Nature

087 - Gut Fungi, Green Acres, and Counting Sheep - HealthHippieMD Week In Review

Burning the Midnight Oil

A recent study underscores the alarming effects of working late shifts and variable schedules in young adulthood. The research, spanning three decades and including over 7,000 Americans, reveals that those with volatile work schedules, including night hours and rotating shifts, are more likely to experience poor health and depression at age 50. These findings illuminate the severity of burnout culture, where work demands often surpass the body's capacity, leading to long-term health implications. The study underscores the urgent need for support systems to help individuals maintain a healthy work-life balance and mitigate the risks associated with overwork. Burnout culture: Working late shifts can lead to depression poor health. Burnout culture: Working late shifts can lead to depression, poor health : Shots - Health News : NPR.

The Sound of Silence in Live Music

 Is a love of live music wrecking your hearing? Don't let it. - Washington Post (gift article) discusses the potential harm that loud live music can cause to our hearing. Drawing from personal experience and expertise, the author highlights the dangers of prolonged exposure to high decibel levels, even in seemingly innocuous settings like bars and restaurants. The article provides practical measures for protecting one's hearing, such as using earplugs and limiting exposure time, while advocating for increased awareness and responsible practices in live music venues. Opinion | Is a love of live music wrecking your hearing? Don’t let it. - Washington Post.

Green Acres, Strong Minds

According to research, spending time in green spaces like parks can significantly improve physical and mental health. Studies show that regular exposure to nature can lower blood pressure, strengthen the immune system, reduce the risk of cardiovascular disease, and improve sleep quality. Moreover, it is associated with reduced depressive symptoms, stress alleviation, and improved cognitive function. However, access to green spaces is unequal, with lower-income communities having less access to parks and trees. Scientists are using innovative methods, such as machine learning and satellite imagery, to measure the impact of greenery on health outcomes, aiming to address health disparities. Walks in Green Parks Mean Stronger Immune Systems and Better Mental Health | Scientific American (paywall).

Counting Sheep

A recent Gallup poll reveals a concerning trend: a majority of American adults are experiencing insufficient sleep, a first in the survey's history. This lack of rest is closely tied to increased stress levels, with many individuals reporting feeling frequently stressed. The situation has worsened over the years, with more people now feeling the effects of sleep deprivation. Women, especially those under 50, are disproportionately affected compared to men. The connection between poor sleep and stress is bidirectional, underscoring the need for strategies to improve sleep quality and reduce stress levels, particularly among younger Americans. Americans aren't sleeping enough, Gallup poll says. Americans aren't sleeping enough, Gallup poll says.

Unveiling the Brain's Symphony

Scientific American had an article about a study that reveals that the brain's cortex operates like a symphony, with each layer specializing in generating different brain waves. The study, conducted across 14 cortical regions and four species, shows that outer layers process sensory input while deeper layers control how the brain processes that information. This discovery could have significant implications for understanding and treating neuropsychiatric disorders. By identifying the specific brain layers involved in generating different waves, researchers hope to shed light on conditions such as schizophrenia, where imbalances in brain waves are evident. Scientists Discover Extensive Brain-Wave Patterns | Scientific American (paywall).

Mouth Microbe May Muddle with Colon Cancer

Researchers have uncovered a potential link between colon cancer and a bacterium commonly found in the human mouth. The study identified a specific subtype of Fusobacterium nucleatum that appears to be associated with colon cancer growth and progression. This discovery could lead to improved screening methods and new therapies for the disease. The bacteria's presence in colon tumors suggests a connection to disease development, highlighting the need for further research. The findings may pave the way for a vaccine targeting this bacterium, similar to the approach used for the human papillomavirus. Colon Cancer Linked to Mouth Bacteria | Scientific American (paywall)(thanks, Amy).

How Gut Fungi Worsen Covid

In a study published in Nature Immunology, researchers discovered that severe COVID-19 patients exhibit an imbalance of certain gut fungi, triggering a prolonged immune response that outlasts the initial infection. This imbalance leads to increased neutrophils, causing inflammation characteristic of Covid-19. The study highlights the intricate relationship between the gut microbiome and the immune system, suggesting the potential for personalized medicine in treating COVID-19 patients with antifungal drugs. The findings also raise questions about the long-term effects of fungal overgrowth in COVID-19 recovery and the potential for future fungal infections. Unruly Gut Fungi Can Make Your Covid Worse | WIRED.

A Dietary Puzzle for I.B.S. Relief

A new study suggests dietary changes trump medication to tame irritable bowel syndrome (I.B.S.). I.B.S., afflicting an estimated 6% of Americans, presents chronic abdominal pain, bloating, diarrhea, and constipation. Though its cause remains elusive and no cure exists, managing symptoms through diet adjustments or medication helps. The study, featured in The Lancet Gastroenterology and Hepatology, reveals promising clues. Notably, in most cases, a low-FODMAP diet—avoiding certain foods like wheat, legumes, and dairy—has shown symptom reduction. This discovery offers hope for those grappling with the complexities of I.B.S. What's the Best Way to Treat I.B.S.? - The New York Times (gift article).

075 - Nature Prescriptions, Nutritional Psychiatry, and Aging Happily - HealthHippieMD Week In Review

Netflix Twin Experiment

I'm enjoying the Netflix mini-documentary You Are What You Eat: A Twin Experiment | Netflix Official Site. I'm halfway through, so I don't know what they will find in twins exposed to different diets, but I think I can guess.

Keeping Medical Diagnosis Private

There was a kerfuffle over Defense Secretary Lloyd J. Austin III's disclosure (or lack thereof) of his prostate cancer diagnosis. It turns out non-disclosure is a coping mechanism. "I always validate a person's desire for privacy, whatever their reasons," Dr. Fann said. "But I also explain that keeping their diagnosis fully secret, or not being able to talk about it, may make it harder for them to ask for help when it's needed — very concretely, getting a ride to treatment or getting a sympathetic ear when you're stressed." Lloyd Austin's Hidden Diagnosis: Why Some People Keep Serious Illnesses Private - The New York Times (gift article).

Plastic Peril

A groundbreaking study reveals that bottled water contains a staggering 240,000 minuscule plastic particles per liter, far more than previously estimated. These tiny plastic fragments, as small as a virus, pose serious health and environmental concerns. Researchers at Columbia and Rutgers universities employed innovative techniques to identify and count nanoplastics, highlighting their prevalence in bottled water. Surprisingly, most particles were not from the bottle material but from contaminants in the filling and purification. The implications for human health are concerning, as nanoplastics can enter the bloodstream and potentially cause damage. This study calls for further research and heightened awareness of plastic pollution. Bottled Water Contains 240,000 Plastic Particles per Liter, Study Finds – Mother Jones (thanks, Diana).

Feeding Your Calm

In the article 7 foods that can help you reduce anxiety (gift article), the emerging field of nutritional psychiatry explores the powerful connection between what we eat and our mental health. Nutritional psychiatrist Uma Naidoo reveals that an anti-anxiety diet can significantly improve mental well-being, emphasizing the gut-brain connection. Research indicates that specific foods can boost mood, enhance cognition, and alleviate symptoms of anxiety and depression. To calm the mind, Naidoo recommends a diet rich in whole foods and shares seven anxiety-busting foods, including extra dark chocolate, leafy greens, cruciferous vegetables, avocados, green tea, omega-3 sources, and fiber-packed legumes. These foods offer a holistic approach to mental health through nutrition.

+And an article on social anxiety and the microbiome: Scientists Identified A Strange Connection Between Our Gut Microbes and Anxiety.

Data Diagnosis: Your Medical Records are Code Blue

In an alarming revelation, it has come to light that millions of individuals have had their medical data exposed due to security breaches at healthcare providers and transcription services. This eye-opening article explores the recent incidents where unauthorized parties gained access to sensitive medical records, including diagnoses, operative reports, and personal information. Despite promises of improved security measures, the healthcare industry grapples with data breaches, leaving patients vulnerable to identity theft and fraud. With medical information becoming a prized target for malicious actors, the need for stricter laws and better security practices is more apparent than ever. Your Medical Data Is Code Blue | WIRED.

Nature's Rx: How Much Green is Good for You?

Most people intuitively know that spending time in nature benefits their well-being, and scientific research supports this notion. Nature enthusiasts experience lower rates of depression, healthier blood pressure, improved eyesight, better pain control, enhanced immune function, and even lower mortality rates. "The healthiest forests are the ones that have the most different types of trees," he says. He likens the health benefits to food: there's evidence that eating diverse foods leads to a healthier gut microbiome. "I think the same thing is true with nature." To harness these health benefits, researchers in the U.S. have developed tracking and assessment technology. The NatureScore app rates the richness of nature in different geographical areas, while NatureDose monitors a person's time spent outdoors and encourages a weekly nature goal. The aim is to help doctors prescribe "nature prescriptions" alongside traditional medications, emphasizing the importance of green spaces for human health. How Much Nature Is Enough? - Nautilus.

Protein Recommendations Through Life's Stages

Protein is a crucial component of our diets, with varying needs at different stages of life. This article explains how protein requirements change as you age. Growing bodies require more protein during childhood and adolescence, while young and middle-aged adults have maintenance-level protein needs. Protein recommendations may increase in older adulthood to support muscle health and recovery. The article also highlights the importance of meeting these protein needs and suggests protein-rich foods for different age groups, emphasizing the significance of protein intake in maintaining overall health throughout life. How Much Protein You Need As You Age - The New York Times (gift article).

The Secrets to Growing Old Happily

"And therein lies the last lesson to help you prepare for your golden years: Start appreciating seniors more for their natural gifts. The practice of seeing yourself as valuing older adults will reprogram the way you think and feel about your aging. That will allay your fears and free you up to get on with the important business of becoming happier.". The author delves into the concept of aging and happiness in the article How to Be Happy Growing Older, . While society often emphasizes youth and fears the passage of time, research shows that growing old can improve happiness. As people age, they experience more positive and less negative emotions. Personality traits like agreeableness, conscientiousness, and kindness improve with age, leading to higher self-esteem. The article encourages individuals to consciously practice these positive traits throughout their lives, making aging a time of personal growth and happiness. Additionally, it suggests appreciating seniors' wisdom and perspective, thus ultimately changing how society views aging.

044 - Biophilic Design, Hallucinations, and Erasing Memories - HealthHippieMD Week In Review

Strobe Lights Induce Visual Hallucinations

Wired U.K. featured a story about Dreamachine, where people experience hallucinatory effects through stroboscopic lights and music. The project aims to explore the impact of stroboscopic lights on the brain and investigate the neural basis of visual experience. Participants, even with closed eyes, reported vivid and kaleidoscopic visual experiences. The Dreamachine's potential applications extend to mental health therapy due to the reported common emotion of peace experienced by participants. This Machine Makes You Hallucinate | WIRED

Erasing Psychedelic Trips for the Good of Science

To address criticisms of psychedelic research, scientists at the University of Wisconsin–Madison Transdisciplinary Center for Research in Psychoactive Substances conducted a pilot study involving eight individuals, exploring the possibility of combining psychedelics with memory erasure. The study addresses the challenge of studying psychedelics in traditional randomized clinical trials due to the subjective nature of the experiences and the role of expectations. By exploring innovative study designs, scientists strive to better understand psychedelics' effects and potential therapeutic applications. Scientists Gave People Psychedelics—and Then Erased Their Memory

The Whimsy of Honoring Body Donors

Medical students and faculty members across the United States are organizing gratitude ceremonies to honor body donors who have contributed to medical research and education. These ceremonies involve music performances, speeches, and artistic expressions, allowing students to express appreciation for the donors who have served as their "first patients." The ceremonies aim to re-humanize the donors, recognizing their selfless acts and the sacrifice made by their families. The events provide closure and foster a sense of gratitude while imparting essential lessons in ethics and professionalism. Honoring the Body Donors Who Are a Medical Student's 'First Patient' (gift article)

Conversational Receptiveness: Mastering the Art of Disagreement

To have better disagreements, change your words – here are four ways to make your counterpart feel heard and keep the conversation going discusses the importance of changing our words and behaviors during disagreements to foster productive conversations. Instead of solely focusing on persuading others, the research suggests adopting a communication style called "conversational receptiveness." This style involves four key elements: hedging claims, emphasizing agreement, acknowledging the opposing perspective, and reframing to the positive. By employing these techniques, conversations become less confrontational and more constructive, allowing both parties to feel heard and maintaining relationships.

Rousing Revelations: Some Mental Illness May Have Autoimmune Origin

WaPo published a story about a groundbreaking case involving April Burrell, a catatonic woman diagnosed with schizophrenia. Researchers discovered that lupus, an autoimmune disease, attacked April's brain, leading to severe symptoms. After targeted treatments, including immunotherapy, April regained consciousness after being trapped in her mind for over two decades. This discovery has the potential to revolutionize the care for psychiatric patients worldwide and reshape the way mental illnesses are diagnosed and treated, bringing hope to "forgotten souls" who were deemed untreatable. How autoimmune disease can attack the brain, cause psychiatric symptoms - The Washington Post (gift article)

Function Over Flaws

A revolutionary new health metric called human functioning could alter the treatment of chronic illnesses. Traditionally, health has been measured based on morbidity and mortality rates, focusing solely on disease and death. However, the proposed metric considers a person's illness and available resources to gauge their condition's impact on daily life activities. This approach aims to shift the healthcare system toward a patient-centered approach, promoting well-being and enabling individuals to live their best lives. This New Metric For Health Could Revolutionize How We Treat Chronic Illnesses

Byte-Size Nutrition

Artificial intelligence (A.I.) nutritionist apps are revolutionizing healthy eating by offering personalized diet solutions. These apps use A.I. algorithms to analyze data on an individual's blood sugar, microbiome, and other metabolic measurements. By understanding how different foods affect each person's body, these apps can suggest healthier meal options. While personalized nutrition is still evolving, A.I. programs hold the potential for addressing obesity, heart disease, and other health concerns. Here Come the Artificial Intelligence Nutritionists

+A reminder, buyer-beware when it comes to A.I. advice (although the chatbot mentioned in this article is different than ChatGPT): An Eating Disorder Chatbot Is Suspended for Giving Harmful Advice^4a50c0

Music and Health: The Evidence

The NCCIH has a web page focused on Music and Health: What You Need To Know.

Nature at Home: A Prescription for Well-being

WaPo had an article about the science-backed concept of "biophilic design" that promotes connecting with nature indoors. 7 ways to bring nature into your home, according to science. (gift article)

Green Brain: Brain Aging Delayed with Mediterranean Diet

A recent study reveals that a Mediterranean diet can slow brain aging. The research indicates that a mere 1% reduction in body weight resulted in brains appearing almost nine months younger. Greener Diet, Younger Brain: Mediterranean Diet Slows Brain Aging.

Ultra-processed Food and Sleep Quality

"No study had previously investigated what happens if we consume an unhealthy diet and then compare it to the quality of sleep after that person follows a healthy diet." In this small preliminary study, an unhealthy diet impacted each individual's sleep quality. Junk Food vs. Sleep: New Study Reveals Impact of Diet on Sleep Quality.

042 - Quantum Biology, Wearables, and Birdsong - HealthHippieMD Week In Review

Quantum Biology

This scientist believes nature has harnessed "quantumness" and that our current beliefs about biology are sorely incomplete: Quantum physics proposes a new way to study biology – and the results could revolutionize our understanding of how life works.

Pushing Our Kids to Achieve

Do we do our kids a disservice by pushing them to achieve? This author thinks so: Opinion | What We Lose When We Push Our Kids to 'Achieve' - The New York Times (gift article)

The Newest College Admission Scam: Publish a "Scholarly" Paper

An emerging industry of research services is helping high school students produce and publish research papers to boost their college applications. Online programs, such as Scholar Launch, charge thousands of dollars to connect students with mentors who guide them in writing articles, which are then published in journals of questionable quality. The Newest Way to Buy an Advantage in College Admissions.

Resisting Alzheimer's

Patients whose health doesn't conform to expectations can offer new insight into a possible disease treatment. Such is the case with a man who, based on his D.N.A., "should of" developed Alzheimer's in his 40s but showed resilience to the disease. Mutation Protected Man From Alzheimer's Disease, Hinting at Treatment. (gift article)

WHO Says "No" to Non-Nutritive Sweeteners

The World Health Organization (W.H.O.) has cautioned against using artificial sweeteners for weight control and reducing the risk of noncommunicable diseases. The W.H.O. stated that these alternatives to sugar do not effectively reduce body fat in adults or children and could potentially increase the risk of Type 2 diabetes, cardiovascular diseases, and mortality. This recommendation contradicts previous studies that suggested no harm from sweeteners. Based on a comprehensive review, the W.H.O.'s advice emphasizes the importance of reducing overall sugar intake and relying on naturally occurring sugars found in fruits and unsweetened foods and beverages. World Health Organization Warns Against Using Artificial Sweeteners (gift article)

Therapy Unpacked

Therapy once stigmatized as a luxury for the neurotic, has gained acceptance and popularity over the years. This article explores the effectiveness of talk therapy in improving mental health. While studies suggest that therapy indeed works and yields positive results, there are ongoing debates and challenges in the field. Researchers are trying to determine the best types of therapy for different individuals and understand the impact of the therapist-patient relationship. Some argue for a shift toward more innovative strategies, while others believe therapy's potential hasn't been fully unlocked. Ultimately, the therapist's skills and the bond formed with the patient are crucial to therapy's success. Does Therapy Work? Let’s Unpack That. (gift article)

New Manuscript Defines Frequency of Chronic Pain

"New cases of chronic pain occur more often among U.S. adults than new cases of several other common conditions, including diabetes, depression, and high blood pressure." A new analysis points to the high disease burden of chronic pain in the U.S. U.S. National Survey Data Show High Rates of New Cases and Persistence of Chronic Pain.

The Slumbering Successes of Innovation in Nature and Culture

In his book "Sleeping Beauties: The Mystery of Dormant Innovations in Nature and Culture,", biologist Andreas Wagner discusses how many brilliant ideas and innovations fail immediately but instead emerge and persist in the shadows until the right time arrives for them to step into the limelight. Wagner argues that the success of an innovative product, whether it's a new form of life or a work of art, depends not only on its inner qualities but also on the right environment and timing. He emphasizes the importance of understanding delayed success and empathizing with oneself in the creative process. Why Many Brilliant Ideas Don't Succeed Immediately.

Patients Hack Wearables to Monitor Chronic Illness

"What we have right now is a health and wellness industry that provides data-driven insights and data-driven advice, so long as their physiology is typical." How Chronic Illness Patients Are 'Hacking' Their Wearables describes how patients are using consumer electronics, such as the Oura Ring, Fitbit, and Apple Watch to monitor less common chronic illnesses.

Burned-Out on Burnout

How to address physician burnout. discusses the issue of physician burnout and challenges the prevailing approach to addressing it by embracing the humanities. I think the article misses the point or at least gives only a partial solution. Rather than implying burnout is a personal failing, it should be considered a healthcare system failure. One of my favorite papers on this subject was written by Tait Shanafelt before the pandemic: Executive Leadership and Physician Well-being: Nine Organizational Strategies to Promote Engagement and Reduce Burnout.

Birdsong and Mental Health

Research has consistently demonstrated that more contact and interaction with nature improves physical and mental well-being. Scientists are examining whether birdsong contributes to nature's positive effects: Why birds and their songs are good for our mental health. (gift article)

Banning Food Dyes

"They have no known nutritional benefits and potentially carry several health risks." The Atlantic had a story on efforts around the world to ban artificial food coloring: The True Danger of Food Dye.

005 - Long Covid, Gut Health, and Cognition - HealthHippie Week In Review - August 14, 2022

Long Covid

Eric Topol wrote an excellent overview of Long Covid: Some Light on Long Covid. The article includes prevalence, mechanisms and biomarkers, and potential treatments. Nature published a summary of Long Covid treatments, Long-COVID treatments: why the world is still waiting. My takeaway: there still is no consensus on either mechanism or therapy. I did learn from these papers that the adrenal axis is involved.

Eating to Improve Gut Health and Microbial Diversity

I'm often asked what people can do to improve their gut health. I received an email from Michael Greger's Nutrition Facts linking to the following video: How to Cultivate a Healthy Gut Microbiome with Food. Nutrition Facts is a fantastic resource full of free bite-sized videos. I like the site so much that, at various times, I have been a monetary supporter.

Gimme S'More

Ever wonder where S'mores came from? Me either. Regardless, I read an article that covers the history of the S'More--ingredients and all. A brief history of the s'more, America's favorite campfire snack

Orthopedic Surgery and Breast Cancer

I read a disturbing article Why Do Orthopedic Surgeons Have Such High Breast Cancer Rates. Female orthopedic surgeons have four times the breast cancer rate of the general population. The article zeroes in on the radiation that orthopedic surgeons use regularly. In my experience, surgeons are diligent about wearing a radiation shield when using x-rays / fluoroscopy. I am far more suspicious about chemical exposure to methyl methacrylate, the substance orthopedic surgeons use as the "grout" in knee and hip replacements. Even if an orthopedic surgeon is not currently using the compound regularly in their practice, they likely had significant exposure during training. Food for thought.

Walking+

The article, One type of walking reliably boosts fitness more than any other, mentions that adding hand-poles to your walking routine (Nordic walking) will increase caloric expenditure by close to 20%. Nordic walking has many other health benefits as well. That sounds like a no-brainer to me. I ordered a pair of poles today: TrailBuddy Trekking Poles - 7075 Aluminum with Cork Grip: Sports & Outdoors

Linking Nature to Well-Being

I came across the Inverse article, How is nature connected to well-being? It's complicated, scientists say that summarizes an exciting review in Science Advances: Linking the nonmaterial dimensions of human-nature relations and human well-being through cultural ecosystem services Nature, outside of tangible offerings like food, water, and other resources, offers nonmaterial contributions to well-being such as recreation and leisure, spiritual fulfillment, personal development, social relations, and aesthetic experiences. The article reviews existing literature to build a framework/rubric for how nature influences well-being.

+More about nature and well-being with some practical tips from the Atlantic: To Get Out of Your Head, Get Out of Your House

Reversing Lactose Intolerance

About 1/4 of the U.S. population is lactose intolerant. The symptoms of lactose intolerance (bloating, gas, abdominal discomfort, diarrhea) are caused by the absence of lactase, the enzyme that breaks down milk. Lactase production, in many people, turns off after weaning. If you are intolerant but want to enjoy dairy products, all is not lost. You can increase your tolerance of dairy by strategically using food. The article Can you become more tolerant of lactose? explains the method and mentions the ancient New England Journal of Medicine paper on the same topic: Yogurt — An Autodigesting Source of Lactose.

The Hippocampus and PTSD

Interesting scientific output from the AURORA Project (Advancing Understanding of Recovery after Trauma) housed at UNC. A recent paper in The Journal of Neuroscience, Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms focuses on the memory forming region of the brain, the hippocampus, and its role in the variability of PTSD development in the general population. Read the summary article here: The brain's memory hub may explain why some people get PTSD and some don't

Emotional WellBeing and Whole Person Health

I look forward to receiving emails from the National Center for Complementary and Integrative Medicine (NCCIH). The Director's message this week was about emotional well-being and its impact on the various pillars of health. Emotional Well-Being and Whole Person Health. I learned of the NIH networks to advance emotional well-being research. One disturbing fact that had me wanting to learn more-"A recent analysis of U.S. national data showed that 2 years after the diagnosis of cancer, 42 percent of survivors had depleted their entire net worth."_ Here are two of the free lectures the article mentions:

  1. Well-Being and the Economic Burden of Disease: What Are We Learning From Cancer Survivors?
  2. Advancing Research on Emotional Well-Being and Regulation of Eating

Dietary Supplements and Cognition

Another email this week touched on the science of supplements to slow cognitive decline, 7 Things To Know About Dietary Supplements and Alzheimer's Disease I'm a big fan of the NCCIH Tip Sheets: Tips on Complementary Health Practices

Mental Fatigue and Cognition

Just as our bodies get tired with prolonged physical activity, our minds show fatigue after long bouts of thinking. The article, How thinking hard makes the brain tired zeroes in on a neurometabolic cause for mental exhaustion (altered glutamate levels in specific regions of the brain).

Gut Microbiome in Anesthesiology and Pain Medicine

An interesting article published on WebMD, although a good part of the article is focused on pre-clinical findings: Gut Microbiome in Anesthesiology and Pain Medicine

Quote of the Week

"Do the best you can until you know better. Then when you know better, do better." ― Maya Angelou