflix

Is It Toxic to Tell Everyone to Get Therapy? is a quick overview of Stutz, a new Jonah Hill documentary on Netflix. I'm going to check it out....

Doctors Spreading Misinformation

Is Spreading Medical Misinformation a Doctor's Free Speech Right?(gift article) discusses a recent California law, slated to begin January 1, written to combat the spread of false information by healthcare professionals. The law is being challenged.

Viruses and Alzheimer's Disease

Is Herpes Simplex 1 involved in the development of Alzheimer's Disease? The article's author, The link between viruses and Alzheimer's disease, thinks so. The article offers some compelling justification for pursuing the science. Reading the article brought to mind one of my favorite quotes by George Bernard Shaw, "All great truths begin as blasphemies." Although this scientist's theories may be incorrect, her words resonated with me: "Most researchers acknowledge that new, surprising, and challenging ideas should be viewed with caution. But ideas should not be dismissed without any deliberation." The author is definately a Dark Horses.

Tips to Extend your Healthspan with Minimum Effort and Maximal Reward

The BBC had an article I will refer to often, offering practical tips to live a longer, healthier life. Minimum effort, maximum reward

The Folly of Expiration Dates

Food waste is a huge issue in the United States. The implications? Wasted money and a profound effect on the environment/climate. The article, Go Ahead, Ignore Expiration Dates discusses the phenomenon of the "expiration date." One of useful facts mentioned was expiration dates denote an estimate of preserved food quality, NOT safety. If you're worried about whether your food is still edible, the authors suggest the Sniff Test.

Paging Dr. Amazon

I read several articles about Amazon's push into healthcare. Amazon's Creep Into Health Care Has Some Experts Spooked discusses the impetus and some of the controversies surrounding Amazon's healthcare efforts. Amazon makes a new push into health care echoes many of the same sentiments. See also: 011 - CVS, Amazon, and the Disruption of Primary Care, Anxiety Inoculants, Wabi Sabi, and AI.

Unnecessary Death

I am an advocate for the U.S. adopting a single payer system of healthcare where incentives align with patient health rather than corporate profit. Universal Health Care Could Have Saved More Than 330,000 U.S. Lives during COVID discusses the lost opportunity for the U.S for not having universal healthcare during the pandemic: 338,000 lives and a $105 billion.

Social Media and Mental Health

Why does social media impact our mental health? Why Social Media Makes People Unhappy--And Simple Ways to Fix It offers answers and ways to combat the negative feelings.

Covert Consciousness

Views on coma and consciousness are changing. Some People Who Appear to Be in a Coma May Be Conscious is a nice overview of the evolving science.

Genetic Resistance to Coronavirus?

Some scientists wonder if genetics offer protection from Coronavirus. The article Could Genetics Be the Key to Never Getting the Coronavirus explains the rationale. Since SARS-CoV2 binds to the ACE Receptor, I wondered if the commonly prescribed anti-hypertensive ACE inhibitors had any effect on infection rates or disease progression. At least one study demonstrated a protective effect.

011 - CVS, Amazon, and the Disruption of Primary Care, Anxiety Inoculants, Wabi Sabi, and AI. - HealthHippieMD Week In Review

Wabi Sabi - An Inoculant for Perfectionism

Perfectionism can have a devastating effect on mental health. The Japanese concept of wabi-sabi can help: Escape the perfectionist trap with the philosophy of "wabi-sabi"

CVS, Amazon, and the Disruption of Traditional Primary Care

Traditional primary care practices and healthcare systems should be quaking in their boots. The article CVS, Amazon Deals Might Be Good for Patients, Bad for Primary Care, gives the good and bad of the disruption of healthcare. We are in the early days of this transformation that will include technology and place a much greater emphasis on preventative care/wellness. Exciting times!

+For some of the challenges, see this article extracted from a recent Harvard Business Review: Amazon's Foray into Primary Care Won't Be Easy "....a fundamental question looms: Can profit-driven entrepreneurship and bottom-up innovation make the U.S. health care system work anywhere nearly as well as those in places like France, Sweden, Norway, Australia, the Netherlands, New Zealand, Germany, and Switzerland? They may be relatively dull, but they keep people healthy at an affordable cost.".

How to be Bold

Anxiety short-circuits many decision-making processes for a wide range of the population. The article How to Be Bold discusses the implications and how to overcome anxiety inertia. Thanks, Laura!

Fasting and Cancer

I am interested in extending lifespan and health span, so I have read many papers on caloric restriction. Fasting to combat cancer is somewhat controversial but gaining momentum. Dr. Michael Gregor over at NutritionFacts has a great series of introductory videos for you:

+For a decent scientific review on caloric restriction and cancer, see this 2018 paper from Valter Longo's Lab: Starvation, Stress Resistance, and Cancer

Immersive Rights in the Metaverse

The Metaverse, "a broad societal shift in how we engage digital content, going from flat media viewed in the 3rd person to immersive experiences engaged in the 1st person," is coming, ready or not. As with all powerful technologies, we must consider their use and implications. The article The case for demanding "immersive rights" in the Metaverse touches on many of the potential issues. This article reminded me of some of the early warnings on the use and potential abuse of social media.

Immersive Virtual Environments Eases Pain During Hand Surgery

The article, Gaming tech could ease pain during surgery, reports the findings of a recent preliminary study looking at the effects of immersive VR on surgical pain: Virtual reality immersion compared to monitored anesthesia care for hand surgery. Adding this to my reading list.

Life Lessons Gleaned from Free Soloing El Capitan

The advice and life lessons came rapidly in the podcast, How free solo climber Alex Honnold faces fear. The interviewer, Adam Grant, an organizational psychologist at Penn, was positively giddy during the interview. This episode is well worth your time.

Rethinking Alzheimers

Last week I mentioned the re-examination of a foundational paper whose findings have been questioned. That re-examination, coupled with the little to no progress in the prevention or treatment of the disease, has led to renewed interest in alternate theories. The article Alzheimer's Might Not Be Primarily a Brain Disease, examines some of the leading alternate views.

A panel of experts gathered by the U.S. Department of Health and Human Services issued a draft guidance this week recommending all adults 65 and younger are screened for anxiety: Health Panel Recommends Anxiety Screening for All Adults Under 65. One of the issues mentioned is what the U.S. will do with the increased volume of newly diagnosed anxious adults. The mental health infrastructure was inadequate before the pandemic. During the pandemic, the existing volume of patients struggled to find licensed mental health providers. It is unlikely the system will be able to keep up with all the newly diagnosed patients in need of services.

Stool Banking - Your Poop May Hold the Secret to Longevity

As we learn more about the microbiome and the aging process, the two are intertwined--especially around inflammation. Ten years ago, when trying to convince my chairman about the importance of this emerging area, I remember telling him that as we learn how important the microbiome is to health and wellbeing, the inevitable outcome would be the prevalence of personal stool banking. The article Your Poop May Hold the Secret to Long Life focuses on the logistical and ethical questions surrounding storing your stool.

Eric Topol

Eric Topol is constantly tweeting out fantastic resources. My favorite finds from this week:

Humans Evolved with their Microbiomes

The gut microbiome plays many vital roles in health and well-being. Humans evolved with their microbiomes, and like genes, gut microbes pass from one generation to the next discusses the co-evolution of humans and their microbial passengers.

The Search for New Pain Medication

The Economist had a great article on the search for new analgesics: Better medicines are needed to relieve pain

Quote of the Week

"Blind belief in authority is the greatest enemy of truth." - Albert Einstein.

004 - Fighting Food Waste, Dark Cheerfulness, What We Smell in Our Friends - HealthHippie Week In Review - August 7, 2022

Revamping the Food Expiration System

Americans waste about one-third of their food. The article, Food expiration dates are broken — a microbiologist explains how to fix them discusses revamping the system to be more beneficial for consumers (and to decrease food waste).

Hospital Rankings

This week, the U.S. News and World Report released its hospital rankings. The podcast episode, Should We Trust Hospital Rankings? is an interesting discussion of the ranking system and how the rankings could be improved. "Hospitals compete for prime spots on the U.S. News rankings — but could those lists do more harm than good?"

The Dark Side of Cheerfulness

"Emotions are usually defined by their ungovernability, experienced as forces that wash over us and challenge our sense of agency. That quality is what makes most seem authentic and trustworthy to us. Fake anger or love feels like a betrayal. But fake cheer?..." The excerpt is taken from the book review, The Dark Side of American Cheerfulness on the book: Cheerfulness: A Literary and Cultural History. The review is well worth the read, touching on psychology, culture, history, philosophy, and politics.

Smell you Later

Many of us believe we have cognitive control over most aspects of our lives, including the people we call friends and the people we choose as romantic partners. With all types of human connections, some just "click," but the basis behind interpersonal chemistry remains elusive. As with all things physiological, the story is complex. Do we like our friends because they stink like we do is a reminder that at our core, we are just evolved animals. These researchers claim they can determine "chemistry" between two individuals with 71% accuracy using only their smell.

Pandemic and Positive Emotions

Listened to the Pushkin Podcast from the Happiness Lab with Laurie Santos, What Did the Pandemic Teach Us About Happiness? about the role the pandemic played in happiness. The discussion referred to Surgeon General Vivek Murthy's NEJM article, Confronting Health Worker Burnout and Well-Being. In 2017 I tried to get my proposal, Measuring the impact of biofeedback-enhanced meditation on resident stress, burnout, and well-being, funded. The plan was to begin with residents but ultimately study the entire perioperative healthcare workforce. The proposal was not funded. I remain just as interested today as I was back then, maybe more so now that my daughter has started her long medical training.

Questioning the Theory of Chemical Imbalance in Depression

The manuscript, The serotonin theory of depression: a systematic umbrella review of the evidence. stirred quite a bit of controversy. The commentary in Slate, Why has the misleading chemical imbalance theory of mental illness persisted for so long was one of the better articles I read.

Nutrition and Mental Health

And while we are on the topic of mental health, I discovered a new podcast this week from ZOE Science and Nutrition. I listened to two of the episodes. Both were excellent with a mix of science and actionable advice: How food can improve your mood and Can you reverse damage from a bad diet?

Can We Cure Aging?

Medscape published an excellent brief overview of longevity research: Is There a Cure for Aging?

Dr. Amazon is In

Several interesting stories about Amazon this week. First, an article about Alexa's potential utility in early diagnosis of cognitive decline: Alexa could diagnose Alzheimer's and other brain conditions — should it? The article discusses the technology and some of the ethics behind continuous digital monitoring—food for thought. Voice technology will continue to improve in its ability to "diagnose" many mood and cognitive disorders.

+I woke up to news that Amazon is interested in purchasing iRobot, the company that makes the Roomba. Roomba has a "Smart Maps" feature that maps the interior of your living area. The article focuses on Amazon as a surveillance company. I don't necessarily agree. I wouldn't be surprised if Amazon's interest in iRobot has medical applications--perhaps mapping the safety of an elder's environment to minimize falls. I look forward to hearing more about this deal.

Bacteriophages and IBD

I read an exciting news story on Inverse, Bacteria-eating virus cocktails may effectively treat gut inflammation, that covers the findings in the manuscript, Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation. An Israeli-led team (that includes UNC's Dr. Ryan Balfour Sartor) zeroed in on a strain of bacteria, Klebsiella pneumoniae, and demonstrated the bacteria could cause IBD like symptoms in mice. They then developed a cocktail of phages (viruses that selectively attack particular bacteria) that targeted K. pneumonia and ameliorated damage caused by the bacteria. The authors are now beginning clinical trials. I plan to follow this work carefully.

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