Antidepressants

120 - Mirror Cells, Fighting Inflammation with Food, and Artful Healing - HealthHippieMD Week In Review

120 -- HealthHippieMD Week In Review Audio Overview

Curiosity Killed the Bias

How to see the humanity in anyone | Psyche Guides explores the transformative practice of "deep curiosity," a tool for fostering empathy, connection, and understanding across divides. The author recounts a yearlong journey meeting individuals with opposing beliefs and challenging stereotypes fueled by assumptions and social media. Through the DIVE model—Detach, Intend, Value, Embrace—he teaches how to unlearn biases, prepare for meaningful dialogue, and honor others' dignity. By viewing challenges as opportunities for growth, deep curiosity strengthens relationships and enriches self-awareness. This guide empowers readers to break barriers and connect authentically in an increasingly polarized world. (Thanks, Laura!).

+see also: The War For Kindness - The Happiness Lab with Dr. Laurie Santos - Apple Podcasts.

Food Fights Inflammation

An anti-inflammatory diet swaps processed foods for whole, nutrient-dense options to combat chronic inflammation. Foods rich in antioxidants, polyphenols, and essential nutrients help reduce oxidative stress and regulate hormones. A Mediterranean-inspired diet—packed with fruits, vegetables, fish, nuts, and olive oil—nurtures a healthy gut biome, while magnesium-rich and brightly colored foods fight stress and free radicals. Spices like turmeric and garlic add flavor and anti-inflammatory benefits. While diet is just one piece of the wellness puzzle, adopting these habits offers long-term physical and mental health benefits—making it a marathon worth running. An anti-inflammatory diet can boost your health. What to eat and what to avoid | Fortune Well.

How Seed Oils May Ignite Cancer Risks

A new study highlights the potential role of omega-6 fatty acids—abundant in seed oils used in ultra-processed foods—in promoting inflammation that fuels colon cancer. Researchers found high levels of these proinflammatory lipids in tumor samples, alongside a deficiency in inflammation-resolving omega-3s. Experts point to dietary shifts since the 1950s, with ultra-processed foods and seed oils dominating modern diets, as a likely factor. While diet isn't the sole contributor, the findings emphasize the complex interplay of food, lifestyle, and genetics in cancer risk, advocating for moderation in omega-6 consumption pending further research. Ultraprocessed Foods High in Seed Oils Could Be Fueling Colon Cancer Risk | Scientific American.

Chasing Happiness

What can ancient philosophy teach us about a well lived life? Examining different schools of philosophical thought can teach us a lot about different ways to create happiness. The philosophy of happiness, explained in 10 minutes - Big Think.

Love Is a Marathon, Not a Sprint

Arthur C. Brooks explores the paradox of love and happiness, arguing that the exhilarating, passionate phase of romance—while thrilling—isn't what brings enduring joy. Instead, he highlights "companionate love," rooted in friendship, mutual understanding, and commitment, as the foundation of lasting happiness. Backed by research like the Harvard Study of Adult Development, Brooks demonstrates that stable relationships, especially those built on deep friendship, are the strongest predictors of lifelong contentment. With humor and personal anecdotes, he underscores that the secret to staying in love lies in simply liking your partner—your best friend. The Kind of Love That Makes People Happiest - The Atlantic.

+see also: This heartwarming video from Coldplay featuring Dick Van Dyke. All My Love Official Version, Director's Cut.

Press Paws

A recent study suggests that dogs may communicate intentionally by pressing buttons linked to words. Researchers found that some dogs form two- or three-word combinations, such as "want food," which appear deliberate rather than random. The study monitored button-pressing behaviors in over 150 dogs using soundboards, finding that dogs can express needs akin to a young child. However, skeptics argue the behavior could stem from training or reinforcement rather than true language understanding. While questions remain, the research highlights dogs' intelligence and their potential for deeper interaction with humans. Dogs may be able to communicate by pressing buttons, research suggests - The Washington Post (gift article).

Snooze You Can Use

Science-Backed Sleep Tips from 2024 to Help You Snooze Better | Scientific American explores 2024's popular sleep trends and their scientific validity. Highlights include the benefits of short naps for memory and mood and caution against "bed rotting," which disrupts circadian rhythms. TikTok's "sleepy girl mocktail" sheds light on magnesium's role in relaxation, while sleeping on the floor offers mixed results for back health. Sleep divorces—partners sleeping separately—can improve rest for mismatched sleepers. To combat election-induced insomnia, experts recommend unplugging, meditating, and reframing anxious thoughts with gratitude. These evidence-backed strategies aim to optimize sleep quality for a more restful 2025.

Artful Healing

Susan Magsamen's exploration of neuroaesthetics reveals the profound effects of art on mental health, trauma recovery, and cognitive disorders. This emerging field connects art, science, and well-being, showing how aesthetic experiences—from painting and dance to music—positively reshape our brains. Programs like Creative Forces empower trauma survivors, while dance improves cognition and mobility in Parkinson's patients. The arts, accessible to all, offer transformative benefits, reducing stress and fostering resilience. By embracing creativity, we can enhance our mental and physical health, proving that the arts are as essential as exercise or nutrition. 'Neuroaesthetics' Reveals How the Arts Help with Dementia and Trauma | Scientific American.

Neuroinflammation and Muscle Fatigue

Neuroinflammation, sparked by the brain's immune response to infections or chronic diseases like Long COVID and Alzheimer's, disrupts the brain-muscle connection, leading to muscle fatigue. This research uncovers how brain-released cytokines alter muscle energy production without damaging muscle structure. Studying fruit flies and mice, scientists identify a universal brain-to-muscle communication pathway that reallocates energy to combat infection. Potential treatments, such as neutralizing antibodies, aim to block this signaling. With further exploration, targeting this axis could alleviate fatigue in long COVID and other neuroinflammatory conditions, improving life for millions worldwide. Brain inflammation may be the reason behind muscle fatigue after infection and injury.

Mirror Cells: The Dark Reflection of Life

Scientists warn of the existential risks posed by "mirror cells," organisms built with reverse-handed DNA and proteins, defying the fundamental biology of Earth's life forms. These synthetic microbes, immune to natural defenses and capable of ecological devastation, could trigger pandemics or disrupt ecosystems if released. While promising medical advancements like long-acting drugs, their potential to bypass immune systems and evolve uncontrollably outweighs the benefits. Leading researchers advocate banning this technology, urging global dialogue to prevent catastrophic consequences before these innovations take root. A 'Second Tree of Life' Could Wreak Havoc, Scientists Warn - The New York Times (gift article).

+see also: one of the most memorable articles from Wired (from 25 years ago!)-Why the Future Doesn't Need Us | WIRED.

The Gut: The New Frontier of Mental Health Treatment

Emerging research highlights the potential of targeting gut cells, rather than brain cells, to treat depression and anxiety. Traditional SSRIs, while effective, often cause systemic side effects. Scientists have observed mood improvements in mice without the usual drawbacks by focusing on serotonin production in the intestines, unveiling the gut-brain connection's crucial role in emotional regulation. This novel approach may also address concerns about SSRI safety during pregnancy, offering a safer alternative for both mothers and babies. These findings could revolutionize mental health care by delivering effective relief without compromising physical well-being. Drugs targeting gut cells, not brain cells, fight depression better - Earth.com. (thanks, Amy!).

+see also: Gut Feelings: The Role of the Microbiome in Behavioral Health — HealthHippieMD.

015 - Deja Vu, Pilates, and Recycling Theater - HealthHippieMD Week In Review

Fight for the Soul of Pilates

An interesting story in the NY Times about the fight over Joseph Pilate's legacy (gift article) The Fight for the Soul of Pilates.

Technology and Shallow Relationships

It's well-known that frequent social media use contributes to feelings of loneliness and depression. Despite this, technology use accelerated during the pandemic. Arthur Brooks talks about how to combat over-reliance on technology in our relationships: Technology Can Make Your Relationships Shallower.

Predicting Long-Covid

A manuscript published this week, Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study, describes the use of multi-omics and machine learning to predict individuals who will develop long-covid.

Banana Genealogy

Everything you wanted to know about the origins of the modern banana: The Search Is on for Mysterious Banana Ancestors.

The Paradox of Atypical Anorexia

Eating disorders can affect anyone of any body, shape, or type. I learned quite a bit from 'You Don't Look Anorexic.' (gift article)

Lessons from a "Difficult Patient"

I enjoyed an essay in the NY Times about how medicine, in many ways, has lost its humanity. The article, Lessons From a 'Difficult Patient' (gift article), follows one physician's internal journey as she cares for a challenging patient throughout her training.

Understanding Deja Vu

I learned a few new things about the neuropsychological underpinnings of deja vu in the article: What is déjà vu? A psychologist explains this common but creepy phenomenon.

More Terramation

It seems like stories about human composting are everywhere. This article was in Slate: Composting offers a greener way to dispose of human remains.

Brain Cells on a Chip Learn to Play Pong

I found this article on brain-machine interfaces: Brain cells on a chip learn to play Pong within 5 minutes. Although the title is a bit sensational, I still find the concept disturbing.

Omega-3 Fatty Acids and Brain Health

In a new study, Omega-3's Linked to Improved Brain Structure and Cognition at Midlife, , the authors opined increasing omega-3 fatty intake might help preserve brain health and cognition in middle age. We still don't understand the mechanism of how omega-3 fatty acids work in the brain. My guess is the mechanism involves our endogenous endocannabinoid system, as I mentioned in 006 - Loneliness, Mucus, and Cannabinoids - HealthHippie Week In Review.

Return on Investment for Employee Wellness Programs

Michael Greger released the first video in a series focused on the business case for offering wellness programs in corporate environments: The Return on Investment (ROI) for Employee Health and Wellness Programs. His take after reviewing the literature: $3 returned for every $1 spent.

Rethinking Healthy Eating in Terms of the Microbiome

I loved the manuscript, Rethinking healthy eating in light of the gut microbiome. The manuscript synthesizes a wide range of information from around the world and makes recommendations on what constitutes healthy eating by promoting a healthy gut microbiome. I will be referring to this paper for a time to come.

The Rocky Road of Aspartame

I've had a long-standing interest in non-nutritive sweeteners. Aspartame, only one of many artificial sweeteners, is a multi-billion dollar product. Aspartame: Decades of Science Point to Serious Health Risks is a compilation of the primarily negative data on the multi-billion dollar substance. For a less critical view, see: The_History_of_Aspartame

Think You Are Responsible with your Recycling? Think again.

The article Big Plastic Wants You to Think You Can Recycle Your Yogurt Container, was eye-opening for me. Only a tiny fraction of plastics are recycled, and there is incredible resistance to doing so, given the cost. The take-home point of the article for me: buy fewer products made of ANY plastic.

Our Pets, Our Microbiome

I enjoyed reading Does owning a pet boost your gut health? on how humans and our animal companions swap bacteria -likely beneficial to our overall health and well-being. The one downside of the article is not being able to unsee the phrase "fecal patina."

Behold Envy, The Happiness Killer

Arthur Brooks tackles the topic of envy in the article How to Stop Being So Envious. The article touches on social comparison, social media, and the importance of authenticity. In addition, he offers a few practical suggestions to minimize the role of envy in your life.

Making Better Use of Antidepressants

I learned a lot from the article, How to make better use of antidepressants (pay-wall). I did not realize that 10-15% of the population is on antidepressants, many for a very long time. With the serotonin theory of depression recently called into doubt coupled with a re-examination of this class of drug's efficacy (only about 15% response rate, mainly in severely depressed), it is likely time to reexamine our overuse of these medications, especially in the elderly.

New Evidence Linking the Microbiome to Rheumatoid Arthritis

The 2017 paper, Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis, hypothesized that a protein produced by a common gut bacteria, Prevotella copri, could trigger the immune system and lead to arthritic inflammation. A new study summarized in New evidence linking gut bacteria with rheumatoid arthritis development provides further evidence supporting the 2017 hypothesis.

Quote of the Week

"Without music, life would be a mistake." - Friedrich Nietzsche (thanks, Lauren!)