Pharmaceutical

093 - Electric Dreams, Face Time, and Your Gut on Salt - HealthHippieMD Week In Review

Face Time

Unlike virtual connections, regular face-to-face interactions with friends significantly enhance physical and mental health. Studies reveal that in-person meetings boost the immune system, reduce stress, and improve overall well-being, comparable to the effects of a Mediterranean diet. Frequent physical contact, such as hugs, also benefits the hypothalamic-pituitary-adrenal axis, lowering inflammation and improving sleep. Additionally, our sense of smell and neural synchrony are crucial in forming deeper, more empathetic connections. Decreased time spent with friends underscores the importance of rekindling in-person socializing for better health. In-person friendships are better for health than virtual connections - The Washington Post (gift article) (Thanks, Amy!).

Paws-in

The viral "paws-in" challenge on TikTok sees dogs imitating their owners by placing a paw atop a stack of human hands. The trend delights viewers, showcasing dogs' ability to mimic, seek attention, and connect with their human families. Experts highlight the role of training and innate behavior in dogs' responses. Even if some dogs don't join in perfectly, their varied reactions—using their muzzle or looking for cues—emphasize the deep bond between humans and their pets. The challenge underscores the joy and heartwarming connection pets bring to their owners' lives. Dogs are doing the viral 'paws in' challenge. Here's why. - The Washington Post (gift article).

Electric Dreams

Researchers have explored using electricity to control the immune system for over a decade, promising a revolution in treating chronic diseases like rheumatoid arthritis and diabetes. Despite substantial investment, electroceuticals—implants designed to replace drugs—haven't yet fulfilled their early promise. Meanwhile, new research into bioelectric medicine shows potential for innovative treatments, including fast-healing bandages and cancer therapies. The field faces challenges, including precise targeting and overcoming biases toward nervous system-centric approaches. As research evolves, the dream of electrically hacking the body for better health remains an electrifying possibility. The decade-long quest to hack the body's immune system with electricity | MIT Technology Review.

+see also: 091 - Meta Heads, Embracing Solitude, and The Brain's Immunity Master Switch - HealthHippieMD Week In Review — HealthHippieMD.

Mediterranean Eating May Boost Brain Health

A new study in Nature Aging suggests the Mediterranean diet, rich in fatty acids, carotenoids, and vitamin E, may slow cognitive decline. Researchers from the University of Illinois and the University of Nebraska-Lincoln found that participants aged 65-75 with delayed brain aging had larger brain volumes, better connectivity, and higher cognitive scores. Essential nutrients included α-linolenic acid and eicosapentaenoic acid from fish and plants, carotenoids from colorful vegetables, and vitamin E from nuts and oils. While promising, the study calls for further research across diverse populations. New Study Suggests Mediterranean Diet May Slow Cognitive Decline.

Cognitive Harmony

Understanding cognition requires viewing the brain's large-scale coordination of neural activity, driven by rhythmic electric fields, rather than focusing on individual neurons. MIT neuroscientists argue that brain rhythms, once dismissed as mere byproducts, are crucial for organizing neural activity. These rhythms influence cognition and could be key to treating disorders like schizophrenia and epilepsy. Brain waves like beta and gamma rhythms coordinate complex cognitive tasks, acting like stencils guiding neural activity. Scientists hope to unlock deeper insights into how thoughts and memories form and function by studying these rhythms. To understand cognition, neuroscientists must learn its rhythms - Big Think.

The Brain-Belly Connection

In this episode of the Huberman Lab Podcast, Stanford's Dr. Andrew Huberman hosts Dr. Diego Bohórquez of Duke University. Dr. Bohórquez, an expert in gastrointestinal physiology and neuroscience, delves into the gut-brain axis, focusing on how our gut senses food. Unlike the popular microbiome focus, Dr. Bohórquez explores how our gut detects nutrients like amino acids, fats, and sugars, akin to how our eyes sense light. This episode reveals the intricate sensory mechanisms within our digestive system, offering a deeper understanding of how our gut communicates with our brain. ‎Huberman Lab: Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis.

Following the Pharma Funds

How much Big Pharma is paying doctors discusses the financial relationships between doctors and pharmaceutical companies, highlighting the Open Payments website. This platform, run by Medicare, allows the public to see the payments made to doctors by healthcare companies. A recent JAMA study revealed that many physicians endorsing products on social media have received payments from the companies behind these products. The article emphasizes the importance of transparency in understanding these financial ties and their potential impact on healthcare costs and quality in the U.S.

Your Gut on Salt

Excessive salt, though essential historically, disrupts the gut microbiome, likely contributing to health issues like high blood pressure, heart disease, and metabolic disorders. Modern diets, laden with processed foods, exacerbate these problems. High sodium intake alters beneficial gut bacteria, leading to inflammation and metabolic disruptions and increasing cravings and weight gain. Reducing salt intake and focusing on unprocessed, plant-based foods can help maintain a healthy microbiome and prevent disease. The push for lower sodium in diets faces challenges from industry lobbyists, but evidence for its necessity continues to grow. How Salty Food Can Poison Your Microbiome.

Jazz Mind and Flow

Researchers at Drexel University's Creativity Research Lab studied how jazz musicians reach a creative "flow state." They discovered that flow involves a balance between expertise and releasing focus. Using EEG, they recorded the brain activity of 32 jazz guitarists, finding that flow states correlated with reduced frontal lobe activity, indicating low cognitive control. Experienced musicians showed enhanced sensory brain activity. The study suggests achieving flow requires extensive practice and the ability to let go of conscious control, allowing automatic, creative responses. This dual approach can help in mastering any creative task. Brain Scans of Jazz Musicians Reveal How to Reach a Creative' Flow State' | Scientific American.

+see also: We all can reach a "flow state." Here's how. - Big Think.

056 - Dementia Prediction, Button Dogs, Prosody, and Ink Therapy - HealthHippieMD Week In Review

Mind Your Risk: New Tool Predicts Dementia Likelihood

To crack the code of dementia risks, researchers have unveiled an innovative tool that forecasts an individual's chances of developing the condition within the next 14 years. This predictive model, known as the U.K. Biobank Dementia Risk Score (UKBDRS), delves into 11 crucial factors, including age, education, diabetes history, depression history, stroke history, parental dementia history, deprivation levels, blood pressure, cholesterol levels, living arrangement, and gender. The tool, which also considers the influence of the APOE gene, trumps other risk assessments and offers a 40% chance of preventing cases by targeting modifiable factors. Dementia risk study finds 11 key factors behind condition.

Feeling the Beat: Haptic Suits

This article features haptic suits—backpack-like devices that translate music into vibrations on the skin. Haptic technology advancements have fueled innovations in creating shared musical experiences for all concertgoers, blurring the lines between hearing and feeling the groove. Haptic Suits Let You Feel Music Through Your Skin - The New York Times. (gift article)

Another Brick in the Wall: Neuroscience of Prosody

You may have heard scientists recreated parts of Pink Floyd's Another Brick in the Wall using only the brain's electrical signals. Here is a short video on the research and its implications: Tuning into the Brain's Music: Decoding Song from Brainwaves - Neuroscience News.

Button Dogs

If you spend time on TikTok or Instagram, you're probably familiar with "button dogs" who communicate with their families by stepping on electronic pads that speak words when pressed. Can dogs use language in this way? Scientific American elaborates: Can Dogs Use Language? - Scientific American.

Nurses TRAPped

Healthcare employers use a sneaky tactic called "Training Repayment Agreements" (or TRAPs) to keep nurses from leaving their jobs. These agreements make nurses repay training costs if they quit within a specific time, essentially trapping them with financial obligations. Neil Rudis, a nurse, found himself stuck in this web, unable to leave due to the debt. These debt-based schemes are rising in nursing as companies try to deter nurses from changing jobs. While some companies are ditching TRAPs, many nurses still grapple with these financial shackles, affecting their well-being and worsening workforce shortages. Health Care Companies Are Using Debt to Trap Nurses on the Job – Mother Jones.

Feed Me: A.I. Sparks Race for Information

The escalating demand for A.I. model training data prompts a creative scramble among A.I. makers. As larger models require vast datasets, A.I. companies are hunting for new sources of information while organizations with substantial data holdings seek ways to monetize them. This article discusses how the scarcity of quality training text, the legal battles around copyright infringement, and the push for compensation for ingested material reshape the A.I. landscape. The pursuit of data has led to partnerships and deals with media outlets, record labels, scientific publishers, and other data-rich entities, igniting a fervent competition for valuable information. A.I. is setting off a great scramble for data.

Sleep Debt

A large percentage of the American public is sleep-deprived. Unfortunately, repaying a sleep debt is more demanding than you might think: Here's why there's no quick fix for sleep deprivation - Big Think.

Aging Well

Aging isn't a one-size-fits-all journey – it's a tangled interplay of biology and environment. This expert breakdown by biologist Ellen Quarles reveals why aging is a unique experience for each person and even for cells within our bodies. Unraveling the intricate web of cellular processes, from DNA repair to protein recycling, Quarles explains how aging disrupts this delicate network. While there's no magic cure, interventions that target multiple critical cellular processes might hold the key to extending our healthier years. So, don't expect a universal anti-aging remedy, but rather embrace the intricate puzzle of your own unique aging path. Aging is complicated – a biologist explains why no two people or cells age the same way, and what this means for anti-aging interventions.

Nurturing Gut Microbes for Well-Being

Your body is a reflection of what you eat. These Gut Microbes Are Crucial To Well-Being — What To Eat To Cultivate Them delves into the pivotal role of gut microbes in regulating your well-being.

Drug Cost and Value-Based Pricing

When Dying Patients Want Unproven Drugs | The New Yorker got me thinking about incentives for the pharmaceutical industry in the U.S. I went down a rabbit hole and ended up learning quite a bit about value-based pharmaceutical pricing. Value-Based Pricing of Prescription Drugs Benefits Patients and Promotes Innovation - Center for American Progress. is well worth a read.

A.I. Helps Stroke Survivor Speak Again

In a heartwarming breakthrough combining neuroscience and artificial intelligence, a paralyzed woman's thoughts are translated into speech through an avatar. Ann Johnson, who lost her speaking ability after a stroke at 30, saw her brain signals converted into vocalized language by implanted electrodes. This achievement, reported in the journal Nature, is a first in synthesizing spoken words and facial expressions directly from brain activity. This milestone holds promise for those who've lost speech due to strokes or conditions like cerebral palsy. The aim? To restore not just words but the essence of who people are. A.I. Helps a Stroke Patient Speak Again, a Milestone for Tech and Neuroscience - The New York Times. (gift article)

Avocado Odyssey

Avocado aficionados know the disappointment of bringing home what appears to be the perfect avocado only to find it mushy or tasteless. The capricious nature of avocados is due to their unique ripening process, setting them apart from other fruits. The article, How to select a perfectly ripe avocado. delves into choosing the perfect avocado.

Ink Therapy

A new study suggests that combatting post-traumatic stress disorder (PTSD) could be as simple as putting pen to paper. This innovative treatment involves supervised 30-minute writing sessions where patients recount their traumatic experiences. , this approach proved as effective as traditional talk therapy in a study involving 178 veterans. Importantly, dropout rates were significantly lower in the writing group. This method, known as written exposure therapy, inspired by "expressive writing" experiments from the 1980s, offers a quicker, potentially more accessible alternative to established PTSD treatments. As the field evolves, the healing power of words gains renewed attention. Writing Therapy Shows Promise for PTSD - The New York Times. (gift article)

039 - Centenarian Excrement, Creativity, and Cannabinoids - HealthHippieMD Week In Review

How to Make Peace with Your Feelings

How Leaning Into Negative Emotions Can Help Your Mental Health (gift article) is about accepting negative emotions for what they are: part of the human experience. What you do with the experience strongly influences your health and well-being.

Generative AI in Medicine

Wired had a story about ways generative AI will impact medicine, along with several caveats: ChatGPT Can Help Doctors—and Hurt Patients.

The Two Personality Traits that Predict Well-being

If you lack either (I'm strongly introverted, not extroverted), hope is not lost. Study Finds 2 Personality Traits Predict Well-being — But Don't Worry if You Don't Have Them.

The World's Rarest Eye Colors

Do you have one of the six rarest types of eye color? Read What Is the Rarest Eye Color?.

Is Alcohol in Moderation Good for You?

The Great Alcohol Health Flip-Flop Isn't That Hard to Understand—if You Know Who Was Behind It is an interesting article on how the supposed health benefits of a small amount of alcohol have been turned on its head, again.

What You See Is Not Always What You Get

The NY Times had an article about a recent publication in JAMA focused on melatonin gummies: "A team of researchers analyzed 25 melatonin gummy products from different brands and found that 22 contained different amounts of melatonin than what was listed on their labels; one contained only 74 percent of the advertised amount of melatonin, while another had 347 percent of the labeled amount. Yet another product contained no detectable melatonin at all." 22 Out of 25 Melatonin Products Were Mislabeled, Study Finds. (gift article) See also: ConsumerLab: Independent Testing of Supplements and Botanicals.

Hope

The Atlantic had an interesting article, Why Economists Should Study Hope, that discusses why hope is so important and how to cultivate more.

The Quest for Longevity

The Quest for Longevity Is Already Over is an interesting read. One of the points I strongly agree with in the article is that extending healthspan (the length of time one is healthy) is far more important than extending longevity (the length of time one lives).

Oura Partners with Best Buy

I love my Oura smart ring. I've worn mine for years. The hardest part of the purchase process was the sizing. Sizing will be less of an issue as you can soon walk into Best Buy and find a fitting station. The article Oura Is Proof That Smart Rings Are Here to Stay discusses the Oura Ring and some of the upcoming competitors.

Cannabis, Cannabinoids, and Delta-8 THC / Delta-10 THC

Cannabis-derived products like delta-8 THC and delta-10 THC have flooded the US market – two immunologists explain the medicinal benefits and potential risks is a quick overview of some of medicinal and side effects of cannabinoids. The article discusses hemp, cannabis, and a few of the cannabinoids.

Creativity / Rick Rubin

I enjoy writing words and music. I'm not good at either, but the process brings me joy. Rick Rubin's new book is about the creative process: The Creative Act: A Way of Being: Rubin, Rick. I've been a big fan of Rubin's Broken Record Podcast. I also enjoyed watching Rick Rubin: The 60 Minutes Interview - CBS News and hearing him interviewed on Rick Rubin on How to Make Something Great. I'm adding the book to my "must-read" list.

Brainstorming with ChatGPT

Wired had an article on how to brainstorm better with the generative AI platform: 6 Tips for Using ChatGPT to Brainstorm Better

What Can We Learn About Aging from Centenarian Excrement?

The longest-living people have a more diverse microbiome than their less healthy peers. A study published this month, Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures looked at the gut microbiomes of centenarians — individuals who've reached or surpassed a century in age — and compared them against old, middle-aged, and young adults. Their results showed, "regardless of health status, the centenarians had a unique enterotype that is a combination of the two found in young adults aged 20 to 44 — Bacteroides — and older adults — Escherichia and/or Shigella." Read the study synopsis here: Centenarians Have Super Healthy Gut Microbiomes — Can This Help Us Live Longer?

Pill Popping Polypharmacy

"Getting people off drugs is unfamiliar terrain for modern health systems, mostly set up to put patients on them. But that is beginning to change. Doctors, pharmacists, and nurses are setting up "deprescribing networks" to try to spread the word." The Economist published an article on the overprescription of medication: Too many people take too many pills.

FDA-Approved Video Games

Much of my research at Duke focused on using video game technology in healthcare and healthcare education. It was fantastic to read this synopsis of Akili [^1] and EndeavorRX, an FDA-approved video game for treating ADHD. I can think of many more uses of the platform. The story behind an FDA-Approved Video Game Treatment for ADHD


[^1]: I am an Akili Interactive shareholder.

027 - Wise-Selfishness, Horvath's Clock and GrimAge - HealthHippieMD Week In Review

Wise Selfishness

"....a truly enlightened self-interest also means recognizing that acting in great and altruistic ways makes you happier than solely being out for yourself." I enjoyed reading The Benefits of Being Selfish.

Nobody Has My Condition But Me

We often think that in modern medicine all maladies have been cataloged. That is far from the truth. Nobody Has My Condition But Me is about the trials and tribulations of a woman with a unique condition.

Recycling Plastic

More on recycling of plastic: Is plastic recycling a scam? Here's the truth about the common practice. We have a long way to go....

David Crosby's 15 Essential Songs

Another rock icon passed away last week. The NY Times published a list of David Crosby's best songs: David Crosby's 15 Essential Songs. (gift article)

10 Myths in Nutrition

An interesting article for both the myth-busting and the experts consulted: 10 Nutrition Myths Experts Wish Would Die (gift article)

The Microbiome and Thermoregulation

This summary article had a wealth of provocative information:

  1. The presence or absence of certain bacteria was associated with the body's temperature response in sepsis (in both humans and mice).
  2. Mice without a microbiome have a lower basal body temperature than conventional mice.
  3. The administration of antibiotics lowers basal body temperature.

The authors of the study opine that changes in the microbiome may account for the reduction in basal body temperatures of humans over the last 150 years: Gut Microbes Control the Body's Thermostat

Mixed Feelings

Feeling conflicted can feel worse than feeling bad and can bring with them a great deal of distress. Mixed Feelings Can Be Worse Than Bad Ones offers advice on how to overcome the distress.

Amazon is Happy to be Your Pharmacy

Here's an article on Amazon's RxPass, the newest service from Amazon. With a Prime Membership, you can receive as many of the 80 generic medications the service offers for a flat fee of $5 (assuming you have insurance and are not on Medicare or Medicaid). Amazon Will Now Be Your Pharmacist, If You Subscribe to Prime

Food Compass

A relatively new system aims to demystify identifying healthy and unhealthy foods. Parsing which foods are healthy and which are less so isn't always straightforward – a new rating system aims to demystify the process explains.

Gene Snippets from Mother Shape a Baby's Microbiome

A recent study published in Cell demonstrated that it's not just pure bacterial transfer between mother and baby that's important in developing a newborn's microbiome. Small pieces of DNA called mobile genetic elements hop between maternal and newborn bacteria and ultimately influence the baby's microbial development: Mobile Genes From the Mother Shape the Baby's Microbiome.

Odors Change Purchasing Decisions

I did not realize there was a body of research on the sense of smell and consumerism. How body odors influence your buying behavior explains the latest research.

Yerba Mate

Although Yerba Mate is a staple of South American dietary traditions, traction in the U.S. has slowly evolved. The recurrent description of the taste, "like freshly cut green grass," will not help to stimulate demand. The Coffee Alternative Americans Just Can't Get Behind

The Universal Aging Clock and GrimAge

Aging research is all the rage. Here is an interesting article on Horvath's Clock, GrimAge, and the effects of umbilical and young blood plasma transfusion: The Universal Clock of Aging. I learned about the GrimAge metric. I'm continuing to keep a close eye on this body of research.

The Benefits of Yoga

Another article on the benefits of yoga: Yoga: Modern research shows a variety of benefits to both body and mind from the ancient practice. For the latest science: Yoga: What You Need To Know | NCCIH

Adding New Life to Friendships and Relationships

TED had an article with helpful information on how to revitalize interactions with the people most important to you: How to add new life to your relationships (even your best ones!) |

Neurocognitive Testing for Aging Physicians

An interesting interview tackling the subject of competency exams for physicians: Age Competency Exams for Physicians -- Yes or No? For the record, I think it's a good idea.

Physicians Open Notes

Being able to read what your physician writes about you in your chart is a good thing, right? Not so fast. Why Reading Your Doctor's Notes Can Be Painful covers some of the issues.

013 - Horseshoe Crabs, Nightmares, and Dementia - HealthHippieMD Week In Review

Nightmares and Dementia

Are frequent nightmares an early sign of impending dementia? This researcher thinks so. Having this many nightmares a week may be tied to extreme brain aging.

Horseshoe Crabs and the Pharmaceutical Industry

Most people don't realize that crab blood is critical to the modern pharmaceutical industry. Horseshoe crab's blue blood contains a compound that protects humans from infected medical supplies. How horseshoe crab blood became one of the most valuable liquids in medicine. Radiolab also has a great episode on this topic: Baby Blue Blood Drive.

Understanding the High Cost of Living Life Online

Studies have found that frequent social media use is connected with increased symptoms of anxiety and depression. The article, The High Cost of Living Your Life Online, discusses some reasons and how to combat those negative feelings.

The Healthiest Bedtime for Metabolic Health

A recent study, Early chronotype with metabolic syndrome favors resting and exercise fat oxidation in relation to insulin‐stimulated non‐oxidative glucose disposal, found that being a night owl negatively affects metabolic health. Early risers burn more fat when fasting or exercising: Going to bed before this time could boost your metabolic health.

Paul McCartney's Freakish Memory

This article is a stretch from medicine and wellness, but being a music and Beatles lover, I had to include it. Paul McCartney's freakish memory, delighted me, offering insight into the unconscious mind and a glimpse into McCartney's songwriting process. And now I love Paul McCartney even more.....

Ten Modern Paradoxes

I include this thought-provoking article because of the first paradox mentioned, hedonism. _"...psychologist Viktor Frankl wrote, "Happiness cannot be pursued; it must ensue, and it only does so as the unintended side effect of one's personal dedication to a cause greater than oneself or as the by-product of one's surrender to a person other than oneself." 10 paradoxes that will stretch your mind.

The Gut-Brain Axis in Mental Health

Thought to be fringe science only a few years ago, hundreds of scientists are now racing to unravel the microbiome's role in mental health. The article, What does the latest science tell us about our brain, gut, and mental health, gives a whirlwind tour. Also, see my lecture on the gut-brain axis: Gut Feelings: the role of the microbiome in behavioral health.

The Physiology and Neuroscience of Tickling

I approached the article, Why Can't You Tickle Yourself, with skepticism, but ended up learning quite a bit. I'm going to look more into the science of playfulness.

Why We Do Things We Know We'll Regret

" Use your resources joyfully, without guilt or shame for your abundance. But use your bounty in service of the love you have for others. Beyond your everyday needs, buy time and experiences with your loved ones. Support the people and causes you care about. Invest in getting to know others deeply. While you're at it, beyond your generosity with your money, give more of yourself by sharing your heart with honesty and defenselessness. Tell more people you love them, even when it is a little awkward or scary." I enjoyed this article by Arthur Brooks: Why We Do Things We Know We'll Regret.

The Pandemic Changed our Personalities, and not for the Better

Social scientists think of personality as being relatively stable throughout one's life. But, there is increasing evidence that the pandemic altered many of our personalities, and not for the better: The COVID pandemic may have had a lasting impact on personality traits

Fungi and Cancer

Two interesting articles were published in this week's Cell demonstrating an association between intracellular fungal DNA and cancer lethality in multiple cancer types. Despite the finding, neither study can definitively say if fungi drive these poor outcomes or if aggressive cancers create an environment where these fungi can quickly grow. The studies also don't address if fungi can contribute to cancer development, pushing healthy cells to turn cancerous. The finding opens the door to a new research domain: Fungi grow inside cancerous tumors, scientists discover.

Facing Down Loneliness and Heartbreak

Emerging scientific data suggests that social rejection — often in the form of heartbreak — can spark a similar firestorm of brain activity as physical pain. Vivek Murthy, United States Surgeon General, classifies loneliness as a public health crisis. But loneliness can be hacked: An antidote to heartbreak? Science reveals how to hack loneliness. See also the book, Heartbreak: A Personal and Scientific Journey, mentioned in the article and Vivek Murthy's book Together.

Physician Burnout

Physician burnout was a problem before the pandemic and has only accelerated during Covid times. I was well aware of the phenomenon, but what I was not aware of was that burnout is contagious: Physician Burnout Has Reached Distressing Levels, New Research Finds.

Can Technology Prevent Suicide?

Finally, I read an article on attempts to use technology to predict and contribute to suicide prevention: Can Smartphones Help Predict Suicide

Quote of the Week

"The saddest aspect of life right now is that science gathers knowledge faster than society gathers wisdom." ―Isaac Asimov