Autoimmunity

071 - Bitter Truths, F-Bombs, and Twinning - HealthHippieMD Week In Review

Twinning to Understand the Impact of Food

New research published in JAMA Network Open involved identical twins on an eight-week dietary trial comparing vegan and omnivorous diets. The vegan group experienced notable health benefits: a 10-15% reduction in LDL cholesterol, 25% lower insulin levels, and a 3% weight loss. This study, unique for using genetically identical twins, highlighted the efficacy of a plant-based diet in improving cardiovascular markers and suggested even partial dietary shifts away from animal products can be beneficial. The findings underscore the potential health advantages of vegan diets while acknowledging the challenges of dietary changes. One identical twin went vegan while the other didn't. See what happened | CNN.

The Rising Tide of Autoimmunity

The article Autoimmunity Has Reached Epidemic Levels. We Need Urgent Action to Address It | Scientific American highlights the alarming increase in autoimmune diseases, now considered an epidemic. It emphasizes the urgent need for action to address this growing health crisis. Autoimmune conditions, where the immune system mistakenly attacks the body, affect an increasing number of people worldwide. The article calls for more research, better public awareness, and improved healthcare strategies to combat these diseases. It underscores the importance of understanding environmental triggers and genetic factors contributing to this surge, advocating for a comprehensive approach to tackle the autoimmune epidemic

A Bitter Truth

"Artificial sweeteners were originally intended to stave off the increasing obesity and metabolic disease epidemic, but instead, they may have directly contributed to it." Artificial Sweeteners May Have Despicable Impacts on Gut Microbes - Scientific American Blog Network delves into the potentially harmful effects of artificial sweeteners on gut microbes. It highlights a study suggesting that these sugar substitutes can inhibit the growth of certain beneficial gut bacteria. This disruption may lead to negative health consequences, as a healthy gut microbiome is crucial for overall well-being. The article underscores the importance of further research to fully understand the impact of artificial sweeteners on our gut health and the broader implications for our diet and lifestyle choices.

AI Travel Tips

Who has "packing a suitcase" on their valuable applications of AI Bingo Card? I certainly didn't. AI Teaches Robots the Best Way to Pack a Car, a Suitcase--Or a Rocket to Mars | Scientific American.

What Ails the NHS

Many people (including me) believe a single-payer system is the only way out of the United State's current healthcare morass. Detractors often point to the issues facing Britain's National Health Service (NHS). The New York Times had an interesting opinion on the origins of the current problems with the British System. As with everything in healthcare, the issue is far more complicated than it first appears: Opinion | Britain Ruined One of the Best Healthcare Systems in the World - The New York Times (gift article).

CVS's New Prescription for Pricing

CVS Health has announced a significant shift in pricing prescription drugs, aiming to simplify and make a traditionally complex system more transparent. Set to launch on January 1, 2025, for commercial payers, the new model, named CVS CostVantage, will calculate drug prices and pharmacy reimbursements using a precise formula. This formula includes the cost of the drug, a defined markup, and a dispensing fee. While this change may not uniformly reduce the cost of all medications, it is expected to generally lower prescription costs for consumers, employers, and health insurers. This initiative follows years of criticism over the U.S. healthcare system's lack of clarity and inflated prices. CVS's move mirrors a similar approach by Mark Cuban's online pharmacy, Cost Plus Drugs, which also aims to reduce medicine prices by selling them at a set markup over cost, plus pharmacy fees. Count me as skeptical that the change will benefit consumers. CVS Says It Will Change the Way Its Pharmacies Are Paid - The New York Times (gift article).

Scientific Grounds

A recent study has brewed up a simple yet effective solution to the messy business of coffee grinding. The research, focusing on the role of moisture in reducing static electricity in coffee grounds, found that a spritz of water on beans before grinding can significantly reduce static. This makes for a tidier grinding process and results in a more consistent and stronger-tasting espresso shot. The study, published in the journal Matter, is a part of the growing field of coffee science, which combines diverse disciplines to enhance our understanding of coffee preparation. Interestingly, the collaboration began through a shared interest in electric charge buildup, a common thread between coffee grinding and volcanic eruptions. This interdisciplinary approach led to the discovery that moisture levels in coffee beans play a crucial role in how they accumulate electric charge during grinding, with lighter roasts gaining less static due to higher internal moisture. The practical takeaway from this study is clear: a little water can go a long way in improving both the cleanliness of coffee grinding and the quality of the brew. There's a better way to grind the coffee, according to science - The Washington Post (gift article).

F-Bombs

Expletive use is on the rise. I present to you A very short history of the F-word - Big Think.

Present Tense

"Traumatic memories are not experienced as memories as such," but as "fragments of prior events, subjugating the present moment." A recent study in Nature Neuroscience delves into the unique neural mechanisms of traumatic memories, which may illuminate why they are so vivid and intrusive. Researchers at Yale University and the Icahn School of Medicine at Mount Sinai conducted brain scans on 28 individuals with PTSD, analyzing their responses to recorded narrations of their memories, ranging from neutral to traumatic. The study revealed that traumatic memories engage the posterior cingulate cortex, a brain area typically involved in introspection or daydreaming. This groundbreaking research offers new insights into the workings of PTSD, suggesting that traumatic memories are processed as ongoing experiences, thereby explaining their persistent and disruptive nature in everyday life. Brain Study Suggests Traumatic Memories Are Processed as Present Experience - The New York Times (gift article).

Harvard's Morgue Mystery

In a shocking scandal at Harvard, the Anatomical Gift Program, where people donate their bodies for scientific study, was exploited for a macabre trade. Cedric Lodge, the morgue manager, along with several others, was indicted for stealing body parts and selling them to oddity collectors. Families who had donated their loved one's body were horrified to discover that the remains might have been part of this gruesome trade. This betrayal of trust at such a prestigious institution has left many in disbelief and mourning, questioning the integrity of body donation programs and the dark underbelly of oddity collecting. Inside The Harvard Morgue Scandal: Missing Body Parts, Mourning Families.

044 - Biophilic Design, Hallucinations, and Erasing Memories - HealthHippieMD Week In Review

Strobe Lights Induce Visual Hallucinations

Wired U.K. featured a story about Dreamachine, where people experience hallucinatory effects through stroboscopic lights and music. The project aims to explore the impact of stroboscopic lights on the brain and investigate the neural basis of visual experience. Participants, even with closed eyes, reported vivid and kaleidoscopic visual experiences. The Dreamachine's potential applications extend to mental health therapy due to the reported common emotion of peace experienced by participants. This Machine Makes You Hallucinate | WIRED

Erasing Psychedelic Trips for the Good of Science

To address criticisms of psychedelic research, scientists at the University of Wisconsin–Madison Transdisciplinary Center for Research in Psychoactive Substances conducted a pilot study involving eight individuals, exploring the possibility of combining psychedelics with memory erasure. The study addresses the challenge of studying psychedelics in traditional randomized clinical trials due to the subjective nature of the experiences and the role of expectations. By exploring innovative study designs, scientists strive to better understand psychedelics' effects and potential therapeutic applications. Scientists Gave People Psychedelics—and Then Erased Their Memory

The Whimsy of Honoring Body Donors

Medical students and faculty members across the United States are organizing gratitude ceremonies to honor body donors who have contributed to medical research and education. These ceremonies involve music performances, speeches, and artistic expressions, allowing students to express appreciation for the donors who have served as their "first patients." The ceremonies aim to re-humanize the donors, recognizing their selfless acts and the sacrifice made by their families. The events provide closure and foster a sense of gratitude while imparting essential lessons in ethics and professionalism. Honoring the Body Donors Who Are a Medical Student's 'First Patient' (gift article)

Conversational Receptiveness: Mastering the Art of Disagreement

To have better disagreements, change your words – here are four ways to make your counterpart feel heard and keep the conversation going discusses the importance of changing our words and behaviors during disagreements to foster productive conversations. Instead of solely focusing on persuading others, the research suggests adopting a communication style called "conversational receptiveness." This style involves four key elements: hedging claims, emphasizing agreement, acknowledging the opposing perspective, and reframing to the positive. By employing these techniques, conversations become less confrontational and more constructive, allowing both parties to feel heard and maintaining relationships.

Rousing Revelations: Some Mental Illness May Have Autoimmune Origin

WaPo published a story about a groundbreaking case involving April Burrell, a catatonic woman diagnosed with schizophrenia. Researchers discovered that lupus, an autoimmune disease, attacked April's brain, leading to severe symptoms. After targeted treatments, including immunotherapy, April regained consciousness after being trapped in her mind for over two decades. This discovery has the potential to revolutionize the care for psychiatric patients worldwide and reshape the way mental illnesses are diagnosed and treated, bringing hope to "forgotten souls" who were deemed untreatable. How autoimmune disease can attack the brain, cause psychiatric symptoms - The Washington Post (gift article)

Function Over Flaws

A revolutionary new health metric called human functioning could alter the treatment of chronic illnesses. Traditionally, health has been measured based on morbidity and mortality rates, focusing solely on disease and death. However, the proposed metric considers a person's illness and available resources to gauge their condition's impact on daily life activities. This approach aims to shift the healthcare system toward a patient-centered approach, promoting well-being and enabling individuals to live their best lives. This New Metric For Health Could Revolutionize How We Treat Chronic Illnesses

Byte-Size Nutrition

Artificial intelligence (A.I.) nutritionist apps are revolutionizing healthy eating by offering personalized diet solutions. These apps use A.I. algorithms to analyze data on an individual's blood sugar, microbiome, and other metabolic measurements. By understanding how different foods affect each person's body, these apps can suggest healthier meal options. While personalized nutrition is still evolving, A.I. programs hold the potential for addressing obesity, heart disease, and other health concerns. Here Come the Artificial Intelligence Nutritionists

+A reminder, buyer-beware when it comes to A.I. advice (although the chatbot mentioned in this article is different than ChatGPT): An Eating Disorder Chatbot Is Suspended for Giving Harmful Advice^4a50c0

Music and Health: The Evidence

The NCCIH has a web page focused on Music and Health: What You Need To Know.

Nature at Home: A Prescription for Well-being

WaPo had an article about the science-backed concept of "biophilic design" that promotes connecting with nature indoors. 7 ways to bring nature into your home, according to science. (gift article)

Green Brain: Brain Aging Delayed with Mediterranean Diet

A recent study reveals that a Mediterranean diet can slow brain aging. The research indicates that a mere 1% reduction in body weight resulted in brains appearing almost nine months younger. Greener Diet, Younger Brain: Mediterranean Diet Slows Brain Aging.

Ultra-processed Food and Sleep Quality

"No study had previously investigated what happens if we consume an unhealthy diet and then compare it to the quality of sleep after that person follows a healthy diet." In this small preliminary study, an unhealthy diet impacted each individual's sleep quality. Junk Food vs. Sleep: New Study Reveals Impact of Diet on Sleep Quality.

038 - Ice Cream, Understanding Animal Communication, and Circadian Immunity - HealthHippieMD Week In Review

Wait, Ice Cream Might be Healthy?

I enjoyed the article, Could Ice Cream Possibly Be Good for You?. The report not only discusses the controversial, non-spurious outcome that won't go away but also demonstrates what happens in the scientific world when a new finding bucks traditional thinking. And the article contains puns.....

How Generative AI Will Change the Music Industry

Generative AI is not just for text and image creation. AI-Generated Music Is About to Flood Streaming Platforms discusses how AI is changing the music industry and music itself.....

Amyloidosis

The same misfolded proteins found in Alzheimer's Disease can also be found in other organs. Alzheimer's-Like Diseases Can Affect the Body — Scientists Are Working to Find Out Why is an overview of Amyloidosis and its treatment.

Chartreuse Shortage

For my 21st birthday, some friends bought me Chartreuse, a bright green herbal liqueur. That was the only time I tasted it. But now, even if I wanted more, it might not be possible. Chartreuse is getting more difficult to find. Why Is There a Chartreuse Shortage? Ask the Monks Who Make It.

Altered States of Memory

"Memory is "reconstructive." People actively alter the information they remember according to their biases and expectations." Short-term memories were thought to be less subject to alteration, but a recent study demonstrates otherwise: Our expectations can create fake short-term memories. If you'd like to learn more about the fragility/malleability of memory, take a listen to one of my favorite Revisionist History episodes: Free Brian Williams.

How Ultra-processed Food Starves the Microbiome

Another article on how processing alters food--and not in healthy ways: You Could Be Unknowingly Starving Your Gut Bacteria — But The Fix Is Surprisingly Simple. I feel like a broken record....

Is "Non-Communicable Disease" a Misnomer?

Human ailments such as heart disease were thought to be non-communicable. But findings from microbiome research call that belief into question: The Biggest Microbiome Study Sheds New Light on Shared Health Risks.

Covid, Population Risk, and Personal Risk

There is a 1% mortality rate from COVID. If 1% of COVID-19 cases result in death, does that mean you have a 1% chance of dying if you catch it?

FDA Approves Second Bivalent COVID Booster

"Federal health officials will not formally urge that people get a second booster. Instead, the "permissive" policy says they may get a second dose if they want." FDA okays second omicron booster for people at high risk from covid

Why Does Hair Turn Grey?

"A new study suggests stem cells may get stuck as hair ages and lose their ability to mature and maintain hair color." Scientists may have discovered why hair turns grey._

Belated Happy Waldo Day!

This week marked 4/20. In honor of the day, Longreads compiled a list of cannabis-related stories: Weed Between the Lines: A Longreads Cannabis Collection.

Talking to the Animals

I've often joked that I wish Theodore, a six-year-old Labradoodle, could talk. Now, thanks to AI and bioacoustics, my wish may become a reality: How Scientists Are Using AI to Talk to Animals.

Food and Hot Flashes

We don't understand the physiology of hot flashes, but it appears food can influence the severity of this common occurrence: Could Certain Foods Help With Hot Flashes? (gift article)

Us versus Them

"It's been said, "There are two kinds of people in the world: those who divide the world into two kinds of people and those who don't." In reality, there are lots more of the former. And it can be vastly consequential when people are divided into Us and Them, ingroup and outgroup, "the people" (i.e., our kind) and the Others." An stimulating article in Nautilus about us/them dichotomies: Why Your Brain Hates Other People.

Reinvent Yourself According to Experts

Giving credence to your "possible selves" is an evidence-based way to reinvent yourself. How to Reinvent Yourself, According to the Experts tells you how. See also the fantastic podcast: zigzag project.

A Key Character Trait for Happiness

Enthusiasm Is Key to Happiness is an interesting article that touches on psychology and finishes with ways of improving your happiness, regardless of personality type.

Huge Umbrella Analysis of Dietary Sugar

The British Medical Journal published an article that aggregated a huge (8600+) studies on the effects of sugar on health outcomes: Dietary sugar consumption and health: an umbrella review. Read the synopsis here: Study Offers Dozens of Reasons to Cut Sugar

Circadian Rhythms and Immunity

How Circadian Rhythms and Time of Day Control the Immune System describes recent breakthroughs into how our body's internal clock seems to regulate immunity and susceptibility to disease.

029 - Coffee College, Facebook, Resilience and Despair - HealthHippieMD Week In Review

Life may get in the way of newsletter publication next week. I'm apologizing in advance for an abreviated or absent edition. I'll resume normal publication on Sunday, February 26.


Demoralization of Healthcare Workers

Here is a provocative piece about diminished morale amongst healthcare workers. Although written by a physician about physicians, the same is true for other healthcare professionals. Opinion | Doctors Aren't Burned Out From Overwork. We’re Demoralized by Our Health System (gift article)

Food Choice and Cognition / Dementia

Here is another article on the cognitive value of eating whole, plant-based food: How Your Diet Could Help (or Hurt) Your Aging Brain. For a nice review paper on food and supplements, see: In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function.

Exercise and Resilience

"Resilience is the ability to bounce back from adversity... Resilience is essentially an emotional muscle, but a growing body of research shows that exercising our physical muscles is one way to increase our capacity to cope with daily stress." WaPo had an article on the physiology behind the phenomenon: How exercise can help you build resilience at any age (gift article)

Your Lying Mind

The Atlantic procured several articles on how our minds can deceive us, especially when something threatens our identity: Your Lying Mind - The Atlantic (requires subscription)

Psychedelics Medically Approved Down-Under

Starting July 1, 2023, authorized Australian psychiatrists have another tool in their armamentarium: psychedelics. On February 3, MDMA and psilocybin, but the training standards and hoops to jump through to prescribe these drugs are still formidable: MDMA and Psilocybin Are Approved as Medicines for the First Time | WIRED (thanks, Richard!)

Relationship Contracts

A relationship contract looks pretty unromantic, but it seems to work for this couple: Creating a contract — yes, a contract! — could help you get what you want from your relationship |

Sound Therapy

Sound therapy instruments like the Digeridoo and Tibetan Singing Bowls have been used for thousands of years to calm the mind and heal the body. Is Sound Therapy the New Way to Zen? discusses the phenomenon. I was skeptical about sound therapy until I read literature on how specific frequencies of sound activate immune pathways (in rodents): Alzheimer's Disease and Gamma Waves

Coffee College

I'm interested in perfecting my coffee-making abilities. In the article, Coffee College: Everything You Wanted to Know about Coffee Making in One Lecture, I learned of the coffee-education service Barista Hustle and its associated Youtube channel. I'm setting aside 80 minutes to watch: Advanced Coffee Making Lecture at Assembly Coffee London.

Your Healthcare System: Official Corporate Partner of the NFL

A provocative opinion piece in WaPo about hospital marketing. "So when people see any TV commercial or billboard highlighting a hospital system's quality of care, then walk into that same hospital system's emergency room only to find it dangerously overcrowded and understaffed, it is worth connecting the dots. Imagine how many lives would be saved if only we were to take the bold step of demanding that our healthcare dollars be spent on actual healthcare." Opinion | Super Bowl ads are not where hospitals in crisis should spend money (gift article)

Artificial Intelligence Primer: Wired Complete Guides

Wired has been doing background pieces on today's important technology. Two examples to help you get up to speed: What Is Blockchain? The Complete WIRED Guide and What Defines Artificial Intelligence? The Complete WIRED Guide. Both are worth a read.

A New Approach to Graft-vs-Host Disease and Inflammatory Bowel Disease (pre-clinical)

GI GVHD Link to Microbiome Dysbiosis Addressed by Reducing Intestinal Oxygen discusses a study looking at treating GVHD (and perhaps inflammatory bowel disease) by decreasing the oxygen content in the bowel using iron chelation. "The findings suggested that restoring the normal environment by reducing the oxygen level in the intestine could help re-establish the balance of the microbial community and lead to attenuation of GVHD."

The Science of Pleasurable Touch (pre-clinical)

You've probably heard of "skin hunger," the craving to be touched by another. Scientists are beginning to unravel why being touched by others is pleasurable: Scientists mapped the brain circuitry involved in pleasing touch in mice

How Do You Serve a Friend in Despair

Love oozed from a journalist's writing about his good friend who sunk into depression and ultimately committed suicide. "I learned, very gradually, that a friend's job in these circumstances is not to cheer the person up. It's to acknowledge the reality of the situation; it's to hear, respect, and love the person; it's to show that you haven't given up on them or walked away." Opinion | How Do You Serve a Friend in Despair? (gift article)

All Things Zuckerberg

"We are the germs, but Facebook is the wind." Facebook seems to be at the center of many controversies today. I just read the 2018 article, Can Mark Zuckerberg Fix Facebook Before It Breaks Democracy?, The article was insightful and informative and is a must-read for anyone that wonders what all the hullaballoo is about.

Covid Evolved

A Crucial Group of Covid Drugs Has Stopped Working discusses how Covid has evolved, negating the effectiveness of drugs that were once the mainstay of prophylaxis for immunocompromised patients.