Ketamine

064 - AI Lucid Dreams, Long Covid, and Glowing Guts - HealthHippieMD Week In Review

Getting Gold through Crowdfunding

Olympic gymnast Mary Lou Retton joined the ranks of countless Americans, turning to crowdfunding to cover her substantial medical expenses incurred during a battle with rare pneumonia. Her daughter launched a fundraising campaign on Spotfund, and the public rallied, astonishingly raising $350,000 in under two days, surpassing the $50,000 goal. This peculiar juxtaposition highlights the harsh reality of healthcare costs in the U.S., where a quarter million Americans initiate crowdfunding campaigns yearly. Sadly, most don't reach their targets; studies show that 16% receive no donations. This underscores the stark inequalities within the American healthcare system. Mary Lou Retton Crowdfunded Her Medical Debt, Like Many Thousands of Others - The New York Times. (gift article)

Scientists Unearth New Clues to Long Covid

In an unexpected twist in Long Covid, researchers suggest that the villain might be lurking in the gut. In a study published in the journal Cell, scientists from the University of Pennsylvania propose that the remnants of the coronavirus residing in the digestive tract could be suppressing serotonin production, the brain's feel-good neurotransmitter. This serotonin shortage could explain the cognitive and neurological symptoms experienced by many Long Covid sufferers. The research offers a fresh perspective on the condition and potential treatment avenues, proving that sometimes the gut feeling isn't just a metaphor. Scientists Offer a New Explanation for Long Covid - The New York Times. (gift article)

FDA Sounds Alarm on Ketamine Misuse

The FDA is raising eyebrows about the reckless use of ketamine, the anesthetic pharmaceutical (and sometimes party drug) that's been rebranded as a depression and anxiety remedy. They're concerned about the growing trend of online marketers doling out ketamine prescriptions via telemedicine, sidelining the need for medical supervision. While ketamine therapy for mental health shows promise, the regulatory haze around it has spurred abuse. The FDA warns that unsupervised use could lead to serious health problems despite its "off-label" legality. Before you consider a virtual consultation for ketamine, think twice. FDA Issues Warning Over Misuse of Ketamine Therapy - The New York Times. (gift article)

How Not To Age

I'm a big fan of Michael Greger and NutritionFacts. Dr. Gregor's new book, How Not to Age, is coming out this December. He has a few previews of the information here: anti-aging | Health Topics | NutritionFacts.org.

Emotional Costs of Sleepless Nights

A Psychology Today article highlights the emotional toll of sleep deprivation. Beyond the evident fatigue, insufficient sleep can destabilize our delicate equilibrium, leading to intensified negative emotions and unpredictable mood swings. It's a poignant reminder that sleep doesn't merely rejuvenate our bodies but also plays a pivotal role in mental well-being. In essence, to remain emotionally balanced, it's imperative to count the hours and make them count. 4 Ways That Sleep Deprivation Can Harm Your Emotional Health | Psychology Today.

Ear's a Thought: Brainwave Buds

Researchers from the University of California, San Diego, have unveiled innovative earbuds to monitor brainwaves and assess health via ear sweat metabolites. Unlike traditional bulky EEG machines, these compact "neuro-buds" offer a non-invasive peek into cognitive states, potentially aiding early diagnosis of neurodegenerative diseases and even providing neurofeedback. The earbuds, embedded with minute electrodes, detect neural electrical activity during various tasks. Additionally, they can gauge stress levels, predict seizure risks, and measure vital metabolites like glucose. As a bonus, they're designed to play calming sounds based on detected neural patterns, offering users real-time mind management. New Brain-Earbuds Can Listen to Brainwaves, Improve Mood, Decrease Stress, and Possibly Predict Stroke and Neurodegenerative Diseases. ^

NCCIH on Rheumatoid Arthritis

NCCIH has a page on the science behind complementary approaches to Rheumatoid Arthritis: 6 Things To Know About Complementary Health Approaches for Rheumatoid Arthritis | NCCIH.

+And a page on paying for Integrative and Complementary Medicine (including insurance coverage): Paying for Complementary and Integrative Health Approaches | NCCIH.

Mediterranean Diet and Exercise Melt Visceral Fat

A recent study revealed that a combination of a reduced-calorie Mediterranean diet and regular exercise can significantly reduce total fat mass and dangerous visceral belly fat. Older participants following this regime gained muscle and lost considerable body fat within a year, with benefits lasting up to three years. Notably, this wasn't merely about weight loss; the program reshaped body composition from fat to muscle. The study underscores the health risks of visceral fat, linked to diabetes, heart disease, and stroke, and emphasizes the transformative potential of diet and exercise on metabolic health. Mediterranean diet and exercise reduce dangerous belly fat, study says | CNN.

Glowing Guts for IBD

An MIT team designed a pill filled with genetically engineered E. coli bacteria that emit light when detecting gut inflammation. The new device was built to aid in treating Inflammatory Bowel Disease. Photodiodes inside the pill capture this glow, while a radio chip broadcasts it externally. Merging moist microbes with dry electronics was tricky, solved with a clever adhesive barrier. After promising tests in pigs, the next step is human trials. As some pursue a "pill cam" for visual diagnostics, this pill offers a luminescent alternative. This microbe-filled pill could track inflammation in the gut | MIT Technology Review.

Sobering Stories: Physicians and Their Mental Health

The Guardian had an article on the physical and mental toll of medicine and medical training, told through the experience of a Harvard Endocrine Surgeon. U.S. surgeons are killing themselves at an alarming rate. One decided to speak out.

Lucid Dreaming with the Help of AI

Eric Wollberg and Wesley Berry have embarked on a futuristic quest with their startup, Prophetic. Taking inspiration from ancient prophets, their "Halo" device pledges to induce lucid dreams through the wonders of generative A.I. After a whirlwind fundraising season garnering over $1 million and support from tech bigwigs like Apple's neurotech team and Elon Musk's Neuralink, the buzz is palpable. But there's a hiccup: Prophetic hasn't triggered lucid dreams yet. Science suggests that inducing such dreams is feasible, but consistently doing so remains unproven, especially with Prophetic's unique method. Prophetic says its Halo device can cause lucid dreams using generative A.I. Can it?

043 - Brain Stimulation, Hacking Sleep, and Sad Music - HealthHippieMD Week In Review

Falling

About 25% of adults 65 and older will fall each year. Falls lead to bodily injury that speeds up the need for nursing care and, in some cases, death. Balance declines with age, but exercise can help stave off some of the risks of falling has some practical advice on how to minimize the risk for yourself and your loved ones.

Ozempic: A New Treatment for Addiction?

The weight-loss drug Ozempic, also known as semaglutide, shows unexpected side effects in patients. Along with suppressing appetite, people taking Ozempic have reported losing interest in addictive and compulsive behaviors such as drinking, smoking, shopping, nail-biting, and even skin picking. Scientists are intrigued by these anecdotes and have been studying drugs similar to liraglutide for their potential to curb addiction. The drug affects the brain's reward circuitry, making it a potential anti-addiction medication. Could Ozempic Also Be an Anti-addiction Drug?

Sad Music: Seeking Connection, Not Sorrow

A new study explores why we are drawn to sad songs, suggesting that it's not about experiencing sadness but seeking a sense of connection. While some theories propose that specific musical elements trigger sadness, the study emphasizes cognitive mechanisms and empathy as key factors. The findings indicate that people value emotional expression over technical proficiency in music and that listening to sad songs provides a connection, making us feel less alone. Why Do We Listen to Sad Songs? A New Study Offers an Answer. (gift article)

Mindfulness and Meditation

How meditation can change your life and mind explores the potential benefits of meditation and its ability to bring positive changes to people's lives. While the hype around meditation often includes extravagant claims, research suggests that mindfulness meditation, in particular, can have a significant impact. It enhances awareness and attention, improves emotional regulation, reduces stress, and fosters prosocial behaviors. However, it's important to approach meditation with an experimental mindset and find a practice that aligns with individual goals. Meditation is a valuable mental health tool but should not replace conventional care.

Peter Attia Publishes a Book

One of my favorite podcasts is Peter Attia's Drive.. He has been making the rounds promoting his new book: Outlive: The Science and Art of Longevity. The New York Times interviewed him, and I have to say, his intensity shined through: Want to Live Longer and Healthier? Peter Attia Has a Plan. (gift article)

Chronic Pain Linked to Orbitofrontal Cortex

A new, tiny study linked chronic pain to activity in the orbitofrontal cortex, an area involved in emotion regulation, self-evaluation, and decision-making. "The research suggests that such patterns of brain activity could serve as biomarkers to guide diagnosis and treatment for millions of people with shooting or burning chronic pain linked to a damaged nervous system." Although this article is intriguing, reader beware. Given the tiny sample size, it is hard to consider this finding much more than an intriguing idea. Much more research is needed. Chronic Pain Linked to Brain Signals in Orbitofrontal Cortex.

Hacking Sleep to Improve Creativity

Researchers at the MIT Media Lab and the Center for Sleep and Cognition have discovered that the first ten minutes of sleep, known as N1 sleep, can enhance creativity and problem-solving abilities. The study found that those who experienced N1 sleep and had their dreams incubated scored significantly higher in creativity tests than non-sleepers and those who only took naps. This research highlights the potential of N1 sleep for boosting creativity and finding innovative solutions. Harness the Creativity-Boosting Power of "N1" Sleep

Persistence Enhances Creativity

In the article Why We Get More Creative Over Time , the authors discuss the misconception that our creativity diminishes as we persist with a problem. Research shows that persistence is the key to generating more original ideas. Experiment participants consistently produced more creative ideas than they anticipated during subsequent attempts. The serial-order effect suggests that each successive idea will likely be better than the previous one. This pattern applies not only to individuals but also to companies and markets. The article challenges the myth of novelty and highlights the importance of persistence in achieving breakthroughs.

Ketamine vs. ECT for Depression in New England Journal

Electroconvulsive Therapy, for 80 years, has been considered the gold standard for refractory depression. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression, published in New England Journal of Medicine demonstrates that ketamine may be a viable option to ECT. Ketamine Matches 'Gold Standard' in Major Depression Trial. More research is needed.

Electrifying the Mind: Rhythmic Brain Stimulation Enhances Cognitive Function

A meta-analysis suggests that tACS improves cognition in healthy, aging, and psychiatric populations is a recently published paper of over 100 studies on transcranial alternating current stimulation (tACS) reveals that rhythmically stimulating the brain with electrical currents can significantly boost cognitive function. By applying controlled currents to specific brain regions, tACS induces rhythmic brain activity, enhancing mental capabilities. The analysis suggests consistent and immediate improvements in mental function, particularly in executive function, attention, and memory. Furthermore, tACS proves effective in older adults and individuals with neuropsychiatric conditions. Rhythmically stimulating the brain with electrical currents could boost cognitive function, according to an analysis of over 100 studies.

Blood Types Ranked

Here is a quick overview of blood types and their frequency in the population: What Is the Rarest Blood Type in the World?

Conspiracy Detection Kit

Political races are heating up, and with them, various conspiracy theories. Here is a toolkit to help you determine what is real: 10 rules to tell if a conspiracy theory is true or false

030 - Hard Dew, Endocannabinoids, and Thinking Like a Monk - HealthHippieMD Week In Review

ChatGPT Writes Obituaries Too

This author experimented with ChatGPT, having it write her eulogy: I Had An AI Chatbot Write My Eulogy. It Was Very Weird Although I found the concept of the article interesting, the author lost me with the last paragraph, "Regardless of how advanced these tools become, one thing should now be obvious: their well-documented biases and flawed decision-making abilities mean they should never be used to do anything of consequence." Totally disagree!

ChatGPT and Science

Are you using generative AI to generate research ideas and scholarly publications? It's already possible: "...a chatbot was deemed capable of generating quality academic research ideas." Why ChatGPT Could Usher in a New Era of Scientific Discovery

Tim Urban Writes a Book

I'm rarely excited by an upcoming book. But Tim Urban, the creative force behind Wait But Why (one of my favorite websites), is publishing a book this week (Amazon | Apple). In his latest blog post, A Short History of My Last Six Years — Wait But Why, he explains the six-year journey examining our society. "This book is my best crack at explaining what I think is an existential risk to liberal societies and what I think we need to do to get to that awesome future I used to be so excited about."

ME/CFS and the Microbiome

I've written about how Long Covid has ignited interest in a long-time ignored and misunderstood medical condition, ME/CFS. The NIH Director's blog mentioned recent clues to the disease in the microbiome: "... suggesting that imbalances in certain bacterial species inhabiting the gut could be used as measurable biomarkers to aid in the accurate and timely diagnosis of ME/CFS. It also points to a possible therapeutic target to explore."_ More Clues into ME/CFS Discovered in Gut Microbiome – NIH Director's Blog

Vibrating Pills for Constipation

Here is a new, FDA-approved medical device for the drug-free treatment of constipation: Vibrating Pill for Constipation Now Available This adds a whole new meaning to moving your bowels.....

You are not Your Attachment Style

I love the book Attached.. Here is an interesting article that offers an overview of Attachment Theory and some of the more common misperceptions: You Can Change Your Attachment Style

Friendship

The Atlantic curated a series of articles on enduring friendship: Why We Lose Our Friends as We Age - The Atlantic (subscription required)

Relationships and Serious Disease

Being diagnosed with a severe illness is challenging enough. But medical issues also can have a devastating effect on relationships/marriages: Why Men Leave Sick Wives - Facing Illness Alone

Optimism and Pessimism

"_Optimism and pessimism, it turns out, are all about the stories we tell ourselves after both our successes and our failures._" Are You (Still) an Optimist? These Questions Might Help Explain Why (gift article)

Six Steps to Improve Your Mood for Good

An academic happiness researcher advises on improving your life: The Key to Happiness: 6 Strategies To Boost Your Mood for Good

Asthma Drug Recovers "Lost" Memories (Pre-Clinical)

A side effect of sleep deprivation is amnesia, but whether memory loss is a storage or retrieval problem has been unclear. These scientists are zeroing in on the answer: "This study shows that neurons in the hippocampus retain the memories, albeit in an inaccessible state, but that they can be rescued artificially." Asthma drug brings back "lost" memories

Ultra-processed Foods and Obesity

Wired had a great overview of the impact of ultra-processed foods on body weight. "The results of the study surprised Hall. On the ultra-processed diet, people ate around 500 extra calories daily and weighed about two pounds more pounds." Fat, Sugar, Salt ... You’ve Been Thinking About Food All Wrong

Endocannabinoids and Health

Just like opiates, your body produces endogenous compounds that bind to the same receptors as compounds in marijuana. Research on endocannabinoids lags far behind opiates, but research has shown "An imbalance in the production of endocannabinoids, or in the body's responsiveness to them, can lead to major clinical disorders, including obesity as well as neurodegenerative, cardiovascular and inflammatory diseases." People produce endocannabinoids – similar to compounds found in marijuana – that are critical to many bodily functions is a nice overview. For more on endocannabinoids, see: Why does running give you a high? A look at the science and Cannabinoids - HealthHippieMD

The Brain and the Immune Response

Nature had an excellent overview of efforts to unravel further how the brain affects immune function: Your brain could be controlling how sick you get — and how you recover (subscription required)

The Dark Side of Ketamine Telemedicine

Covid influenced many changes in medicine. One of those changes was a loosening of regulations surrounding the remote prescription of controlled substances. A Fraught New Frontier in Telehealth: Ketamine (gift article) talks about the dark side of the remote prescription trend.

The Book of Blue Zones

The Economist had an interesting article on Blue Zones, an area of the world with a disproportionate share of centenarians: Christian Californians may have a solution to America's obesity | The Economist (subscription required)

Hard Dew

I had no idea about the roots of Mountain Dew. I had no idea Mountain Dew was a nickname for moonshine. Why PepsiCo's and Coca-Cola's Alcohol Drinks Worry Health Experts (gift article) discusses the worrisome trend of "hardening" traditional soft drinks. Next up, marijuana tinged soft-drinks.....

Think Like A Monk

In addition to Tim Urban's book, I've started reading Think Like a Monk by Jay Shetty. I'm about three chapters in and enjoying the material. Highly recommended! (Thanks, Sandy!)