046 - Holobionts, Embracing Death, and the Moral Crisis of Physicians - HealthHippieMD Week In Review

Embrace Death for a Happier Life

Contemplating mortality may seem grim, but it is critical to a fulfilling existence. Drawing inspiration from Randy Pausch's remarkable Last Lecture, experts argue that acknowledging our finite existence enhances happiness. Avoiding thoughts of death leads to regret and postponing meaningful experiences. By embracing the reality of death, we make wiser choices, cherish relationships, and appreciate life's fleeting moments. Deliberately confronting mortality cultivates positive thinking and clarity, enabling us to live each day to the fullest. Think About Your Death and Live Better - The Atlantic

Taurine: a Longer Life or Just Bull?

A recent study in the journal Science suggests that taurine, a common amino acid, may be essential to anti-aging and longevity. Researchers discovered that taurine levels decline as organisms age, leading to tissue damage. However, supplementing taurine in the diets of worms, mice, and monkeys extended their lifespans and reversed age-related damage in their muscles, bones, and brains. More research is needed.Can Taurine, Found in Energy Drinks, Slow Down Aging? - The New York Times

Bots with Bedside Manner

In the article, Doctors Are Using ChatGPT to Improve How They Talk to Patients - The New York Times (gift article) the unexpected use of artificial intelligence (AI) chatbot ChatGPT by doctors is explored. While AI models like ChatGPT have the potential to assist with mundane tasks and improve efficiency, doctors have discovered their value in enhancing compassionate communication with patients. (Thanks, NextDraft)

We Are Multitudes: The Rise of Holobionts in Biology

In a paradigm shift for biology, the concept of "holobionts" is gaining recognition, emphasizing the interconnectedness of animals, plants, and their microbiota. The Leverhulme Centre for the Holobiont studies insects, amphibians, and plants to understand the symbiotic relationships within these organisms. Holobionts challenge the notion of a monogenic individual, highlighting the importance of the microbiome in evolution, health, and even agriculture. By unraveling the intricacies of holobionts, scientists are uncovering new insights into the world of multi-organismal biology. The idea of "holobionts" represents a paradigm shift in biology.

A New Beatles Song, Thanks to AI

The Beatles are going to release a new song later this year. Paul McCartney said he used technology to 'extricate' John Lennon's voice from an old demo and complete a decades-old piece. I can't wait. AI used to create new and final Beatles song, says Paul McCartney | The Guardian

The Military Method for Falling Asleep Quickly

A brief article with a method used by the U.S. Army to promote sleep in the worst conditions: The 5-step "military method" for falling asleep in minutes.

Sound Check: Noise and Health

"Chronic noise exposure is not just a nuisance, scientists say. It's a health risk." The article Are You Exposed to Too Much Noise? Here's How to Check. - The New York Times (gift article) explores the detrimental effects of chronic noise exposure on both hearing and cardiovascular health. As noise levels continue to rise, the risks of cardiovascular disease increase. The article provides resources for measuring noise exposure, such as an online noise map and the NIOSH Sound Level Meter app. It also offers tips for protecting oneself. By understanding and managing noise exposure, individuals can safeguard their well-being.

The Moral Crisis of American Doctors

The article, The Moral Crisis of America's Doctors - The New York Times (gift article), about the corporatization of medicine, spoke deeply to me. A must read.....

Distract to Connect

New research suggests that shared distraction can be a more effective way to foster genuine connections in a world obsessed with constant attention. Engaging in activities that divert focus from ourselves, such as physical exercise or exploring the environment, enhances social connectedness and creative thinking. By embracing distractions and incorporating them into our interactions, whether online or in person, we can strengthen relationships and enjoy more enriching conversations. Embrace Distraction. Your Friends Will Thank You. - The Atlantic

NCCIH Free Online Education

The National Center for Complementary and Integrative Medicine (NCCIH) has an expanding library of free educational seminars on the science behind complementary and integrative approaches: NCCIH Online Continuing Education Series.

Going the Extra Mile

In the article, Overtraining syndrome: How much exercise is too much,, Slate explores the dark side of endurance running and the potential for it to become a form of self-harm. While exercise is widely recognized for its physical and mental health benefits, pushing the boundaries can have detrimental effects. The article delves into personal stories of individuals addicted to pain and extreme physical challenges, highlighting the need to recognize one's limits and prioritize overall well-being. The author emphasizes the importance of finding a balance between perseverance and excess in the pursuit of athletic achievements.

How To Exercise When It's Humid

Humidity is ratcheting up here in North Carolina. The New York Times had a piece on exercising in humid weather: Tips for Exercising in Humidity.

045 - Dying Brains, Frenemies, and the Physiology of Hangry - HealthHippieMD Week In Review

Flavanols Combat Memory Loss in Aging Adults

A new study reveals that flavanols, nutrients found in select fruits and vegetables, are crucial in mitigating age-related memory decline. The research demonstrates a positive correlation between flavanol intake and memory test scores among older adults. Notably, individuals over 60 with low-flavanol diets experienced significant memory improvement after reintroducing these dietary components. This study supports the emerging understanding that specific nutrients are essential for maintaining optimal brain health as we age. By highlighting the power of flavanols, the research offers potential avenues for improving cognitive function in older adults and underscores the importance of a flavanol-rich diet or supplements. Memory Boosting Power of Flavanols in Aging Adults

Gut Check

Scientists have discovered the mechanism behind how chronic stress can lead to gut inflammation. Signals originating in the brain reach gut nerve cells, triggering the release of inflammatory chemicals. The study, The enteric nervous system relays psychological stress to intestinal inflammation glucocorticoids act on gut neurons and glial cells, which then activate immune cells. These immune cells release molecules that cause painful bowel inflammation. The findings suggest that managing stress levels could significantly impact the effectiveness of treatments for inflammatory bowel disease (IBD). The research opens possibilities for targeting the brain-to-gut signaling pathway for new therapies. Chronic stress can inflame the gut — now scientists know why

Frenemies Take a Toll

According to psychologists, ambivalent relationships, known as frenemies, which combine positive and negative aspects, can be more detrimental to health than purely negative relationships. Research reveals that interacting with individuals who evoke mixed feelings can raise blood pressure and lead to negative physical symptoms. Even a single ambivalent interaction can have adverse effects on well-being. Unpredictability increases pain from unpleasant interactions, and rumination contributes to the negative impact of such relationships. Recognizing the harmful effects of frenemies is important for maintaining overall health and well-being. Opinion | Ambivalent Relationships May Be Hazardous to Your Health. (gift article)

The Neuroscience of Hangry

Neuroscientists have discovered a cluster of cells called AgRP neurons that stimulate appetite and play a vital role in the infamous "hangry" feeling. These cells near the brain's blood supply receive signals from the stomach and fat tissue, influencing our hunger levels. By manipulating AgRP neuron activity in mice, researchers have identified how they trigger food-seeking behavior and respond to the presence of nutrients. This breakthrough could lead to new therapies for eating disorders like anorexia and overeating. By understanding and controlling the hangry feeling, scientists hope to revolutionize our ability to manage our diets effectively. Neuroscientists May Have Found the Part of Your Brain That Makes You Hangry

Electrical Activity Surges in the Dying Brain

A new study reveals that dying brains experience a surge of electrical activity, challenging the assumption that brain activity decreases during dying. Researchers monitored four comatose patients who died in a neurointensive care unit and observed a surge of neurophysiological activity in regions associated with conscious processing. This surge included increased synchronization and connectivity between different brain regions. While the study doesn't directly explain near-death experiences, it suggests that the observed brain activity pattern may contribute to the vivid perceptions reported during such experiences, prompting further investigation into the nature of human consciousness. Scientists monitored four dying patients' brains. Here's what they saw . In the late 2000s, David Auyong and I observed the same phenomenon while on call: Processed electroencephalogram during donation after cardiac death.

Biochemistry of Psychedelics, BDNF, and Neuroplasticity

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience reveals that LSD and magic mushrooms dramatically rewire the brain, offering new possibilities for treating depression. The research conducted by an international team of scientists from the University of Helsinki shows that, at least in a test tube, these psychedelics bind to a protein called receptor tyrosine kinase beta (TrkB), which activates brain-derived neurotrophic factor (BDNF). BDNF plays a crucial role in neuron growth and development. This discovery paved the way for developing safer and more effective treatments for mental health disorders. LSD and Magic Mushrooms Dramatically Rewire the Brain, New Study Reveals.

AIHits (Generative AI Music and Podcasts)

"What makes pop work is that it's always changing and always responding. This is just a feedback loop between systems." AI is having a profound effect on artistic expression in music. Now there's a website to listen to. AI Could Usher in a New Era of Music. Will It Suck?

+The Generative AI gold rush is on in the podcasting space, too, as if the genre wasn't already overcrowded: Generative AI Podcasts Are Here. Prepare to Be Bored.

The Evolutionary Significance of Dreaming

"REM [sleep] has been crucial to human creativity."The evolutionary significance of dreaming is an interesting video on BigThink.

External Stressors Affect Cancer Mortality

Surprise, surprise! Higher allostatic load, a quantitive measure of the cumulative physiological damage from stress, is associated with worse cancer outcomes: Evidence Emerges Showing External Stressors Adversely Affect Cancer Outcomes

Sucralose-Genotoxic?

At least in test tubes, new evidence shows that Sucralose (Splenda) can disrupt DNA. "It's time to revisit the safety and regulatory status of sucralose because the evidence is mounting that it carries significant risks." Sucralose Damages DNA, Linked to Leaky Gut: Study (thanks, Diana!)

044 - Biophilic Design, Hallucinations, and Erasing Memories - HealthHippieMD Week In Review

Strobe Lights Induce Visual Hallucinations

Wired U.K. featured a story about Dreamachine, where people experience hallucinatory effects through stroboscopic lights and music. The project aims to explore the impact of stroboscopic lights on the brain and investigate the neural basis of visual experience. Participants, even with closed eyes, reported vivid and kaleidoscopic visual experiences. The Dreamachine's potential applications extend to mental health therapy due to the reported common emotion of peace experienced by participants. This Machine Makes You Hallucinate | WIRED

Erasing Psychedelic Trips for the Good of Science

To address criticisms of psychedelic research, scientists at the University of Wisconsin–Madison Transdisciplinary Center for Research in Psychoactive Substances conducted a pilot study involving eight individuals, exploring the possibility of combining psychedelics with memory erasure. The study addresses the challenge of studying psychedelics in traditional randomized clinical trials due to the subjective nature of the experiences and the role of expectations. By exploring innovative study designs, scientists strive to better understand psychedelics' effects and potential therapeutic applications. Scientists Gave People Psychedelics—and Then Erased Their Memory

The Whimsy of Honoring Body Donors

Medical students and faculty members across the United States are organizing gratitude ceremonies to honor body donors who have contributed to medical research and education. These ceremonies involve music performances, speeches, and artistic expressions, allowing students to express appreciation for the donors who have served as their "first patients." The ceremonies aim to re-humanize the donors, recognizing their selfless acts and the sacrifice made by their families. The events provide closure and foster a sense of gratitude while imparting essential lessons in ethics and professionalism. Honoring the Body Donors Who Are a Medical Student's 'First Patient' (gift article)

Conversational Receptiveness: Mastering the Art of Disagreement

To have better disagreements, change your words – here are four ways to make your counterpart feel heard and keep the conversation going discusses the importance of changing our words and behaviors during disagreements to foster productive conversations. Instead of solely focusing on persuading others, the research suggests adopting a communication style called "conversational receptiveness." This style involves four key elements: hedging claims, emphasizing agreement, acknowledging the opposing perspective, and reframing to the positive. By employing these techniques, conversations become less confrontational and more constructive, allowing both parties to feel heard and maintaining relationships.

Rousing Revelations: Some Mental Illness May Have Autoimmune Origin

WaPo published a story about a groundbreaking case involving April Burrell, a catatonic woman diagnosed with schizophrenia. Researchers discovered that lupus, an autoimmune disease, attacked April's brain, leading to severe symptoms. After targeted treatments, including immunotherapy, April regained consciousness after being trapped in her mind for over two decades. This discovery has the potential to revolutionize the care for psychiatric patients worldwide and reshape the way mental illnesses are diagnosed and treated, bringing hope to "forgotten souls" who were deemed untreatable. How autoimmune disease can attack the brain, cause psychiatric symptoms - The Washington Post (gift article)

Function Over Flaws

A revolutionary new health metric called human functioning could alter the treatment of chronic illnesses. Traditionally, health has been measured based on morbidity and mortality rates, focusing solely on disease and death. However, the proposed metric considers a person's illness and available resources to gauge their condition's impact on daily life activities. This approach aims to shift the healthcare system toward a patient-centered approach, promoting well-being and enabling individuals to live their best lives. This New Metric For Health Could Revolutionize How We Treat Chronic Illnesses

Byte-Size Nutrition

Artificial intelligence (A.I.) nutritionist apps are revolutionizing healthy eating by offering personalized diet solutions. These apps use A.I. algorithms to analyze data on an individual's blood sugar, microbiome, and other metabolic measurements. By understanding how different foods affect each person's body, these apps can suggest healthier meal options. While personalized nutrition is still evolving, A.I. programs hold the potential for addressing obesity, heart disease, and other health concerns. Here Come the Artificial Intelligence Nutritionists

+A reminder, buyer-beware when it comes to A.I. advice (although the chatbot mentioned in this article is different than ChatGPT): An Eating Disorder Chatbot Is Suspended for Giving Harmful Advice^4a50c0

Music and Health: The Evidence

The NCCIH has a web page focused on Music and Health: What You Need To Know.

Nature at Home: A Prescription for Well-being

WaPo had an article about the science-backed concept of "biophilic design" that promotes connecting with nature indoors. 7 ways to bring nature into your home, according to science. (gift article)

Green Brain: Brain Aging Delayed with Mediterranean Diet

A recent study reveals that a Mediterranean diet can slow brain aging. The research indicates that a mere 1% reduction in body weight resulted in brains appearing almost nine months younger. Greener Diet, Younger Brain: Mediterranean Diet Slows Brain Aging.

Ultra-processed Food and Sleep Quality

"No study had previously investigated what happens if we consume an unhealthy diet and then compare it to the quality of sleep after that person follows a healthy diet." In this small preliminary study, an unhealthy diet impacted each individual's sleep quality. Junk Food vs. Sleep: New Study Reveals Impact of Diet on Sleep Quality.

043 - Brain Stimulation, Hacking Sleep, and Sad Music - HealthHippieMD Week In Review

Falling

About 25% of adults 65 and older will fall each year. Falls lead to bodily injury that speeds up the need for nursing care and, in some cases, death. Balance declines with age, but exercise can help stave off some of the risks of falling has some practical advice on how to minimize the risk for yourself and your loved ones.

Ozempic: A New Treatment for Addiction?

The weight-loss drug Ozempic, also known as semaglutide, shows unexpected side effects in patients. Along with suppressing appetite, people taking Ozempic have reported losing interest in addictive and compulsive behaviors such as drinking, smoking, shopping, nail-biting, and even skin picking. Scientists are intrigued by these anecdotes and have been studying drugs similar to liraglutide for their potential to curb addiction. The drug affects the brain's reward circuitry, making it a potential anti-addiction medication. Could Ozempic Also Be an Anti-addiction Drug?

Sad Music: Seeking Connection, Not Sorrow

A new study explores why we are drawn to sad songs, suggesting that it's not about experiencing sadness but seeking a sense of connection. While some theories propose that specific musical elements trigger sadness, the study emphasizes cognitive mechanisms and empathy as key factors. The findings indicate that people value emotional expression over technical proficiency in music and that listening to sad songs provides a connection, making us feel less alone. Why Do We Listen to Sad Songs? A New Study Offers an Answer. (gift article)

Mindfulness and Meditation

How meditation can change your life and mind explores the potential benefits of meditation and its ability to bring positive changes to people's lives. While the hype around meditation often includes extravagant claims, research suggests that mindfulness meditation, in particular, can have a significant impact. It enhances awareness and attention, improves emotional regulation, reduces stress, and fosters prosocial behaviors. However, it's important to approach meditation with an experimental mindset and find a practice that aligns with individual goals. Meditation is a valuable mental health tool but should not replace conventional care.

Peter Attia Publishes a Book

One of my favorite podcasts is Peter Attia's Drive.. He has been making the rounds promoting his new book: Outlive: The Science and Art of Longevity. The New York Times interviewed him, and I have to say, his intensity shined through: Want to Live Longer and Healthier? Peter Attia Has a Plan. (gift article)

Chronic Pain Linked to Orbitofrontal Cortex

A new, tiny study linked chronic pain to activity in the orbitofrontal cortex, an area involved in emotion regulation, self-evaluation, and decision-making. "The research suggests that such patterns of brain activity could serve as biomarkers to guide diagnosis and treatment for millions of people with shooting or burning chronic pain linked to a damaged nervous system." Although this article is intriguing, reader beware. Given the tiny sample size, it is hard to consider this finding much more than an intriguing idea. Much more research is needed. Chronic Pain Linked to Brain Signals in Orbitofrontal Cortex.

Hacking Sleep to Improve Creativity

Researchers at the MIT Media Lab and the Center for Sleep and Cognition have discovered that the first ten minutes of sleep, known as N1 sleep, can enhance creativity and problem-solving abilities. The study found that those who experienced N1 sleep and had their dreams incubated scored significantly higher in creativity tests than non-sleepers and those who only took naps. This research highlights the potential of N1 sleep for boosting creativity and finding innovative solutions. Harness the Creativity-Boosting Power of "N1" Sleep

Persistence Enhances Creativity

In the article Why We Get More Creative Over Time , the authors discuss the misconception that our creativity diminishes as we persist with a problem. Research shows that persistence is the key to generating more original ideas. Experiment participants consistently produced more creative ideas than they anticipated during subsequent attempts. The serial-order effect suggests that each successive idea will likely be better than the previous one. This pattern applies not only to individuals but also to companies and markets. The article challenges the myth of novelty and highlights the importance of persistence in achieving breakthroughs.

Ketamine vs. ECT for Depression in New England Journal

Electroconvulsive Therapy, for 80 years, has been considered the gold standard for refractory depression. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression, published in New England Journal of Medicine demonstrates that ketamine may be a viable option to ECT. Ketamine Matches 'Gold Standard' in Major Depression Trial. More research is needed.

Electrifying the Mind: Rhythmic Brain Stimulation Enhances Cognitive Function

A meta-analysis suggests that tACS improves cognition in healthy, aging, and psychiatric populations is a recently published paper of over 100 studies on transcranial alternating current stimulation (tACS) reveals that rhythmically stimulating the brain with electrical currents can significantly boost cognitive function. By applying controlled currents to specific brain regions, tACS induces rhythmic brain activity, enhancing mental capabilities. The analysis suggests consistent and immediate improvements in mental function, particularly in executive function, attention, and memory. Furthermore, tACS proves effective in older adults and individuals with neuropsychiatric conditions. Rhythmically stimulating the brain with electrical currents could boost cognitive function, according to an analysis of over 100 studies.

Blood Types Ranked

Here is a quick overview of blood types and their frequency in the population: What Is the Rarest Blood Type in the World?

Conspiracy Detection Kit

Political races are heating up, and with them, various conspiracy theories. Here is a toolkit to help you determine what is real: 10 rules to tell if a conspiracy theory is true or false

042 - Quantum Biology, Wearables, and Birdsong - HealthHippieMD Week In Review

Quantum Biology

This scientist believes nature has harnessed "quantumness" and that our current beliefs about biology are sorely incomplete: Quantum physics proposes a new way to study biology – and the results could revolutionize our understanding of how life works.

Pushing Our Kids to Achieve

Do we do our kids a disservice by pushing them to achieve? This author thinks so: Opinion | What We Lose When We Push Our Kids to 'Achieve' - The New York Times (gift article)

The Newest College Admission Scam: Publish a "Scholarly" Paper

An emerging industry of research services is helping high school students produce and publish research papers to boost their college applications. Online programs, such as Scholar Launch, charge thousands of dollars to connect students with mentors who guide them in writing articles, which are then published in journals of questionable quality. The Newest Way to Buy an Advantage in College Admissions.

Resisting Alzheimer's

Patients whose health doesn't conform to expectations can offer new insight into a possible disease treatment. Such is the case with a man who, based on his D.N.A., "should of" developed Alzheimer's in his 40s but showed resilience to the disease. Mutation Protected Man From Alzheimer's Disease, Hinting at Treatment. (gift article)

WHO Says "No" to Non-Nutritive Sweeteners

The World Health Organization (W.H.O.) has cautioned against using artificial sweeteners for weight control and reducing the risk of noncommunicable diseases. The W.H.O. stated that these alternatives to sugar do not effectively reduce body fat in adults or children and could potentially increase the risk of Type 2 diabetes, cardiovascular diseases, and mortality. This recommendation contradicts previous studies that suggested no harm from sweeteners. Based on a comprehensive review, the W.H.O.'s advice emphasizes the importance of reducing overall sugar intake and relying on naturally occurring sugars found in fruits and unsweetened foods and beverages. World Health Organization Warns Against Using Artificial Sweeteners (gift article)

Therapy Unpacked

Therapy once stigmatized as a luxury for the neurotic, has gained acceptance and popularity over the years. This article explores the effectiveness of talk therapy in improving mental health. While studies suggest that therapy indeed works and yields positive results, there are ongoing debates and challenges in the field. Researchers are trying to determine the best types of therapy for different individuals and understand the impact of the therapist-patient relationship. Some argue for a shift toward more innovative strategies, while others believe therapy's potential hasn't been fully unlocked. Ultimately, the therapist's skills and the bond formed with the patient are crucial to therapy's success. Does Therapy Work? Let’s Unpack That. (gift article)

New Manuscript Defines Frequency of Chronic Pain

"New cases of chronic pain occur more often among U.S. adults than new cases of several other common conditions, including diabetes, depression, and high blood pressure." A new analysis points to the high disease burden of chronic pain in the U.S. U.S. National Survey Data Show High Rates of New Cases and Persistence of Chronic Pain.

The Slumbering Successes of Innovation in Nature and Culture

In his book "Sleeping Beauties: The Mystery of Dormant Innovations in Nature and Culture,", biologist Andreas Wagner discusses how many brilliant ideas and innovations fail immediately but instead emerge and persist in the shadows until the right time arrives for them to step into the limelight. Wagner argues that the success of an innovative product, whether it's a new form of life or a work of art, depends not only on its inner qualities but also on the right environment and timing. He emphasizes the importance of understanding delayed success and empathizing with oneself in the creative process. Why Many Brilliant Ideas Don't Succeed Immediately.

Patients Hack Wearables to Monitor Chronic Illness

"What we have right now is a health and wellness industry that provides data-driven insights and data-driven advice, so long as their physiology is typical." How Chronic Illness Patients Are 'Hacking' Their Wearables describes how patients are using consumer electronics, such as the Oura Ring, Fitbit, and Apple Watch to monitor less common chronic illnesses.

Burned-Out on Burnout

How to address physician burnout. discusses the issue of physician burnout and challenges the prevailing approach to addressing it by embracing the humanities. I think the article misses the point or at least gives only a partial solution. Rather than implying burnout is a personal failing, it should be considered a healthcare system failure. One of my favorite papers on this subject was written by Tait Shanafelt before the pandemic: Executive Leadership and Physician Well-being: Nine Organizational Strategies to Promote Engagement and Reduce Burnout.

Birdsong and Mental Health

Research has consistently demonstrated that more contact and interaction with nature improves physical and mental well-being. Scientists are examining whether birdsong contributes to nature's positive effects: Why birds and their songs are good for our mental health. (gift article)

Banning Food Dyes

"They have no known nutritional benefits and potentially carry several health risks." The Atlantic had a story on efforts around the world to ban artificial food coloring: The True Danger of Food Dye.

041 - Doctor Dog, AI Mind-Reading, and Smelling Virtual Roses - HealthHippieMD Week In Review

Long Telomeres

"Short telomeres were thought to be bad — people with premature aging syndromes had short telomeres — so, by analogy, long telomeres were thought to be good..." A paper published last week, Familial Clonal Hematopoiesis in a Long Telomere Syndrome | NEJM, challenged current assumptions about telomere length. Link Between Long Telomeres and Long Life Is a Tall Tale, Study Finds - The New York Times

Rapamycin

"Rapamycin is a paradoxical drug. It improves anti-cancer immunity, but it may also cause cancer. It protects against bacterial infection, halts viral replication, and suppresses the immune system. It reverses symptoms of Alzheimer's disease but also increases plaque deposits in the brain. It improves metabolic function, but it also causes type 2 diabetes. This list of contradictions goes on and on; however, there is one thing about Rapamycin that scientists tend to agree on: it is potentially the most powerful anti-aging drug ever discovered." I learned quite a bit from the article: Rapamycin: Unlucky history of the most powerful anti-aging drug.

ChatGPT's Empathetic Bedside Manner

In a recent study, healthcare professionals preferred the responses from A.I. over those from flesh-and-blood doctors. Could generative A.I. have a place in the future of healthcare-patient interaction? ChatGPT Has a Better 'Bedside Manner' Than Doctors.

+Quartz has some suggestions on how to get more out of your ChatGPT queries: How to use ChatGPT at work.

Futile Care

The Atlantic had an interesting opinion piece on the importance of end-of-life planning: An ICU nurse reflects on futile care. _"But what I think and feel doesn't matter. What matters is what the patient would think and whether the people who make choices about their care both know what the patient would think and understand the likelihood that their choices will have this result. This is often not the case."

Inside the Upcoming $1.5 Trillion Farm Bill

The Conversation published a peek behind the curtain as the government ramps its efforts to bring forth the next farm bill. These four challenges will shape the next farm bill – and how the U.S. eats.

The Association Between Season Allergies and Mood Disorders

"Not only are the physical symptoms draining, but a growing body of research also shows an association between allergic rhinitis — commonly known as hay fever — and mood disorders like anxiety and depression." How Seasonal Allergies Can Affect Mental Health.

Childhood Obesity

Obesity in U.S. children was already high and was exacerbated by the pandemic.Obesity in children is rising dramatically, and it comes with major – and sometimes lifelong – health consequences talks about the trend and its implications.

Mindfulness and Meditation

The benefits of mindfulness and meditation practice are numerous. The article Mindfulness, meditation, and self-compassion discusses benefits and gives practical steps to begin your practice.

Noggin Reading

Scientists have developed a mind-reading technology powered by A.I. that can decode a person's thoughts into speech. The researchers used functional magnetic resonance imaging (fMRI) and a large language model to analyze brain recordings and translate them into sentences. Although the technology's potential to help those who have lost their ability to speak, like stroke victims, is promising, it raises ethical privacy concerns. Mind-reading technology, powered by A.I., sparks ethical concerns.

Oh, Look At All the Lonely People

A recent study suggests that the brains of lonely people respond to visual stimuli in unique ways, unlike non-lonely people, implying that lonely people may view the world differently. The findings also suggest that being surrounded predominantly by people who view the world differently from oneself may be a risk factor for loneliness. The brains of lonely people process the world differently

Ode to the Human Genome Project

The Economist had an excellent article on the Human Genome Project, How the Human Genome Project revolutionized biology, although I was disappointed not to see the microbiome mentioned. As Julien Davies pointed out, the HGP is incomplete until we understand the role of microbial DNA: In a Map for Human Life, Count the Microbes, Too | Science.

Tweaking Vegetable Genes for Taste

Scientific American published an article on how CRISPR gene editing technology is being used to improve the taste of food: Tweaking Vegetables' Genes Could Make Them Tastier--And You'll Get to Try Them Soon - Scientific American (Thanks Dave Pell - NextDraft)

Doctor Dog

The article How My Dog Knows When I'm Sick is about how dogs can sense when their owners are sick and the signals they use to detect it. According to researchers, dogs can smell changes in their owners, including a virus or bacteria infection. They can also pick up on emotional changes, such as depression or lethargy, through the owner's voice changes. While it's unclear what dogs make of these changes, they may be more curious or suspicious than concerned. Nonetheless, dogs' empathy has significant benefits for human health.

Smell the (Virtual) Roses

Olfaction is tightly coupled with the parts of the brain responsible for emotions and memory. The evocative nature of the sense of smell is why companies are interested in deploying smell in the Metaverse: How to bring scents to the Metaverse and Smelling in V.R. environment possible with new gaming technology.

040 - Terminal Lucidity, Longevity, and Empathetic ChatBots - HealthHippieMD Week In Review

Terminal Lucidity

"Sometimes, people with dementia who hadn't been coherent for years will suddenly revert to their mentally sharp selves for up to several hours -- and then die shortly after." Scientists are interested in the cause of "paradoxical lucidity" and how it might inform the neuroscience of dementia. Scientists are finally taking a closer look at terminal lucidity.

The Hidden Cost of Amazon Clinic

Amazon's foray into healthcare, Amazon Clinic, (011 - CVS, Amazon, and the Disruption of Primary Care, Anxiety Inoculants, Wabi Sabi, and A.I. - HealthHippieMD Week In Review — HealthHippieMD) keeps the monetary cost of seeing a healthcare professional low but at the cost of your medical privacy. "Signing an authorization isn't a "waiver" of your rights, but you're consenting to your data being disclosed for additional purposes, at which point it leaves the protections of HIPAA." The Washington Post explains: Amazon Clinic patients must sign away some privacy rights under HIPAA. (gift article)

Gut Feelings

"As we wait to establish causal influences through clinical trials, clinicians should advise patients suffering from mood disorders to modify their diet by increasing the intake of fresh fruits, vegetables, and whole grains, as these provide the required fuel/fiber to the gut microbiota for their enrichment, and more short-chain fatty acids are produced for the optimal functioning of the body." More evidence that the microbiome and metabolome drive major depressive episodes. Read the manuscript here: Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs. Control Individuals | Depressive Disorders and synopsis here: Disrupted Gut Microbiome a Key Driver of Major Depression?

+More on the link between ultra-processed foods, mental health, and cognition: How Eating Ultra-processed Foods Can Affect Your Mental Health. (gift article)

Learning Man

You've heard of the music/culture festivals Burning Man and Coachella, but did you know there is a similar gathering focused on immersing attendees in education, play, and creation? Yep, 'Learning Man' is becoming a thing

The Mechanics of Smell

These scientists are striving to understand the mechanism behind human olfaction: How a Human Smell Receptor Works Is Finally Revealed.

Loneliness

Vivek Murthy, America's Surgeon General, is back in the news again, talking about the loneliness epidemic: Loneliness is a Health Crisis, Surgeon General Says. Here's How to Combat It. (gift article) Also see his excellent book on the topic: Together: The Healing Power of Human Connection in a Sometimes Lonely World.

The Modern World is Aging You and Your Brain

An interesting article in Wired about studies examining the brains of non-industrialized societies vs. Western Society: The Modern World Is Aging Your Brain. And the manuscript that inspired the article: Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.

Mental Health Chatbots

An article in the N.Y. Times about Pi, an emotional support chatbot: My Weekend With an Emotional Support A.I. Companion. (gift article) These new products remind me of the science fiction movies: Her (film))and Ex Machina (film).) The lines of human characteristics such as empathy and even consciousness are blurring......

"Functional Neurological Disorders"

A long-form read about how Long Covid influences understanding "functional" disorders like ME/CFS (Chronic Fatigue). Contrary to historical thinking, the diseases ARE NOT in the patient's head: We Might Have Long Covid All Wrong

Shady Longevity Research

The quest to conquer aging rages on. Mixed in with traditional scientists are upstarts trying to cash in on a human fountain of youth. Wired had an expose/overview of one of these companies, BioViva, and its founder Liz Parrish: Inside the Secretive Life-Extension Clinic.

Run AwAI

AI has constantly been in the news since last November when OpenAI made its public debut. This week President Biden hosted a meeting at the White House concerning the dangers of A.I. Along those lines, one of the scientists who made significant contributions to the birth of A.I. quit his decade-long stint at Google to talk freely about the risks: Geoffrey Hinton leaves Google, warns about the dangers of AI. (gift article)

+AI is getting better at translating brain activity into words: A.I. Is Getting Better at Mind-Reading

Do Ovaries Hold the Secret of Longevity?

The ovaries age much more quickly than the other tissues of the human body. Scientists think understanding why may hold the key to a longer, healthier life: The Secrets of Aging Are Hidden in Your Ovaries.

Seven Types of People You Need in Your Life

Interesting article in TED about the people you need in your life to counteract stress: The seven types of people you need in your life to be resilient

039 - Centenarian Excrement, Creativity, and Cannabinoids - HealthHippieMD Week In Review

How to Make Peace with Your Feelings

How Leaning Into Negative Emotions Can Help Your Mental Health (gift article) is about accepting negative emotions for what they are: part of the human experience. What you do with the experience strongly influences your health and well-being.

Generative AI in Medicine

Wired had a story about ways generative AI will impact medicine, along with several caveats: ChatGPT Can Help Doctors—and Hurt Patients.

The Two Personality Traits that Predict Well-being

If you lack either (I'm strongly introverted, not extroverted), hope is not lost. Study Finds 2 Personality Traits Predict Well-being — But Don't Worry if You Don't Have Them.

The World's Rarest Eye Colors

Do you have one of the six rarest types of eye color? Read What Is the Rarest Eye Color?.

Is Alcohol in Moderation Good for You?

The Great Alcohol Health Flip-Flop Isn't That Hard to Understand—if You Know Who Was Behind It is an interesting article on how the supposed health benefits of a small amount of alcohol have been turned on its head, again.

What You See Is Not Always What You Get

The NY Times had an article about a recent publication in JAMA focused on melatonin gummies: "A team of researchers analyzed 25 melatonin gummy products from different brands and found that 22 contained different amounts of melatonin than what was listed on their labels; one contained only 74 percent of the advertised amount of melatonin, while another had 347 percent of the labeled amount. Yet another product contained no detectable melatonin at all." 22 Out of 25 Melatonin Products Were Mislabeled, Study Finds. (gift article) See also: ConsumerLab: Independent Testing of Supplements and Botanicals.

Hope

The Atlantic had an interesting article, Why Economists Should Study Hope, that discusses why hope is so important and how to cultivate more.

The Quest for Longevity

The Quest for Longevity Is Already Over is an interesting read. One of the points I strongly agree with in the article is that extending healthspan (the length of time one is healthy) is far more important than extending longevity (the length of time one lives).

Oura Partners with Best Buy

I love my Oura smart ring. I've worn mine for years. The hardest part of the purchase process was the sizing. Sizing will be less of an issue as you can soon walk into Best Buy and find a fitting station. The article Oura Is Proof That Smart Rings Are Here to Stay discusses the Oura Ring and some of the upcoming competitors.

Cannabis, Cannabinoids, and Delta-8 THC / Delta-10 THC

Cannabis-derived products like delta-8 THC and delta-10 THC have flooded the US market – two immunologists explain the medicinal benefits and potential risks is a quick overview of some of medicinal and side effects of cannabinoids. The article discusses hemp, cannabis, and a few of the cannabinoids.

Creativity / Rick Rubin

I enjoy writing words and music. I'm not good at either, but the process brings me joy. Rick Rubin's new book is about the creative process: The Creative Act: A Way of Being: Rubin, Rick. I've been a big fan of Rubin's Broken Record Podcast. I also enjoyed watching Rick Rubin: The 60 Minutes Interview - CBS News and hearing him interviewed on Rick Rubin on How to Make Something Great. I'm adding the book to my "must-read" list.

Brainstorming with ChatGPT

Wired had an article on how to brainstorm better with the generative AI platform: 6 Tips for Using ChatGPT to Brainstorm Better

What Can We Learn About Aging from Centenarian Excrement?

The longest-living people have a more diverse microbiome than their less healthy peers. A study published this month, Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures looked at the gut microbiomes of centenarians — individuals who've reached or surpassed a century in age — and compared them against old, middle-aged, and young adults. Their results showed, "regardless of health status, the centenarians had a unique enterotype that is a combination of the two found in young adults aged 20 to 44 — Bacteroides — and older adults — Escherichia and/or Shigella." Read the study synopsis here: Centenarians Have Super Healthy Gut Microbiomes — Can This Help Us Live Longer?

Pill Popping Polypharmacy

"Getting people off drugs is unfamiliar terrain for modern health systems, mostly set up to put patients on them. But that is beginning to change. Doctors, pharmacists, and nurses are setting up "deprescribing networks" to try to spread the word." The Economist published an article on the overprescription of medication: Too many people take too many pills.

FDA-Approved Video Games

Much of my research at Duke focused on using video game technology in healthcare and healthcare education. It was fantastic to read this synopsis of Akili [^1] and EndeavorRX, an FDA-approved video game for treating ADHD. I can think of many more uses of the platform. The story behind an FDA-Approved Video Game Treatment for ADHD

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[^1]: I am an Akili Interactive shareholder.

038 - Ice Cream, Understanding Animal Communication, and Circadian Immunity - HealthHippieMD Week In Review

Wait, Ice Cream Might be Healthy?

I enjoyed the article, Could Ice Cream Possibly Be Good for You?. The report not only discusses the controversial, non-spurious outcome that won't go away but also demonstrates what happens in the scientific world when a new finding bucks traditional thinking. And the article contains puns.....

How Generative AI Will Change the Music Industry

Generative AI is not just for text and image creation. AI-Generated Music Is About to Flood Streaming Platforms discusses how AI is changing the music industry and music itself.....

Amyloidosis

The same misfolded proteins found in Alzheimer's Disease can also be found in other organs. Alzheimer's-Like Diseases Can Affect the Body — Scientists Are Working to Find Out Why is an overview of Amyloidosis and its treatment.

Chartreuse Shortage

For my 21st birthday, some friends bought me Chartreuse, a bright green herbal liqueur. That was the only time I tasted it. But now, even if I wanted more, it might not be possible. Chartreuse is getting more difficult to find. Why Is There a Chartreuse Shortage? Ask the Monks Who Make It.

Altered States of Memory

"Memory is "reconstructive." People actively alter the information they remember according to their biases and expectations." Short-term memories were thought to be less subject to alteration, but a recent study demonstrates otherwise: Our expectations can create fake short-term memories. If you'd like to learn more about the fragility/malleability of memory, take a listen to one of my favorite Revisionist History episodes: Free Brian Williams.

How Ultra-processed Food Starves the Microbiome

Another article on how processing alters food--and not in healthy ways: You Could Be Unknowingly Starving Your Gut Bacteria — But The Fix Is Surprisingly Simple. I feel like a broken record....

Is "Non-Communicable Disease" a Misnomer?

Human ailments such as heart disease were thought to be non-communicable. But findings from microbiome research call that belief into question: The Biggest Microbiome Study Sheds New Light on Shared Health Risks.

Covid, Population Risk, and Personal Risk

There is a 1% mortality rate from COVID. If 1% of COVID-19 cases result in death, does that mean you have a 1% chance of dying if you catch it?

FDA Approves Second Bivalent COVID Booster

"Federal health officials will not formally urge that people get a second booster. Instead, the "permissive" policy says they may get a second dose if they want." FDA okays second omicron booster for people at high risk from covid

Why Does Hair Turn Grey?

"A new study suggests stem cells may get stuck as hair ages and lose their ability to mature and maintain hair color." Scientists may have discovered why hair turns grey._

Belated Happy Waldo Day!

This week marked 4/20. In honor of the day, Longreads compiled a list of cannabis-related stories: Weed Between the Lines: A Longreads Cannabis Collection.

Talking to the Animals

I've often joked that I wish Theodore, a six-year-old Labradoodle, could talk. Now, thanks to AI and bioacoustics, my wish may become a reality: How Scientists Are Using AI to Talk to Animals.

Food and Hot Flashes

We don't understand the physiology of hot flashes, but it appears food can influence the severity of this common occurrence: Could Certain Foods Help With Hot Flashes? (gift article)

Us versus Them

"It's been said, "There are two kinds of people in the world: those who divide the world into two kinds of people and those who don't." In reality, there are lots more of the former. And it can be vastly consequential when people are divided into Us and Them, ingroup and outgroup, "the people" (i.e., our kind) and the Others." An stimulating article in Nautilus about us/them dichotomies: Why Your Brain Hates Other People.

Reinvent Yourself According to Experts

Giving credence to your "possible selves" is an evidence-based way to reinvent yourself. How to Reinvent Yourself, According to the Experts tells you how. See also the fantastic podcast: zigzag project.

A Key Character Trait for Happiness

Enthusiasm Is Key to Happiness is an interesting article that touches on psychology and finishes with ways of improving your happiness, regardless of personality type.

Huge Umbrella Analysis of Dietary Sugar

The British Medical Journal published an article that aggregated a huge (8600+) studies on the effects of sugar on health outcomes: Dietary sugar consumption and health: an umbrella review. Read the synopsis here: Study Offers Dozens of Reasons to Cut Sugar

Circadian Rhythms and Immunity

How Circadian Rhythms and Time of Day Control the Immune System describes recent breakthroughs into how our body's internal clock seems to regulate immunity and susceptibility to disease.

037 - Deep Fakes, Dangerous Cheese, and Astronaut Nutrition - HealthHippieMD Week In Review

The Most Dangerous Cheese in the World

Casu marzu, or "rotten cheese," is a delicacy in Sardinia, Italy. The cheese is also illegal in the U.S. due to food safety laws regarding eating food with insects and parasites. Despite the cheese's legal status, "epicurious" individuals are figuring out ways to give it a try: Would You Eat Casu Marzu, the Illegal Cheese With Maggots?

New Insights into Aging

Research on how stem cells destroy aberrant material offers new insight into the aging process: Stem Cell' Junk Yards' Reveal a New Clue About Aging.

Fighting Antimicrobial Resistance

Another call for the government to reign in the misuse of antibiotics in livestock: To Fight Antimicrobial Resistance, Start with Farm Animals. See my old opinion piece in the Huffington Post on the same topic: Antibiotics, Obesity and You.

How to Detect Lies

"A new study demonstrates that simply focusing on the level of detail in a person's story can be a surprisingly accurate way to detect a lie. The more detail there is, the less likely that a story is fabricated." Here's a simple way to detect lies — that works.

Brain Tempo

A new study out of Australia shows that "Changing between slow and fast integration of information, the brain can flexibly modulate the timescales on which it operates." How the Brain Slows Down When We Focus Our Gaze.

Turning Negative Thinkers Into Positive Ones

The NY Times, back in 2017, published an interesting article on fostering positive emotions. Well worth a (re)read: Turning Negative Thinkers Into Positive Ones. (gift article)

Help, Heard, or Hug?

A simple question can improve the quality of communication in relationships: Helped, Heard, or Hugged? What to Ask When Someone You Love Is Upset. (gift article)

Ghosting Between Friends

Ghosting doesn't just happen on the dating scene. Ghosting by a friend hurts just as much (or more) than that experienced in the apps. What to Do if a Friend Ghosts You. (gift article)

Hibernating Bears

Bears hibernate for a good portion of the year, but unlike other mammals, they don't suffer from blood clots and other cardiovascular problems from their long bouts of inactivity. These scientists are trying to understand why: Hibernating Bears Reveal How to Prevent Blood Clots in Humans.

How to Argue Effectively

Disagreements are inevitable. Here are some strategies to argue more effectively: Harvard negotiator explains how to argue.

Self-Aware Fish

I enjoyed the article, Are Fish Self-Aware? that touches on animal cognition and consciousness. The article also highlights a problem with science and scientific publication: entrenched, dogmatic ideas are defended vehemently by their proponents, even when there is plenty of evidence to refute their beliefs.

Two States Want to Ban Food Additives Linked to Health Concerns

What do Red dye no.3, titanium dioxide, brominated vegetable oil, potassium bromate, and propylparaben have in common? They are all common in certain processed foods and could soon be banned in N.Y. and C.A. The food industry is vehemently opposed: California and New York Could Ban 5 Food Additives Linked to Health Concerns. (gift article)

London Lonely Girls Club

She was lonely. She started a friends club, and 35,000 people joined (gift article) tells the story of how one lonely woman started a club to fight her isolation. Similar groups are emerging throughout the world.

The Positive Side of Anxiety

Anxiety causes much suffering, but there is an upside to worry as well: Positive strengths of having anxiety.

Out-of-this-World Nutrition

Here is an interesting article about the program researching the impact of diet on well-being in space: Diet-Mental Health Relationship in Astronaut Performance.

Deep Fakes in Space

Curious about deep fakes (A.I. generated videos)? To Make a Deepfake is a fascinating video from Scientific American that touches on the technology and its implications using the context of a Richard Nixon speech.