Science

122 - Dressing Dogs, Octopus Farming, and Lemnian Earth - HealthHippieMD Week In Review

Important Notice:

As you may have noticed, I’ve been changing the newsletter. The audio overview (below) is the first of those changes. With the new year, I plan to migrate the newsletter from Mailchimp to Substack (the HealthHippieMD website won’t change). With the migration you will receive a welcome email, but from a reader’s standpoint, I hope everything will be seamless. Please check your spam folder if you don’t receive the newsletter next weekend after the migration. I hope you’ll bear with me as I troubleshoot the inevitable wrinkles over the next few weeks. Thanks again for reading and your support!

122 - HealthHippieMD Newsletter Audio Overview

Dream Machines

Artificial intelligence's so-called hallucinations, often dismissed as errors, are redefining innovation in science. These imaginative outputs aid researchers in creating novel proteins, designing advanced medical devices, and unlocking biological mysteries. Pioneers like Nobel laureate David Baker have harnessed AI's creative leaps to design over 10 million new proteins, some with transformative medical applications. Beyond biochemistry, A.I.-inspired designs improve technologies such as catheters and weather modeling. While "hallucinations" may evoke skepticism, scientists prefer seeing them as exploratory tools grounded in physics and biology. With careful testing, these bursts of computational creativity could propel breakthroughs, from fighting diseases to reimagining sustainable technologies​. How Hallucinatory AI Helps Science Dream Up Big Breakthroughs - The New York Times (gift article).

Befriend Your Other Selves

How connected do you feel to the person you once were or hope to become? Psychologists call this "self-continuity," a trait that enhances emotional resilience and guides long-term decision-making. By fostering a sense of coherence—through practices like writing letters to your future self or reflecting on personal growth—you can bridge the gap between past regrets and aspirations​. Back in 2014, I was interested in this topic. I wrote a grant proposal using self-continuity to promote health-related behaviors, but it was never funded. Making Friends with Your Past and Future Selves.

The Friendship Deficit

In an increasingly isolated world, Americans spend half as much time with friends as they did two decades ago. This growing loneliness has profound effects on mental and physical health. The solution isn't grand gestures but integrating friendship into everyday life—sharing meals, running errands, or watching TV together. Simple connections nurture profound relationships​. Opinion | Feeling alone? Here's what the data says about how to fix that. - Washington Post.

Strengthening Relationship Maturity

Emotional immaturity can leave you feeling drained and disconnected, but emotional maturity transforms relationships into spaces of clarity and joy. This article explores recognizing immature traits, like an inability to apologize or accept feedback and offers strategies to foster healthier dynamics. It emphasizes the importance of firm boundaries, clear communication, and surrounding yourself with emotionally reliable people who uplift and energize you. How to Build an Emotionally Mature Relationship | Psychology Today.

Outwitting AI Scams

As AI-powered scams grow more sophisticated, families face new challenges in verifying identity. This article emphasizes the importance of creating unique family passphrases to protect against fraudsters exploiting voice cloning and deepfakes. It's a low-tech but highly effective way to maintain control, ensuring security in a digital age of deception​. You Need to Create a Secret Password With Your Family | WIRED.

+see also: Emotional intelligence is the best defence against GenAI threats - Big Think.

Health Bots and Hiccups

AI tools are rapidly becoming part of healthcare, assisting doctors with note-taking and drafting patient communications. While promising, these systems bring bias, inaccuracies, and over-reliance risks. This exploration highlights the potential to ease physician workloads and the critical need for human oversight to ensure safe, personalized care​. Doctors are using AI. Will it make health care better or break it? - The Washington Post (gift article).

Dressing Dogs for the Chill

Not all dogs are naturally equipped for winter weather. Small, short-haired, or elderly pups often need protective gear to brave the cold. Do dogs need winter jackets in the cold? In most cases, yes. - The Washington Post (gift article) examines the practical need for canine winter wear, blending safety with the growing trend of stylish pet apparel. From sweaters to booties, dog fashion meets function in cold climates​.

Rethinking Octopus Farming

Octopuses are remarkable creatures with complex intelligence, memory, and problem-solving skills. As demand for octopus farming grows, ethical concerns mount. Are Octopuses Too Smart to Be Farmed? | Scientific American delves into the cognitive sophistication of cephalopods, questioning whether their intellect and behavior make them unsuitable for mass farming, despite their popularity in global cuisines​.

Pain Points

Pain avoidance often leads to more suffering, both physically and emotionally. By reframing pain through philosophical and therapeutic approaches like mindfulness and acceptance, individuals can transform it from an adversary into a manageable aspect of life. Why the Right Philosophy Is the Best Pain Medication - The Atlantic challenges modern notions of eliminating pain and instead advocates for thriving despite it​. I learned quite a bit from this article. Well worth a read.

Food Math: Scoring Health in the Aisles

Nutrient profiling systems are revolutionizing how we approach food choices, simplifying complex nutrition data into clear, actionable scores. By assessing fiber, sugars, and fats, these systems help consumers identify healthier options while challenging misconceptions about processed foods. This innovation makes grocery shopping smarter and more intuitive​. What if you could rank food by 'healthiness' as you shopped? Nutrient profiling systems use algorithms to simplify picking healthy groceries.

+see also: What are macros? An exercise and nutrition scientist explains.

Life in Bloom

Modern life can feel monotonous, but philosopher Lorraine Besser offers three strategies to infuse daily routines with psychological richness. By embracing "Mindfulness 2.0," noticing without judgment, cultivating curiosity, and exploring creativity, individuals can transform mundane tasks into moments of engagement and wonder. Besser's approach underscores how curiosity and small creative acts—like altering a commute routine or trying something new—can make life more fulfilling by fostering cognitive engagement and novelty​. Transform the daily grind to make life more interesting – a philosopher shares 3 strategies to help you attain the good life.

Clay Revival

Scientists have rediscovered Lemnian earth (LE), a medicinal clay with potential for modern gut health. This clay, combined with beneficial fungi, creates bioactive compounds that positively influence the gut microbiome, combat pathogens, and support intestinal health. Rooted in ancient Greek traditions, LE's antibacterial properties are being reimagined for 21st-century applications, offering a fascinating bridge between historical remedies and cutting-edge biomedical research​. Ancient clay remedy may have potential to boost modern gut health.

Light vs. PFAS Pollutants

PFAS, the "forever chemicals," are infamous for their resistance to degradation and harmful health impacts. Researchers have developed a photocatalytic system using light to break down the carbon-fluorine bonds that make PFAS so persistent. This innovative technique could revolutionize efforts to eliminate these pollutants, transforming them into harmless byproducts. While promising, scalability remains a challenge, with ongoing research aimed at refining this sustainable solution​. We developed a way to use light to dismantle PFAS 'forever chemicals' – long-lasting environmental pollutants.

Tattoos That Think

E-tattoos using polymer-based conductive inks offer a revolutionary approach to EEG monitoring. These tattoos can record brain activity through short hair without the discomfort of traditional caps. This technology developed by researchers could extend to mobile health monitoring, brain-computer interfaces, and organ-based diagnostics, making healthcare more accessible and adaptable​. E-tattoos could make mobile EEGs a reality - Ars Technica.

120 - Mirror Cells, Fighting Inflammation with Food, and Artful Healing - HealthHippieMD Week In Review

120 -- HealthHippieMD Week In Review Audio Overview

Curiosity Killed the Bias

How to see the humanity in anyone | Psyche Guides explores the transformative practice of "deep curiosity," a tool for fostering empathy, connection, and understanding across divides. The author recounts a yearlong journey meeting individuals with opposing beliefs and challenging stereotypes fueled by assumptions and social media. Through the DIVE model—Detach, Intend, Value, Embrace—he teaches how to unlearn biases, prepare for meaningful dialogue, and honor others' dignity. By viewing challenges as opportunities for growth, deep curiosity strengthens relationships and enriches self-awareness. This guide empowers readers to break barriers and connect authentically in an increasingly polarized world. (Thanks, Laura!).

+see also: The War For Kindness - The Happiness Lab with Dr. Laurie Santos - Apple Podcasts.

Food Fights Inflammation

An anti-inflammatory diet swaps processed foods for whole, nutrient-dense options to combat chronic inflammation. Foods rich in antioxidants, polyphenols, and essential nutrients help reduce oxidative stress and regulate hormones. A Mediterranean-inspired diet—packed with fruits, vegetables, fish, nuts, and olive oil—nurtures a healthy gut biome, while magnesium-rich and brightly colored foods fight stress and free radicals. Spices like turmeric and garlic add flavor and anti-inflammatory benefits. While diet is just one piece of the wellness puzzle, adopting these habits offers long-term physical and mental health benefits—making it a marathon worth running. An anti-inflammatory diet can boost your health. What to eat and what to avoid | Fortune Well.

How Seed Oils May Ignite Cancer Risks

A new study highlights the potential role of omega-6 fatty acids—abundant in seed oils used in ultra-processed foods—in promoting inflammation that fuels colon cancer. Researchers found high levels of these proinflammatory lipids in tumor samples, alongside a deficiency in inflammation-resolving omega-3s. Experts point to dietary shifts since the 1950s, with ultra-processed foods and seed oils dominating modern diets, as a likely factor. While diet isn't the sole contributor, the findings emphasize the complex interplay of food, lifestyle, and genetics in cancer risk, advocating for moderation in omega-6 consumption pending further research. Ultraprocessed Foods High in Seed Oils Could Be Fueling Colon Cancer Risk | Scientific American.

Chasing Happiness

What can ancient philosophy teach us about a well lived life? Examining different schools of philosophical thought can teach us a lot about different ways to create happiness. The philosophy of happiness, explained in 10 minutes - Big Think.

Love Is a Marathon, Not a Sprint

Arthur C. Brooks explores the paradox of love and happiness, arguing that the exhilarating, passionate phase of romance—while thrilling—isn't what brings enduring joy. Instead, he highlights "companionate love," rooted in friendship, mutual understanding, and commitment, as the foundation of lasting happiness. Backed by research like the Harvard Study of Adult Development, Brooks demonstrates that stable relationships, especially those built on deep friendship, are the strongest predictors of lifelong contentment. With humor and personal anecdotes, he underscores that the secret to staying in love lies in simply liking your partner—your best friend. The Kind of Love That Makes People Happiest - The Atlantic.

+see also: This heartwarming video from Coldplay featuring Dick Van Dyke. All My Love Official Version, Director's Cut.

Press Paws

A recent study suggests that dogs may communicate intentionally by pressing buttons linked to words. Researchers found that some dogs form two- or three-word combinations, such as "want food," which appear deliberate rather than random. The study monitored button-pressing behaviors in over 150 dogs using soundboards, finding that dogs can express needs akin to a young child. However, skeptics argue the behavior could stem from training or reinforcement rather than true language understanding. While questions remain, the research highlights dogs' intelligence and their potential for deeper interaction with humans. Dogs may be able to communicate by pressing buttons, research suggests - The Washington Post (gift article).

Snooze You Can Use

Science-Backed Sleep Tips from 2024 to Help You Snooze Better | Scientific American explores 2024's popular sleep trends and their scientific validity. Highlights include the benefits of short naps for memory and mood and caution against "bed rotting," which disrupts circadian rhythms. TikTok's "sleepy girl mocktail" sheds light on magnesium's role in relaxation, while sleeping on the floor offers mixed results for back health. Sleep divorces—partners sleeping separately—can improve rest for mismatched sleepers. To combat election-induced insomnia, experts recommend unplugging, meditating, and reframing anxious thoughts with gratitude. These evidence-backed strategies aim to optimize sleep quality for a more restful 2025.

Artful Healing

Susan Magsamen's exploration of neuroaesthetics reveals the profound effects of art on mental health, trauma recovery, and cognitive disorders. This emerging field connects art, science, and well-being, showing how aesthetic experiences—from painting and dance to music—positively reshape our brains. Programs like Creative Forces empower trauma survivors, while dance improves cognition and mobility in Parkinson's patients. The arts, accessible to all, offer transformative benefits, reducing stress and fostering resilience. By embracing creativity, we can enhance our mental and physical health, proving that the arts are as essential as exercise or nutrition. 'Neuroaesthetics' Reveals How the Arts Help with Dementia and Trauma | Scientific American.

Neuroinflammation and Muscle Fatigue

Neuroinflammation, sparked by the brain's immune response to infections or chronic diseases like Long COVID and Alzheimer's, disrupts the brain-muscle connection, leading to muscle fatigue. This research uncovers how brain-released cytokines alter muscle energy production without damaging muscle structure. Studying fruit flies and mice, scientists identify a universal brain-to-muscle communication pathway that reallocates energy to combat infection. Potential treatments, such as neutralizing antibodies, aim to block this signaling. With further exploration, targeting this axis could alleviate fatigue in long COVID and other neuroinflammatory conditions, improving life for millions worldwide. Brain inflammation may be the reason behind muscle fatigue after infection and injury.

Mirror Cells: The Dark Reflection of Life

Scientists warn of the existential risks posed by "mirror cells," organisms built with reverse-handed DNA and proteins, defying the fundamental biology of Earth's life forms. These synthetic microbes, immune to natural defenses and capable of ecological devastation, could trigger pandemics or disrupt ecosystems if released. While promising medical advancements like long-acting drugs, their potential to bypass immune systems and evolve uncontrollably outweighs the benefits. Leading researchers advocate banning this technology, urging global dialogue to prevent catastrophic consequences before these innovations take root. A 'Second Tree of Life' Could Wreak Havoc, Scientists Warn - The New York Times (gift article).

+see also: one of the most memorable articles from Wired (from 25 years ago!)-Why the Future Doesn't Need Us | WIRED.

The Gut: The New Frontier of Mental Health Treatment

Emerging research highlights the potential of targeting gut cells, rather than brain cells, to treat depression and anxiety. Traditional SSRIs, while effective, often cause systemic side effects. Scientists have observed mood improvements in mice without the usual drawbacks by focusing on serotonin production in the intestines, unveiling the gut-brain connection's crucial role in emotional regulation. This novel approach may also address concerns about SSRI safety during pregnancy, offering a safer alternative for both mothers and babies. These findings could revolutionize mental health care by delivering effective relief without compromising physical well-being. Drugs targeting gut cells, not brain cells, fight depression better - Earth.com. (thanks, Amy!).

+see also: Gut Feelings: The Role of the Microbiome in Behavioral Health — HealthHippieMD.

060 - CRISPR, Wellness Tech Warnings, and the Brain's Fountain of Youth - HealthHippieMD Week In Review

More on the Impact of AI on Science

More on how AI is revolutionizing science in the Economist: How scientists are using artificial intelligence (gift article) and Could AI transform science itself? (gift article).

CRISPR and the Microbiome

CRISPR pioneer and Nobel Prize winner Jennifer Doudna is focusing on the microbiome: Crispr Pioneer Jennifer Doudna Has the Guts to Take On the Microbiome | WIRED. I highly recommend Walter Isaacson's biography on Doudna: The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race.

Big Tobacco Stains the Food Industry

"In a broader and much less restricting sense," an executive wrote, "R.J. Reynolds is in the flavor business." Although Big Tobacco is no longer in the food business, they left a terrible legacy: Many junk foods today were made and marketed by Big Tobacco - The Washington Post. (gift article)

Is Junk Food Addictive?

Recent studies suggest highly processed foods may have addictive qualities akin to drugs. Rats opt for sugar over cocaine, even enduring electric shocks for the sweet treat. Humans display similar behavior, consuming processed foods to the point of vomiting and diarrhea post-bariatric surgery. Daily snacking on these foods can rewire our brain's reward circuits, mirroring the cravings induced by cocaine. "In 2022, scientists published an opinion piece in the journal Addiction arguing that highly processed foods should be classified as addictive based on a 1988 Surgeon General report on tobacco products." Food Can Be Literally Addictive, New Evidence Suggests - Scientific American.

Healthy Diet Lowers Dementia Risk

Wapo had an article on the importance of diet in staving off dementia. Recent studies suggest the benefits occur even when started later in life: Eating heart-healthy foods also helps lower your dementia risk - The Washington Post. (gift article)

PANDA-monium: Infections Unmask Childhood Psychiatric Illnesses

Many doctors remain unaware PANDAS (Paediatric Autoimmune-Neuropsychiatric Disorders Associated with Streptococcus and its counterpart, PANS (Paediatric Acute-onset Neuropsychiatric Syndrome), or dismiss them as fictitious. This ignorance results in misdiagnoses, inappropriate treatments, and even parental accusations. Recent research suggests these disorders stem from an autoimmune reaction post-infection. The changing perception may have broader implications for understanding infections' roles in psychiatric conditions (for both children and adults), offering hope for early intervention and effective treatment. How common infections can spark psychiatric illnesses in children. (gift article)

Plasma, Platelets, and PF4: Searching for the Brain's Fountain of Youth

Groundbreaking research in mice may have revealed a key to rejuvenating aging brains. Neuroscientists have uncovered that platelets, specifically a group of molecules called Platelet Factor 4 (PF4), play a vital role in the age-reversal process. Three interventions—transfusions of young blood, the hormone klotho, and physical exercise—all harness PF4 to deliver their benefits to the brain. When 22-month-old mice were injected with young blood plasma or PF4, their cognitive age reversed dramatically. These findings, independently discovered by three research teams, offer new hope for combating age-related cognitive decline and unlocking the secrets of brain rejuvenation. Scientists uncover how young blood rejuvenates aging brains | BBC Science Focus Magazine.

Animal Communication Unveils Surprising Parallels to Human Language

Researchers are uncovering fascinating connections between animal communication and human language. For years, the belief in an unbridgeable gap between human language and animal communication prevailed. However, recent studies challenge this notion, revealing that various species possess intricate vocal learning abilities, from mice to dolphins. These findings suggest that language-related capacities may exist on a continuum across the animal kingdom. Scientists are now delving deeper into deciphering the meanings and intricacies of animal communication, shedding light on the evolution of language and our shared cognitive landscapes with other creatures. The Animals Are Talking. What Does It Mean? - The New York Times. (gift article)

+How AI is being leveraged to decode animal communication: Can We Talk to Whales? | The New Yorker and ‎Unexplainable: Can we talk to animals? on Apple Podcasts.

When the CIA, Artificial Intelligence, and Healthcare Collide

Palantir's Reputation Stalks Its Bid for the UK's National Health Data | WIRED is an interesting article about how Peter Thiel's big data analytics company (and surveillance government contractor), Palantir, is courting Britain's National Health Service for access to their data. What possibly could go wrong?

Big Tech Knows Your Most Intimate Health Details

Your most intimate health details have become data points in the digital realm. Tech giants, often unbeknownst to users, accumulate a treasure trove of personal health information through online interactions, from therapy sessions to fitness apps. Recent cases, like BetterHelp's data-sharing debacle, have exposed the extent of this information harvesting, raising concerns about privacy violations and potential harm. While some believe federal laws like HIPAA shield health data, the truth is more complicated. A fragmented regulatory landscape, limited enforcement resources, and the rapid evolution of technology call for comprehensive data privacy legislation to keep pace with the digital age. What Big Tech Knows About Your Body - The Atlantic.

Build a Real Music Collection

This author cites why she owns her music collection and eschews streaming: Want to Enjoy Music More? Stop Streaming It. - The New York Times. (gift article)

058 - Scientific Spirituality, Supermarket Lies, and Psychedelics - HealthHippieMD Week In Review

Food for Thought: How Your Diet Affects Your Mind

Beyond the immediate joy of a good meal, food can significantly impact your mental health. Animal proteins like roast turkey and fish contain amino acids essential for dopamine and serotonin production, key mood-regulating neurotransmitters. With their rich nutrient content, Brussels sprouts and cranberries play roles in brain function and mood regulation. The emerging field of nutritional psychiatry explores how diet influences mental health, shedding light on diets like the Mediterranean and mind diets. How food affects the mind, as well as the body.

Supermarket Lies

The New Yorker discusses the attorney Spencer Sheehan, who takes food and home goods companies to task for misrepresenting the ingredients in their products. Shocker, he's swamped. The Lies in Your Grocery Store | The New Yorker.

Scientific Spirituality

In a recent study, Julian Huxley's belief that science held a spiritual dimension gained validation. Researchers developed a scale to measure "scientific spirituality," discovering that it stirs feelings of wonder and connection akin to religious spirituality. These feelings boost well-being and life satisfaction, even in atheists and agnostics. Furthermore, those with higher scientific spirituality scores demonstrated a better understanding of scientific subjects. The study suggests that finding "holiness in reality" through science can offer a unique and fulfilling spiritual experience, bridging the gap between empirical and spiritual realms. The Holiness in Reality - Nautilus.

+Asimov also wrote about this topic in one of my favorite series, Foundation..

Paper Cups: Brewing Trouble for the Environment

While paper coffee cups might seem like a greener alternative to plastic, a recent study warns that they can be just as toxic. These seemingly eco-friendly cups are lined with a thin layer of plastic to prevent liquid seepage, and this plastic can release harmful chemicals when it ends up in our natural environment. Researchers found that even midge larvae exposed to water tainted by paper cups suffered ill effects. The exact composition of these chemicals remains a mystery due to limited disclosure from manufacturers. To combat this issue, scientists advocate for innovative, sustainable alternatives and more significant recycling efforts, as disposable paper cups pose a significant environmental hazard. Sorry, Your Paper Coffee Cup Is a Toxic Nightmare | WIRED.

How Psychedelics Work?

"People often talk about psychedelic therapy functioning like a "reset button" for the mind, but until Dölen's work came out, no one could provide a scientifically plausible explanation for "how something so short in duration can have lasting and transformative effects that go well beyond the time that the drug is in there."This scientist and her team believe psychedelics re-open the brain to critical learning. The Psychedelic Scientist Who Sends Brains Back to Childhood | WIRED.

Ode to Emojis

"Emojis have this ability to make the same words seem more emotional or less emotional—to seem alarming versus completely fine or joking even," she says. These are important social functions, she adds. "Through our switch to more text-based communication, we lost this additional layer of meaning that emojis can now provide." Nautilus published a pretty interesting article on the history and science of emojis: Your 🧠 On Emoji - Nautilus.

What are Dreams For?

We've all observed the twitching of babies or animals while they're sleeping. Conventional wisdom has been that twitches reflect movements taking place during a dream. The scientists in this story believe the exact opposite. Rather than the body reflecting brain activity, it is the brain learning from the body. The implications, if true, are striking both in our understanding of ourselves and for emerging technology such as robotics. What Are Dreams For? | The New Yorker.

Weight-Loss Drugs Also Protect the Heart

Another apparent benefit of the new weight-loss drugs was published in the New England Journal of Medicine. "In a trial of more than 500 patients with obesity and heart failure in 13 countries, those who got a weekly injection of semaglutide for a year reduced symptoms such as fatigue, shortness of breath, and swelling. They also had notable improvements in their physical abilities and exercise function." Ozempic and Wegovy Can Also Protect Your Heart | WIRED.

Death of the Calorie

The Economist had a detailed story on the history (and failure) of calorie counting for weight loss. Death of the calorie.

How Play and Art Boost Learning

In the article To Supercharge Learning, Look to Play, , authors Susan Magsamen and Ivy Ross highlight the integral role of play and art in enhancing learning. They stress that play and creativity are inherent to human evolution, aiding cognitive development and emotional well-being. The authors emphasize "guided play" to effectively impart new skills. They also discuss the Playful Learning Landscapes Action Network, which transforms public spaces into interactive learning hubs. Furthermore, the article explores the neuroscience of attention and how immersive video games, like EndeavorRx, can improve focus, particularly in individuals with ADHD, offering a promising alternative to medication. (disclosure: I own shares of Akili Interactive mentioned in the article).

Knocking Out the Wrong Goals to Achieve Happiness

In a punchy revelation, Arthur Brooks discusses the "Tyson Paradox" inspired by boxing legend Mike Tyson. Despite his impressive career, Tyson's pursuit of fame and riches didn't guarantee his happiness. The paradox arises from the "arrival fallacy," where achieving goals doesn't sustain bliss. Instead, we quickly return to an equilibrium. To combat the loss of happiness, the article suggests setting the right goals focused on intrinsic values and relationships. Intrinsic goals like fostering friendships lead to greater well-being, while achievement goals can disappoint, especially when compared to others. Ultimately, the journey, not just the destination, provides lasting satisfaction and meaning. How to Set the Right Life Goals - The Atlantic.