095 - Criticism, Landfills, and Tripping with Toad Venom - HealthHippieMD Week In Review

Dream On

Recent research has made significant strides in understanding sleep. Scientists have discovered more about lucid dreaming and how our brains replay memories during sleep. They've shown that sleep deprivation disrupts brain connectivity, impairing learning and emotional regulation. Furthermore, quality sleep is essential in preventing neurodegenerative diseases by clearing harmful toxins. Finally, new treatments like cognitive behavioral therapy for insomnia (CBT-I) are proving effective in enhancing sleep quality. These breakthroughs highlight the critical role of sleep in overall health and cognitive function. These 5 Sleep Science Breakthroughs Might Help You Get Better Rest.

+see also: Why We Sleep: Unlocking the Power of Sleep and Dreams.

Non-Meditative Mindfulness

Ellen Langer is a psychologist at Harvard who studies the mind-body connection. She's published some of the most counterintuitive studies in Social Science. I learned a lot from this podcast about her work and the history and importance of mindfulness. ‎People I (Mostly) Admire: 133. Pay Attention! (Your Body Will Thank You).

Toadally Psychedelic

5-MeO-DMT, a potent psychedelic from the Sonoran Desert toad, is renowned for its rapid, intense effects. While it holds promise for treating mental health disorders like depression and PTSD, its extraction threatens the toad population. Scientists are developing synthetic versions to alleviate this issue and ensure controlled dosing. Research highlights potential therapeutic benefits and the need for cautious, ethical approaches. As interest in psychedelics rises, the balance between medical advancement and environmental conservation remains crucial. The Promise — And Perils — Of 5-MeO-DMT.

+listen also: my favorite story EVER on NPR: The Dog that Loved to Suck on Toads.

Trimming the Fat on Global Obesity

France bucks the global obesity trend, dropping rates from 10.4% in 1990 to 9.7% in 2020. This contrasts starkly with countries like Egypt and the U.S., where rates have more than doubled. The Programme National Nutrition Santé, launched in 2001, is vital to France's success, focusing on improved nutrition and exercise. The initiative includes public campaigns like Manger Bouger, promoting healthier lifestyles. Meanwhile, Germany's obesity rates have plateaued due to a cultural shift towards healthier eating among younger generations. There's no magical cure, but these nations highlight the impact of proactive health policies and lifestyle changes. How is France dodging the global obesity trend?

Oh, Oh, Oh, Ozempic

Ozempic and other GLP-1 agonists, initially designed for diabetes, now offer benefits beyond weight loss, including reduced risk of heart disease and sleep apnea and potentially aiding in conditions like Alzheimer's and fertility issues. These drugs, often termed a "Swiss Army knife" for health, show promise in treating various ailments through mechanisms involving blood sugar control, organ-specific actions, and reduced inflammation. However, distinguishing the direct effects from those related to weight loss remains complex, and ongoing research is crucial to understand and fully utilize these multi-functional medications. Is Ozempic an Obesity Drug, or an Everything Drug? - The Atlantic.

The Dark Side of Plant-Based Diets

Ultra-processed plant-based foods, such as french fries and pastries, are linked to an increased risk of cardiovascular disease, according to a new study in The Lancet Regional Health-Europe. Research involving 118,000 UK adults reveals that while plant-based diets are beneficial, their health advantages vanish when the foods are ultra-processed. These findings suggest that minimally processed plant-based foods significantly lower the risk of fatal and nonfatal cardiovascular events, unlike their ultra-processed counterparts, which strip away essential nutrients and disrupt the food matrix, undermining heart health. These Ultra-Processed Plant-Based Foods Might Increase the Risk For Many Diseases.

Space Oddities

Four private astronauts spent three days in space aboard Inspiration4, experiencing significant, albeit temporary, changes in their bodies and minds. Research revealed cognitive declines, immune stress, and genetic alterations. Despite returning to normal post-mission, these findings highlight gaps in space medicine. The mission's data, stored in the Space Omics and Medical Atlas, is crucial for future space travel. From diverse backgrounds, the astronauts contributed invaluable insights into the physiological impacts of space, setting the stage for more tailored health measures for upcoming private space missions. Four Astronauts Spent 3 Days in Space. Here's What It Did to Their Bodies and Minds. - The New York Times (gift article).

White House Plans Diet for Landfills

The Biden administration introduced a national strategy to combat food waste, aiming to reduce the 30% of the U.S. food supply in landfills. The plan focuses on extending food shelf life, increasing food donations, and promoting composting. Despite these efforts, the strategy needs to include new regulations and catch up to some state and international laws. Key initiatives include research funding, consumer education, and collaboration with farmers and businesses. Critics view the plan as a positive but insufficient first step towards halving food waste by 2030. White House Takes a Tiny Bite From Giant Pile of Food Waste - The New York Times (gift article).

What Children Remember

Happy Father's Day! The Atlantic published a curated list of stories on fathers. I'm working my way through the list. What children remember - The Atlantic.

Criticism: The Gift That Keeps on Giving

In today's feedback-driven world, mastering the art of receiving and giving criticism is essential for personal happiness and professional growth. Criticism, significantly negative, is challenging to accept due to its impact on our brains and emotions. People with low self-esteem or high competitiveness struggle the most. Individuals can thrive by depersonalizing feedback, viewing it as insider information, and using it constructively. Criticism should be given with care, respect, and good intentions, always privately if negative. Embracing these practices can lead to improved well-being and performance. How to Take—And Give—Criticism Well - The Atlantic.

Gut Instincts

Microbiome research has traditionally focused on stool samples, but recent advancements allow scientists to explore the small intestine, revealing critical insights into gut health. The small intestine microbiome plays a crucial role in digestion, metabolism, and immunity. Disturbances in this area are linked to conditions like IBS, SIBO, and Celiac disease. New technologies like camera capsules facilitate better understanding and treatment development. This shift from focusing solely on the colon to including the small intestine promises significant advancements in microbiome medicine and gut health therapies. Poop has been an easy target for microbiome research, but voyages into the small intestine shed new light on ways to improve gut health.

094 - When Drugs Go Wild, Dodging Microplastics, and The Brain's Fear Gear - HealthHippieMD Week In Review

The Brain's Fear Gear

A recent study, published in Science, elucidated a chemical "switch" in the brainstem's dorsal raphe nucleus of mice that converts stress into fear by altering neurotransmitter release, leading to anxiety disorders and PTSD. This switch involves neurons shifting from releasing glutamate to GABA. Experiments showed that blocking GABA synthesis or using fluoxetine (Prozac) could prevent generalized fear responses. Post-mortem studies on human PTSD patients confirmed this mechanism, opening avenues for targeted treatments. Understanding these molecular processes provides a pathway for developing specific interventions for stress-induced fear and related disorders. The brain's "switch" that puts fear into overdrive - Big Think

Put the 230 Genie Back in the Bottle

The article argues for reforming Section 230 of the Communications Decency Act, which protects online platforms from liability for user-generated content. Originally intended to encourage moderation of harmful content, Section 230 has instead enabled the spread of misinformation, online harassment, and social polarization. The article suggests a "notice-and-takedown" approach and other modifications to hold platforms accountable while preserving the law's benefits. Reform is necessary to mitigate the negative impacts on social discourse and restore some responsibility to the internet. It's Time to Restore Some Sanity to the Internet-Mother Jones.

A Trip Full of Pitfalls

MDMA's approval for PTSD treatment faces significant hurdles after an FDA advisory panel voted against recommending approval due to issues like biased self-reporting and inconsistent psychotherapy standards. The "unblinding" effect, where participants likely knew if they received MDMA or a placebo, raises concerns about the validity of positive outcomes. Allegations of therapist misconduct and insufficient monitoring of side effects further complicate the case. With the FDA's decision pending, the future of MDMA-assisted therapy remains uncertain, highlighting the challenges in proving the efficacy and safety of psychedelic treatments. The panel's decision will slow but likely not dampen interest in the use of psychedelics for mental health. "In many ways, we're creating a new field of medicine," said Lykos' senior medical director, Alia Lilienstein. The Case for MDMA's Approval Is Riddled With Problems | WIRED.

The Potential of Psychedelics

Gül Dölen, a neuroscientist and psychiatric researcher at the University of California, Berkeley, discusses the surprising potential of psychedelics to change the lives of those grappling with addiction, depression, and post-traumatic stress. A must-listen if you're curious about psychedelics and before you get too discouraged by the FDA Panel's decision this week. ‎The Joy of Why: Can Psychedelics Improve Mental Health?

Xylitol's Hidden Risks

Recent research highlights a concerning link between the popular sugar substitute xylitol and an increased risk of heart attack and stroke. While xylitol is widely used for its dental benefits and low-calorie content, new findings suggest potential cardiovascular dangers. This revelation urges caution for those seeking healthier sweetener alternatives, emphasizing the need for further investigation into xylitol's long-term effects on heart health. Xylitol Increases Heart-Health Risks (Thanks, Dave - NextDraft).

When Drugs Go Wild

Modern drug pollution is transforming wildlife, with meth-addicted trout, fearless perch, and sex-changed fish among the casualties. Pharmaceuticals like antidepressants and contraceptives, entering ecosystems via inadequate waste treatment, are altering animal behavior and physiology. Diclofenac, an anti-inflammatory, caused a dramatic decline in India's vultures, leading to increased rabies from unconsumed cattle carcasses. Experts urge urgent reform in drug design to mitigate these unintended ecological impacts, emphasizing that the same properties that make drugs effective in humans pose severe risks to biodiversity. Environmental exposure to pharmaceuticals is a pressing global issue demanding immediate attention. Meth-addict fish, aggro starlings, caffeinated minnows: animals radically changed by human drugs. (Thanks again Dave-NextDraft).

Food Waste Unpeeled

America's apple obsession reveals the broader issue of food waste. Despite producing 4.36 million metric tons of apples annually, a significant portion rots due to factors like overproduction and market fluctuations. This waste is emblematic of a more substantial problem, with 30-40% of all food in the U.S. wasted, equating to 133 billion pounds annually. The waste spans all stages of food production, exacerbated by weather, inefficient storage, and consumer habits. Innovations like controlled-atmosphere storage and advocacy from groups like The Farmlink Project show promise, but systemic change is essential to curb this massive loss and its environmental impact. America's Favorite Fruit Reveals The Hidden Truth About Food Waste.

+See Also: The Rotten Secret Plaguing America's Grocery Stores.

An Operating Room "Black Box."

Teodor Grantcharov's AI-powered "black box" aims to revolutionize surgical safety by recording and analyzing all OR activities. The technology captures everything from instrument use to environmental factors, offering a comprehensive view of operations. Despite the potential for significant improvements in safety and efficiency, the system faces resistance due to privacy concerns and fear of legal repercussions. Hospitals are divided between leveraging this data for quality improvements and managing the overwhelming influx of information. As the black box spreads, it promises a new era of transparency and enhanced patient care. This AI-powered "black-box" could make surgery safer | MIT Technology Review. (paywall).

Dodging Microplastics

Microplastics in food, air, and household items pose potential health risks. To minimize exposure, opt for less processed foods, use glass containers, avoid heating plastics, and switch to loose-leaf tea. Limit plastic use in furniture and clothing; frequent vacuuming with a HEPA filter and damp cloths can reduce indoor microplastics. Choose reusable water bottles and consider laundry solutions like special filters or washing less often. While complete avoidance is impossible, making informed choices can reduce microplastic intake, emphasizing the importance of manageable, everyday actions.How to Minimize Your Exposure to Microplastics - The New York Times (gift article).

074 - The Yips, Resilience, and Pig-Plant Hybrids - HealthHippieMD Week In Review

Mitochondria: Unmasking the Culprit Behind Long COVID Fatigue

In the article Scientists Pinpoint Key Part of Cells That Could Drive Long Covid Fatigue researchers shed light on the mysterious fatigue that often plagues long COVID sufferers. They reveal how the mitochondria, tiny energy factories within our cells, play a pivotal role. By studying the dysfunctional mitochondria in long COVID patients, scientists hope to uncover new treatment avenues, offering relief and insight into the lingering exhaustion that many survivors face. This research illuminates the cellular culprit behind post-COVID fatigue and opens doors to potential solutions for this debilitating condition.

The Magic of Immersive Tasks

Amid the 6-Day Energy Challenge, the New York Times explores the concept of flow states, where individuals become wholly absorbed in an activity, losing track of time and self-consciousness. These moments of intense focus, as described by positive psychology pioneer Mihaly Csikszentmihalyi, can lead to increased alertness and motivation. The article suggests finding your "low-stakes flow state" by identifying past immersive experiences and hobbies that bring joy. It offers various time-friendly activities, from learning a foreign language to tackling an adult Lego set, emphasizing the rejuvenating power of losing oneself in a task. The Energy Challenge: How Losing Yourself in A Task Can Boost Your Mood - The New York Times. (gift article)

The Mediterranean Diet's Heart-Healthy Legacy

The Mediterranean Diet, rooted in decades of research and the lifestyle choices of millions, emerges as a powerhouse for heart health. This lifestyle, emphasizing whole, unprocessed foods and rich in fruits, vegetables, legumes, nuts, and olive oil, showcases an impressive array of benefits, including lowered blood pressure, cholesterol and a reduced risk of Type 2 diabetes. Moderation is key, with occasional indulgences allowed. While not a guaranteed cure, the Mediterranean Diet can substantially enhance heart health with other healthy habits. With the potential for cognitive improvements within days and lasting benefits with commitment, this diet is a delicious and sensible choice. The Mediterranean Diet Is That Good for You. Here's Why. - The New York Times. (gift article)

Ozempic's Potential: Beyond Weight Loss, a Medical Revolution in Progress

The article Can Ozempic and Weight-Loss Drugs Treat Other Diseases? - The New York Times(gift article) explores the groundbreaking impact of drugs like Ozempic, which have revolutionized the treatment of obesity and diabetes. Scientists are now embarking on numerous clinical trials to investigate their potential in treating a wide array of conditions, from alcohol use disorder to polycystic ovary syndrome, liver disease, cardiovascular issues, sleep apnea, and kidney disease. These medications could offer hope to millions of patients with limited treatment options while presenting a lucrative pharmaceutical company market. As researchers unravel the mysteries of these drugs, they promise to reshape the future of medicine.

Reducing Food Waste

"In the United States, most dates consumers see on food items are for freshness, not safety, according to the U.S. Department of Agriculture." "A product past its 'best, if used by' date, may not taste as good as something fresh off the shelf. But it is often perfectly healthy to eat." The Washington Post had some great tips on how to minimize food waste. How to reduce food waste while cooking at home - The Washington Post (gift article).

A Surgeon Faces the Yips

"The principle "everything else is fixable" can apply to so much of life." The Washington Post published an opinion piece on the folly of perfectionism. Opinion | I had the yips as a young surgeon. Here's what it taught me. - The Washington Post (gift article).

Stepping into Creativity

In this article, titled How Walking Fosters Creativity Stanford researchers validate a timeless belief held by philosophers and writers - that walking enhances creativity. The study underscores how strolls can significantly boost creative thinking and problem-solving abilities. By examining participants' cognitive processes and neural activity while walking, the research confirms that walking sparks innovative thoughts and ideas. The findings provide scientific evidence for the age-old practice of "thinking on your feet" and highlight the valuable role of walking in nurturing creative thinking.

Building Resilience: The Recipe for Stress Management

In the article, What is resilience? A psychologist explains the main ingredients that help people manage stress, the author explores the concept of resilience and its vital role in handling stress effectively. Drawing on psychological insights, the article highlights the key components that contribute to resilience, such as adaptability, social support, and a positive mindset. By delving into these main ingredients, the author offers valuable insights into how individuals can cultivate resilience to better cope with life's challenges and stresses, ultimately leading to improved mental well-being and overall success.

Plant-Pig Hybrids Fake Meat Revolution

Moolecs, a cutting-edge biotech company, has unveiled a novel approach to enhance the taste and texture of plant-based meat alternatives. By creating plant-pig hybrids, Moolecs is bridging the gap between plant-based and animal-derived meats, promising consumers a more authentic, meatier experience. Through innovative genetic engineering, they have integrated essential flavor and texture components from pigs into plants, offering a sustainable and ethical solution for meat production. This exciting breakthrough can potentially revolutionize the fake meat industry and satisfy the cravings of even the most devoted carnivores. I have three words: No, thank you. The Plan to Put Pig Genes in Soy Beans for Tastier Fake Meat | WIRED.

004 - Fighting Food Waste, Dark Cheerfulness, What We Smell in Our Friends - HealthHippie Week In Review - August 7, 2022

Revamping the Food Expiration System

Americans waste about one-third of their food. The article, Food expiration dates are broken — a microbiologist explains how to fix them discusses revamping the system to be more beneficial for consumers (and to decrease food waste).

Hospital Rankings

This week, the U.S. News and World Report released its hospital rankings. The podcast episode, Should We Trust Hospital Rankings? is an interesting discussion of the ranking system and how the rankings could be improved. "Hospitals compete for prime spots on the U.S. News rankings — but could those lists do more harm than good?"

The Dark Side of Cheerfulness

"Emotions are usually defined by their ungovernability, experienced as forces that wash over us and challenge our sense of agency. That quality is what makes most seem authentic and trustworthy to us. Fake anger or love feels like a betrayal. But fake cheer?..." The excerpt is taken from the book review, The Dark Side of American Cheerfulness on the book: Cheerfulness: A Literary and Cultural History. The review is well worth the read, touching on psychology, culture, history, philosophy, and politics.

Smell you Later

Many of us believe we have cognitive control over most aspects of our lives, including the people we call friends and the people we choose as romantic partners. With all types of human connections, some just "click," but the basis behind interpersonal chemistry remains elusive. As with all things physiological, the story is complex. Do we like our friends because they stink like we do is a reminder that at our core, we are just evolved animals. These researchers claim they can determine "chemistry" between two individuals with 71% accuracy using only their smell.

Pandemic and Positive Emotions

Listened to the Pushkin Podcast from the Happiness Lab with Laurie Santos, What Did the Pandemic Teach Us About Happiness? about the role the pandemic played in happiness. The discussion referred to Surgeon General Vivek Murthy's NEJM article, Confronting Health Worker Burnout and Well-Being. In 2017 I tried to get my proposal, Measuring the impact of biofeedback-enhanced meditation on resident stress, burnout, and well-being, funded. The plan was to begin with residents but ultimately study the entire perioperative healthcare workforce. The proposal was not funded. I remain just as interested today as I was back then, maybe more so now that my daughter has started her long medical training.

Questioning the Theory of Chemical Imbalance in Depression

The manuscript, The serotonin theory of depression: a systematic umbrella review of the evidence. stirred quite a bit of controversy. The commentary in Slate, Why has the misleading chemical imbalance theory of mental illness persisted for so long was one of the better articles I read.

Nutrition and Mental Health

And while we are on the topic of mental health, I discovered a new podcast this week from ZOE Science and Nutrition. I listened to two of the episodes. Both were excellent with a mix of science and actionable advice: How food can improve your mood and Can you reverse damage from a bad diet?

Can We Cure Aging?

Medscape published an excellent brief overview of longevity research: Is There a Cure for Aging?

Dr. Amazon is In

Several interesting stories about Amazon this week. First, an article about Alexa's potential utility in early diagnosis of cognitive decline: Alexa could diagnose Alzheimer's and other brain conditions — should it? The article discusses the technology and some of the ethics behind continuous digital monitoring—food for thought. Voice technology will continue to improve in its ability to "diagnose" many mood and cognitive disorders.

+I woke up to news that Amazon is interested in purchasing iRobot, the company that makes the Roomba. Roomba has a "Smart Maps" feature that maps the interior of your living area. The article focuses on Amazon as a surveillance company. I don't necessarily agree. I wouldn't be surprised if Amazon's interest in iRobot has medical applications--perhaps mapping the safety of an elder's environment to minimize falls. I look forward to hearing more about this deal.

Bacteriophages and IBD

I read an exciting news story on Inverse, Bacteria-eating virus cocktails may effectively treat gut inflammation, that covers the findings in the manuscript, Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation. An Israeli-led team (that includes UNC's Dr. Ryan Balfour Sartor) zeroed in on a strain of bacteria, Klebsiella pneumoniae, and demonstrated the bacteria could cause IBD like symptoms in mice. They then developed a cocktail of phages (viruses that selectively attack particular bacteria) that targeted K. pneumonia and ameliorated damage caused by the bacteria. The authors are now beginning clinical trials. I plan to follow this work carefully.

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